- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2007-04-13 01:55:49+12:00
- Desc:
- committing version02 of iyer_mazhari_winslow_2004
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/iyer_mazhari_winslow_2004/rawfile/d8a3f900c0e47b3fdbc0ca5652afbaa215c41b8e/iyer_mazhari_winslow_2004.cellml
<?xml version='1.0' encoding='utf-8'?>
<!--
This CellML file was generated on 02/10/2006 at 14:58:24 using:
COR (0.9.31.365)
Copyright 2002-2006 Oxford Cardiac Electrophysiology Group
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
--><!-- FILE : iyer_mazhari_winslow_2005_version02.cellml
CREATED : 14th September 2004
LAST MODIFIED : 13/04/07 by James Lawson
AUTHOR : Catherine Lloyd
The Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the CellML Metadata 1.0 Specification released on 16th
January, 2002.
DESCRIPTION : This file contains a CellML description of Iyer et al.'s 2004 mathematical model of the human left ventricular epicardial myocyte.
CHANGES:
27/04/2005 - PJV - Made MathML id's unique. Removed undefined
initial values. Removed extraneous character.
Date unknown: Version 02 was created by Penny Noble of Oxford University. Errors were fixed such that the model now runs in COR and PCEnv. Version 02 also now produces a train of action potentials.
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<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>A Computational Model of the Human Left-Ventricular Epicardial Myocyte</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
Version 02 was created from Version 01 by Penny Noble of Oxford University. This model now runs in COR and PCEnv and produces a train of action potentials.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Computational models of the mammalian ventricular myocyte have played a significant role in improving our understanding of the molecular mechanisms underlying the ventricular action potential, both in the normal, healthy individual and also in diseased states. As experimental techniques have become more sophisticated, more detailed biophysical data have been generated, and in turn, the mathematical models which are based on this data have also become more complex and physiologically more accurate. Examples of such computational models include:
</para>
<itemizedlist>
<listitem>
<para>
<ulink url="${HTML_EXMPL_LR_I_MODEL}">The Luo-Rudy Ventricular Model I, 1991</ulink>;</para>
</listitem>
<listitem>
<para>
<ulink url="${HTML_EXMPL_LR_II_MODEL}">The Luo-Rudy Ventricular Model II (dynamic), 1994</ulink>;</para>
</listitem>
<listitem>
<para>
<ulink url="${HTML_EXMPL_N98_MODEL}">The Noble <emphasis>et al.</emphasis> Ventricular Cell Model, 1998</ulink>;</para>
</listitem>
<listitem>
<para>
<ulink url="${HTML_EXMPL_PRIEBE_MODEL}">The Priebe and Beuckelmann, Electrophysiological Model of the Human Ventricular Myocyte, 1998</ulink>
</para>;</listitem>
<listitem>
<para>
<ulink url="${HTML_EXMPL_W_MODEL}">The Winslow <emphasis>et al.</emphasis> Canine Ventricular Cell Model, 1999</ulink>
</para>
</listitem>
<listitem>
<para>and most recently, <ulink url="${HTML_EXMPL_TEN_TUSSCHER_MODEL04}">The Ten Tusscher <emphasis>et al</emphasis>. Model For Human Ventricular Tissue, 2004</ulink>
</para>
</listitem>.
</itemizedlist>
<para>
Please note that this list is not exhaustive and there are more examples of ventricular myocyte models (some of which can be found in the Ventricular Myocyte section of the CellML model repository).
</para>
<para>
The Priebe-Beuckelmann model and the Ten Tusscher <emphasis>et al.</emphasis> models are able to adequately describe the qualitative features of the human ventricular action potential and also the calcium transient morphology, however, these models utilise little of the existing experimental data on channel properties, whole-cell currents, excitation-contraction coupling, or on the processes which regulate intracellular sodium concentration. By contrast, in the Iyer <emphasis>et al.</emphasis> 2004 publication described here, the authors use this more extensive experimental data to develop their computational model of the human left-ventricular epicardial myocyte (see <xref linkend="fig_cell_diagram"/> below). The resulting model displays long-term stability of intracellular ion concentrations over a range of pacing frequencies, and it is also able to reproduce and predict the diverse behaviours which have been measured experimentally in isolated human ventricular myocytes.
</para>
<para>
The model has been described here in CellML (the raw CellML description of the Iyer <emphasis>et al.</emphasis> 2004 model can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>).
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.biophysj.org/cgi/content/abstract/87/3/1507">A Computational Model of the Human Left-Ventricular Epicardial Myocyte</ulink>, Vivek Iyer, Reza Mazhari and Raimond L. Winslow, 2004, <ulink url="http://www.biophysj.org/">
<emphasis>Biophysical Journal</emphasis>
</ulink>, 87, 1507-1525. (<ulink url="http://www.biophysj.org/cgi/content/full/87/3/1507">Full text (HTML)</ulink> and <ulink url="http://www.biophysj.org/cgi/reprint/87/3/1507.pdf">PDF</ulink> versions of the article are available to subscribers on the <emphasis>Biophysical Journal</emphasis> website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15345532&dopt=Abstract">PubMed ID: 15345532</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell diagram</title>
</objectinfo>
<imagedata fileref="cell_diagram.gif"/>
</imageobject>
</mediaobject>
<caption>A schematic diagram describing the ion movement across the cell surface membrane and the sarcoplasmic reticulum, which are described by the Iyer <emphasis>et al.</emphasis> 2004 mathematical model of the human left-ventricular epicardial myocyte.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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<cn cellml:units="joule_per_kelvin_mole">225.175</cn>
<ci>R</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>eta</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Q</ci>
<ci>K</ci>
<ci>T</ci>
</apply>
<ci>H</ci>
</apply>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="joule_per_mole">147814</cn>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="joule_per_kelvin_mole">338.915</cn>
<ci>R</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.136</cn>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>nu</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Q</ci>
<ci>K</ci>
<ci>T</ci>
</apply>
<ci>H</ci>
</apply>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="joule_per_mole">121322</cn>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="joule_per_kelvin_mole">193.265</cn>
<ci>R</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.7429</cn>
</apply>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Cn</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Q</ci>
<ci>K</ci>
<ci>T</ci>
</apply>
<ci>H</ci>
</apply>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="joule_per_mole">287913</cn>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="joule_per_kelvin_mole">786.217</cn>
<ci>R</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Cf</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Q</ci>
<ci>K</ci>
<ci>T</ci>
</apply>
<ci>H</ci>
</apply>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="joule_per_mole">59565</cn>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="joule_per_kelvin_mole">0.00711</cn>
<ci>R</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C0Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>beta</ci>
<ci>C1Na</ci>
</apply>
<apply>
<times/>
<ci>Cf</ci>
<ci>CI0Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha</ci>
</apply>
<ci>Cn</ci>
</apply>
<ci>C0Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha</ci>
<ci>C0Na</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta</ci>
<ci>C2Na</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>Cf</ci>
<ci>a</ci>
</apply>
<ci>CI1Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>beta</ci>
<apply>
<times/>
<ci>Cn</ci>
<ci>a</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha</ci>
</apply>
</apply>
<ci>C1Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha</ci>
<ci>C1Na</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta</ci>
<ci>C3Na</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>Cf</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<ci>CI2Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta</ci>
</apply>
<apply>
<times/>
<ci>Cn</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha</ci>
</apply>
</apply>
<ci>C2Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha</ci>
<ci>C2Na</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta</ci>
<ci>C4Na</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>Cf</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<ci>CI3Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta</ci>
</apply>
<apply>
<times/>
<ci>Cn</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<ci>alpha</ci>
</apply>
<ci>C3Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C4Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha</ci>
<ci>C3Na</ci>
</apply>
<apply>
<times/>
<ci>delta</ci>
<ci>O1Na</ci>
</apply>
<apply>
<times/>
<ci>nu</ci>
<ci>O2Na</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>Cf</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
<ci>CI4Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta</ci>
</apply>
<apply>
<times/>
