- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2008-07-21 21:47:52+12:00
- Desc:
- committing version01 of wang_lin_lin_wu_2008
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/wang_lin_lin_wu_2008/rawfile/adc1f632c8d6aa127eee143ed68a10ed157e1e9a/wang_lin_lin_wu_2008.cellml
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<!--
This CellML file was generated on 22/07/2008 at 9:33:04 at a.m. using:
COR (0.9.31.979)
Copyright 2002-2008 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.CellML.org/
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<article>
<articleinfo>
<title>Effect of riluzole on action potential in cultured human skeletal muscle cells</title>
<author>
<firstname>Geoffrey</firstname>
<surname>Nunns</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This model runs in both PCEnv and COR to recreate the published results. While it is accurate to the paper equations and figures, in the paper I_Ca is missing the term (V_m - E_Ca), so while this is a match for the published results the math is not entirely correct.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Abstract: Riluzole is known to be of therapeutic use in the management of amyotrophic lateral sclerosis. In this study, we investigated the effects of riluzole on ion currents in cultured differentiated human skeletal muscle cells (dHSkMCs). Western blotting revealed the protein expression of greek small letter alpha-subunits for both large-conductance Ca2+-activated K+ (BKCa) channel and Na+ channel (Nav1.5) in these cells. Riluzole could reduce the frequency of spontaneous beating in dHSkMCs. In whole-cell configuration, riluzole suppressed voltage-gated Na+ current (INa) in a concentration-dependent manner with an IC50 value of 2.3 uM. Riluzole (10 uM) also effectively increased Ca2+-activated K+ current (IK(Ca)) which could be reversed by iberiotoxin (200 nM) and paxilline (1 uM), but not by apamin (200 nM). In inside-out patches, when applied to the inside of the cell membrane, riluzole (10 uM) increased BKCa-channel activity with a decrease in mean closed time. Simulation studies also unraveled that both decreased conductance of INa and increased conductance of IK(Ca) utilized to mimic riluzole actions in skeletal muscle cells could combine to decrease the amplitude of action potentials and increase the repolarization of action potentials. Taken together, inhibition of INa and stimulation of BKCa-channel activity caused by this drug are partly, if not entirely, responsible for its muscle relaxant actions in clinical setting.
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T99-4R1KVY0-4&_user=140507&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000011498&_version=1&_urlVersion=0&_userid=140507&md5=897aa9c7c0cbb3c49dea337c880dfcd5">Effect of riluzole on action potential in cultured human skeletal muscle cells</ulink>, Ya-Jean Wang, Ming-Wei Lin, An-An Lin, Sheng-Nan Wu, 2007, <ulink url="http://www.sciencedirect.com/science/journal/00243205">
<emphasis>Life Sciences</emphasis>
</ulink>, 82, 11-20. (<ulink url="http://jn.physiology.org/cgi/reprint/93/2/723">PDF</ulink> versions of the article are available for Journal Members on the Science Direct website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18068197 &dopt=Abstract">PubMed ID: 18068197 </ulink>
</para>
</sect1>
</article>
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<ci>j_er</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>cer</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<ci>f_er</ci>
</apply>
<ci>v_cytver</ci>
<ci>j_er</ci>
</apply>
</apply>
</math>
</component>
<component name="I_Ca">
<variable units="picoampere" public_interface="out" name="I_Ca"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V_m"/>
<variable units="millisecond" public_interface="in" private_interface="out" name="time"/>
<variable units="dimensionless" private_interface="in" name="d"/>
<variable units="nanosiemens" name="g_Ca"/>
<variable units="nanosiemens_per_millivolt" name="g_Ca0" initial_value="0.05"/>
<variable units="millivolt" name="E_Ca" initial_value="50"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_Ca</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>g_Ca0</ci>
