<?xml version="1.0"?>
<!-- FILE : tyson_model_1991.xml
CREATED : 29th May 2007
LAST MODIFIED : 29th May 2007
AUTHOR : Catherine Lloyd
Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.1 Specification.
DESCRIPTION : This file contains a CellML description of John Tyson's
1991 model of the cell division cycle.
CHANGES:
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" cmeta:id="tyson_1991" name="tyson_1991">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Modelling the Cell Division Cycle: cdc2 and Cyclin Interactions</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This CellML version of the model has been checked in COR and OpenCell and the model runs to replicate the results in the original published paper. The units have been checked and are consistent.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
ABSTRACT: The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells.</para>
<para>
The original paper reference is cited below:
</para>
<para>
Modeling the cell division cycle: cdc2 and cyclin interactions, John J. Tyson, 1991, <emphasis>Proceedings of the National Academy of Sciences</emphasis>, 88, 7328-7332. <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/1831270">PubMed ID: 1831270</ulink>
</para>
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<imageobject>
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<title>cell diagram</title>
</objectinfo>
<imagedata fileref="tyson_1991.png"/>
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<caption>A schematic diagram of the interactions between cyclin and cdc2 during the cell cycle.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">John Tyson's 1991 model of the cell division cycle.</dc:title>
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<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Modeling the Cell Division Cycle:cdc2 and Cyclin Interactions</dc:title>
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<rdf:value>This CellML version of the model has been checked in COR and PCEnv and the model runs to replicate the results in the original published paper. The units have been checked and are consistent.</rdf:value>
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<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Proceedings of the National Academy of Sciences USA</dc:title>
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The model runs in the PCEnv simulator but very quickly produces NaNs.</rdf:value>
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<rdf:value>This is the CellML description of John Tyson's 1991 model of the cell
division cycle.</rdf:value>
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<vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine Lloyd</vCard:FN>
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