<ci>Cn</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
<ci>gamma</ci>
<ci>eta</ci>
</apply>
<ci>C4Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O1Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>gamma</ci>
<ci>C4Na</ci>
</apply>
<apply>
<times/>
<ci>omega</ci>
<ci>O2Na</ci>
</apply>
<apply>
<times/>
<ci>Of</ci>
<ci>INa</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>delta</ci>
<ci>epsilon</ci>
<ci>On</ci>
</apply>
<ci>O1Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O2Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>epsilon</ci>
<ci>O1Na</ci>
</apply>
<apply>
<times/>
<ci>eta</ci>
<ci>C4Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>omega</ci>
<ci>nu</ci>
</apply>
<ci>O2Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI0Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<divide/>
<ci>beta</ci>
<ci>a</ci>
</apply>
<ci>CI1Na</ci>
</apply>
<apply>
<times/>
<ci>Cn</ci>
<ci>C0Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>Cf</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha</ci>
<ci>a</ci>
</apply>
</apply>
<ci>CI0Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI1Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha</ci>
<ci>a</ci>
<ci>CI0Na</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta</ci>
</apply>
<ci>a</ci>
</apply>
<ci>CI2Na</ci>
</apply>
<apply>
<times/>
<ci>Cn</ci>
<ci>a</ci>
<ci>C1Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<ci>beta</ci>
<ci>a</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha</ci>
<ci>a</ci>
</apply>
<apply>
<divide/>
<ci>Cf</ci>
<ci>a</ci>
</apply>
</apply>
<ci>CI1Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI2Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha</ci>
<ci>a</ci>
<ci>CI1Na</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta</ci>
</apply>
<ci>a</ci>
</apply>
<ci>CI3Na</ci>
</apply>
<apply>
<times/>
<ci>Cn</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>C2Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta</ci>
</apply>
<ci>a</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha</ci>
<ci>a</ci>
</apply>
<apply>
<divide/>
<ci>Cf</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<ci>CI2Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI3Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha</ci>
<ci>a</ci>
<ci>CI2Na</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta</ci>
</apply>
<ci>a</ci>
</apply>
<ci>CI4Na</ci>
</apply>
<apply>
<times/>
<ci>Cn</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>C3Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta</ci>
</apply>
<ci>a</ci>
</apply>
<apply>
<times/>
<ci>alpha</ci>
<ci>a</ci>
</apply>
<apply>
<divide/>
<ci>Cf</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
<ci>CI3Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI4Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha</ci>
<ci>a</ci>
<ci>CI3Na</ci>
</apply>
<apply>
<times/>
<ci>delta_delta</ci>
<ci>INa</ci>
</apply>
<apply>
<times/>
<ci>Cn</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
<ci>C4Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta</ci>
</apply>
<ci>a</ci>
</apply>
<ci>gamma_gamma</ci>
<apply>
<divide/>
<ci>Cf</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
</apply>
<ci>CI4Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>INa</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>gamma_gamma</ci>
<ci>CI4Na</ci>
</apply>
<apply>
<times/>
<ci>On</ci>
<ci>O1Na</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>delta_delta</ci>
<ci>Of</ci>
</apply>
<ci>INa</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rapidly_activating_delayed_rectifier_potassium_current">
<variable units="picoA_per_picoF" public_interface="out" name="i_Kr"/>
<variable units="millivolt" public_interface="out" name="E_K"/>
<variable units="milliS_per_microF" name="g_Kr" initial_value="0.0186"/>
<variable units="dimensionless" name="f_Ko"/>
<variable units="dimensionless" name="IKr" initial_value="1.533e-6"/>
<variable units="dimensionless" name="C1Kr" initial_value="9.967e-1"/>
<variable units="dimensionless" name="C2Kr" initial_value="4.341e-4"/>
<variable units="dimensionless" name="C3Kr" initial_value="7.634e-5"/>
<variable units="dimensionless" name="OKr" initial_value="9.512e-6"/>
<variable units="first_order_rate_constant" name="alpha0"/>
<variable units="first_order_rate_constant" name="beta0"/>
<variable units="first_order_rate_constant" name="alpha1"/>
<variable units="first_order_rate_constant" name="beta1"/>
<variable units="first_order_rate_constant" name="alphai"/>
<variable units="first_order_rate_constant" name="betai"/>
<variable units="first_order_rate_constant" name="alphai3"/>
<variable units="first_order_rate_constant" name="kf"/>
<variable units="first_order_rate_constant" name="kb"/>
<variable units="dimensionless" name="psi"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="joule_per_kelvin_mole" public_interface="in" name="R"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="coulomb_per_millimole" public_interface="in" name="F"/>
<variable units="millimolar" public_interface="in" name="Ki"/>
<variable units="millimolar" public_interface="in" name="Ko"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kr</ci>
<apply>
<times/>
<ci>g_Kr</ci>
<ci>f_Ko</ci>
<ci>OKr</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>f_Ko</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Ko</ci>
<cn cellml:units="millimolar">4</cn>
</apply>
<cn cellml:units="dimensionless">0.5</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>kf</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">5.32</cn>
<cn cellml:units="first_order_rate_constant">0.0261</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>kb</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">5.32</cn>
<cn cellml:units="first_order_rate_constant">0.1483</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha0</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">5.32</cn>
<cn cellml:units="first_order_rate_constant">0.0171</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.033</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta0</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">5.32</cn>
<cn cellml:units="first_order_rate_constant">0.0397</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.0431</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">5.32</cn>
<cn cellml:units="first_order_rate_constant">0.0206</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0262</cn>
<ci>V</ci>
</apply>
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<ci>beta1</ci>
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<times/>
<cn cellml:units="dimensionless">5.32</cn>
<cn cellml:units="first_order_rate_constant">0.0013</cn>
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<exp/>
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<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.0269</cn>
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<ci>V</ci>
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<apply>
<eq/>
<ci>alphai</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">5.32</cn>
<cn cellml:units="first_order_rate_constant">0.1067</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0057</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>betai</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">5.32</cn>
<cn cellml:units="first_order_rate_constant">0.0065</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.0454</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alphai3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">5.32</cn>
<cn cellml:units="first_order_rate_constant">8.04e-5</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">6.98e-7</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>psi</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>beta1</ci>
<ci>betai</ci>
<ci>alphai3</ci>
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<apply>
<times/>
<ci>alpha1</ci>
<ci>alphai</ci>
</apply>
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<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1Kr</ci>
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<apply>
<minus/>
<apply>
<times/>
<ci>beta0</ci>
<ci>C2Kr</ci>
</apply>
<apply>
<times/>
<ci>alpha0</ci>
<ci>C1Kr</ci>
</apply>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2Kr</ci>
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<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha0</ci>
<ci>C1Kr</ci>
</apply>
<apply>
<times/>
<ci>kb</ci>
<ci>C3Kr</ci>
</apply>
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<apply>
<times/>
<apply>
<plus/>
<ci>beta0</ci>
<ci>kf</ci>
</apply>
<ci>C2Kr</ci>
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</apply>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
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<ci>C3Kr</ci>
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<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>psi</ci>
<ci>IKr</ci>
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<apply>
<times/>
<ci>beta1</ci>
<ci>OKr</ci>
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<apply>
<times/>
<ci>kf</ci>
<ci>C2Kr</ci>
</apply>
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<times/>
<apply>
<plus/>
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<ci>alpha1</ci>
<ci>alphai3</ci>
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<ci>C3Kr</ci>
</apply>
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<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>OKr</ci>
