- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2009-06-17 16:07:40+12:00
- Desc:
- committing version02 of stern_song_sham_yang_boheler_rios_1999
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/stern_song_sham_yang_boheler_rios_1999/rawfile/23f81f6a70e64870043820ecfef51a59e1be5c65/stern_song_sham_yang_boheler_rios_1999.cellml
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<!-- FILE : stern_model_1999_version02.xml
CREATED : 23rd May 2007
LAST MODIFIED : 23rd May 2007
AUTHOR : Catherine Lloyd
Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.1 Specification.
DESCRIPTION : This file contains a CellML description of Stern et al's
1999 model of ryanodine receptors in cardiac muscle.
CHANGES:
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<title>Ryanodine Receptor Gating Kinetics in Cardiac Muscle</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
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<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
In cardiac muscle, release of activator calcium from the sarcoplasmic reticulum occurs by calcium-induced calcium release through ryanodine receptors (RyRs). In their 1999 paper, Michael D. Stern <emphasis>et al</emphasis> represented the ryanodine receptor with a phenomenological four-state gating scheme, with channel opening resulting from simultaneous binding of two Ca<superscript>2+</superscript> ions, and either calcium-dependent or activation-linked inactivation (see <xref linkend="fig_reaction_diagram"/> below).
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.jgp.org/cgi/content/abstract/113/3/469">Local Control Models of Cardiac Excitation-Contraction Coupling <emphasis>A Possible Role for Allosteric Interactions between Ryanodine Receptors</emphasis>
</ulink>, Michael D. Stern, Long-Sheng Song, Heping Cheng, James S.K. Sham, Huang Tian Yang, Kenneth R. Boheler and Eduardo Rios, 1999, <ulink url="http://www.jgp.org/">
<emphasis>The Journal Of General Physiology</emphasis>
</ulink>, 113, 469-489. (<ulink url="http://www.jgp.org/cgi/content/full/113/3/469">Full text</ulink> and <ulink url="http://www.jgp.org/cgi/reprint/113/3/469.pdf">PDF versions</ulink> of the article are available to subscribers on the JGP website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10051521&dopt=Abstract">PubMed ID: 10051521</ulink>
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The raw CellML description of the kinetic model of cardiac ryanodine receptor gating can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>.
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Stern et al's 1999 model of a gating scheme for ryanodine receptors.
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<vCard:Given>Kenneth</vCard:Given>
<vCard:Family>Boheler</vCard:Family>
<vCard:Other>R</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#1c3bf761-4cb7-42e6-8857-e1b253f39e05">
<dcterms:W3CDTF>1999-03-01</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#0b362a02-9130-4a03-87b0-a2adfbcdc066">
<vCard:Given>James</vCard:Given>
<vCard:Family>Sham</vCard:Family>
<vCard:Other>K</vCard:Other>
<vCard:Other>S</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#49f2cc0c-7ab6-4631-a91d-41a740acc45f">
<dcterms:W3CDTF>2007-06-05T10:46:00+12:00</dcterms:W3CDTF>
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<rdf:Description rdf:about="rdf:#c9137d23-c19c-4f86-9461-15766c5de40f">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#712b25c7-b350-4d98-a8f1-9fef7bf9c017"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#b63d0233-9e90-496f-9317-9c334571b8d6">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#0b362a02-9130-4a03-87b0-a2adfbcdc066"/>
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<rdf:Description rdf:about="rdf:#6d0cc074-4e1a-430c-8ecf-661c69fbaedf">
<dcterms:modified rdf:resource="rdf:#49f2cc0c-7ab6-4631-a91d-41a740acc45f"/>
<rdf:value>The new version of this model has been re-coded to remove the reaction element and replace it with a simple MathML description of the model reaction kinetics. This is thought to be truer to the original publication, and information regarding the enzyme kinetics etc will later be added to the metadata through use of an ontology.
The model runs in the PCEnv simulator but gives a flat output.</rdf:value>
<cmeta:modifier rdf:resource="rdf:#9fd515e4-13f3-4386-8f06-ea68f430b4d1"/>
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<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#4cfb5e9b-a2cb-4a8f-bc49-9ee618486965"/>
</rdf:Description>
</rdf:RDF>
</model>
