Location: Computational analysis of the human sinus node action potential @ 2408209b7612 / HumanSAN_Fabbri_Fantini_Wilders_Severi_2017.cellml

Author:
nima <nafs080@aucklanduni.ac.nz>
Date:
2021-09-14 11:51:06+12:00
Desc:
matplotlib.use('agg') is added
Permanent Source URI:
https://models.physiomeproject.org/workspace/648/rawfile/2408209b761288e46e32e5ad86d7ee30ae110579/HumanSAN_Fabbri_Fantini_Wilders_Severi_2017.cellml

<?xml version='1.0' encoding='UTF-8'?>
<!--
This CellML file was generated on 24/01/2017 at 12:48:23 using:

COR (0.9.31.1409)
Copyright 2002-2017 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk

CellML 1.0 was used to generate this model
http://www.cellml.org/
-->
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                                    <cn cellml:units="dimensionless">1</cn>
                                    <apply>
                                        <exp/>
                                        <apply>
                                            <divide/>
                                            <apply>
                                                <minus/>
                                                <apply>
                                                    <minus/>
                                                    <apply>
                                                        <minus/>
                                                        <apply>
                                                            <plus/>
                                                            <ci>V</ci>
                                                            <cn cellml:units="millivolt">97.134</cn>
                                                        </apply>
                                                        <ci>ACh_shift</ci>
                                                    </apply>
                                                    <ci>Iso_shift</ci>
                                                </apply>
                                                <ci>y_shift</ci>
                                            </apply>
                                            <cn cellml:units="millivolt">8.1752</cn>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <lt/>
                            <ci>V</ci>
                            <apply>
                                <minus/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <minus/>
                                            <cn cellml:units="millivolt">80</cn>
                                            <ci>ACh_shift</ci>
                                        </apply>
                                        <ci>Iso_shift</ci>
                                    </apply>
                                    <ci>y_shift</ci>
                                </apply>
                            </apply>
                        </apply>
                    </piece>
                    <otherwise>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">0.0002501</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <minus/>
                                            <apply>
                                                <minus/>
                                                <apply>
                                                    <minus/>
                                                    <ci>V</ci>
                                                    <ci>ACh_shift</ci>
                                                </apply>
                                                <ci>Iso_shift</ci>
                                            </apply>
                                            <ci>y_shift</ci>
                                        </apply>
                                    </apply>
                                    <cn cellml:units="millivolt">12.861</cn>
                                </apply>
                            </apply>
                        </apply>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>y</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>y_infinity</ci>
                        <ci>y</ci>
                    </apply>
                    <ci>tau_y</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_NaK">
        <variable name="i_NaK" public_interface="out" units="nanoA"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable initial_value="1.4" name="Km_Kp" units="millimolar"/>
        <variable initial_value="14" name="Km_Nap" units="millimolar"/>
        <variable initial_value="0.08105" name="i_NaK_max" units="nanoA"/>
        <variable name="Nai" public_interface="in" units="millimolar"/>
        <variable name="Ko" public_interface="in" units="millimolar"/>
        <variable name="E_Na" public_interface="in" units="millivolt"/>
        <variable name="Iso_increase" units="dimensionless"/>
        <variable name="Iso_1_uM" private_interface="out" public_interface="in" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>Iso_increase</ci>
                <piecewise>
                    <piece>
                        <cn cellml:units="dimensionless">1.2</cn>
                        <apply>
                            <gt/>
                            <ci>Iso_1_uM</ci>
                            <cn cellml:units="dimensionless">0</cn>
                        </apply>
                    </piece>
                    <otherwise>
                        <cn cellml:units="dimensionless">1</cn>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <ci>i_NaK</ci>
                <apply>
                    <times/>
                    <ci>Iso_increase</ci>
                    <ci>i_NaK_max</ci>
                    <apply>
                        <power/>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <power/>
                                <apply>
                                    <divide/>
                                    <ci>Km_Kp</ci>
                                    <ci>Ko</ci>
                                </apply>
                                <cn cellml:units="dimensionless">1.2</cn>
                            </apply>
                        </apply>
                        <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">1</cn>
                        </apply>
                    </apply>
                    <apply>
                        <power/>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <power/>
                                <apply>
                                    <divide/>
                                    <ci>Km_Nap</ci>
                                    <ci>Nai</ci>
                                </apply>
                                <cn cellml:units="dimensionless">1.3</cn>
                            </apply>
                        </apply>
                        <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">1</cn>
                        </apply>
                    </apply>
                    <apply>
                        <power/>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <plus/>
                                            <apply>
                                                <minus/>
                                                <ci>V</ci>
                                                <ci>E_Na</ci>
                                            </apply>
                                            <cn cellml:units="millivolt">110</cn>
                                        </apply>
                                    </apply>
                                    <cn cellml:units="millivolt">20</cn>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">1</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_NaCa">
        <variable name="i_NaCa" public_interface="out" units="nanoA"/>
        <variable initial_value="3.343" name="K_NaCa" units="nanoA"/>
        <variable name="x1" units="dimensionless"/>
        <variable name="x2" units="dimensionless"/>
        <variable name="x3" units="dimensionless"/>
        <variable name="x4" units="dimensionless"/>
        <variable name="k41" units="dimensionless"/>
        <variable name="k34" units="dimensionless"/>
        <variable name="k23" units="dimensionless"/>
        <variable name="k21" units="dimensionless"/>
        <variable name="k32" units="dimensionless"/>
        <variable name="k43" units="dimensionless"/>
        <variable name="k12" units="dimensionless"/>
        <variable name="k14" units="dimensionless"/>
        <variable initial_value="0.1369" name="Qci" units="dimensionless"/>
        <variable initial_value="0.4315" name="Qn" units="dimensionless"/>
        <variable initial_value="0" name="Qco" units="dimensionless"/>
        <variable initial_value="26.44" name="K3ni" units="millimolar"/>
        <variable initial_value="0.0207" name="Kci" units="millimolar"/>
        <variable initial_value="395.3" name="K1ni" units="millimolar"/>
        <variable initial_value="2.289" name="K2ni" units="millimolar"/>
        <variable initial_value="26.44" name="Kcni" units="millimolar"/>
        <variable initial_value="4.663" name="K3no" units="millimolar"/>
        <variable initial_value="1628" name="K1no" units="millimolar"/>
        <variable initial_value="561.4" name="K2no" units="millimolar"/>
        <variable initial_value="3.663" name="Kco" units="millimolar"/>
        <variable name="do" units="dimensionless"/>
        <variable name="di" units="dimensionless"/>
        <variable name="Cao" public_interface="in" units="millimolar"/>
        <variable name="Nao" public_interface="in" units="millimolar"/>
        <variable name="Ca_sub" public_interface="in" units="millimolar"/>
        <variable name="Nai" public_interface="in" units="millimolar"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="RTONF" public_interface="in" units="millivolt"/>
        <variable initial_value="0" name="blockade_NaCa" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_NaCa</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <ci>blockade_NaCa</ci>
                        </apply>
                        <ci>K_NaCa</ci>
                        <apply>
                            <minus/>
                            <apply>
                                <times/>
                                <ci>x2</ci>
                                <ci>k21</ci>
                            </apply>
                            <apply>
                                <times/>
                                <ci>x1</ci>
                                <ci>k12</ci>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>x1</ci>
                        <ci>x2</ci>
                        <ci>x3</ci>
                        <ci>x4</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>x1</ci>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <ci>k41</ci>
                        <ci>k34</ci>
                        <apply>
                            <plus/>
                            <ci>k23</ci>
                            <ci>k21</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k21</ci>
                        <ci>k32</ci>
                        <apply>
                            <plus/>
                            <ci>k43</ci>
                            <ci>k41</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>x2</ci>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <ci>k32</ci>
                        <ci>k43</ci>
                        <apply>
                            <plus/>
                            <ci>k14</ci>
                            <ci>k12</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k41</ci>
                        <ci>k12</ci>
                        <apply>
                            <plus/>
                            <ci>k34</ci>
                            <ci>k32</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>x3</ci>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <ci>k14</ci>
                        <ci>k43</ci>
                        <apply>
                            <plus/>
                            <ci>k23</ci>
                            <ci>k21</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k12</ci>
                        <ci>k23</ci>
                        <apply>
                            <plus/>
                            <ci>k43</ci>
                            <ci>k41</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>x4</ci>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <ci>k23</ci>
                        <ci>k34</ci>
                        <apply>
                            <plus/>
                            <ci>k14</ci>
                            <ci>k12</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k14</ci>
                        <ci>k21</ci>
                        <apply>
                            <plus/>
                            <ci>k34</ci>
                            <ci>k32</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k43</ci>
                <apply>
                    <divide/>
                    <ci>Nai</ci>
                    <apply>
                        <plus/>
                        <ci>K3ni</ci>
                        <ci>Nai</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k12</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <divide/>
                            <ci>Ca_sub</ci>
                            <ci>Kci</ci>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <apply>
                                        <minus/>
                                        <ci>Qci</ci>
                                    </apply>
                                    <ci>V</ci>
                                </apply>
                                <ci>RTONF</ci>
                            </apply>
                        </apply>
                    </apply>
                    <ci>di</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k14</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <apply>
                                    <divide/>
                                    <ci>Nai</ci>
                                    <ci>K1ni</ci>
                                </apply>
                                <ci>Nai</ci>
                            </apply>
                            <ci>K2ni</ci>
                        </apply>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <divide/>
                                <ci>Nai</ci>
                                <ci>K3ni</ci>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <ci>Qn</ci>
                                    <ci>V</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">2</cn>
                                    <ci>RTONF</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <ci>di</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k41</ci>
                <apply>
                    <exp/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <ci>Qn</ci>
                            </apply>
                            <ci>V</ci>
                        </apply>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">2</cn>
                            <ci>RTONF</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>di</ci>
                <apply>
                    <plus/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <times/>
                        <apply>
                            <divide/>
                            <ci>Ca_sub</ci>
                            <ci>Kci</ci>
                        </apply>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <times/>
                                        <apply>
                                            <minus/>
                                            <ci>Qci</ci>
                                        </apply>
                                        <ci>V</ci>
                                    </apply>
                                    <ci>RTONF</ci>
                                </apply>
                            </apply>
                            <apply>
                                <divide/>