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<minus/>
<apply>
<plus/>
<apply>
<times/>
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<ci>C3Kr</ci>
</apply>
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<times/>
<ci>betai</ci>
<ci>IKr</ci>
</apply>
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<times/>
<apply>
<plus/>
<ci>beta1</ci>
<ci>alphai</ci>
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<ci>OKr</ci>
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<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IKr</ci>
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<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alphai3</ci>
<ci>C3Kr</ci>
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<times/>
<ci>alphai</ci>
<ci>OKr</ci>
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<times/>
<apply>
<plus/>
<ci>psi</ci>
<ci>betai</ci>
</apply>
<ci>IKr</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="slowly_activating_delayed_rectifier_potassium_current">
<variable units="picoA_per_picoF" public_interface="out" name="i_Ks"/>
<variable units="milliS_per_microF" name="g_Ks" initial_value="0.0035"/>
<variable units="dimensionless" name="C0Ks" initial_value="9.646e-1"/>
<variable units="dimensionless" name="C1Ks" initial_value="3.543e-2"/>
<variable units="dimensionless" name="O1Ks" initial_value="2.492e-7"/>
<variable units="dimensionless" name="O2Ks" initial_value="1.299e-5"/>
<variable units="first_order_rate_constant" name="alpha" initial_value="7.956e-3"/>
<variable units="first_order_rate_constant" name="beta"/>
<variable units="first_order_rate_constant" name="gamma" initial_value="3.97e-2"/>
<variable units="first_order_rate_constant" name="delta"/>
<variable units="first_order_rate_constant" name="epsilon"/>
<variable units="first_order_rate_constant" name="omega"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="millivolt" public_interface="in" name="V"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Ks</ci>
<apply>
<times/>
<ci>g_Ks</ci>
<apply>
<plus/>
<ci>O1Ks</ci>
<ci>O2Ks</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">2.16e-1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.00002</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>delta</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">7e-3</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.15</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>epsilon</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">7.67e-3</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.087</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>omega</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">3.8e-3</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.014</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C0Ks</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>beta</ci>
<ci>C1Ks</ci>
</apply>
<apply>
<times/>
<ci>alpha</ci>
<ci>C0Ks</ci>
</apply>
</apply>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1Ks</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha</ci>
<ci>C0Ks</ci>
</apply>
<apply>
<times/>
<ci>delta</ci>
<ci>O1Ks</ci>
</apply>
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<times/>
<apply>
<plus/>
<ci>beta</ci>
<ci>gamma</ci>
</apply>
<ci>C1Ks</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O1Ks</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>gamma</ci>
<ci>C1Ks</ci>
</apply>
<apply>
<times/>
<ci>omega</ci>
<ci>O2Ks</ci>
</apply>
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<apply>
<times/>
<apply>
<plus/>
<ci>delta</ci>
<ci>epsilon</ci>
</apply>
<ci>O1Ks</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O2Ks</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>epsilon</ci>
<ci>O1Ks</ci>
</apply>
<apply>
<times/>
<ci>omega</ci>
<ci>O2Ks</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="transient_outward_potassium_current_fast_recovering_component">
<variable units="picoA_per_picoF" public_interface="out" name="i_Kv4_3"/>
<variable units="milliS_per_microF" name="g_Kv4_3" initial_value="0.0775208"/>
<variable units="dimensionless" name="C1Kvf" initial_value="9.514e-1"/>
<variable units="dimensionless" name="C2Kvf" initial_value="2.668e-2"/>
<variable units="dimensionless" name="C3Kvf" initial_value="2.806e-4"/>
<variable units="dimensionless" name="C4Kvf" initial_value="1.312e-6"/>
<variable units="dimensionless" name="OKvf" initial_value="2.3e-9"/>
<variable units="dimensionless" name="CI1Kvf" initial_value="1.513e-2"/>
<variable units="dimensionless" name="CI2Kvf" initial_value="5.443e-3"/>
<variable units="dimensionless" name="CI3Kvf" initial_value="9.918e-4"/>
<variable units="dimensionless" name="CI4Kvf" initial_value="9.5144e-5"/>
<variable units="dimensionless" name="OIKvf" initial_value="2.743e-6"/>
<variable units="first_order_rate_constant" name="alphaa"/>
<variable units="first_order_rate_constant" name="betaa"/>
<variable units="first_order_rate_constant" name="alphai"/>
<variable units="first_order_rate_constant" name="betai"/>
<variable units="first_order_rate_constant" name="f1" initial_value="1.8936"/>
<variable units="first_order_rate_constant" name="f2" initial_value="14.2246"/>
<variable units="first_order_rate_constant" name="f3" initial_value="158.5743"/>
<variable units="first_order_rate_constant" name="f4" initial_value="142.9366"/>
<variable units="first_order_rate_constant" name="b1" initial_value="6.77348"/>
<variable units="first_order_rate_constant" name="b2" initial_value="15.6212"/>
<variable units="first_order_rate_constant" name="b3" initial_value="28.7532"/>
<variable units="first_order_rate_constant" name="b4" initial_value="524.5762"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="millivolt" public_interface="in" name="V"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kv4_3</ci>
<apply>
<times/>
<ci>g_Kv4_3</ci>
<ci>OKvf</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alphaa</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">0.543708</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.02898</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>betaa</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">0.080185</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.04684</cn>
</apply>
<ci>V</ci>
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</apply>
</apply>
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<eq/>
<ci>alphai</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">0.0498424</cn>
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<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.000373016</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>betai</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">0.000819482</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.00000005374</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1Kvf</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>betaa</ci>
<ci>C2Kvf</ci>
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<apply>
<times/>
<ci>alphai</ci>
<ci>CI1Kvf</ci>
</apply>
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<times/>
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<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alphaa</ci>
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<ci>betai</ci>
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<ci>C1Kvf</ci>
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<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2Kvf</ci>
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<minus/>
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<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alphaa</ci>
<ci>C1Kvf</ci>
</apply>
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<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>betaa</ci>
<ci>C3Kvf</ci>
</apply>
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<times/>
<apply>
<divide/>
<ci>alphai</ci>
<ci>b1</ci>
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<ci>CI2Kvf</ci>
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<times/>
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<plus/>
<ci>betaa</ci>
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<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alphaa</ci>
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<times/>
<ci>f1</ci>
<ci>betai</ci>
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<ci>C2Kvf</ci>
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<eq/>
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<diff/>
<bvar>
<ci>time</ci>
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<ci>C3Kvf</ci>
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<minus/>
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<plus/>
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<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alphaa</ci>
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<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>betaa</ci>
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<times/>
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<divide/>
<ci>alphai</ci>
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<ci>CI3Kvf</ci>
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<times/>
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<plus/>
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<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>betaa</ci>