</apply>
<ci>V_m</ci>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.117</cn>
<ci>V_m</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_Ca</ci>
<apply>
<times/>
<ci>g_Ca</ci>
<apply>
<power/>
<ci>d</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="d">
<variable units="dimensionless" public_interface="out" name="d" initial_value="0"/>
<variable units="millivolt" public_interface="in" name="V_m"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="per_millisecond" name="alpha_d"/>
<variable units="per_millisecond" name="beta_d"/>
<variable units="millisecond" name="tau_d"/>
<variable units="dimensionless" name="d_infinity"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>d_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="millivolt">24.6</cn>
</apply>
<ci>V_m</ci>
</apply>
<cn cellml:units="millivolt">11.3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_d</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millisecond">80</cn>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<cosh/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.031</cn>
</apply>
<apply>
<plus/>
<ci>V_m</ci>
<cn cellml:units="millivolt">37.1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_d</ci>
<apply>
<divide/>
<ci>d_infinity</ci>
<ci>tau_d</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_d</ci>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>d_infinity</ci>
</apply>
<ci>tau_d</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_d</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>d</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_d</ci>
<ci>d</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="I_L">
<variable units="picoampere" public_interface="out" name="I_L"/>
<variable units="millivolt" public_interface="in" name="V_m"/>
<variable units="millivolt" name="E_L" initial_value="-75"/>
<variable units="nanosiemens" name="g_Lmax" initial_value="0.0024"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>I_L</ci>
<apply>
<times/>
<ci>g_Lmax</ci>
<apply>
<minus/>
<ci>V_m</ci>
<ci>E_L</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="I_K">
<variable units="picoampere" public_interface="out" name="I_K"/>
<variable units="millisecond" public_interface="in" private_interface="out" name="time"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V_m"/>
<variable units="dimensionless" private_interface="in" name="n"/>
<variable units="millivolt" public_interface="out" name="E_K" initial_value="-70"/>
<variable units="nanosiemens" name="g_K" initial_value="0.415"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>I_K</ci>
<apply>
<times/>
<ci>g_K</ci>
<apply>
<power/>
<ci>n</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
<apply>
<minus/>
<ci>V_m</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="n">
<variable units="dimensionless" public_interface="out" name="n" initial_value="0"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="millivolt" public_interface="in" name="V_m"/>
<variable units="millivolt" name="E_n" initial_value="-40"/>
<variable units="millivolt" name="V_alpha_n" initial_value="7"/>
<variable units="millivolt" name="V_beta_n" initial_value="40"/>
<variable units="per_millisecond" name="alpha_n"/>
<variable units="per_millisecond" name="beta_n"/>
<variable units="per_millivolt_per_millisecond" name="alpha_n_max" initial_value="0.0229"/>
<variable units="per_millisecond" name="beta_n_max" initial_value="0.09616"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_n</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_n_max</ci>
<apply>
<minus/>
<ci>V_m</ci>
<ci>E_n</ci>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>E_n</ci>
<ci>V_m</ci>
</apply>
<ci>V_alpha_n</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_n</ci>
<apply>
<times/>
<ci>beta_n_max</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>E_n</ci>
<ci>V_m</ci>
</apply>
<ci>V_beta_n</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>n</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_n</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>n</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_n</ci>