                                <ci>Nai</ci>
                                <ci>Kcni</ci>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <apply>
                            <divide/>
                            <ci>Nai</ci>
                            <ci>K1ni</ci>
                        </apply>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <times/>
                                <apply>
                                    <divide/>
                                    <ci>Nai</ci>
                                    <ci>K2ni</ci>
                                </apply>
                                <apply>
                                    <plus/>
                                    <cn cellml:units="dimensionless">1</cn>
                                    <apply>
                                        <divide/>
                                        <ci>Nai</ci>
                                        <ci>K3ni</ci>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k34</ci>
                <apply>
                    <divide/>
                    <ci>Nao</ci>
                    <apply>
                        <plus/>
                        <ci>K3no</ci>
                        <ci>Nao</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k21</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <divide/>
                            <ci>Cao</ci>
                            <ci>Kco</ci>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <ci>Qco</ci>
                                    <ci>V</ci>
                                </apply>
                                <ci>RTONF</ci>
                            </apply>
                        </apply>
                    </apply>
                    <ci>do</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k23</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <apply>
                                    <divide/>
                                    <ci>Nao</ci>
                                    <ci>K1no</ci>
                                </apply>
                                <ci>Nao</ci>
                            </apply>
                            <ci>K2no</ci>
                        </apply>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <divide/>
                                <ci>Nao</ci>
                                <ci>K3no</ci>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <apply>
                                        <minus/>
                                        <ci>Qn</ci>
                                    </apply>
                                    <ci>V</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">2</cn>
                                    <ci>RTONF</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <ci>do</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k32</ci>
                <apply>
                    <exp/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <ci>Qn</ci>
                            <ci>V</ci>
                        </apply>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">2</cn>
                            <ci>RTONF</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>do</ci>
                <apply>
                    <plus/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <times/>
                        <apply>
                            <divide/>
                            <ci>Cao</ci>
                            <ci>Kco</ci>
                        </apply>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <times/>
                                        <ci>Qco</ci>
                                        <ci>V</ci>
                                    </apply>
                                    <ci>RTONF</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <apply>
                            <divide/>
                            <ci>Nao</ci>
                            <ci>K1no</ci>
                        </apply>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <times/>
                                <apply>
                                    <divide/>
                                    <ci>Nao</ci>
                                    <ci>K2no</ci>
                                </apply>
                                <apply>
                                    <plus/>
                                    <cn cellml:units="dimensionless">1</cn>
                                    <apply>
                                        <divide/>
                                        <ci>Nao</ci>
                                        <ci>K3no</ci>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_Na">
        <variable name="i_Na_" public_interface="out" units="nanoA"/>
        <variable name="i_Na_L" public_interface="out" units="nanoA"/>
        <variable name="i_Na" public_interface="out" units="nanoA"/>
        <variable initial_value="0.0223" name="g_Na" units="microS"/>
        <variable initial_value="0" name="g_Na_L" units="microS"/>
        <variable name="E_mh" units="millivolt"/>
        <variable name="time" private_interface="out" public_interface="in" units="second"/>
        <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
        <variable name="RTONF" public_interface="in" units="millivolt"/>
        <variable name="Nao" public_interface="in" units="millimolar"/>
        <variable name="Nai" public_interface="in" units="millimolar"/>
        <variable name="Ko" public_interface="in" units="millimolar"/>
        <variable name="Ki" public_interface="in" units="millimolar"/>
        <variable name="m" private_interface="in" units="dimensionless"/>
        <variable name="h" private_interface="in" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>E_mh</ci>
                <apply>
                    <times/>
                    <ci>RTONF</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <divide/>
                            <apply>
                                <plus/>
                                <ci>Nao</ci>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">0.12</cn>
                                    <ci>Ko</ci>
                                </apply>
                            </apply>
                            <apply>
                                <plus/>
                                <ci>Nai</ci>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">0.12</cn>
                                    <ci>Ki</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_Na_</ci>
                <apply>
                    <times/>
                    <ci>g_Na</ci>
                    <apply>
                        <power/>
                        <ci>m</ci>
                        <cn cellml:units="dimensionless">3</cn>
                    </apply>
                    <ci>h</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_mh</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_Na_L</ci>
                <apply>
                    <times/>
                    <ci>g_Na_L</ci>
                    <apply>
                        <power/>
                        <ci>m</ci>
                        <cn cellml:units="dimensionless">3</cn>
                    </apply>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_mh</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_Na</ci>
                <apply>
                    <plus/>
                    <ci>i_Na_</ci>
                    <ci>i_Na_L</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_Na_m_gate">
        <variable initial_value="0.447724" name="m" public_interface="out" units="dimensionless"/>
        <variable name="alpha_m" units="per_second"/>
        <variable name="beta_m" units="per_second"/>
        <variable name="m_infinity" units="dimensionless"/>
        <variable name="tau_m" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable initial_value="1e-5" name="delta_m" units="millivolt"/>
        <variable name="E0_m" units="millivolt"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>m_infinity</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <plus/>
                                        <ci>V</ci>
                                        <cn cellml:units="millivolt">42.0504</cn>
                                    </apply>
                                </apply>
                                <cn cellml:units="millivolt">8.3106</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>E0_m</ci>
                <apply>
                    <plus/>
                    <ci>V</ci>
                    <cn cellml:units="millivolt">41</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_m</ci>
                <piecewise>
                    <piece>
                        <cn cellml:units="per_second">2000</cn>
                        <apply>
                            <lt/>
                            <apply>
                                <abs/>
                                <ci>E0_m</ci>
                            </apply>
                            <ci>delta_m</ci>
                        </apply>
                    </piece>
                    <otherwise>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <cn cellml:units="per_millivolt_second">200</cn>
                                <ci>E0_m</ci>
                            </apply>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">1</cn>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <times/>
                                        <apply>
                                            <minus/>
                                            <cn cellml:units="per_millivolt">0.1</cn>
                                        </apply>
                                        <ci>E0_m</ci>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <ci>beta_m</ci>
                <apply>
                    <times/>
                    <cn cellml:units="per_second">8000</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <cn cellml:units="per_millivolt">0.056</cn>
                            </apply>
                            <apply>
                                <plus/>
                                <ci>V</ci>
                                <cn cellml:units="millivolt">66</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_m</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <ci>alpha_m</ci>
                        <ci>beta_m</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>m</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>m_infinity</ci>
                        <ci>m</ci>
                    </apply>
                    <ci>tau_m</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_Na_h_gate">
        <variable initial_value="0.003058" name="h" public_interface="out" units="dimensionless"/>
        <variable name="alpha_h" units="per_second"/>
        <variable name="beta_h" units="per_second"/>
        <variable name="h_infinity" units="dimensionless"/>
        <variable name="tau_h" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>h_infinity</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">69.804</cn>
                                </apply>
                                <cn cellml:units="millivolt">4.4565</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_h</ci>
                <apply>
                    <times/>
                    <cn cellml:units="per_second">20</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <cn cellml:units="per_millivolt">0.125</cn>
                            </apply>
                            <apply>
                                <plus/>
                                <ci>V</ci>
                                <cn cellml:units="millivolt">75</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_h</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="per_second">2000</cn>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">320</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <times/>
                                    <apply>
                                        <minus/>
                                        <cn cellml:units="per_millivolt">0.1</cn>
                                    </apply>
                                    <apply>
                                        <plus/>
                                        <ci>V</ci>
                                        <cn cellml:units="millivolt">75</cn>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                        <cn cellml:units="dimensionless">1</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_h</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <ci>alpha_h</ci>
                        <ci>beta_h</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>h</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>h_infinity</ci>
                        <ci>h</ci>
                    </apply>
                    <ci>tau_h</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_CaL">
        <variable name="i_CaL" public_interface="out" units="nanoA"/>
        <variable name="i_siCa" public_interface="out" units="nanoA"/>
        <variable name="i_siK" public_interface="out" units="nanoA"/>
        <variable name="i_siNa" public_interface="out" units="nanoA"/>
        <variable name="ACh_block" units="dimensionless"/>
        <variable name="ACh" public_interface="in" units="millimolar"/>
        <variable name="time" private_interface="out" public_interface="in" units="second"/>
        <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
        <variable initial_value="0.4578" name="P_CaL" units="nanoA_per_millimolar"/>
        <variable name="RTONF" public_interface="in" units="millivolt"/>
        <variable name="Nao" public_interface="in" units="millimolar"/>
        <variable name="Nai" public_interface="in" units="millimolar"/>
        <variable name="Ko" public_interface="in" units="millimolar"/>
        <variable name="Ki" public_interface="in" units="millimolar"/>
        <variable name="Cao" public_interface="in" units="millimolar"/>
        <variable name="Ca_sub" private_interface="out" public_interface="in" units="millimolar"/>
        <variable name="dL" private_interface="in" units="dimensionless"/>
        <variable name="fL" private_interface="in" units="dimensionless"/>
        <variable name="fCa" private_interface="in" units="dimensionless"/>
        <variable name="Iso_increase" units="dimensionless"/>
        <variable name="Iso_1_uM" private_interface="out" public_interface="in" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>Iso_increase</ci>
                <piecewise>
                    <piece>
                        <cn cellml:units="dimensionless">1.23</cn>
                        <apply>
                            <gt/>
                            <ci>Iso_1_uM</ci>
                            <cn cellml:units="dimensionless">0</cn>
                        </apply>
                    </piece>
                    <otherwise>
                        <cn cellml:units="dimensionless">1</cn>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <ci>i_siCa</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">2</cn>
                            <ci>P_CaL</ci>
                            <apply>
                                <minus/>
                                <ci>V</ci>
                                <cn cellml:units="millivolt">0</cn>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <ci>RTONF</ci>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">1</cn>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <divide/>
                                        <apply>
                                            <times/>
                                            <apply>
                                                <minus/>
                                                <cn cellml:units="dimensionless">1</cn>
                                            </apply>
                                            <apply>
                                                <minus/>
                                                <ci>V</ci>
                                                <cn cellml:units="millivolt">0</cn>