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<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alphaa</ci>
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<times/>
<ci>f2</ci>
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<ci>C3Kvf</ci>
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<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C4Kvf</ci>
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<minus/>
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<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alphaa</ci>
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<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>betaa</ci>
<ci>OKvf</ci>
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<times/>
<apply>
<divide/>
<ci>alphai</ci>
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<ci>CI4Kvf</ci>
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<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>betaa</ci>
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<times/>
<ci>f3</ci>
<ci>betai</ci>
</apply>
</apply>
<ci>C4Kvf</ci>
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<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>OKvf</ci>
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<minus/>
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<plus/>
<apply>
<times/>
<ci>alphaa</ci>
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<apply>
<divide/>
<ci>alphai</ci>
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<ci>OIKvf</ci>
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<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>betaa</ci>
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<times/>
<ci>f4</ci>
<ci>betai</ci>
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<ci>OKvf</ci>
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<diff/>
<bvar>
<ci>time</ci>
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<ci>CI1Kvf</ci>
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<divide/>
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<ci>CI2Kvf</ci>
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<times/>
<ci>betai</ci>
<ci>C1Kvf</ci>
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<plus/>
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<times/>
<ci>b1</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>alphaa</ci>
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<ci>CI1Kvf</ci>
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<apply>
<diff/>
<bvar>
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<ci>CI2Kvf</ci>
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<plus/>
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<times/>
<ci>b1</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>alphaa</ci>
<ci>CI1Kvf</ci>
</apply>
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<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>f1</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>betaa</ci>
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<ci>f2</ci>
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<ci>CI3Kvf</ci>
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<times/>
<ci>f1</ci>
<ci>betai</ci>
<ci>C2Kvf</ci>
</apply>
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<times/>
<apply>
<plus/>
<apply>
<divide/>
<ci>betaa</ci>
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<ci>b2</ci>
<cn cellml:units="dimensionless">3</cn>
<ci>alphaa</ci>
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<ci>CI2Kvf</ci>
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<apply>
<diff/>
<bvar>
<ci>time</ci>
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<ci>CI3Kvf</ci>
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<apply>
<minus/>
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<plus/>
<apply>
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<apply>
<divide/>
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<times/>
<ci>b2</ci>
<cn cellml:units="dimensionless">3</cn>
<ci>alphaa</ci>
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<ci>CI2Kvf</ci>
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<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>f2</ci>
<cn cellml:units="dimensionless">3</cn>
<ci>betaa</ci>
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<ci>f3</ci>
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<ci>CI4Kvf</ci>
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<times/>
<ci>f2</ci>
<ci>betai</ci>
<ci>C3Kvf</ci>
</apply>
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<times/>
<apply>
<plus/>
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<divide/>
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<ci>f1</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>betaa</ci>
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<apply>
<times/>
<ci>b3</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>alphaa</ci>
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<ci>b2</ci>
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<divide/>
<ci>alphai</ci>
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<ci>CI3Kvf</ci>
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<diff/>
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<ci>time</ci>
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<ci>CI4Kvf</ci>
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<apply>
<minus/>
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<plus/>
<apply>
<times/>
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<times/>
<ci>b3</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>alphaa</ci>
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<ci>b2</ci>
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<ci>CI3Kvf</ci>
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<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>f3</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>betaa</ci>
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<ci>f4</ci>
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<ci>OIKvf</ci>
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<times/>
<ci>f3</ci>
<ci>betai</ci>
<ci>C4Kvf</ci>
</apply>
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<apply>
<times/>
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<plus/>
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<divide/>
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<times/>
<ci>f2</ci>
<cn cellml:units="dimensionless">3</cn>
<ci>betaa</ci>
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<ci>f3</ci>
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<apply>
<divide/>
<apply>
<times/>
<ci>b4</ci>
<ci>alphaa</ci>
</apply>
<ci>b3</ci>
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<apply>
<divide/>
<ci>alphai</ci>
<ci>b3</ci>
</apply>
</apply>
<ci>CI4Kvf</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>OIKvf</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<divide/>
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<times/>
<ci>b4</ci>
<ci>alphaa</ci>
</apply>
<ci>b3</ci>
</apply>
<ci>CI4Kvf</ci>
</apply>
<apply>
<times/>
<ci>f4</ci>
<ci>betai</ci>
<ci>OKvf</ci>
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<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>f3</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>betaa</ci>
</apply>
<ci>f4</ci>
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<apply>
<divide/>
<ci>alphai</ci>
<ci>b4</ci>
</apply>
</apply>
<ci>OIKvf</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="transient_outward_potassium_current_slowly_recovering_component">
<variable units="picoA_per_picoF" public_interface="out" name="i_Kv1_4"/>
<variable units="picoA_per_picoF" public_interface="out" name="i_Kv1_4Na"/>
<variable units="picoA_per_picoF" public_interface="out" name="i_Kv1_4K"/>
<variable units="cm_per_second" name="P_Kv1_4" initial_value="4.161e-8"/>
<variable units="dimensionless" name="C1Kvs" initial_value="5.977e-1"/>
<variable units="dimensionless" name="C2Kvs" initial_value="1.731e-1"/>
<variable units="dimensionless" name="C3Kvs" initial_value="1.881e-2"/>
<variable units="dimensionless" name="C4Kvs" initial_value="9.161e-4"/>
<variable units="dimensionless" name="OKvs" initial_value="1.976e-5"/>
<variable units="dimensionless" name="CI1Kvs" initial_value="3.539e-2"/>
<variable units="dimensionless" name="CI2Kvs" initial_value="5.429e-3"/>
<variable units="dimensionless" name="CI3Kvs" initial_value="2.288e-2"/>
<variable units="dimensionless" name="CI4Kvs" initial_value="3.234e-2"/>
<variable units="dimensionless" name="OIKvs" initial_value="1.134e-1"/>
<variable units="first_order_rate_constant" name="alphaa"/>
<variable units="first_order_rate_constant" name="betaa"/>
<variable units="first_order_rate_constant" name="alphai" initial_value="0.003058"/>
<variable units="first_order_rate_constant" name="betai" initial_value="2.44936e-6"/>
<variable units="first_order_rate_constant" name="f1" initial_value="0.52465"/>
<variable units="first_order_rate_constant" name="f2" initial_value="17.5188"/>
<variable units="first_order_rate_constant" name="f3" initial_value="938.587"/>
<variable units="first_order_rate_constant" name="f4" initial_value="54749.2"/>
<variable units="first_order_rate_constant" name="b1" initial_value="1.00948"/>
<variable units="first_order_rate_constant" name="b2" initial_value="1.171"/>
<variable units="first_order_rate_constant" name="b3" initial_value="0.63903"/>