<ci>n</ci>
</apply>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="I_Na">
<component_ref component="m"/>
<component_ref component="h"/>
</component_ref>
<component_ref component="I_T">
<component_ref component="V_T"/>
</component_ref>
<component_ref component="I_K">
<component_ref component="n"/>
</component_ref>
<component_ref component="I_Ca">
<component_ref component="d"/>
</component_ref>
<component_ref component="I_KCa">
<component_ref component="o"/>
<component_ref component="w"/>
</component_ref>
</group>
<connection>
<map_components component_2="environment" component_1="I_stim"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="I_KCa"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="membrane"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="calcium_handling"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="I_Na" component_1="environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="I_K" component_1="environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="I_T" component_1="environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="I_Ca" component_1="environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="I_Na" component_1="membrane"/>
<map_variables variable_2="V_m" variable_1="V_m"/>
<map_variables variable_2="I_Na" variable_1="I_Na"/>
</connection>
<connection>
<map_components component_2="I_T" component_1="membrane"/>
<map_variables variable_2="V_m" variable_1="V_m"/>
<map_variables variable_2="I_T" variable_1="I_T"/>
</connection>
<connection>
<map_components component_2="I_KCa" component_1="membrane"/>
<map_variables variable_2="V_m" variable_1="V_m"/>
<map_variables variable_2="I_KCa" variable_1="I_KCa"/>
</connection>
<connection>
<map_components component_2="I_Ca" component_1="membrane"/>
<map_variables variable_2="V_m" variable_1="V_m"/>
<map_variables variable_2="I_Ca" variable_1="I_Ca"/>
</connection>
<connection>
<map_components component_2="I_L" component_1="membrane"/>
<map_variables variable_2="V_m" variable_1="V_m"/>
<map_variables variable_2="I_L" variable_1="I_L"/>
</connection>
<connection>
<map_components component_2="I_K" component_1="membrane"/>
<map_variables variable_2="V_m" variable_1="V_m"/>
<map_variables variable_2="I_K" variable_1="I_K"/>
</connection>
<connection>
<map_components component_2="m" component_1="I_Na"/>
<map_variables variable_2="V_m" variable_1="V_m"/>
<map_variables variable_2="m" variable_1="m"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="h" component_1="I_Na"/>
<map_variables variable_2="V_m" variable_1="V_m"/>
<map_variables variable_2="h" variable_1="h"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="n" component_1="I_K"/>
<map_variables variable_2="V_m" variable_1="V_m"/>
<map_variables variable_2="n" variable_1="n"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="V_T" component_1="I_T"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V_m" variable_1="V_m"/>
<map_variables variable_2="V_T" variable_1="V_T"/>
<map_variables variable_2="R_s" variable_1="R_s"/>
<map_variables variable_2="C_t" variable_1="C_t"/>
</connection>
<connection>
<map_components component_2="I_KCa" component_1="I_K"/>
<map_variables variable_2="E_K" variable_1="E_K"/>
</connection>
<connection>
<map_components component_2="d" component_1="I_Ca"/>
<map_variables variable_2="d" variable_1="d"/>
<map_variables variable_2="V_m" variable_1="V_m"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="I_stim" component_1="membrane"/>
<map_variables variable_2="I_stim" variable_1="I_stim"/>
</connection>
<connection>
<map_components component_2="parameters" component_1="I_KCa"/>
<map_variables variable_2="RT" variable_1="RT"/>
</connection>
<connection>
<map_components component_2="calcium_handling" component_1="I_KCa"/>
<map_variables variable_2="c" variable_1="c"/>
</connection>
<connection>
<map_components component_2="o" component_1="I_KCa"/>
<map_variables variable_2="o" variable_1="o"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V_m" variable_1="V_m"/>
<map_variables variable_2="c" variable_1="c"/>
<map_variables variable_2="RT" variable_1="RT"/>