                                            </apply>
                                            <cn cellml:units="dimensionless">2</cn>
                                        </apply>
                                        <ci>RTONF</ci>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <ci>Ca_sub</ci>
                        <apply>
                            <times/>
                            <ci>Cao</ci>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <times/>
                                        <apply>
                                            <minus/>
                                            <cn cellml:units="dimensionless">2</cn>
                                        </apply>
                                        <apply>
                                            <minus/>
                                            <ci>V</ci>
                                            <cn cellml:units="millivolt">0</cn>
                                        </apply>
                                    </apply>
                                    <ci>RTONF</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <ci>dL</ci>
                    <ci>fL</ci>
                    <ci>fCa</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_siK</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">0.000365</cn>
                            <ci>P_CaL</ci>
                            <apply>
                                <minus/>
                                <ci>V</ci>
                                <cn cellml:units="millivolt">0</cn>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <ci>RTONF</ci>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">1</cn>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <divide/>
                                        <apply>
                                            <times/>
                                            <apply>
                                                <minus/>
                                                <cn cellml:units="dimensionless">1</cn>
                                            </apply>
                                            <apply>
                                                <minus/>
                                                <ci>V</ci>
                                                <cn cellml:units="millivolt">0</cn>
                                            </apply>
                                        </apply>
                                        <ci>RTONF</ci>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <ci>Ki</ci>
                        <apply>
                            <times/>
                            <ci>Ko</ci>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <times/>
                                        <apply>
                                            <minus/>
                                            <cn cellml:units="dimensionless">1</cn>
                                        </apply>
                                        <apply>
                                            <minus/>
                                            <ci>V</ci>
                                            <cn cellml:units="millivolt">0</cn>
                                        </apply>
                                    </apply>
                                    <ci>RTONF</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <ci>dL</ci>
                    <ci>fL</ci>
                    <ci>fCa</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_siNa</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">0.0000185</cn>
                            <ci>P_CaL</ci>
                            <apply>
                                <minus/>
                                <ci>V</ci>
                                <cn cellml:units="millivolt">0</cn>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <ci>RTONF</ci>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">1</cn>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <divide/>
                                        <apply>
                                            <times/>
                                            <apply>
                                                <minus/>
                                                <cn cellml:units="dimensionless">1</cn>
                                            </apply>
                                            <apply>
                                                <minus/>
                                                <ci>V</ci>
                                                <cn cellml:units="millivolt">0</cn>
                                            </apply>
                                        </apply>
                                        <ci>RTONF</ci>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <ci>Nai</ci>
                        <apply>
                            <times/>
                            <ci>Nao</ci>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <times/>
                                        <apply>
                                            <minus/>
                                            <cn cellml:units="dimensionless">1</cn>
                                        </apply>
                                        <apply>
                                            <minus/>
                                            <ci>V</ci>
                                            <cn cellml:units="millivolt">0</cn>
                                        </apply>
                                    </apply>
                                    <ci>RTONF</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <ci>dL</ci>
                    <ci>fL</ci>
                    <ci>fCa</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>ACh_block</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn cellml:units="dimensionless">0.31</cn>
                        <ci>ACh</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>ACh</ci>
                        <cn cellml:units="millimolar">0.00009</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_CaL</ci>
                <apply>
                    <times/>
                    <apply>
                        <plus/>
                        <ci>i_siCa</ci>
                        <ci>i_siK</ci>
                        <ci>i_siNa</ci>
                    </apply>
                    <apply>
                        <minus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <ci>ACh_block</ci>
                    </apply>
                    <cn cellml:units="dimensionless">1</cn>
                    <ci>Iso_increase</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_CaL_dL_gate">
        <variable initial_value="0.001921" name="dL" public_interface="out" units="dimensionless"/>
        <variable name="dL_infinity" units="dimensionless"/>
        <variable name="tau_dL" units="second"/>
        <variable name="alpha_dL" units="per_second"/>
        <variable name="beta_dL" units="per_second"/>
        <variable name="adVm" units="millivolt"/>
        <variable name="bdVm" units="millivolt"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="Iso_1_uM" public_interface="in" units="dimensionless"/>
        <variable initial_value="4.3371" name="k_dL" units="millivolt"/>
        <variable initial_value="-16.4508" name="V_dL" units="millivolt"/>
        <variable name="Iso_shift_dL" units="millivolt"/>
        <variable name="Iso_slope_dL" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>Iso_shift_dL</ci>
                <piecewise>
                    <piece>
                        <apply>
                            <minus/>
                            <cn cellml:units="millivolt">8</cn>
                        </apply>
                        <apply>
                            <gt/>
                            <ci>Iso_1_uM</ci>
                            <cn cellml:units="dimensionless">0</cn>
                        </apply>
                    </piece>
                    <otherwise>
                        <cn cellml:units="millivolt">0</cn>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <ci>Iso_slope_dL</ci>
                <piecewise>
                    <piece>
                        <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">27</cn>
                        </apply>
                        <apply>
                            <gt/>
                            <ci>Iso_1_uM</ci>
                            <cn cellml:units="dimensionless">0</cn>
                        </apply>
                    </piece>
                    <otherwise>
                        <cn cellml:units="dimensionless">0</cn>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <ci>dL_infinity</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <minus/>
                                            <ci>V</ci>
                                            <ci>V_dL</ci>
                                        </apply>
                                        <ci>Iso_shift_dL</ci>
                                    </apply>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>k_dL</ci>
                                    <apply>
                                        <plus/>
                                        <cn cellml:units="dimensionless">1</cn>
                                        <apply>
                                            <divide/>
                                            <ci>Iso_slope_dL</ci>
                                            <cn cellml:units="dimensionless">100</cn>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_dL</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">0.001</cn>
                    <apply>
                        <plus/>
                        <ci>alpha_dL</ci>
                        <ci>beta_dL</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_dL</ci>
                <apply>
                    <minus/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <cn cellml:units="per_millivolt_second">0.02839</cn>
                            </apply>
                            <apply>
                                <plus/>
                                <ci>adVm</ci>
                                <cn cellml:units="millivolt">41.8</cn>
                            </apply>
                        </apply>
                        <apply>
                            <minus/>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <plus/>
                                            <ci>adVm</ci>
                                            <cn cellml:units="millivolt">41.8</cn>
                                        </apply>
                                    </apply>
                                    <cn cellml:units="millivolt">2.5</cn>
                                </apply>
                            </apply>
                            <cn cellml:units="dimensionless">1</cn>
                        </apply>
                    </apply>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <cn cellml:units="per_millivolt_second">0.0849</cn>
                            <apply>
                                <plus/>
                                <ci>adVm</ci>
                                <cn cellml:units="millivolt">6.8</cn>
                            </apply>
                        </apply>
                        <apply>
                            <minus/>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <plus/>
                                            <ci>adVm</ci>
                                            <cn cellml:units="millivolt">6.8</cn>
                                        </apply>
                                    </apply>
                                    <cn cellml:units="millivolt">4.8</cn>
                                </apply>
                            </apply>
                            <cn cellml:units="dimensionless">1</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>adVm</ci>
                <piecewise>
                    <piece>
                        <apply>
                            <minus/>
                            <cn cellml:units="millivolt">41.80001</cn>
                        </apply>
                        <apply>
                            <eq/>
                            <ci>V</ci>
                            <apply>
                                <minus/>
                                <cn cellml:units="millivolt">41.8</cn>
                            </apply>
                        </apply>
                    </piece>
                    <piece>
                        <cn cellml:units="millivolt">0</cn>
                        <apply>
                            <eq/>
                            <ci>V</ci>
                            <cn cellml:units="millivolt">0</cn>
                        </apply>
                    </piece>
                    <piece>
                        <apply>
                            <minus/>
                            <cn cellml:units="millivolt">6.80001</cn>
                        </apply>
                        <apply>
                            <eq/>
                            <ci>V</ci>
                            <apply>
                                <minus/>
                                <cn cellml:units="millivolt">6.8</cn>
                            </apply>
                        </apply>
                    </piece>
                    <otherwise>
                        <ci>V</ci>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <ci>beta_dL</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn cellml:units="per_millivolt_second">0.01143</cn>
                        <apply>
                            <plus/>
                            <ci>bdVm</ci>
                            <cn cellml:units="millivolt">1.8</cn>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>bdVm</ci>
                                    <cn cellml:units="millivolt">1.8</cn>
                                </apply>
                                <cn cellml:units="millivolt">2.5</cn>
                            </apply>
                        </apply>
                        <cn cellml:units="dimensionless">1</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>bdVm</ci>
                <piecewise>
                    <piece>
                        <apply>
                            <minus/>
                            <cn cellml:units="millivolt">1.80001</cn>
                        </apply>
                        <apply>
                            <eq/>
                            <ci>V</ci>
                            <apply>
                                <minus/>
                                <cn cellml:units="millivolt">1.8</cn>
                            </apply>
                        </apply>
                    </piece>
                    <otherwise>
                        <ci>V</ci>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>dL</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>dL_infinity</ci>
                        <ci>dL</ci>
                    </apply>
                    <ci>tau_dL</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_CaL_fL_gate">
        <variable initial_value="0.846702" name="fL" public_interface="out" units="dimensionless"/>
        <variable name="fL_infinity" units="dimensionless"/>
        <variable name="tau_fL" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable initial_value="0" name="shift_fL" units="millivolt"/>
        <variable initial_value="0" name="k_fL" units="millivolt"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>fL_infinity</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">37.4</cn>
                                    <ci>shift_fL</ci>
                                </apply>
                                <apply>
                                    <plus/>
                                    <cn cellml:units="millivolt">5.3</cn>