<variable units="first_order_rate_constant" name="b4" initial_value="2.12035"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="joule_per_kelvin_mole" public_interface="in" name="R"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="coulomb_per_millimole" public_interface="in" name="F"/>
<variable units="picoA_per_picoF" public_interface="in" name="C_sc"/>
<variable units="millimolar" public_interface="in" name="Nai"/>
<variable units="millimolar" public_interface="in" name="Nao"/>
<variable units="millimolar" public_interface="in" name="Ki"/>
<variable units="millimolar" public_interface="in" name="Ko"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kv1_4</ci>
<apply>
<plus/>
<ci>i_Kv1_4K</ci>
<ci>i_Kv1_4Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Kv1_4K</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_Kv1_4</ci>
<ci>OKvs</ci>
<ci>C_sc</ci>
<ci>V</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
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<times/>
<ci>Ki</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<ci>Ko</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
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<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
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<eq/>
<ci>i_Kv1_4Na</ci>
<apply>
<divide/>
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<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.02</cn>
<ci>P_Kv1_4</ci>
<ci>OKvs</ci>
<ci>C_sc</ci>
<ci>V</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Nai</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
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<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
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<ci>Nao</ci>
</apply>
</apply>
<apply>
<minus/>
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<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
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<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
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<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
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<apply>
<eq/>
<ci>alphaa</ci>
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<times/>
<cn cellml:units="first_order_rate_constant">1.840024</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0077</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>betaa</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">0.010817</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.0779</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1Kvs</ci>
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<minus/>
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<plus/>
<apply>
<times/>
<ci>betaa</ci>
<ci>C2Kvs</ci>
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<apply>
<times/>
<ci>alphai</ci>
<ci>CI1Kvs</ci>
</apply>
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<times/>
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<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alphaa</ci>
</apply>
<ci>betai</ci>
</apply>
<ci>C1Kvs</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2Kvs</ci>
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<minus/>
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<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alphaa</ci>
<ci>C1Kvs</ci>
</apply>
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<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>betaa</ci>
<ci>C3Kvs</ci>
</apply>
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<times/>
<apply>
<divide/>
<ci>alphai</ci>
<ci>b1</ci>
</apply>
<ci>CI2Kvs</ci>
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<times/>
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<plus/>
<ci>betaa</ci>
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<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alphaa</ci>
</apply>
<apply>
<times/>
<ci>f1</ci>
<ci>betai</ci>
</apply>
</apply>
<ci>C2Kvs</ci>
</apply>
</apply>
</apply>
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<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3Kvs</ci>
</apply>
<apply>
<minus/>
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<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alphaa</ci>
<ci>C2Kvs</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>betaa</ci>
<ci>C4Kvs</ci>
</apply>
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<times/>
<apply>
<divide/>
<ci>alphai</ci>
<ci>b2</ci>
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<ci>CI3Kvs</ci>
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<times/>
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<plus/>
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<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>betaa</ci>
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<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alphaa</ci>
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<times/>
<ci>f2</ci>
<ci>betai</ci>
</apply>
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<ci>C3Kvs</ci>
</apply>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C4Kvs</ci>
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<minus/>
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<plus/>
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<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alphaa</ci>
<ci>C3Kvs</ci>
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<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>betaa</ci>
<ci>OKvs</ci>
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<times/>
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<divide/>
<ci>alphai</ci>
<ci>b3</ci>
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<ci>CI4Kvs</ci>
</apply>
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<times/>
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<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>betaa</ci>
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<ci>alphaa</ci>
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<times/>
<ci>f3</ci>
<ci>betai</ci>
</apply>
</apply>
<ci>C4Kvs</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>OKvs</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alphaa</ci>
<ci>C4Kvs</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>alphai</ci>
<ci>b4</ci>
</apply>
<ci>OIKvs</ci>
</apply>
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<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>betaa</ci>
</apply>
<apply>
<times/>
<ci>f4</ci>
<ci>betai</ci>
</apply>
</apply>
<ci>OKvs</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI1Kvs</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<divide/>
<ci>betaa</ci>
<ci>f1</ci>
</apply>
<ci>CI2Kvs</ci>
</apply>
<apply>
<times/>
<ci>betai</ci>
<ci>C1Kvs</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>b1</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>alphaa</ci>
</apply>
<ci>alphai</ci>
</apply>
<ci>CI1Kvs</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI2Kvs</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>b1</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>alphaa</ci>
<ci>CI1Kvs</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>f1</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>betaa</ci>
</apply>
<ci>f2</ci>
</apply>
<ci>CI3Kvs</ci>
</apply>
<apply>
<times/>
<ci>f1</ci>
<ci>betai</ci>
<ci>C2Kvs</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<ci>betaa</ci>
<ci>f1</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>b2</ci>
<cn cellml:units="dimensionless">3</cn>
<ci>alphaa</ci>
</apply>
<ci>b1</ci>
</apply>
<apply>
<divide/>
<ci>alphai</ci>
<ci>b1</ci>
</apply>
</apply>
<ci>CI2Kvs</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI3Kvs</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>b2</ci>
<cn cellml:units="dimensionless">3</cn>
<ci>alphaa</ci>
</apply>
<ci>b1</ci>
</apply>
<ci>CI2Kvs</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>f2</ci>
<cn cellml:units="dimensionless">3</cn>
<ci>betaa</ci>
</apply>
<ci>f3</ci>
</apply>
<ci>CI4Kvs</ci>
</apply>
<apply>
<times/>
<ci>f2</ci>
<ci>betai</ci>
<ci>C3Kvs</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>f1</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>betaa</ci>
</apply>
<ci>f2</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>b3</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>alphaa</ci>
</apply>
<ci>b2</ci>
</apply>
<apply>
<divide/>
<ci>alphai</ci>
<ci>b2</ci>
</apply>
</apply>
<ci>CI3Kvs</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI4Kvs</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>b3</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>alphaa</ci>
</apply>
<ci>b2</ci>
</apply>
<ci>CI3Kvs</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>f3</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>betaa</ci>
</apply>
<ci>f4</ci>
</apply>
<ci>OIKvs</ci>
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<apply>
<times/>
<ci>f3</ci>
<ci>betai</ci>
<ci>C4Kvs</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
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<times/>
<ci>f2</ci>
<cn cellml:units="dimensionless">3</cn>
<ci>betaa</ci>
</apply>
<ci>f3</ci>
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<apply>
<divide/>
<apply>
<times/>
<ci>b4</ci>
<ci>alphaa</ci>
</apply>
<ci>b3</ci>
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<apply>
<divide/>
