- Author:
- Hanne <Hanne@hanne-nielsens-macbook.local>
- Date:
- 2009-12-14 15:25:24+13:00
- Desc:
- Added images in ai and svg format, removed non pub med references
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/schuster_beny_meister_2003/rawfile/8320ff37fa3b709bbfcff96d5b4aa662ff2ab12c/schuster_beny_meister_2003.cellml
<?xml version='1.0' encoding='utf-8'?>
<!-- FILE : schuster_model_2003.xml
CREATED : 20th January 2004
LAST MODIFIED : 20th January 2004
AUTHOR : Catherine Lloyd
Bioengineering Instute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/01/2002 CellML Metadata 1.0 Specification.
DESCRIPTION : This file contains a CellML description of Schuster et al.'s 2003 mathematical model of the electrophysiological endothelial cell response to bradykinin.
CHANGES:
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<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Modelling the Electrophysiological Endothelial Cell Response to Bradykinin</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Through their synthesis of vasoactive substances, such as nitric oxide and prostacyclin, the endothelial cells which line the blood vessels play an important role in the the local control of the vascular tone. Synthesis of the vasoactive agents is often induced by membrane hyperpolarisation, and the activation of the endothelial cells leads to an increase in the intracellular calcium concentration ([Ca<superscript>2+</superscript>]<subscript>i</subscript>), due to Ca<superscript>2+</superscript> release from the intracellular stores, and Ca<superscript>2+</superscript> influx from the extracellular space.
</para>
<para>
The peptide bradykinin is an endothelium-dependent vasodilator for most arteries. It stimulates the endothelial cells to secrete nitric oxide and endothelium-derived hyperpolarising factor, which act as relaxing agents. In coronary artery endothelial cells bradykinin produces a transient hyperpolarisation, which is also associated with an increase in [Ca<superscript>2+</superscript>]<subscript>i</subscript>. The binding of bradykinin to its cell surface receptor triggers a signal transduction cascade involving phospholipase C (PLC) and the production of inositol 1,4,5-trisphosphate (IP<subscript>3</subscript>), which in turn stimulates the release of Ca<superscript>2+</superscript> from the intracellular stores (the sarcoplasmic reticulum, or SR).
</para>
<para>
In the Schuster <emphasis>et al.</emphasis> 2003 publication described here, the authors present a biophysical model of the membrane potential response of pig coronary artery endothelial cells in primary culture upon bradykinin stimulation (see the figure below). Model simulations demonstrate the model's ability to reproduce experimental results for both Ca<superscript>2+</superscript> and membrane potential (V<subscript>m</subscript>) dynamics.
</para>
<para>
The model has been described here in CellML (the raw CellML description of the Schuster <emphasis>et al.</emphasis> 2003 model can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>).
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
Modelling the electrophysiological endothelial cell response to bradykinin, Alexander Schuster, Jean-Louis Beny, and Jean-Jacques Meister, 2003, <<emphasis>European Biophysics Journal</emphasis>, 32, 370-380. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12851795&dopt=Abstract">PubMed ID: 12851795</ulink>
</para>
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<imagedata fileref="schuster_2003.png"/>
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<caption>Schematic diagram of the model, describing the electrophysiological endothelial cell response to bradykinin.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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<rdf:li>pharmacology</rdf:li>
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Modelling the electrophysiological endothelial cell response to bradykinin
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<dcterms:W3CDTF>2003-07</dcterms:W3CDTF>
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<vCard:Given>Catherine</vCard:Given>
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Schuster et al.'s 2003 mathematical model of the electrophysiological endothelial cell response to bradykinin.
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