- Author:
- Dougal Cowan <devnull@localhost>
- Date:
- 2011-05-16 09:09:22+12:00
- Desc:
- removed file:// URIs from graphing metadata
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/guyton_volume_receptors_2008/rawfile/5a3365827fa6034c635acc3bdf9de155b7a2efeb/volume_receptors.cellml
<?xml version="1.0" encoding="utf-8"?>
<model
name="volume_receptors_model"
cmeta:id="volume_receptors_model"
xmlns="http://www.cellml.org/cellml/1.1#"
xmlns:cellml="http://www.cellml.org/cellml/1.1#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:xlink="http://www.w3.org/1999/xlink">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#volume_receptors_model">
<rdf:value>
The volume receptor nervous feedback mechanism:
The volume receptors are considered to be activated by right atrial pressure (PRA),
and feedback is provided to control non-muscle arterial resistance and venous tone.
</rdf:value>
</rdf:Description>
</rdf:RDF>
<!-- ============================================= Import the required units from the Units file ==================================================== -->
<import xlink:href="units.cellml">
<units name="minute" units_ref="minute"/>
<units name="per_minute" units_ref="per_minute"/>
<units name="beats_per_minute" units_ref="beats_per_minute"/>
<units name="beats_per_minute_per_mmHg" units_ref="beats_per_minute_per_mmHg"/>
<units name="minute_per_L" units_ref="minute_per_L"/>
<units name="mmHg" units_ref="mmHg"/>
<units name="per_mmHg" units_ref="per_mmHg"/>
<units name="mmHg_per_mL" units_ref="mmHg_per_mL"/>
<units name="mmHg_L" units_ref="mmHg_L"/>
<units name="per_mmHg2" units_ref="per_mmHg2"/>
<units name="mmHg3" units_ref="mmHg3"/>
<units name="monovalent_mEq" units_ref="monovalent_mEq"/>
<units name="monovalent_mEq_per_minute" units_ref="monovalent_mEq_per_minute"/>
<units name="monovalent_mEq_per_litre" units_ref="monovalent_mEq_per_litre"/>
<units name="mOsm" units_ref="mOsm"/>
<units name="mOsm_per_litre" units_ref="mOsm_per_litre"/>
<units name="mOsm_per_minute" units_ref="mOsm_per_minute"/>
<units name="monovalent_mEq_per_litre_per_minute" units_ref="monovalent_mEq_per_litre_per_minute"/>
<units name="litre2_per_monovalent_mEq_per_minute" units_ref="litre2_per_monovalent_mEq_per_minute"/>
<units name="L_per_minute" units_ref="L_per_minute"/>
<units name="per_mmHg_per_minute" units_ref="per_mmHg_per_minute"/>
<units name="mL" units_ref="mL"/>
<units name="gram_per_L" units_ref="gram_per_L"/>
<units name="L_mmHg_per_gram" units_ref="L_mmHg_per_gram"/>
<units name="L2_mmHg_per_gram2" units_ref="L2_mmHg_per_gram2"/>
<units name="mmHg_minute_per_L" units_ref="mmHg_minute_per_L"/>
<units name="mmHg_L_per_minute" units_ref="mmHg_L_per_minute"/>
<units name="gram_per_minute" units_ref="gram_per_minute"/>
<units name="mL_per_L" units_ref="mL_per_L"/>
<units name="mL_per_L_per_mmHg" units_ref="mL_per_L_per_mmHg"/>
<units name="mL_per_L_per_minute" units_ref="mL_per_L_per_minute"/>
<units name="mL_per_minute_per_mmHg" units_ref="mL_per_minute_per_mmHg"/>
<units name="L_mL_per_minute_per_mmHg" units_ref="L_mL_per_minute_per_mmHg"/>
<units name="L_per_mL" units_ref="L_per_mL"/>
<units name="L_per_mmHg" units_ref="L_per_mmHg"/>
<units name="mL_per_minute" units_ref="mL_per_minute"/>
<units name="L_per_minute_per_mmHg" units_ref="L_per_minute_per_mmHg"/>
<units name="L_per_minute_per_mmHg2" units_ref="L_per_minute_per_mmHg2"/>
</import>
<!-- ===================================== Import all Parameters and State Variables from the Parameter file ============================================== -->
<import xlink:href="parameters.cellml">
<component component_ref="parameter_values" name="parameter_values"/>
<component component_ref="state_variables" name="state_variables"/>
</import>
<!-- ======================================== VOLUME RECEPTORS TOP-LEVEL COMPONENT ============================================= -->
<component name="volume_receptors"
cmeta:id="volume_receptors">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#volume_receptors">
<rdf:value>
Encapsulation grouping component containing all the components in the Volume Receptors Model. The inputs and
outputs of the Volume Receptors Model must be passed by this component.