<ci>alphai</ci>
<ci>b3</ci>
</apply>
</apply>
<ci>CI4Kvs</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>OIKvs</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>b4</ci>
<ci>alphaa</ci>
</apply>
<ci>b3</ci>
</apply>
<ci>CI4Kvs</ci>
</apply>
<apply>
<times/>
<ci>f4</ci>
<ci>betai</ci>
<ci>OKvs</ci>
</apply>
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<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>f3</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>betaa</ci>
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<ci>f4</ci>
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<apply>
<divide/>
<ci>alphai</ci>
<ci>b4</ci>
</apply>
</apply>
<ci>OIKvs</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="time_independent_potassium_current">
<variable units="picoA_per_picoF" public_interface="out" name="i_K1"/>
<variable units="milliS_per_microF_millimolar_half" name="g_K1" initial_value="0.125305"/>
<variable units="dimensionless" name="K1_infinity"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="millimolar" public_interface="in" name="Ko"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="joule_per_kelvin_mole" public_interface="in" name="R"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="coulomb_per_millimole" public_interface="in" name="F"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_K1</ci>
<apply>
<times/>
<ci>g_K1</ci>
<ci>K1_infinity</ci>
<apply>
<power/>
<ci>Ko</ci>
<cn cellml:units="dimensionless">0.5</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K1_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.94</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.26</cn>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_calcium_exchange_current">
<variable units="picoA_per_picoF" public_interface="out" name="i_NaCa"/>
<variable units="microA_per_microF" name="k_NaCa" initial_value="0.44"/>
<variable units="millimolar" name="Km_Na" initial_value="87.5"/>
<variable units="millimolar" name="Km_Ca" initial_value="1.38"/>
<variable units="dimensionless" name="k_sat" initial_value="0.2"/>
<variable units="dimensionless" name="eta" initial_value="0.35"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="joule_per_kelvin_mole" public_interface="in" name="R"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="coulomb_per_millimole" public_interface="in" name="F"/>
<variable units="millimolar" public_interface="in" name="Nai"/>
<variable units="millimolar" public_interface="in" name="Nao"/>
<variable units="millimolar" public_interface="in" name="Cai"/>
<variable units="millimolar" public_interface="in" name="Cao"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaCa</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>k_NaCa</ci>
<cn cellml:units="dimensionless">5000</cn>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<power/>
<ci>Km_Na</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>k_sat</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>Km_Ca</ci>
<ci>Cao</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>eta</ci>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cao</ci>
</apply>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_background_current">
<variable units="picoA_per_picoF" public_interface="out" name="i_Nab"/>
<variable units="milliS_per_microF" name="g_Nab" initial_value="0.001"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millivolt" public_interface="in" name="E_Na"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Nab</ci>
<apply>
<times/>
<ci>g_Nab</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_potassium_pump_current">
<variable units="picoA_per_picoF" public_interface="out" name="i_NaK"/>
<variable units="microA_per_microF" name="k_NaK" initial_value="2.387"/>
<variable units="millimolar" name="f_NaK"/>
<variable units="dimensionless" name="sigma"/>
<variable units="millimolar" name="Km_Nai" initial_value="20"/>
<variable units="millimolar" name="Km_Ko" initial_value="1.5"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="joule_per_kelvin_mole" public_interface="in" name="R"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="coulomb_per_millimole" public_interface="in" name="F"/>
<variable units="millimolar" public_interface="in" name="Nai"/>
<variable units="millimolar" public_interface="in" name="Ko"/>
<variable units="millimolar" public_interface="in" name="Nao"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>k_NaK</ci>
<ci>f_NaK</ci>
<ci>Ko</ci>
</apply>
<apply>
<plus/>
<ci>Ko</ci>
<ci>Km_Ko</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Nai</ci>
<ci>Nai</ci>
</apply>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>f_NaK</ci>
<apply>
<divide/>
<cn cellml:units="millimolar">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0365</cn>
<ci>sigma</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.33</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>sigma</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">7</cn>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Nao</ci>
<cn cellml:units="millimolar">67.3</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sarcolemmal_calcium_pump_current">
<variable units="picoA_per_picoF" public_interface="out" name="i_pCa"/>
<variable units="nanoS_per_picoF" name="I_pCa" initial_value="0.05"/>
<variable units="millimolar" name="Km_pCa" initial_value="0.0005"/>
<variable units="millimolar" public_interface="in" name="Cai"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_pCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>I_pCa</ci>
<ci>Cai</ci>
</apply>
<apply>
<plus/>
<ci>Km_pCa</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_background_current">
<variable units="picoA_per_picoF" public_interface="out" name="i_Cab"/>
<variable units="milliS_per_microF" name="g_Cab" initial_value="7.684e-5"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millivolt" public_interface="in" name="E_Ca"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Cab</ci>
<apply>
<times/>
<ci>g_Cab</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_calcium_current">
<variable units="picoA_per_picoF" public_interface="out" name="i_Ca"/>
<variable units="picoA_per_picoF" public_interface="out" name="i_CaK"/>
<variable units="millivolt" public_interface="out" name="E_Ca"/>
<variable units="cm_per_second" name="P_Ca" initial_value="2.469e-4"/>
<variable units="dimensionless" name="Pscale" initial_value="7"/>
<variable units="cm_per_second" name="PK" initial_value="4.574e-7"/>
<variable units="cm_per_second" name="P_K"/>
<variable units="picoA_per_picoF" name="i_Ca_half" initial_value="-0.265"/>
<variable units="dimensionless" name="I_Ca"/>
<variable units="dimensionless" name="C0L" initial_value="8.622e-1"/>
<variable units="dimensionless" name="C1L" initial_value="1.141e-2"/>
<variable units="dimensionless" name="C2L" initial_value="5.666e-5"/>
<variable units="dimensionless" name="C3L" initial_value="1.25e-7"/>
<variable units="dimensionless" name="C4L" initial_value="1.034e-10"/>
<variable units="dimensionless" name="OL" initial_value="7.758e-12"/>
<variable units="dimensionless" name="CCa0L" initial_value="1.199e-1"/>
<variable units="dimensionless" name="CCa1L" initial_value="6.347e-3"/>
<variable units="dimensionless" name="CCa2L" initial_value="1.26e-4"/>
<variable units="dimensionless" name="CCa3L" initial_value="1.112e-6"/>
<variable units="dimensionless" name="CCa4L" initial_value="3.681e-9"/>
<variable units="first_order_rate_constant" name="alpha"/>
<variable units="first_order_rate_constant" name="beta"/>
<variable units="first_order_rate_constant" name="gamma"/>
<variable units="first_order_rate_constant" name="alpha_"/>
<variable units="first_order_rate_constant" name="beta_"/>
<variable units="dimensionless" name="y" initial_value="9.997e-1"/>
<variable units="first_order_rate_constant" name="f" initial_value="0.3"/>
<variable units="first_order_rate_constant" name="g" initial_value="4"/>
<variable units="dimensionless" name="a" initial_value="2"/>
<variable units="dimensionless" name="b" initial_value="2"/>
<variable units="per_millisecond_millimetre" name="omega" initial_value="2.5e-3"/>
<variable units="dimensionless" name="y_infinity"/>
<variable units="millisecond" name="tau_y"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="picoA_per_picoF" public_interface="in" name="C_sc"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="joule_per_kelvin_mole" public_interface="in" name="R"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="coulomb_per_millimole" public_interface="in" name="F"/>
<variable units="millimolar" public_interface="in" name="Cai"/>
<variable units="millimolar" public_interface="in" name="Cao"/>
<variable units="millimolar" public_interface="in" name="Ki"/>
<variable units="millimolar" public_interface="in" name="Ko"/>
<variable units="millimolar" public_interface="in" name="Ca_ss"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Ca</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">1.9968</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.012</cn>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">35</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta</ci>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">0.0882</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.065</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">22</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_</ci>
<apply>
<times/>
<ci>alpha</ci>