                                    <ci>k_fL</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_fL</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">0.001</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="second">44.3</cn>
                        <apply>
                            <times/>
                            <cn cellml:units="second">230</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <power/>
                                        <apply>
                                            <divide/>
                                            <apply>
                                                <plus/>
                                                <ci>V</ci>
                                                <cn cellml:units="millivolt">36</cn>
                                            </apply>
                                            <cn cellml:units="millivolt">10</cn>
                                        </apply>
                                        <cn cellml:units="dimensionless">2</cn>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>fL</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>fL_infinity</ci>
                        <ci>fL</ci>
                    </apply>
                    <ci>tau_fL</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_CaL_fCa_gate">
        <variable initial_value="0.844449" name="fCa" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.0075" name="alpha_fCa" units="per_second"/>
        <variable name="fCa_infinity" units="dimensionless"/>
        <variable name="tau_fCa" units="second"/>
        <variable initial_value="0.000338" name="Km_fCa" units="millimolar"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="Ca_sub" public_interface="in" units="millimolar"/>
        <variable name="time" public_interface="in" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>fCa_infinity</ci>
                <apply>
                    <divide/>
                    <ci>Km_fCa</ci>
                    <apply>
                        <plus/>
                        <ci>Km_fCa</ci>
                        <ci>Ca_sub</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_fCa</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn cellml:units="dimensionless">0.001</cn>
                        <ci>fCa_infinity</ci>
                    </apply>
                    <ci>alpha_fCa</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>fCa</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>fCa_infinity</ci>
                        <ci>fCa</ci>
                    </apply>
                    <ci>tau_fCa</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_CaT">
        <variable name="i_CaT" public_interface="out" units="nanoA"/>
        <variable name="time" private_interface="out" public_interface="in" units="second"/>
        <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
        <variable initial_value="0.04132" name="P_CaT" units="nanoA_per_millimolar"/>
        <variable name="RTONF" public_interface="in" units="millivolt"/>
        <variable name="Cao" public_interface="in" units="millimolar"/>
        <variable name="Ca_sub" private_interface="out" public_interface="in" units="millimolar"/>
        <variable name="dT" private_interface="in" units="dimensionless"/>
        <variable name="fT" private_interface="in" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_CaT</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">2</cn>
                            <ci>P_CaT</ci>
                            <ci>V</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>RTONF</ci>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">1</cn>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <divide/>
                                        <apply>
                                            <times/>
                                            <apply>
                                                <minus/>
                                                <cn cellml:units="dimensionless">1</cn>
                                            </apply>
                                            <ci>V</ci>
                                            <cn cellml:units="dimensionless">2</cn>
                                        </apply>
                                        <ci>RTONF</ci>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <ci>Ca_sub</ci>
                        <apply>
                            <times/>
                            <ci>Cao</ci>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <times/>
                                        <apply>
                                            <minus/>
                                            <cn cellml:units="dimensionless">2</cn>
                                        </apply>
                                        <ci>V</ci>
                                    </apply>
                                    <ci>RTONF</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <ci>dT</ci>
                    <ci>fT</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_CaT_dT_gate">
        <variable initial_value="0.268909" name="dT" public_interface="out" units="dimensionless"/>
        <variable name="dT_infinity" units="dimensionless"/>
        <variable name="tau_dT" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>dT_infinity</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <plus/>
                                        <ci>V</ci>
                                        <cn cellml:units="millivolt">38.3</cn>
                                    </apply>
                                </apply>
                                <cn cellml:units="millivolt">5.5</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_dT</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="second">0.001</cn>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">1.068</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <plus/>
                                        <ci>V</ci>
                                        <cn cellml:units="millivolt">38.3</cn>
                                    </apply>
                                    <cn cellml:units="millivolt">30</cn>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">1.068</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <plus/>
                                            <ci>V</ci>
                                            <cn cellml:units="millivolt">38.3</cn>
                                        </apply>
                                    </apply>
                                    <cn cellml:units="millivolt">30</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>dT</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>dT_infinity</ci>
                        <ci>dT</ci>
                    </apply>
                    <ci>tau_dT</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_CaT_fT_gate">
        <variable initial_value="0.020484" name="fT" public_interface="out" units="dimensionless"/>
        <variable name="fT_infinity" units="dimensionless"/>
        <variable name="tau_fT" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable initial_value="0" name="offset_fT" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>fT_infinity</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">58.7</cn>
                                </apply>
                                <cn cellml:units="millivolt">3.8</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_fT</ci>
                <apply>
                    <plus/>
                    <apply>
                        <divide/>
                        <cn cellml:units="second">1</cn>
                        <apply>
                            <plus/>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless">16.67</cn>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <divide/>
                                        <apply>
                                            <minus/>
                                            <apply>
                                                <plus/>
                                                <ci>V</ci>
                                                <cn cellml:units="millivolt">75</cn>
                                            </apply>
                                        </apply>
                                        <cn cellml:units="millivolt">83.3</cn>
                                    </apply>
                                </apply>
                            </apply>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless">16.67</cn>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <divide/>
                                        <apply>
                                            <plus/>
                                            <ci>V</ci>
                                            <cn cellml:units="millivolt">75</cn>
                                        </apply>
                                        <cn cellml:units="millivolt">15.38</cn>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <ci>offset_fT</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>fT</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>fT_infinity</ci>
                        <ci>fT</ci>
                    </apply>
                    <ci>tau_fT</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Ca_SR_release">
        <variable name="j_SRCarel" public_interface="out" units="millimolar_per_second"/>
        <variable initial_value="0.9308" name="R" units="dimensionless"/>
        <variable initial_value="6.181512e-9" name="O" units="dimensionless"/>
        <variable initial_value="4.595622e-10" name="I" units="dimensionless"/>
        <variable initial_value="0.069199" name="RI" units="dimensionless"/>
        <variable initial_value="148041085.1" name="ks" units="per_second"/>
        <variable initial_value="15" name="MaxSR" units="dimensionless"/>
        <variable initial_value="1" name="MinSR" units="dimensionless"/>
        <variable initial_value="0.45" name="EC50_SR" units="millimolar"/>
        <variable initial_value="2.5" name="HSR" units="dimensionless"/>
        <variable name="koSRCa" units="per_millimolar2_second"/>
        <variable name="kiSRCa" units="per_millimolar_second"/>
        <variable initial_value="10000" name="koCa" units="per_millimolar2_second"/>
        <variable initial_value="500" name="kiCa" units="per_millimolar_second"/>
        <variable name="kCaSR" units="dimensionless"/>
        <variable initial_value="5" name="kim" units="per_second"/>
        <variable initial_value="660" name="kom" units="per_second"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="Ca_sub" public_interface="in" units="millimolar"/>
        <variable name="Ca_jsr" public_interface="in" units="millimolar"/>
        <variable name="diff" units="millimolar"/>
        <variable name="P_tot" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>j_SRCarel</ci>
                <apply>
                    <times/>
                    <ci>ks</ci>
                    <ci>O</ci>
                    <apply>
                        <minus/>
                        <ci>Ca_jsr</ci>
                        <ci>Ca_sub</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>diff</ci>
                <apply>
                    <minus/>
                    <ci>Ca_jsr</ci>
                    <ci>Ca_sub</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>kCaSR</ci>
                <apply>
                    <minus/>
                    <ci>MaxSR</ci>
                    <apply>
                        <divide/>
                        <apply>
                            <minus/>
                            <ci>MaxSR</ci>
                            <ci>MinSR</ci>
                        </apply>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <power/>
                                <apply>
                                    <divide/>
                                    <ci>EC50_SR</ci>
                                    <ci>Ca_jsr</ci>
                                </apply>
                                <ci>HSR</ci>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>koSRCa</ci>
                <apply>
                    <divide/>
                    <ci>koCa</ci>
                    <ci>kCaSR</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>kiSRCa</ci>
                <apply>
                    <times/>
                    <ci>kiCa</ci>
                    <ci>kCaSR</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>R</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <apply>
                            <times/>
                            <ci>kim</ci>
                            <ci>RI</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>kiSRCa</ci>
                            <ci>Ca_sub</ci>
                            <ci>R</ci>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <times/>
                            <ci>koSRCa</ci>
                            <apply>
                                <power/>
                                <ci>Ca_sub</ci>
                                <cn cellml:units="dimensionless">2</cn>
                            </apply>
                            <ci>R</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>kom</ci>
                            <ci>O</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>O</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <apply>
                            <times/>
                            <ci>koSRCa</ci>
                            <apply>
                                <power/>
                                <ci>Ca_sub</ci>
                                <cn cellml:units="dimensionless">2</cn>
                            </apply>
                            <ci>R</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>kom</ci>
                            <ci>O</ci>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <times/>
                            <ci>kiSRCa</ci>
                            <ci>Ca_sub</ci>
                            <ci>O</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>kim</ci>
                            <ci>I</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>I</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <apply>
                            <times/>
                            <ci>kiSRCa</ci>
                            <ci>Ca_sub</ci>
                            <ci>O</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>kim</ci>
                            <ci>I</ci>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <times/>
                            <ci>kom</ci>
                            <ci>I</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>koSRCa</ci>
                            <apply>
                                <power/>
                                <ci>Ca_sub</ci>
                                <cn cellml:units="dimensionless">2</cn>
                            </apply>
                            <ci>RI</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>RI</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <apply>
                            <times/>
                            <ci>kom</ci>
                            <ci>I</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>koSRCa</ci>
                            <apply>
                                <power/>
                                <ci>Ca_sub</ci>
                                <cn cellml:units="dimensionless">2</cn>
                            </apply>
                            <ci>RI</ci>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <times/>
                            <ci>kim</ci>
                            <ci>RI</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>kiSRCa</ci>
                            <ci>Ca_sub</ci>
                            <ci>R</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>P_tot</ci>
                <apply>
                    <plus/>
                    <ci>R</ci>
                    <ci>O</ci>
                    <ci>I</ci>
