- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2006-07-09 08:00:47+12:00
- Desc:
- committing version01 of neumann_lam_dahari_gretch_wiley_layden_perelson_1998
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/neumann_lam_dahari_gretch_wiley_layden_perelson_1998/rawfile/7ccf40cb146d0af180db32c9670682ef7b104a01/neumann_lam_dahari_gretch_wiley_layden_perelson_1998.cellml
<?xml version='1.0' encoding='utf-8'?>
<!-- FILE : neumann_model_1998.xml
CREATED : 8th September 2004
LAST MODIFIED : 8th September 2004
AUTHOR : Catherine Lloyd
Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/1/02 CellML Metadata 1.0 Specification.
DESCRIPTION : This file contains a CellML description of Neumann et al's 1998 mathematical model of hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy.
CHANGES:
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<article>
<articleinfo>
<title>Modelling Hepatitis C Viral Dynamics <emphasis>in Vivo</emphasis> and investigating the Antiviral Efficacy of Interferon-alpha Therapy</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
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<section id="sec_status">
<title>Model Status</title>
<para>
This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
It is estimated that 2 to 15 percent of the world's population is infected with the hepatitis C virus. Of these people, 20 to 30 percent develop cirrhosis of the liver, and 1 to 3 percent develop liver cancer. Hepatitis C is currently treated with interferon (IFN), but unfortunately, this treatment is only successful in about 11 to 30 percent of cases, and the mechanism by which it acts is not well understood. In other viral infections, such as HIV, studying the viral dynamics during antiviral therapy has helped improve our understanding of the pathogenesis of the disease and also how the drugs function.
</para>
<para>
The mathematical model presented here by Neumann <emphasis>et al.</emphasis> is based on the kinetic data generated from a study of 23 patients with hepatitis C. These patients were administered with daily injections of IFN, at one of three possible doses, over the course of 14 days. The model uses three differential equations to describe how the numbers of target (uninfected) cells, and productively infected cells, and the viral load change over time and how they differ under different IFN treatments (see <xref linkend="fig_reaction_diagram"/> below).
</para>
<para>
The model has been described here in CellML (the raw CellML description of the Neumann <emphasis>et al.</emphasis> 1998 model can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>).
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.sciencemag.org/cgi/content/abstract/282/5386/103">Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-alpha Therapy</ulink>, Avidan U. Neumann, Nancy P. Lam, Harel Dahari, David R. Gretch, Thelma E. Wiley, Thomas J. Layden, and Alan S. Perelson, 1998, <ulink url="http://www.sciencemag.org/">
<emphasis>Science</emphasis>
</ulink>, 282, 103-107. (<ulink url="http://www.sciencemag.org/cgi/content/full/282/5386/103">Full text (HTML)</ulink> and <ulink url="http://www.sciencemag.org/cgi/reprint/282/5386/103.pdf">PDF</ulink> versions of the article are available to subscribers on the <emphasis>Science</emphasis> website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9756471&dopt=Abstract">PubMed ID: 9756471</ulink>
</para>
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<title>reaction diagram</title>
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<caption>Schematic diagram of the viral dynamics of Hepatitis C <emphasis>in vivo</emphasis>.</caption>
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Neumann et al's 1998 mathematical model of hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy.
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