<ci>a</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_</ci>
<apply>
<divide/>
<ci>beta</ci>
<ci>b</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>gamma</ci>
<apply>
<times/>
<cn cellml:units="per_millimolar">0.055398</cn>
<ci>Ca_ss</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C0L</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>beta</ci>
<ci>C1L</ci>
</apply>
<apply>
<times/>
<ci>omega</ci>
<ci>CCa0L</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha</ci>
</apply>
<ci>gamma</ci>
</apply>
<ci>C0L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1L</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha</ci>
<ci>C0L</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta</ci>
<ci>C2L</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>omega</ci>
<ci>b</ci>
</apply>
<ci>CCa1L</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha</ci>
</apply>
<ci>beta</ci>
<apply>
<times/>
<ci>gamma</ci>
<ci>a</ci>
</apply>
</apply>
<ci>C1L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2L</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha</ci>
<ci>C1L</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta</ci>
<ci>C3L</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>omega</ci>
<apply>
<power/>
<ci>b</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<ci>CCa2L</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<ci>C2L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3L</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha</ci>
<ci>C2L</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta</ci>
<ci>C4L</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>omega</ci>
<apply>
<power/>
<ci>b</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<ci>CCa3L</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
<ci>C3L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C4L</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha</ci>
<ci>C3L</ci>
</apply>
<apply>
<times/>
<ci>g</ci>
<ci>OL</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>omega</ci>
<apply>
<power/>
<ci>b</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
<ci>CCa4L</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>f</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
</apply>
<ci>C4L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>OL</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>f</ci>
<ci>C4L</ci>
</apply>
<apply>
<times/>
<ci>g</ci>
<ci>OL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa0L</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>beta_</ci>
<ci>CCa1L</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<ci>C0L</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha_</ci>
</apply>
<ci>omega</ci>
</apply>
<ci>CCa0L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa1L</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha_</ci>
<ci>CCa0L</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta_</ci>
<ci>CCa2L</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<ci>a</ci>
<ci>C1L</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha_</ci>
</apply>
<ci>beta_</ci>
<apply>
<divide/>
<ci>omega</ci>
<ci>b</ci>
</apply>
</apply>
<ci>CCa1L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa2L</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha_</ci>
<ci>CCa1L</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta_</ci>
<ci>CCa3L</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>C2L</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha_</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta_</ci>
</apply>
<apply>
<divide/>
<ci>omega</ci>
<apply>
<power/>
<ci>b</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<ci>CCa2L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa3L</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha_</ci>
<ci>CCa2L</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta_</ci>
<ci>CCa4L</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>C3L</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta_</ci>
</apply>
<apply>
<divide/>
<ci>omega</ci>
<apply>
<power/>
<ci>b</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
<ci>CCa3L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa4L</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_</ci>
<ci>CCa3L</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<power/>
<ci>a</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
<ci>C4L</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta_</ci>
</apply>
<apply>
<divide/>
<ci>omega</ci>
<apply>
<power/>
<ci>b</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
</apply>
<ci>CCa4L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_infinity</ci>
<ci>y</ci>
</apply>
<ci>tau_y</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>y_infinity</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.82</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">28.5</cn>
</apply>
<cn cellml:units="millivolt">7.8</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">0.18</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_y</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.0033634</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.5</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">5.539</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.00779</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">49.51</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_Ca</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Pscale</ci>
<ci>P_Ca</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>C_sc</ci>
<ci>V</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.341</cn>
<ci>Cao</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca</ci>
<apply>
<times/>
<ci>I_Ca</ci>
<ci>y</ci>
<ci>OL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_K</ci>
<ci>C_sc</ci>
<ci>y</ci>
<ci>OL</ci>
<ci>V</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Ki</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<ci>Ko</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_K</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<ci>Pscale</ci>
<ci>PK</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>I_Ca</ci>
<ci>i_Ca_half</ci>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>I_Ca</ci>
<cn cellml:units="picoA_per_picoF">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<ci>Pscale</ci>
<ci>PK</ci>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="RyR_channel">
<variable units="flux" public_interface="out" name="J_rel"/>
<variable units="dimensionless" name="PC1" initial_value="4.448e-1"/>
<variable units="dimensionless" name="PO1" initial_value="6.602e-4"/>
<variable units="dimensionless" name="PO2" initial_value="5.545e-1"/>
<variable units="dimensionless" name="PC2" initial_value="3.974e-9"/>
<variable units="fifth_order_rate_constant" name="ka_plus" initial_value="0.01215"/>
<variable units="first_order_rate_constant" name="ka_minus" initial_value="0.576"/>
<variable units="forth_order_rate_constant" name="kb_plus" initial_value="0.00405"/>
<variable units="first_order_rate_constant" name="kb_minus" initial_value="1.93"/>
<variable units="first_order_rate_constant" name="kc_plus" initial_value="0.1"/>
<variable units="first_order_rate_constant" name="kc_minus" initial_value="0.0008"/>
<variable units="first_order_rate_constant" name="v1" initial_value="1.8"/>
<variable units="dimensionless" name="m" initial_value="3"/>
<variable units="dimensionless" name="n" initial_value="4"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="millimolar" public_interface="in" name="Ca_JSR"/>
<variable units="millimolar" public_interface="in" name="Ca_ss"/>
<variable units="picoA_per_picoF" public_interface="in" name="C_sc"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_rel</ci>
<apply>
<times/>
<ci>v1</ci>
<apply>
<plus/>
<ci>PO1</ci>
<ci>PO2</ci>
</apply>
<apply>
<minus/>
<ci>Ca_JSR</ci>
<ci>Ca_ss</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PC1</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>ka_minus</ci>
<ci>PO1</ci>
</apply>
<apply>
<times/>
<ci>ka_plus</ci>
<apply>
<power/>
<apply>
<times/>
<ci>Ca_ss</ci>
<ci>C_sc</ci>
</apply>
<ci>n</ci>
</apply>
<ci>PC1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PO1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>ka_plus</ci>
<apply>
<power/>
<apply>
<times/>
<ci>Ca_ss</ci>
<ci>C_sc</ci>
</apply>
<ci>n</ci>
</apply>
<ci>PC1</ci>
</apply>
<apply>
<times/>
<ci>kb_minus</ci>
<ci>PO2</ci>
</apply>
<apply>
<times/>
<ci>kc_minus</ci>
<ci>PC2</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>ka_minus</ci>
<ci>PO1</ci>
</apply>
<apply>
<times/>
<ci>kb_plus</ci>
<apply>
<power/>
<apply>
<times/>
<ci>Ca_ss</ci>
<ci>C_sc</ci>
</apply>
<ci>m</ci>
</apply>
<ci>PO1</ci>
</apply>
<apply>
<times/>
<ci>kc_plus</ci>
<ci>PO1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PO2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kb_plus</ci>
<apply>
<power/>
<apply>
<times/>
<ci>Ca_ss</ci>
<ci>C_sc</ci>
</apply>
<ci>m</ci>
</apply>
<ci>PO1</ci>
</apply>
<apply>
<times/>
<ci>kb_minus</ci>
<ci>PO2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PC2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kc_plus</ci>
<ci>PO1</ci>
</apply>
<apply>
<times/>
<ci>kc_minus</ci>
<ci>PC2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SERCA2a_pump">
<variable units="flux" public_interface="out" name="J_up"/>
<variable units="millimolar" name="Kfb" initial_value="0.000168"/>
<variable units="dimensionless" name="fb"/>
<variable units="dimensionless" name="rb"/>