                    <ci>RI</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Ca_intracellular_fluxes">
        <variable name="j_Ca_dif" public_interface="out" units="millimolar_per_second"/>
        <variable name="j_up" public_interface="out" units="millimolar_per_second"/>
        <variable name="j_tr" public_interface="out" units="millimolar_per_second"/>
        <variable initial_value="5.469e-5" name="tau_dif_Ca" units="second"/>
        <variable initial_value="0.04" name="tau_tr" units="second"/>
        <variable name="P_up" units="millimolar_per_second"/>
        <variable initial_value="5" name="P_up_basal" units="millimolar_per_second"/>
        <variable name="b_up" units="dimensionless"/>
        <variable name="ACh" public_interface="in" units="millimolar"/>
        <variable name="Iso_1_uM" public_interface="in" units="dimensionless"/>
        <variable initial_value="0.000286113" name="K_up" units="millimolar"/>
        <variable name="Ca_nsr" public_interface="in" units="millimolar"/>
        <variable name="Cai" public_interface="in" units="millimolar"/>
        <variable name="Ca_sub" public_interface="in" units="millimolar"/>
        <variable name="Ca_jsr" public_interface="in" units="millimolar"/>
        <variable initial_value="5e-5" name="slope_up" units="millimolar"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>b_up</ci>
                <piecewise>
                    <piece>
                        <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">0.25</cn>
                        </apply>
                        <apply>
                            <gt/>
                            <ci>Iso_1_uM</ci>
                            <cn cellml:units="dimensionless">0</cn>
                        </apply>
                    </piece>
                    <piece>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless">0.7</cn>
                                <ci>ACh</ci>
                            </apply>
                            <apply>
                                <plus/>
                                <cn cellml:units="millimolar">0.00009</cn>
                                <ci>ACh</ci>
                            </apply>
                        </apply>
                        <apply>
                            <gt/>
                            <ci>ACh</ci>
                            <cn cellml:units="millimolar">0</cn>
                        </apply>
                    </piece>
                    <otherwise>
                        <cn cellml:units="dimensionless">0</cn>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <ci>P_up</ci>
                <apply>
                    <times/>
                    <ci>P_up_basal</ci>
                    <apply>
                        <minus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <ci>b_up</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>j_Ca_dif</ci>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>Ca_sub</ci>
                        <ci>Cai</ci>
                    </apply>
                    <ci>tau_dif_Ca</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>j_up</ci>
                <apply>
                    <divide/>
                    <ci>P_up</ci>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <apply>
                                        <minus/>
                                        <ci>Cai</ci>
                                    </apply>
                                    <ci>K_up</ci>
                                </apply>
                                <ci>slope_up</ci>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>j_tr</ci>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>Ca_nsr</ci>
                        <ci>Ca_jsr</ci>
                    </apply>
                    <ci>tau_tr</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Ca_buffering">
        <variable initial_value="0.031" name="TC_tot" public_interface="out" units="millimolar"/>
        <variable initial_value="0.062" name="TMC_tot" public_interface="out" units="millimolar"/>
        <variable initial_value="0.045" name="CM_tot" public_interface="out" units="millimolar"/>
        <variable initial_value="10" name="CQ_tot" public_interface="out" units="millimolar"/>
        <variable name="delta_fTC" public_interface="out" units="per_second"/>
        <variable name="delta_fTMC" public_interface="out" units="per_second"/>
        <variable name="delta_fCMs" public_interface="out" units="per_second"/>
        <variable name="delta_fCMi" public_interface="out" units="per_second"/>
        <variable name="delta_fCQ" public_interface="out" units="per_second"/>
        <variable name="delta_fTMM" units="per_second"/>
        <variable initial_value="0.653777" name="fTMM" units="dimensionless"/>
        <variable initial_value="0.217311" name="fCMi" units="dimensionless"/>
        <variable initial_value="0.158521" name="fCMs" units="dimensionless"/>
        <variable initial_value="0.017929" name="fTC" units="dimensionless"/>
        <variable initial_value="0.259947" name="fTMC" units="dimensionless"/>
        <variable initial_value="0.138975" name="fCQ" units="dimensionless"/>
        <variable initial_value="88800" name="kf_TC" units="per_millimolar_second"/>
        <variable initial_value="2277" name="kf_TMM" units="per_millimolar_second"/>
        <variable initial_value="227700" name="kf_TMC" units="per_millimolar_second"/>
        <variable initial_value="1.642e6" name="kf_CM" units="per_millimolar_second"/>
        <variable initial_value="175.4" name="kf_CQ" units="per_millimolar_second"/>
        <variable initial_value="446" name="kb_TC" units="per_second"/>
        <variable initial_value="7.51" name="kb_TMC" units="per_second"/>
        <variable initial_value="751" name="kb_TMM" units="per_second"/>
        <variable initial_value="542" name="kb_CM" units="per_second"/>
        <variable initial_value="445" name="kb_CQ" units="per_second"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable initial_value="2.5" name="Mgi" units="millimolar"/>
        <variable name="Cai" public_interface="in" units="millimolar"/>
        <variable name="Ca_sub" public_interface="in" units="millimolar"/>
        <variable name="Ca_jsr" public_interface="in" units="millimolar"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>fTC</ci>
                </apply>
                <ci>delta_fTC</ci>
            </apply>
            <apply>
                <eq/>
                <ci>delta_fTC</ci>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>kf_TC</ci>
                        <ci>Cai</ci>
                        <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <ci>fTC</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>kb_TC</ci>
                        <ci>fTC</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>fTMC</ci>
                </apply>
                <ci>delta_fTMC</ci>
            </apply>
            <apply>
                <eq/>
                <ci>delta_fTMC</ci>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>kf_TMC</ci>
                        <ci>Cai</ci>
                        <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <plus/>
                                <ci>fTMC</ci>
                                <ci>fTMM</ci>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>kb_TMC</ci>
                        <ci>fTMC</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>fTMM</ci>
                </apply>
                <ci>delta_fTMM</ci>
            </apply>
            <apply>
                <eq/>
                <ci>delta_fTMM</ci>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>kf_TMM</ci>
                        <ci>Mgi</ci>
                        <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <plus/>
                                <ci>fTMC</ci>
                                <ci>fTMM</ci>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>kb_TMM</ci>
                        <ci>fTMM</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>fCMi</ci>
                </apply>
                <ci>delta_fCMi</ci>
            </apply>
            <apply>
                <eq/>
                <ci>delta_fCMi</ci>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>kf_CM</ci>
                        <ci>Cai</ci>
                        <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <ci>fCMi</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>kb_CM</ci>
                        <ci>fCMi</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>fCMs</ci>
                </apply>
                <ci>delta_fCMs</ci>
            </apply>
            <apply>
                <eq/>
                <ci>delta_fCMs</ci>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>kf_CM</ci>
                        <ci>Ca_sub</ci>
                        <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <ci>fCMs</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>kb_CM</ci>
                        <ci>fCMs</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>fCQ</ci>
                </apply>
                <ci>delta_fCQ</ci>
            </apply>
            <apply>
                <eq/>
                <ci>delta_fCQ</ci>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>kf_CQ</ci>
                        <ci>Ca_jsr</ci>
                        <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <ci>fCQ</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>kb_CQ</ci>
                        <ci>fCQ</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Ca_dynamics">
        <variable initial_value="9.15641e-05" name="Cai" public_interface="out" units="millimolar"/>
        <variable initial_value="0.40758460316336464" name="Ca_nsr" public_interface="out" units="millimolar"/>
        <variable initial_value="0.3704741444853376" name="Ca_jsr" public_interface="out" units="millimolar"/>
        <variable initial_value="5.9426453173741103e-05" name="Ca_sub" public_interface="out" units="millimolar"/>
        <variable name="V_i" public_interface="in" units="millimetre3"/>
        <variable name="V_jsr" public_interface="in" units="millimetre3"/>
        <variable name="V_nsr" public_interface="in" units="millimetre3"/>
        <variable name="V_sub" public_interface="in" units="millimetre3"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="F" public_interface="in" units="coulomb_per_mole"/>
        <variable name="i_siCa" public_interface="in" units="nanoA"/>
        <variable name="i_CaT" public_interface="in" units="nanoA"/>
        <variable name="i_NaCa" public_interface="in" units="nanoA"/>
        <variable name="j_SRCarel" public_interface="in" units="millimolar_per_second"/>
        <variable name="j_Ca_dif" public_interface="in" units="millimolar_per_second"/>
        <variable name="j_tr" public_interface="in" units="millimolar_per_second"/>
        <variable name="j_up" public_interface="in" units="millimolar_per_second"/>
        <variable name="TMC_tot" public_interface="in" units="millimolar"/>
        <variable name="CM_tot" public_interface="in" units="millimolar"/>
        <variable name="TC_tot" public_interface="in" units="millimolar"/>
        <variable name="CQ_tot" public_interface="in" units="millimolar"/>
        <variable name="delta_fTMC" public_interface="in" units="per_second"/>
        <variable name="delta_fCMi" public_interface="in" units="per_second"/>
        <variable name="delta_fCMs" public_interface="in" units="per_second"/>
        <variable name="delta_fTC" public_interface="in" units="per_second"/>
        <variable name="delta_fCQ" public_interface="in" units="per_second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Cai</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <minus/>
                                <apply>
                                    <times/>
                                    <ci>j_Ca_dif</ci>
                                    <ci>V_sub</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>j_up</ci>
                                    <ci>V_nsr</ci>
                                </apply>
                            </apply>
                        </apply>
                        <ci>V_i</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>CM_tot</ci>
                            <ci>delta_fCMi</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>TC_tot</ci>
                            <ci>delta_fTC</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>TMC_tot</ci>
                            <ci>delta_fTMC</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Ca_sub</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <ci>j_SRCarel</ci>
                            <ci>V_jsr</ci>
                        </apply>
                        <ci>V_sub</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <divide/>
                            <apply>
                                <minus/>
                                <apply>
                                    <plus/>
                                    <ci>i_siCa</ci>
                                    <ci>i_CaT</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">2</cn>
                                    <ci>i_NaCa</ci>
                                </apply>
                            </apply>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless">2</cn>
                                <ci>F</ci>
                                <ci>V_sub</ci>
                            </apply>
                        </apply>
                        <ci>j_Ca_dif</ci>
                        <apply>
                            <times/>
                            <ci>CM_tot</ci>
                            <ci>delta_fCMs</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Ca_nsr</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>j_up</ci>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <ci>j_tr</ci>
                            <ci>V_jsr</ci>
                        </apply>
                        <ci>V_nsr</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Ca_jsr</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>j_tr</ci>
                    <apply>
                        <plus/>
                        <ci>j_SRCarel</ci>
                        <apply>
                            <times/>
                            <ci>CQ_tot</ci>
                            <ci>delta_fCQ</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Cell_parameters">
        <variable name="V_sub" public_interface="out" units="millimetre3"/>
        <variable name="V_jsr" public_interface="out" units="millimetre3"/>
        <variable name="V_nsr" public_interface="out" units="millimetre3"/>
        <variable name="V_i" public_interface="out" units="millimetre3"/>
        <variable name="V_cell" units="millimetre3"/>
        <variable initial_value="0.0012" name="V_jsr_part" units="dimensionless"/>
        <variable initial_value="0.46" name="V_i_part" units="dimensionless"/>
        <variable initial_value="0.0116" name="V_nsr_part" units="dimensionless"/>
        <variable initial_value="3.9" name="R_cell" units="micrometre"/>
        <variable initial_value="67" name="L_cell" units="micrometre"/>
        <variable initial_value="0.02" name="L_sub" units="micrometre"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>V_cell</ci>
                <apply>
                    <times/>
                    <cn cellml:units="micrometre_per_femtometre">0.000000001</cn>
                    <pi/>
                    <apply>
                        <power/>
                        <ci>R_cell</ci>
                        <cn cellml:units="dimensionless">2</cn>
                    </apply>
                    <ci>L_cell</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>V_sub</ci>
                <apply>
                    <times/>
                    <cn cellml:units="micrometre_per_femtometre">0.000000001</cn>
                    <cn cellml:units="dimensionless">2</cn>
                    <pi/>
                    <ci>L_sub</ci>
