Modeling the Cell Division Cycle:cdc2 and Cyclin Interactions

Modeling the Cell Division Cycle:cdc2 and Cyclin Interactions

Model Status

This CellML version of the model has been checked in COR and OpenCell and the model runs to replicate the results in the original published paper. The units have been checked and are consistent.

Model Structure

ABSTRACT: The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells.

The original paper reference is cited below:

Modeling the cell division cycle: cdc2 and cyclin interactions, John J. Tyson, 1991, Proceedings of the National Academy of Sciences, 88, 7328-7332. PubMed ID: 1831270

A schematic diagram of the interactions between cyclin and cdc2 during the cell cycle.