</connection>
<connection>
<map_components component_2="w" component_1="I_KCa"/>
<map_variables variable_2="w" variable_1="w"/>
<map_variables variable_2="c" variable_1="c"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="I_Ca" component_1="calcium_handling"/>
<map_variables variable_2="I_Ca" variable_1="I_Ca"/>
</connection>
<rdf:RDF>
<rdf:Seq rdf:about="rdf:#2adc3758-aaa0-47c5-a089-517ef56df938">
<rdf:li rdf:resource="rdf:#e8efcc62-43b8-4570-bdd7-e430c74ccf3d"/>
<rdf:li rdf:resource="rdf:#52575590-284f-45af-bcc7-cf1c22637562"/>
<rdf:li rdf:resource="rdf:#3ee1e317-a1e5-4dea-935b-524ba421e743"/>
<rdf:li rdf:resource="rdf:#76341c20-7837-40d4-942c-ce3c586e970a"/>
</rdf:Seq>
<rdf:Description rdf:about="rdf:#5441f13a-4ad7-4f4f-980a-365e027d4b4f">
<vCard:Given>Geoffrey</vCard:Given>
<vCard:Family>Nunns</vCard:Family>
<vCard:Other>Rogan</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#e01bee3f-3638-4d94-bdc0-6ae9ecbd8e69">
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
<rdf:value>gnunns1@jhem.jhu.edu</rdf:value>
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<rdf:Description rdf:about="rdf:#68c36479-44cd-485a-a1eb-72bde2ab7064">
<dc:creator rdf:resource="rdf:#fd442d14-6ad4-4229-b946-7ba1c3b5a4d3"/>
<rdf:value>This model runs in both PCEnv and COR to recreate the published results. While it is accurate to the paper equations and figures, in the paper I_Ca is missing the term (V_m - E_Ca), so while this is a match for the published results the math is not entirely correct.</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3ee1e317-a1e5-4dea-935b-524ba421e743">
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<rdf:Description rdf:about="rdf:#c0eb6e5f-a8b6-4372-b2c9-39cbf1bf7bf2">
<vCard:Given>Geoffrey</vCard:Given>
<vCard:Family>Nunns</vCard:Family>
<vCard:Other>Rogan</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#0f8a7868-d27b-4fed-a254-e16def52262d">
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<vCard:N rdf:resource="rdf:#03582fac-99db-4ee6-a3bc-669ef098a64e"/>
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<rdf:Description rdf:about="">
<dc:publisher/>
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<rdf:Description rdf:about="rdf:#$0VMv+3">
<rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
<rdf:first rdf:resource="rdf:#$1VMv+3"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#5358c3ef-75ef-469f-ba80-e23a76e91149">
<vCard:Given>An-An</vCard:Given>
<vCard:Family>Lin</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#03582fac-99db-4ee6-a3bc-669ef098a64e">
<vCard:Given>Geoffrey</vCard:Given>
<vCard:Family>Nunns</vCard:Family>
<vCard:Other>Rogan</vCard:Other>
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<rdf:Description rdf:about="rdf:#bb9beb43-0b41-4e2c-aae8-aa2d544f3a28">
<dcterms:modified rdf:resource="rdf:#108229a1-d8a2-440e-bba2-8e6816cb461e"/>
<rdf:value>Updates equations and units throughout to match the paper equations. </rdf:value>
<cmeta:modifier rdf:resource="rdf:#0f8a7868-d27b-4fed-a254-e16def52262d"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#0117a7d7-0469-41b1-b08e-1f9cb7e812e7">
<dcterms:modified rdf:resource="rdf:#33250c70-01f8-4555-bce3-17ceb3907f62"/>
<rdf:value>Updated Metadata</rdf:value>
<cmeta:modifier rdf:resource="rdf:#8427afc4-2798-4cc6-a64e-dc998af3a95f"/>
</rdf:Description>
<rdf:Description rdf:about="#yang_lin_lin_wu_2007">
<ns7:simulation rdf:resource="rdf:#$+UMv+3"/>
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<rdf:Description rdf:about="rdf:#33250c70-01f8-4555-bce3-17ceb3907f62">
<dcterms:W3CDTF>2008-06-30T15:04:14+12:00</dcterms:W3CDTF>
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<rdf:Description rdf:about="rdf:#$+UMv+3">
<ns7:boundIntervals rdf:resource="rdf:#$0VMv+3"/>
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<rdf:Description rdf:about="rdf:#a982fecd-60a2-44e5-aa39-b994efc02ec4">
<vCard:N rdf:resource="rdf:#c0eb6e5f-a8b6-4372-b2c9-39cbf1bf7bf2"/>
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<rdf:Description rdf:about="rdf:#108229a1-d8a2-440e-bba2-8e6816cb461e">
<dcterms:W3CDTF>2008-07-22T09:46:00+12:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$1VMv+3">