                    <apply>
                        <minus/>
                        <ci>R_cell</ci>
                        <apply>
                            <divide/>
                            <ci>L_sub</ci>
                            <cn cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                    <ci>L_cell</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>V_jsr</ci>
                <apply>
                    <times/>
                    <ci>V_jsr_part</ci>
                    <ci>V_cell</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>V_i</ci>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>V_i_part</ci>
                        <ci>V_cell</ci>
                    </apply>
                    <ci>V_sub</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>V_nsr</ci>
                <apply>
                    <times/>
                    <ci>V_nsr_part</ci>
                    <ci>V_cell</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_Kur">
        <variable name="i_Kur" public_interface="out" units="nanoA"/>
        <variable initial_value="0.1539e-3" name="g_Kur" units="microS"/>
        <variable name="time" private_interface="out" public_interface="in" units="second"/>
        <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
        <variable name="E_K" public_interface="in" units="millivolt"/>
        <variable name="r_Kur" private_interface="in" units="dimensionless"/>
        <variable name="s_Kur" private_interface="in" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_Kur</ci>
                <apply>
                    <times/>
                    <ci>g_Kur</ci>
                    <ci>r_Kur</ci>
                    <ci>s_Kur</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_K</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_Kur_rKur_gate">
        <variable initial_value="0.011845" name="r_Kur" public_interface="out" units="dimensionless"/>
        <variable name="tau_r_Kur" units="second"/>
        <variable name="r_Kur_infinity" units="dimensionless"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>r_Kur</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>r_Kur_infinity</ci>
                        <ci>r_Kur</ci>
                    </apply>
                    <ci>tau_r_Kur</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>r_Kur_infinity</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">6</cn>
                                </apply>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="millivolt">8.6</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_r_Kur</ci>
                <apply>
                    <plus/>
                    <apply>
                        <divide/>
                        <cn cellml:units="second">0.009</cn>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <plus/>
                                        <ci>V</ci>
                                        <cn cellml:units="millivolt">5</cn>
                                    </apply>
                                    <cn cellml:units="millivolt">12</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <cn cellml:units="second">0.0005</cn>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_Kur_sKur_gate">
        <variable initial_value="0.845304" name="s_Kur" public_interface="out" units="dimensionless"/>
        <variable name="tau_s_Kur" units="second"/>
        <variable name="s_Kur_infinity" units="dimensionless"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>s_Kur</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>s_Kur_infinity</ci>
                        <ci>s_Kur</ci>
                    </apply>
                    <ci>tau_s_Kur</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>s_Kur_infinity</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">7.5</cn>
                                </apply>
                                <cn cellml:units="millivolt">10</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_s_Kur</ci>
                <apply>
                    <plus/>
                    <apply>
                        <divide/>
                        <cn cellml:units="second">0.59</cn>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <plus/>
                                        <ci>V</ci>
                                        <cn cellml:units="millivolt">60</cn>
                                    </apply>
                                    <cn cellml:units="millivolt">10</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <cn cellml:units="second">3.05</cn>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_to">
        <variable name="i_to" public_interface="out" units="nanoA"/>
        <variable initial_value="3.5e-3" name="g_to" units="microS"/>
        <variable name="E_K" public_interface="in" units="millivolt"/>
        <variable name="time" private_interface="out" public_interface="in" units="second"/>
        <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
        <variable name="q" private_interface="in" units="dimensionless"/>
        <variable name="r" private_interface="in" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_to</ci>
                <apply>
                    <times/>
                    <ci>g_to</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_K</ci>
                    </apply>
                    <ci>q</ci>
                    <ci>r</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_to_q_gate">
        <variable initial_value="0.430836" name="q" public_interface="out" units="dimensionless"/>
        <variable name="q_infinity" units="dimensionless"/>
        <variable name="tau_q" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>q_infinity</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">49</cn>
                                </apply>
                                <cn cellml:units="millivolt">13</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_q</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">0.001</cn>
                    <cn cellml:units="dimensionless">0.6</cn>
                    <apply>
                        <plus/>
                        <apply>
                            <divide/>
                            <cn cellml:units="dimensionless">65.17</cn>
                            <apply>
                                <plus/>
                                <apply>
                                    <times/>
                                    <cn cellml:units="per_second">0.57</cn>
                                    <apply>
                                        <exp/>
                                        <apply>
                                            <times/>
                                            <apply>
                                                <minus/>
                                                <cn cellml:units="per_millivolt">0.08</cn>
                                            </apply>
                                            <apply>
                                                <plus/>
                                                <ci>V</ci>
                                                <cn cellml:units="millivolt">44</cn>
                                            </apply>
                                        </apply>
                                    </apply>
                                </apply>
                                <apply>
                                    <times/>
                                    <cn cellml:units="per_second">0.065</cn>
                                    <apply>
                                        <exp/>
                                        <apply>
                                            <times/>
                                            <cn cellml:units="per_millivolt">0.1</cn>
                                            <apply>
                                                <plus/>
                                                <ci>V</ci>
                                                <cn cellml:units="millivolt">45.93</cn>
                                            </apply>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                        <cn cellml:units="second">10.1</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>q_infinity</ci>
                        <ci>q</ci>
                    </apply>
                    <ci>tau_q</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_to_r_gate">
        <variable initial_value="0.014523" name="r" public_interface="out" units="dimensionless"/>
        <variable name="r_infinity" units="dimensionless"/>
        <variable name="tau_r" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>r_infinity</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <minus/>
                                        <ci>V</ci>
                                        <cn cellml:units="millivolt">19.3</cn>
                                    </apply>
                                </apply>
                                <cn cellml:units="millivolt">15</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_r</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">0.001</cn>
                    <cn cellml:units="dimensionless">0.66</cn>
                    <cn cellml:units="dimensionless">1.4</cn>
                    <apply>
                        <plus/>
                        <apply>
                            <divide/>
                            <cn cellml:units="second">15.59</cn>
                            <apply>
                                <plus/>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">1.037</cn>
                                    <apply>
                                        <exp/>
                                        <apply>
                                            <times/>
                                            <cn cellml:units="per_millivolt">0.09</cn>
                                            <apply>
                                                <plus/>
                                                <ci>V</ci>
                                                <cn cellml:units="millivolt">30.61</cn>
                                            </apply>
                                        </apply>
                                    </apply>
                                </apply>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">0.369</cn>
                                    <apply>
                                        <exp/>
                                        <apply>
                                            <times/>
                                            <apply>
                                                <minus/>
                                                <cn cellml:units="per_millivolt">0.12</cn>
                                            </apply>
                                            <apply>
                                                <plus/>
                                                <ci>V</ci>
                                                <cn cellml:units="millivolt">23.84</cn>
                                            </apply>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                        <cn cellml:units="second">2.98</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>r</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>r_infinity</ci>
                        <ci>r</ci>
                    </apply>
                    <ci>tau_r</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_Kr">
        <variable name="i_Kr" public_interface="out" units="nanoA"/>
        <variable initial_value="0.00424" name="g_Kr" units="microS"/>
        <variable name="time" private_interface="out" public_interface="in" units="second"/>
        <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
        <variable name="E_K" public_interface="in" units="millivolt"/>
        <variable name="Ko" public_interface="in" units="millimolar"/>
        <variable name="paS" private_interface="in" units="dimensionless"/>
        <variable name="paF" private_interface="in" units="dimensionless"/>
        <variable name="piy" private_interface="in" units="dimensionless"/>
        <variable name="RTONF" public_interface="in" units="millivolt"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_Kr</ci>
                <apply>
                    <times/>
                    <ci>g_Kr</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_K</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">0.9</cn>
                            <ci>paF</ci>
                        </apply>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">0.1</cn>
                            <ci>paS</ci>
                        </apply>
                    </apply>
                    <ci>piy</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_Kr_pa_gate">
        <variable initial_value="0.283185" name="paS" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.011068" name="paF" public_interface="out" units="dimensionless"/>
        <variable name="pa_infinity" units="dimensionless"/>
        <variable name="alfapaF" units="per_second"/>
        <variable name="betapaF" units="per_second"/>
        <variable name="tau_paS" units="second"/>
        <variable name="tau_paF" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>alfapaF</ci>
                <apply>
                    <divide/>
                    <apply>
                        <divide/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <plus/>
                                            <ci>V</ci>
                                            <cn cellml:units="millivolt">23.2</cn>
                                        </apply>
                                    </apply>
                                    <cn cellml:units="millivolt">6.6</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <divide/>
                        <cn cellml:units="second">0.84655354</cn>
                        <apply>
                            <plus/>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless">37.2</cn>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <divide/>
                                        <ci>V</ci>
                                        <cn cellml:units="millivolt">11.9</cn>
                                    </apply>
                                </apply>
                            </apply>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless">0.96</cn>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <divide/>
                                        <apply>
                                            <minus/>
                                            <ci>V</ci>
                                        </apply>
                                        <cn cellml:units="millivolt">18.5</cn>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>betapaF</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">4</cn>
                    <apply>
                        <minus/>
                        <apply>
                            <divide/>
                            <apply>
                                <plus/>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">37.2</cn>
                                    <apply>
                                        <exp/>
                                        <apply>
                                            <divide/>
                                            <ci>V</ci>
                                            <cn cellml:units="millivolt">15.9</cn>
                                        </apply>
                                    </apply>
                                </apply>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">0.96</cn>
                                    <apply>
                                        <exp/>
                                        <apply>
                                            <divide/>
                                            <apply>
                                                <minus/>
