Location: A review of cardiac cellular electrophysiology models @ 0b61cf0bc2ee / models / 1991_luo / experiments / generic.xml

Author:
David Nickerson <nickerso@users.sourceforge.net>
Date:
2010-07-06 16:55:39+12:00
Desc:
correcting errors found with newer versions of the CellML API: e-notation; namespace; and an initial value is required for state variables. The initial value on x1 fixes the problem reported on tracker item 2521
Permanent Source URI:
https://models.physiomeproject.org/workspace/a1/rawfile/0b61cf0bc2ee4a696e08c67f233a2b5708b66974/models/1991_luo/experiments/generic.xml

<?xml version="1.0"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" name="luo_rudy_I_model_1991_experiment_model" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
  <import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="../luo_rudy_I_model_1991_variable_values_model.xml">
    <component component_ref="parameters" name="parameters"/>
    <component component_ref="initial_values" name="initial_values"/>
  </import>
  <import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="../luo_rudy_I_model_1991_interface_model.xml">
    <component component_ref="luo_rudy_I_model_1991_interface_component" name="luo_rudy_I_model_1991_interface_component"/>
  </import>
  <connection>
    <map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="parameters"/>
    <map_variables variable_1="R" variable_2="R"/>
    <map_variables variable_1="T" variable_2="T"/>
    <map_variables variable_1="F" variable_2="F"/>
    <map_variables variable_1="C" variable_2="C"/>
    <map_variables variable_1="g_Na" variable_2="g_Na"/>
    <map_variables variable_1="E_Na" variable_2="E_Na"/>
    <map_variables variable_1="g_si" variable_2="g_si"/>
    <map_variables variable_1="g_K" variable_2="g_K"/>
    <map_variables variable_1="PR_NaK" variable_2="PR_NaK"/>
    <map_variables variable_1="g_K1" variable_2="g_K1"/>
    <map_variables variable_1="g_Kp" variable_2="g_Kp"/>
    <map_variables variable_1="E_b" variable_2="E_b"/>
    <map_variables variable_1="g_b" variable_2="g_b"/>
    <map_variables variable_1="Nao" variable_2="Nao"/>
    <map_variables variable_1="Nai" variable_2="Nai"/>
    <map_variables variable_1="Cao" variable_2="Cao"/>
    <map_variables variable_1="Ki" variable_2="Ki"/>
  </connection>
  <connection>
    <map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="initial_values"/>
    <map_variables variable_1="V_initial" variable_2="V_initial"/>
    <map_variables variable_1="m_initial" variable_2="m_initial"/>
    <map_variables variable_1="h_initial" variable_2="h_initial"/>
    <map_variables variable_1="j_initial" variable_2="j_initial"/>
    <map_variables variable_1="d_initial" variable_2="d_initial"/>
    <map_variables variable_1="f_initial" variable_2="f_initial"/>
    <map_variables variable_1="X_initial" variable_2="X_initial"/>
    <map_variables variable_1="Cai_initial" variable_2="Cai_initial"/>
  </connection>
  <component name="time" cmeta:id="time_component">
    <rdf:RDF
      xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
      xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
      <rdf:Description rdf:about="#time_component">
        <cmeta:comment rdf:parseType="Resource">
          <rdf:value>
            The actual definition of the time variable.
          </rdf:value>
        </cmeta:comment>
      </rdf:Description>
    </rdf:RDF>
    <variable name="time" cmeta:id="time" initial_value="0.0" public_interface="out" units="ms"/>
  </component>
  <connection>
    <map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="time"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>

  <import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="../../protocols/single-pulse-IStim.xml">
    <component name="stimulus_protocol" component_ref="stimulus_protocol"/>
  </import>
  
  <component name="stimulus_parameters" cmeta:id="stimulus_parameters">
    <rdf:RDF
      xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
      xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
      <rdf:Description rdf:about="#stimulus_parameters">
        <cmeta:comment rdf:parseType="Resource">
          <rdf:value>
            Here we define the parameters for the standard stimulus protocol we import for this experiment.
          </rdf:value>
        </cmeta:comment>
      </rdf:Description>
    </rdf:RDF>
    <variable name="stimTime" initial_value="100" public_interface="out" units="ms"/>
    <variable name="stimDuration" initial_value="1.0" public_interface="out" units="ms"/>
    <variable name="stimCurrent" initial_value="100" public_interface="out" units="uA_per_mmcu"/>
    <variable name="Am" initial_value="200" public_interface="out" units="per_mm"/>
  </component>
  <connection>
    <map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="stimulus_protocol"/>
    <map_variables variable_1="I_stim" variable_2="IStim"/>
  </connection>
  <connection>
    <map_components component_1="time" component_2="stimulus_protocol"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="stimulus_parameters" component_2="stimulus_protocol"/>
    <map_variables variable_1="stimTime" variable_2="stimTime"/>
    <map_variables variable_1="stimDuration" variable_2="stimDuration"/>
    <map_variables variable_1="stimCurrent" variable_2="stimCurrent"/>
    <map_variables variable_1="Am" variable_2="Am"/>
  </connection>

  <component name="interface">
    <variable name="Ko" private_interface="out" public_interface="in" units="concentration_units"/>
  </component>
  <connection>
    <map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="interface"/>
    <map_variables variable_1="Ko" variable_2="Ko"/>
  </connection>
  <group>
    <relationship_ref relationship="encapsulation"/>
    <component_ref component="interface">
      <component_ref component="luo_rudy_I_model_1991_interface_component"/>
      <component_ref component="time"/>
      <component_ref component="parameters"/>
      <component_ref component="initial_values"/>
      <component_ref component="stimulus_protocol"/>
      <component_ref component="stimulus_parameters"/>
    </component_ref>
  </group>
  <import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="../luo_rudy_I_model_1991_units_model.xml">
    <units name="ms" units_ref="ms"/>
    <units name="per_ms" units_ref="per_ms"/>
    <units name="mV" units_ref="mV"/>
    <units name="per_mV" units_ref="per_mV"/>
    <units name="per_mV_ms" units_ref="per_mV_ms"/>
    <units name="mS_per_mm2" units_ref="mS_per_mm2"/>
    <units name="uF_per_mm2" units_ref="uF_per_mm2"/>
    <units name="uA_per_mm2" units_ref="uA_per_mm2"/>
    <units name="concentration_units" units_ref="concentration_units"/>
    <units name="gas_constant_units" units_ref="gas_constant_units"/>
    <units name="faradays_constant_units" units_ref="faradays_constant_units"/>
  </import>
  <import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="../../common/units.xml">
    <units name="per_mm" units_ref="per_mm"/>
    <units name="uA_per_mmcu" units_ref="uA_per_mmcu"/>
  </import>
</model>