<ns7:endingValue>20</ns7:endingValue>
<ns7:nonstandard-pointDensity>10000</ns7:nonstandard-pointDensity>
<ns7:maximumStepSize>0.001</ns7:maximumStepSize>
</rdf:Description>
<rdf:Description rdf:about="rdf:#0ff06f33-ba5c-418e-9afb-b8b1a03c327d">
<vCard:Given>Sheng-Nan</vCard:Given>
<vCard:Family>Wu</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#fd442d14-6ad4-4229-b946-7ba1c3b5a4d3">
<vCard:FN>Geoff Nunns</vCard:FN>
</rdf:Description>
<rdf:Description rdf:about="rdf:#ab8a276c-24f0-415f-9f62-939a91802286">
<dc:creator rdf:resource="rdf:#920191fa-d5c9-4b03-8be1-19dca2ea07d1"/>
<rdf:value>This model runs in both PCEnv and COR to recreate the published results. While it is accurate to the paper equations and figures, in the paper I_Ca is missing the term (V_m - E_Ca), so while this is a match for the published results the math is not entirely correct.</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#08522b72-b576-4cf6-85dd-d7057acff3e3">
<vCard:FN>Geoff Nunns</vCard:FN>
</rdf:Description>
<rdf:Description rdf:about="rdf:#10efc058-9fca-4382-926d-66e3a3c6bd46">
<bqs:Pubmed_id>18068197</bqs:Pubmed_id>
<bqs:JournalArticle rdf:resource="rdf:#5adf14f2-80ff-4bfd-bb7a-f9228e344c41"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#337847a3-192e-4a79-9000-a0a999ee793f">
<dcterms:modified rdf:resource="rdf:#93df7600-5116-4660-a721-c4ac29c911a4"/>
<rdf:value>Updates equations and units throughout to match the paper equations. </rdf:value>
<cmeta:modifier rdf:resource="rdf:#a982fecd-60a2-44e5-aa39-b994efc02ec4"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#6b4b2ae0-ae84-41cd-9411-653922cd1731">
<vCard:Given>Ya-Jean</vCard:Given>
<vCard:Family>Wang</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3f3c7af0-6753-4e82-890d-a8f18b65fce5">
<vCard:ORG rdf:resource="rdf:#6b84dc86-7704-4bf4-a38b-1b15c3aba3e4"/>
<vCard:EMAIL rdf:resource="rdf:#e01bee3f-3638-4d94-bdc0-6ae9ecbd8e69"/>
<vCard:N rdf:resource="rdf:#5441f13a-4ad7-4f4f-980a-365e027d4b4f"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#e8efcc62-43b8-4570-bdd7-e430c74ccf3d">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#6b4b2ae0-ae84-41cd-9411-653922cd1731"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#39f80791-028b-451a-b641-2f2d40b94f99">
<dcterms:W3CDTF>2008-06-24T00:00:00+00:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#5adf14f2-80ff-4bfd-bb7a-f9228e344c41">
<dc:creator rdf:resource="rdf:#2adc3758-aaa0-47c5-a089-517ef56df938"/>
<dc:title>Effect of riluzole on action potential in cultured human skeletal muscle cells</dc:title>
<bqs:volume>82</bqs:volume>
<bqs:first_page>11</bqs:first_page>
<bqs:Journal rdf:resource="rdf:#28931525-6f4f-4ed9-8165-cf8b7c59e80e"/>
<dcterms:issued rdf:resource="rdf:#f91ffd46-d46b-41f5-be6f-16d4ac965c87"/>
<bqs:last_page>20</bqs:last_page>
</rdf:Description>
<rdf:Description rdf:about="rdf:#e6c5cbf7-6d1e-4163-bbf6-34c68fae6c84">
<vCard:Given>Geoffrey</vCard:Given>
<vCard:Family>Nunns</vCard:Family>
<vCard:Other>Rogan</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#f91ffd46-d46b-41f5-be6f-16d4ac965c87">
<dcterms:W3CDTF>2008-01-02 00:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#4e8c4a38-34e3-4f0f-92e4-6423be59c18b">
<dc:creator rdf:resource="rdf:#08522b72-b576-4cf6-85dd-d7057acff3e3"/>
<rdf:value>This model runs in both PCEnv and COR to recreate the published results.</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#920191fa-d5c9-4b03-8be1-19dca2ea07d1">
<vCard:FN>Geoff Nunns</vCard:FN>
</rdf:Description>
<rdf:Description rdf:about="rdf:#93df7600-5116-4660-a721-c4ac29c911a4">
<dcterms:W3CDTF>2008-07-22T09:46:00+12:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#28931525-6f4f-4ed9-8165-cf8b7c59e80e">
<dc:title>Life Sciences</dc:title>
</rdf:Description>
<rdf:Description rdf:about="rdf:#d4c51f7e-25dd-4006-a716-a86e7b716b3e">
<vCard:Given>Ming-Wei</vCard:Given>
<vCard:Family>Lin</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#6b84dc86-7704-4bf4-a38b-1b15c3aba3e4">
<vCard:Orgname>Auckland Bioengineering Institute</vCard:Orgname>
<vCard:Orgunit>CellML Team</vCard:Orgunit>
</rdf:Description>
</rdf:RDF>
</model>
