- Author:
- Hanne <Hanne@hanne-nielsens-macbook.local>
- Date:
- 2009-12-15 12:16:20+13:00
- Desc:
- Added images in ai and svg format, removed non pub med references
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/wolf_passarge_somsen_snoep_heinrich_westerhoff_2000/rawfile/6b292bef2e2f80cb793e99a079fc2df5b3bbf4d0/wolf_passarge_somsen_snoep_heinrich_westerhoff_2000.cellml
<?xml version='1.0' encoding='utf-8'?>
<!-- FILE : wolf_model_2000_version02.xml
CREATED : 1st June 2007
LAST MODIFIED : 1st June 2007
AUTHOR : Catherine Lloyd
Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.1 Specification.
DESCRIPTION : This file contains a CellML description of Wolf et al's 2000 model of the intracellular and intercellular dynamics in yeast glycolytic oscillations.
CHANGES:
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:pathway_editor="http://www.physiome.com/pathway_editor/1.0#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" cmeta:id="wolf_model_2000_version02" name="wolf_passarge_somsen_snoep_heinrich_westerhoff_2000_version01">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Yeast Glycolytic Oscillations</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Under certain well-defined conditions, a population of yeast cells exhibits glycolytic oscillations that synchronise through intercellular acetaldehyde. This implies that the dynamic phenomenon of the oscillation propagates within and between cells. Several theories to explain the mechanisms underlying these oscillations have been suggested, including the idea that the frequency of the oscillations is dependent on several molecular processes, especially glucose transport across the plasma membrane. Due to the highly integrated nature of metabolism it is difficult to study metabolites or even metabolic pathways in isolation. They are part of a much larger metabolic network.
</para>
<para>
In 2000, Jana Wolf, Jutta Passarge, Oscar J.G. Somsen, Jacky L. Snoep, Reinhart Heinrich and Hans V. Westerhoff published a kinetic model describing the transduction of intracellular and intercellular dynamics in yeast glycolytic oscillations (see the figure below).
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
Transduction of Intracellular and Intercellular Dynamics in Yeast Glycolytic Oscillations, Jana Wolf, Jutta Passarge, Oscar J.G. Somsen, Jacky L. Snoep, Reinhart Heinrich and Hans V. Westerhoff, 2000, <emphasis>Biophysical Journal</emphasis>, 78, 1145-1153. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10692304&dopt=Abstract">PubMed ID: 10692304</ulink>
</para>
<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>schematic diagram</title>
</objectinfo>
<imagedata fileref="wolf_passarge_2000.png"/>
</imageobject>
</mediaobject>
<caption>Schematic representation of the model. The nine variable model includes all shown metabolites as variables where S1 represents glucose, S2 represents fructose-1,6-bisphosphate, S3 represents the triphopshate pool, S4 represents 3-phosphoglycerate, S5 represents pyruvate, S6 represents intracellular acetaldehyde, S6,ex represents extracellular acetaldehyde, A2 is ADP, A3 is ATP, N1 is NAD<superscript>+</superscript> and N2 is NADH.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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<unit units="second" multiplier="60.0"/>
</units>
<units name="millimolar">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
</units>
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<unit units="millimolar"/>
<unit units="minute" exponent="-1"/>
</units>
<units name="first_order_rate_constant">
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<unit units="minute" exponent="-1"/>
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<times/>
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