                                                <ci>V</ci>
                                            </apply>
                                            <cn cellml:units="millivolt">22.5</cn>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                            <cn cellml:units="second">0.84655354</cn>
                        </apply>
                        <apply>
                            <divide/>
                            <apply>
                                <divide/>
                                <cn cellml:units="dimensionless">1</cn>
                                <apply>
                                    <plus/>
                                    <cn cellml:units="dimensionless">1</cn>
                                    <apply>
                                        <exp/>
                                        <apply>
                                            <divide/>
                                            <apply>
                                                <minus/>
                                                <apply>
                                                    <plus/>
                                                    <ci>V</ci>
                                                    <cn cellml:units="millivolt">23.2</cn>
                                                </apply>
                                            </apply>
                                            <cn cellml:units="millivolt">10.6</cn>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                            <apply>
                                <divide/>
                                <cn cellml:units="second">0.84655354</cn>
                                <apply>
                                    <plus/>
                                    <apply>
                                        <times/>
                                        <cn cellml:units="dimensionless">37.2</cn>
                                        <apply>
                                            <exp/>
                                            <apply>
                                                <divide/>
                                                <ci>V</ci>
                                                <cn cellml:units="millivolt">15.9</cn>
                                            </apply>
                                        </apply>
                                    </apply>
                                    <apply>
                                        <times/>
                                        <cn cellml:units="dimensionless">0.96</cn>
                                        <apply>
                                            <exp/>
                                            <apply>
                                                <divide/>
                                                <apply>
                                                    <minus/>
                                                    <ci>V</ci>
                                                </apply>
                                                <cn cellml:units="millivolt">22.5</cn>
                                            </apply>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>pa_infinity</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <plus/>
                                        <ci>V</ci>
                                        <cn cellml:units="millivolt">10.0144</cn>
                                    </apply>
                                </apply>
                                <cn cellml:units="millivolt">7.6607</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_paS</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="second">0.84655354</cn>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">4.2</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">17</cn>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">0.15</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <ci>V</ci>
                                    </apply>
                                    <cn cellml:units="millivolt">21.6</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_paF</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="second">1</cn>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">30</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">10</cn>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <ci>V</ci>
                                </apply>
                                <cn cellml:units="millivolt">12</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>paS</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>pa_infinity</ci>
                        <ci>paS</ci>
                    </apply>
                    <ci>tau_paS</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>paF</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>pa_infinity</ci>
                        <ci>paF</ci>
                    </apply>
                    <ci>tau_paF</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_Kr_pi_gate">
        <variable initial_value="0.709051" name="piy" public_interface="out" units="dimensionless"/>
        <variable name="pi_infinity" units="dimensionless"/>
        <variable name="tau_pi" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>tau_pi</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="second">1</cn>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">100</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <ci>V</ci>
                                    </apply>
                                    <cn cellml:units="millivolt">54.645</cn>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">656</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">106.157</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>pi_infinity</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">28.6</cn>
                                </apply>
                                <cn cellml:units="millivolt">17.1</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>piy</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>pi_infinity</ci>
                        <ci>piy</ci>
                    </apply>
                    <ci>tau_pi</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_Ks">
        <variable name="i_Ks" public_interface="out" units="nanoA"/>
        <variable name="g_Ks" public_interface="out" units="microS"/>
        <variable initial_value="0.00065" name="g_Ks_" units="microS"/>
        <variable name="E_Ks" units="millivolt"/>
        <variable name="time" private_interface="out" public_interface="in" units="second"/>
        <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
        <variable name="Ki" public_interface="in" units="millimolar"/>
        <variable name="Ko" public_interface="in" units="millimolar"/>
        <variable name="Nai" public_interface="in" units="millimolar"/>
        <variable name="Nao" public_interface="in" units="millimolar"/>
        <variable name="RTONF" public_interface="in" units="millivolt"/>
        <variable name="n" private_interface="in" units="dimensionless"/>
        <variable name="Iso_1_uM" private_interface="out" public_interface="in" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>g_Ks</ci>
                <piecewise>
                    <piece>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">1.2</cn>
                            <ci>g_Ks_</ci>
                        </apply>
                        <apply>
                            <gt/>
                            <ci>Iso_1_uM</ci>
                            <cn cellml:units="dimensionless">0</cn>
                        </apply>
                    </piece>
                    <otherwise>
                        <ci>g_Ks_</ci>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <ci>E_Ks</ci>
                <apply>
                    <times/>
                    <ci>RTONF</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <divide/>
                            <apply>
                                <plus/>
                                <ci>Ko</ci>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">0.12</cn>
                                    <ci>Nao</ci>
                                </apply>
                            </apply>
                            <apply>
                                <plus/>
                                <ci>Ki</ci>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">0.12</cn>
                                    <ci>Nai</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_Ks</ci>
                <apply>
                    <times/>
                    <ci>g_Ks</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_Ks</ci>
                    </apply>
                    <apply>
                        <power/>
                        <ci>n</ci>
                        <cn cellml:units="dimensionless">2</cn>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_Ks_n_gate">
        <variable initial_value="0.1162" name="n" public_interface="out" units="dimensionless"/>
        <variable name="n_infinity" units="dimensionless"/>
        <variable name="tau_n" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="Iso_1_uM" public_interface="in" units="dimensionless"/>
        <variable name="Iso_shift" units="millivolt"/>
        <variable name="alpha_n" units="per_second"/>
        <variable name="beta_n" units="per_second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>Iso_shift</ci>
                <piecewise>
                    <piece>
                        <apply>
                            <minus/>
                            <cn cellml:units="millivolt">14</cn>
                        </apply>
                        <apply>
                            <gt/>
                            <ci>Iso_1_uM</ci>
                            <cn cellml:units="dimensionless">0</cn>
                        </apply>
                    </piece>
                    <otherwise>
                        <cn cellml:units="millivolt">0</cn>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <ci>n_infinity</ci>
                <apply>
                    <root/>
                    <apply>
                        <divide/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <minus/>
                                            <apply>
                                                <plus/>
                                                <ci>V</ci>
                                                <cn cellml:units="millivolt">0.6383</cn>
                                            </apply>
                                            <ci>Iso_shift</ci>
                                        </apply>
                                    </apply>
                                    <cn cellml:units="millivolt">10.7071</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_n</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <ci>alpha_n</ci>
                        <ci>beta_n</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_n</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="per_second">28</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <minus/>
                                            <ci>V</ci>
                                            <cn cellml:units="millivolt">40</cn>
                                        </apply>
                                        <ci>Iso_shift</ci>
                                    </apply>
                                </apply>
                                <cn cellml:units="millivolt">3</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_n</ci>
                <apply>
                    <times/>
                    <cn cellml:units="per_second">1</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <minus/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <minus/>
                                        <ci>V</ci>
                                        <ci>Iso_shift</ci>
                                    </apply>
                                    <cn cellml:units="millivolt">5</cn>
                                </apply>
                            </apply>
                            <cn cellml:units="millivolt">25</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>n</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>n_infinity</ci>
                        <ci>n</ci>
                    </apply>
                    <ci>tau_n</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="i_KACh">
        <variable name="ACh" private_interface="out" public_interface="in" units="millimolar"/>
        <variable name="i_KACh" public_interface="out" units="nanoA"/>
        <variable initial_value="0.00345" name="g_KACh" units="microS"/>
        <variable name="E_K" public_interface="in" units="millivolt"/>
        <variable name="time" private_interface="out" public_interface="in" units="second"/>
        <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
        <variable name="a" private_interface="in" units="dimensionless"/>
        <variable initial_value="1" name="ACh_on" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_KACh</ci>
                <piecewise>
                    <piece>
                        <apply>
                            <times/>
                            <ci>ACh_on</ci>
                            <ci>g_KACh</ci>
                            <apply>
                                <minus/>
                                <ci>V</ci>
                                <ci>E_K</ci>
                            </apply>
                            <apply>
                                <plus/>
                                <cn cellml:units="dimensionless">1</cn>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <divide/>
                                        <apply>
                                            <plus/>
                                            <ci>V</ci>
                                            <cn cellml:units="millivolt">20</cn>
                                        </apply>
                                        <cn cellml:units="millivolt">20</cn>
                                    </apply>
                                </apply>
                            </apply>
                            <ci>a</ci>
                        </apply>
                        <apply>
                            <gt/>
                            <ci>ACh</ci>
                            <cn cellml:units="millimolar">0</cn>
                        </apply>
                    </piece>
                    <otherwise>
                        <cn cellml:units="nanoA">0</cn>
                    </otherwise>
                </piecewise>
            </apply>
        </math>
    </component>
    <component name="i_KACh_a_gate">
        <variable initial_value="0.00277" name="a" public_interface="out" units="dimensionless"/>
        <variable name="alpha_a" units="per_second"/>
        <variable name="beta_a" units="per_second"/>
        <variable name="a_infinity" units="dimensionless"/>
        <variable name="tau_a" units="second"/>
        <variable name="ACh" public_interface="in" units="millimolar"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>alpha_a</ci>
                <apply>
                    <plus/>
                    <apply>
                        <divide/>
                        <apply>
                            <minus/>
                            <cn cellml:units="per_second">3.5988</cn>
                            <cn cellml:units="per_second">0.025641</cn>
                        </apply>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <divide/>
                                <cn cellml:units="dimensionless">0.0000012155</cn>
                                <apply>
                                    <power/>
                                    <apply>
                                        <times/>
                                        <cn cellml:units="per_millimolar">1</cn>
                                        <ci>ACh</ci>