<variable units="dimensionless" name="KSR" initial_value="1.2"/>
<variable units="flux" name="vmax_f" initial_value="0.0748e-3"/>
<variable units="flux" name="vmax_r" initial_value="0.318e-3"/>
<variable units="dimensionless" name="Nrb" initial_value="1"/>
<variable units="dimensionless" name="Nfb" initial_value="1.2"/>
<variable units="millimolar" name="Krb" initial_value="3.29"/>
<variable units="millimolar" public_interface="in" name="Ca_NSR"/>
<variable units="millimolar" public_interface="in" name="Cai"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_up</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>KSR</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>vmax_f</ci>
<ci>fb</ci>
</apply>
<apply>
<times/>
<ci>vmax_r</ci>
<ci>rb</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fb</ci>
<ci>rb</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>fb</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Cai</ci>
<ci>Kfb</ci>
</apply>
<ci>Nfb</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>rb</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca_NSR</ci>
<ci>Krb</ci>
</apply>
<ci>Nrb</ci>
</apply>
</apply>
</math>
</component>
<component name="intracellular_calcium_fluxes">
<variable units="flux" public_interface="out" name="J_tr"/>
<variable units="flux" public_interface="out" name="J_xfer"/>
<variable units="flux" public_interface="out" name="J_trpn"/>
<variable units="millisecond" name="tau_tr" initial_value="0.5747"/>
<variable units="millisecond" name="tau_xfer" initial_value="26.7"/>
<variable units="millimolar" name="HTRPNCa" initial_value="9.772e-1"/>
<variable units="millimolar" name="LTRPNCa" initial_value="8.047e-2"/>
<variable units="millimolar" name="HTRPN_tot" initial_value="0.14"/>
<variable units="millimolar" name="LTRPN_tot" initial_value="0.07"/>
<variable units="flux" name="dHTRPNCa_dt"/>
<variable units="flux" name="dLTRPNCa_dt"/>
<variable units="second_order_rate_constant" name="K_plus_HTRPN" initial_value="20"/>
<variable units="first_order_rate_constant" name="K_minus_HTRPN" initial_value="0.066e-3"/>
<variable units="second_order_rate_constant" name="K_plus_LTRPN" initial_value="40"/>
<variable units="first_order_rate_constant" name="K_minus_LTRPN" initial_value="40e-3"/>
<variable units="millimolar" public_interface="in" name="Km_CMDN"/>
<variable units="millimolar" public_interface="in" name="Km_CSQN"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="millimolar" public_interface="in" name="Ca_NSR"/>
<variable units="millimolar" public_interface="in" name="Ca_JSR"/>
<variable units="millimolar" public_interface="in" name="Ca_ss"/>
<variable units="millimolar" public_interface="in" name="Cai"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_tr</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_NSR</ci>
<ci>Ca_JSR</ci>
</apply>
<ci>tau_tr</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_xfer</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_ss</ci>
<ci>Cai</ci>
</apply>
<ci>tau_xfer</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_trpn</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>HTRPN_tot</ci>
<ci>dHTRPNCa_dt</ci>
</apply>
<apply>
<times/>
<ci>LTRPN_tot</ci>
<ci>dLTRPNCa_dt</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>HTRPNCa</ci>
</apply>
<ci>dHTRPNCa_dt</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>LTRPNCa</ci>
</apply>
<ci>dLTRPNCa_dt</ci>
</apply>
<apply>
<eq/>
<ci>dHTRPNCa_dt</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>K_plus_HTRPN</ci>
<ci>Cai</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>HTRPNCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>K_minus_HTRPN</ci>
<ci>HTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dLTRPNCa_dt</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>K_plus_LTRPN</ci>
<ci>Cai</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>LTRPNCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>K_minus_LTRPN</ci>
<ci>LTRPNCa</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="intracellular_ion_concentrations_and_membrane_potential">
<variable units="millimolar" public_interface="out" name="Nai" initial_value="9.7983"/>
<variable units="millimolar" public_interface="out" name="Ki" initial_value="1.2556e2"/>
<variable units="millimolar" public_interface="out" name="Cai" initial_value="8.6012e-5"/>
<variable units="millimolar" public_interface="out" name="Ca_NSR" initial_value="2.855e-1"/>
<variable units="millimolar" public_interface="out" name="Ca_JSR" initial_value="2.852e-1"/>
<variable units="millimolar" public_interface="out" name="Ca_ss" initial_value="1.42e-4"/>
<variable units="millivolt" public_interface="out" name="V" initial_value="-9.0658e1"/>
<variable units="picoA_per_picoF" name="i_stim"/>
<variable units="dimensionless" name="betai"/>
<variable units="dimensionless" name="betass"/>
<variable units="dimensionless" name="betaJSR"/>
<variable units="microlitre" name="V_myo" initial_value="25.84e-6"/>
<variable units="microlitre" name="V_ss" initial_value="1.2e-9"/>
<variable units="microlitre" name="V_JSR" initial_value="0.16e-6"/>
<variable units="microlitre" name="V_NSR" initial_value="2.1e-6"/>
<variable units="picoF" name="Acap" initial_value="1.534e-4"/>
<variable units="millimolar" name="Km_EGTA" initial_value="1.5e-4"/>
<variable units="millimolar" name="EGTA_tot" initial_value="0"/>
<variable units="millimolar" name="CMDN_tot" initial_value="0.05"/>
<variable units="millimolar" name="CSQN_tot" initial_value="15"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Na"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Ca"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_CaK"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Kr"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Ks"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_K1"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_NaCa"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_NaK"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Kv1_4"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Kv1_4Na"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Kv1_4K"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Kv4_3"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_pCa"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Cab"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Nab"/>
<variable units="coulomb_per_millimole" public_interface="in" name="F"/>
<variable units="millimolar" public_interface="in" name="Km_CMDN"/>
<variable units="millimolar" public_interface="in" name="Km_CSQN"/>
<variable units="picoA_per_picoF" public_interface="in" name="C_sc"/>
<variable units="flux" public_interface="in" name="J_tr"/>
<variable units="flux" public_interface="in" name="J_up"/>
<variable units="flux" public_interface="in" name="J_xfer"/>
<variable units="flux" public_interface="in" name="J_rel"/>
<variable units="flux" public_interface="in" name="J_trpn"/>
<variable units="millisecond" name="stim_start" initial_value="10"/>
<variable units="millisecond" name="stim_end" initial_value="50000"/>
<variable units="millisecond" name="stim_period" initial_value="1000"/>
<variable units="millisecond" name="stim_duration" initial_value="3"/>
<variable units="picoA_per_picoF" name="stim_amplitude" initial_value="-40"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_stim</ci>
<piecewise>
<piece>
<ci>stim_amplitude</ci>
<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<apply>
<leq/>
<ci>time</ci>
<ci>stim_end</ci>
</apply>
<apply>
<leq/>
<apply>
<minus/>
<apply>
<minus/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<apply>
<times/>
<apply>
<floor/>
<apply>
<divide/>
<apply>
<minus/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_duration</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="picoA_per_picoF">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Na</ci>
<ci>i_Ca</ci>
<ci>i_CaK</ci>
<ci>i_Kr</ci>
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<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#author1VcardN"/>
</rdf:Description>
<rdf:Description rdf:about="">
<dcterms:created rdf:resource="rdf:#0acdf4ee-d945-47f2-9f4c-9093aaea1106"/>
<dc:creator rdf:resource="rdf:#b0ec2c37-b583-499b-a73e-14eaa21c6eee"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#81e08997-b294-4293-8a1c-b307dfb32fa9">
<vCard:Given>unknown</vCard:Given>
<vCard:Family>unknown</vCard:Family>
<vCard:Other>unknown</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#de4bbb64-8615-4281-8152-21f5cef3b041">
<vCard:Orgname>unknown</vCard:Orgname>
<vCard:Orgunit>unknown</vCard:Orgunit>
</rdf:Description>
<rdf:Description rdf:about="rdf:#5715a6e5-0fa9-42e8-86cc-1fbfaf95f4b3">
<bqs:Pubmed_id>unknown</bqs:Pubmed_id>
<bqs:JournalArticle rdf:resource="rdf:#845041cc-edcb-4a1b-9fbc-32d743c72378"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#0acdf4ee-d945-47f2-9f4c-9093aaea1106">
<dcterms:W3CDTF>2006-01-01</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#author3VcardN">
<vCard:Given>R</vCard:Given>
<vCard:Family>Winslow</vCard:Family>
<vCard:Other>L</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#44512045-259e-4610-abd5-b97592d46067">
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
<rdf:value>unknown</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#02657033-e03f-47c9-82fe-6c3b605724c4">
<dc:creator rdf:resource="rdf:#7c8eb255-7f6e-43bb-9235-dc8ccfd6f42d"/>
<rdf:value>unknown</rdf:value>
</rdf:Description>
</rdf:RDF>
</model>