                                    </apply>
                                    <cn cellml:units="dimensionless">1.6951</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <cn cellml:units="per_second">0.025641</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_a</ci>
                <apply>
                    <times/>
                    <cn cellml:units="per_second">10</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <cn cellml:units="per_millivolt">0.0133</cn>
                            <apply>
                                <plus/>
                                <ci>V</ci>
                                <cn cellml:units="millivolt">40</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a_infinity</ci>
                <apply>
                    <divide/>
                    <ci>alpha_a</ci>
                    <apply>
                        <plus/>
                        <ci>alpha_a</ci>
                        <ci>beta_a</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_a</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <ci>alpha_a</ci>
                        <ci>beta_a</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>a</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>a_infinity</ci>
                        <ci>a</ci>
                    </apply>
                    <ci>tau_a</ci>
                </apply>
            </apply>
        </math>
    </component>
    <group>
        <relationship_ref relationship="containment"/>
        <component_ref component="Membrane">
            <component_ref component="Ionic_values"/>
            <component_ref component="Voltage_clamp"/>
            <component_ref component="i_NaK"/>
            <component_ref component="i_NaCa"/>
            <component_ref component="Ca_SR_release"/>
            <component_ref component="Ca_intracellular_fluxes"/>
            <component_ref component="Ca_buffering"/>
            <component_ref component="Ca_dynamics"/>
            <component_ref component="Cell_parameters"/>
            <component_ref component="Nai_concentration"/>
            <component_ref component="Rate_modulation_experiments"/>
            <component_ref component="i_f">
                <component_ref component="i_f_y_gate"/>
            </component_ref>
            <component_ref component="i_Na">
                <component_ref component="i_Na_m_gate"/>
                <component_ref component="i_Na_h_gate"/>
            </component_ref>
            <component_ref component="i_Kur">
                <component_ref component="i_Kur_rKur_gate"/>
                <component_ref component="i_Kur_sKur_gate"/>
            </component_ref>
            <component_ref component="i_CaL">
                <component_ref component="i_CaL_dL_gate"/>
                <component_ref component="i_CaL_fL_gate"/>
                <component_ref component="i_CaL_fCa_gate"/>
            </component_ref>
            <component_ref component="i_CaT">
                <component_ref component="i_CaT_dT_gate"/>
                <component_ref component="i_CaT_fT_gate"/>
            </component_ref>
            <component_ref component="i_to">
                <component_ref component="i_to_q_gate"/>
                <component_ref component="i_to_r_gate"/>
            </component_ref>
            <component_ref component="i_Kr">
                <component_ref component="i_Kr_pa_gate"/>
                <component_ref component="i_Kr_pi_gate"/>
            </component_ref>
            <component_ref component="i_Ks">
                <component_ref component="i_Ks_n_gate"/>
            </component_ref>
            <component_ref component="i_KACh">
                <component_ref component="i_KACh_a_gate"/>
            </component_ref>
        </component_ref>
    </group>
    <group>
        <relationship_ref relationship="encapsulation"/>
        <component_ref component="Membrane">
            <component_ref component="Voltage_clamp"/>
        </component_ref>
        <component_ref component="i_f">
            <component_ref component="i_f_y_gate"/>
        </component_ref>
        <component_ref component="i_Na">
            <component_ref component="i_Na_m_gate"/>
            <component_ref component="i_Na_h_gate"/>
        </component_ref>
        <component_ref component="i_Kur">
            <component_ref component="i_Kur_rKur_gate"/>
            <component_ref component="i_Kur_sKur_gate"/>
        </component_ref>
        <component_ref component="i_CaL">
            <component_ref component="i_CaL_dL_gate"/>
            <component_ref component="i_CaL_fL_gate"/>
            <component_ref component="i_CaL_fCa_gate"/>
        </component_ref>
        <component_ref component="i_CaT">
            <component_ref component="i_CaT_dT_gate"/>
            <component_ref component="i_CaT_fT_gate"/>
        </component_ref>
        <component_ref component="i_to">
            <component_ref component="i_to_q_gate"/>
            <component_ref component="i_to_r_gate"/>
        </component_ref>
        <component_ref component="i_Kr">
            <component_ref component="i_Kr_pa_gate"/>
            <component_ref component="i_Kr_pi_gate"/>
        </component_ref>
        <component_ref component="i_Ks">
            <component_ref component="i_Ks_n_gate"/>
        </component_ref>
        <component_ref component="i_KACh">
            <component_ref component="i_KACh_a_gate"/>
        </component_ref>
    </group>
    <connection>
        <map_components component_1="Membrane" component_2="Voltage_clamp"/>
        <map_variables variable_1="V_clamp" variable_2="V_clamp"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="Membrane" component_2="Ionic_values"/>
        <map_variables variable_1="RTONF" variable_2="RTONF"/>
    </connection>
    <connection>
        <map_components component_1="Membrane" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="Nai_concentration" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="i_f" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="i_Kur" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="i_NaK" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="i_NaCa" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="i_Na" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="i_CaL" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="i_CaT" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="Ca_SR_release" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="Ca_buffering" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="Ca_dynamics" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="i_to" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="i_Kr" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="i_Ks" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="i_KACh" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="Nai_concentration" component_2="Membrane"/>
        <map_variables variable_1="F" variable_2="F"/>
    </connection>
    <connection>
        <map_components component_1="i_f" component_2="Membrane"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="RTONF" variable_2="RTONF"/>
        <map_variables variable_1="i_f" variable_2="i_f"/>
    </connection>
    <connection>
        <map_components component_1="i_NaK" component_2="Membrane"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
    </connection>
    <connection>
        <map_components component_1="i_Kur" component_2="Membrane"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="i_Kur" variable_2="i_Kur"/>
    </connection>
    <connection>
        <map_components component_1="i_NaCa" component_2="Membrane"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
        <map_variables variable_1="RTONF" variable_2="RTONF"/>
    </connection>
    <connection>
        <map_components component_1="i_Na" component_2="Membrane"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="i_Na" variable_2="i_Na"/>
        <map_variables variable_1="RTONF" variable_2="RTONF"/>
    </connection>
    <connection>
        <map_components component_1="i_CaL" component_2="Membrane"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="RTONF" variable_2="RTONF"/>
        <map_variables variable_1="i_CaL" variable_2="i_CaL"/>
    </connection>
    <connection>
        <map_components component_1="i_CaT" component_2="Membrane"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="RTONF" variable_2="RTONF"/>
        <map_variables variable_1="i_CaT" variable_2="i_CaT"/>
    </connection>
    <connection>
        <map_components component_1="Ca_dynamics" component_2="Membrane"/>
        <map_variables variable_1="F" variable_2="F"/>
    </connection>
    <connection>
        <map_components component_1="i_to" component_2="Membrane"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="i_to" variable_2="i_to"/>
    </connection>
    <connection>
        <map_components component_1="i_Kr" component_2="Membrane"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="i_Kr" variable_2="i_Kr"/>
        <map_variables variable_1="RTONF" variable_2="RTONF"/>
    </connection>
    <connection>
        <map_components component_1="i_Ks" component_2="Membrane"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="RTONF" variable_2="RTONF"/>
        <map_variables variable_1="i_Ks" variable_2="i_Ks"/>
    </connection>
    <connection>
        <map_components component_1="i_KACh" component_2="Membrane"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="i_KACh" variable_2="i_KACh"/>
    </connection>
    <connection>
        <map_components component_1="Nai_concentration" component_2="Ionic_values"/>
        <map_variables variable_1="Nai" variable_2="Nai"/>
    </connection>
    <connection>
        <map_components component_1="i_f" component_2="Ionic_values"/>
        <map_variables variable_1="E_Na" variable_2="E_Na"/>
        <map_variables variable_1="E_K" variable_2="E_K"/>
        <map_variables variable_1="Ko" variable_2="Ko"/>
    </connection>
    <connection>
        <map_components component_1="i_Kur" component_2="Ionic_values"/>
        <map_variables variable_1="E_K" variable_2="E_K"/>
    </connection>
    <connection>
        <map_components component_1="i_Na" component_2="Ionic_values"/>
        <map_variables variable_1="Nao" variable_2="Nao"/>
        <map_variables variable_1="Ko" variable_2="Ko"/>
        <map_variables variable_1="Ki" variable_2="Ki"/>
    </connection>
    <connection>
        <map_components component_1="i_NaK" component_2="Ionic_values"/>
        <map_variables variable_1="Ko" variable_2="Ko"/>
        <map_variables variable_1="E_Na" variable_2="E_Na"/>
    </connection>
    <connection>
        <map_components component_1="i_NaCa" component_2="Ionic_values"/>
        <map_variables variable_1="Nao" variable_2="Nao"/>
        <map_variables variable_1="Cao" variable_2="Cao"/>
    </connection>
    <connection>
        <map_components component_1="Ca_dynamics" component_2="Ionic_values"/>
        <map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
    </connection>
    <connection>
        <map_components component_1="i_CaL" component_2="Ionic_values"/>
        <map_variables variable_1="Cao" variable_2="Cao"/>
        <map_variables variable_1="Nao" variable_2="Nao"/>
        <map_variables variable_1="Ko" variable_2="Ko"/>
        <map_variables variable_1="Ki" variable_2="Ki"/>
    </connection>
    <connection>
        <map_components component_1="i_CaT" component_2="Ionic_values"/>
        <map_variables variable_1="Cao" variable_2="Cao"/>
    </connection>
    <connection>
        <map_components component_1="i_to" component_2="Ionic_values"/>
        <map_variables variable_1="E_K" variable_2="E_K"/>
    </connection>
    <connection>
        <map_components component_1="i_Kr" component_2="Ionic_values"/>
        <map_variables variable_1="Ko" variable_2="Ko"/>
        <map_variables variable_1="E_K" variable_2="E_K"/>
    </connection>
    <connection>
        <map_components component_1="i_Ks" component_2="Ionic_values"/>
        <map_variables variable_1="Nao" variable_2="Nao"/>
        <map_variables variable_1="Ko" variable_2="Ko"/>
        <map_variables variable_1="Ki" variable_2="Ki"/>
    </connection>
    <connection>
        <map_components component_1="i_KACh" component_2="Ionic_values"/>
        <map_variables variable_1="E_K" variable_2="E_K"/>
    </connection>
    <connection>
        <map_components component_1="i_f" component_2="i_f_y_gate"/>
        <map_variables variable_1="y" variable_2="y"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="ACh" variable_2="ACh"/>
        <map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
    </connection>
    <connection>
        <map_components component_1="i_Na" component_2="i_Na_m_gate"/>
        <map_variables variable_1="m" variable_2="m"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
    </connection>
    <connection>
        <map_components component_1="i_Na" component_2="i_Na_h_gate"/>
        <map_variables variable_1="h" variable_2="h"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
    </connection>
    <connection>
        <map_components component_1="i_Kur" component_2="i_Kur_rKur_gate"/>
        <map_variables variable_1="r_Kur" variable_2="r_Kur"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
    </connection>
    <connection>
        <map_components component_1="i_Kur" component_2="i_Kur_sKur_gate"/>
        <map_variables variable_1="s_Kur" variable_2="s_Kur"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
    </connection>
    <connection>
        <map_components component_1="i_CaL" component_2="i_CaL_dL_gate"/>
        <map_variables variable_1="dL" variable_2="dL"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
    </connection>
    <connection>
        <map_components component_1="i_CaL" component_2="i_CaL_fL_gate"/>
        <map_variables variable_1="fL" variable_2="fL"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
    </connection>
    <connection>
        <map_components component_1="i_CaL" component_2="i_CaL_fCa_gate"/>
        <map_variables variable_1="fCa" variable_2="fCa"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
    </connection>
    <connection>
        <map_components component_1="i_CaT" component_2="i_CaT_dT_gate"/>
        <map_variables variable_1="dT" variable_2="dT"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="i_CaT" component_2="i_CaT_fT_gate"/>
        <map_variables variable_1="fT" variable_2="fT"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="i_to" component_2="i_to_q_gate"/>
        <map_variables variable_1="q" variable_2="q"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
    </connection>
    <connection>
        <map_components component_1="i_to" component_2="i_to_r_gate"/>
        <map_variables variable_1="r" variable_2="r"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
    </connection>
    <connection>
        <map_components component_1="i_Kr" component_2="i_Kr_pa_gate"/>
        <map_variables variable_1="paF" variable_2="paF"/>
        <map_variables variable_1="paS" variable_2="paS"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
    </connection>
    <connection>
        <map_components component_1="i_Kr" component_2="i_Kr_pi_gate"/>
        <map_variables variable_1="piy" variable_2="piy"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
    </connection>
    <connection>
        <map_components component_1="i_Ks" component_2="i_Ks_n_gate"/>
        <map_variables variable_1="n" variable_2="n"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
    </connection>
    <connection>
        <map_components component_1="i_KACh" component_2="i_KACh_a_gate"/>
        <map_variables variable_1="a" variable_2="a"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="ACh" variable_2="ACh"/>
    </connection>
    <connection>
        <map_components component_1="Nai_concentration" component_2="i_Ks"/>
        <map_variables variable_1="Nai" variable_2="Nai"/>
    </connection>
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