</rdf:value>
</rdf:Description>
</rdf:RDF>
<variable name="time" units="minute" private_interface="out" public_interface="in"/>
<!-- Inputs from components in other models -->
<variable name="PRA" units="mmHg" private_interface="out" public_interface="in"/>
<!-- Outputs to components in other models -->
<variable name="ATRRFB" units="dimensionless" private_interface="in" public_interface="out"/>
<variable name="ATRVFB" units="litre" private_interface="in" public_interface="out"/>
</component>
<!-- OUTPUT CONNECTIONS -->
<connection>
<map_components component_1="volume_receptors" component_2="volume_effect_on_arteries"/>
<map_variables variable_1="ATRRFB" variable_2="ATRRFB"/>
</connection>
<connection>
<map_components component_1="volume_receptors" component_2="volume_effect_on_unstressed_venous_volume"/>
<map_variables variable_1="ATRVFB" variable_2="ATRVFB"/>
</connection>
<!-- ======================================== EFFECT OF PRESSURE ON VOLUME RECEPTORS ============================================= -->
<component name="effect_of_pressure_on_volume_receptors"
cmeta:id="effect_of_pressure_on_volume_receptors">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#effect_of_pressure_on_volume_receptors">
<rdf:value>
VR1 and VR2:
The function curve in Block VR1 and sensitivity control in VR2 (controlled by
variable AH9) provide a relationship between right atrial pressure (PRA) and an
intermediate factor (AHZ) that controls the degree of nervous feedback.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#VR1_and_VR2">
<rdf:value>
VR1 and VR2:
The function curve in Block VR1 and sensitivity control in VR2 (controlled by
variable AH9) provide a relationship between right atrial pressure (PRA) and an
intermediate factor (AHZ) that controls the degree of nervous feedback.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#VR1_cont">
<rdf:value>
VR1 and VR2:
The function curve in Block VR1 and sensitivity control in VR2 (controlled by
variable AH9) provide a relationship between right atrial pressure (PRA) and an
intermediate factor (AHZ) that controls the degree of nervous feedback.
</rdf:value>
</rdf:Description>
</rdf:RDF>
<!-- Inputs from other components -->
<variable name="PRA" units="mmHg" private_interface="none" public_interface="in"/>
<!-- Outputs to other components -->
<variable name="AHZ" units="dimensionless" private_interface="none" public_interface="out"/>
<!-- Parameters from parameter_file -->
<variable name="AH10" units="dimensionless" private_interface="none" public_interface="in"/>
<variable name="AH9" units="per_mmHg" private_interface="none" public_interface="in"/>
<!-- Internal variables -->
<variable name="AHZ1" units="dimensionless" private_interface="none" public_interface="none"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="VR1_and_VR2">
<eq/>
<ci>AHZ1</ci>
<apply>
<times/>
<apply>
<power/>
<apply>
<abs/>
<ci>PRA</ci>
</apply>
<ci>AH10</ci>
</apply>
<ci>AH9</ci>
</apply>
</apply>
<apply id="VR1_cont">
<eq/>
<ci>AHZ</ci>
<piecewise>
<piece>
<apply>
<minus/>
<ci>AHZ1</ci>
</apply>
<apply>
<lt/>
<ci>PRA</ci>
<cn cellml:units="mmHg">0</cn>
</apply>
</piece>
<otherwise>
<ci>AHZ1</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<!-- INPUT CONNECTIONS -->
<connection>
<map_components component_1="effect_of_pressure_on_volume_receptors" component_2="volume_receptors"/>
<map_variables variable_1="PRA" variable_2="PRA"/>
</connection>
<!-- PARAMETER CONNECTIONS -->
<connection>
<map_components component_1="effect_of_pressure_on_volume_receptors" component_2="parameter_values"/>
<map_variables variable_1="AH9" variable_2="AH9"/>
<map_variables variable_1="AH10" variable_2="AH10"/>
</connection>
<!-- ======================================== TIME-DEPENDENT VOLUME RECEPTOR ADAPTATION ============================================= -->
<component name="time_dependent_volume_receptor_adaptation"
cmeta:id="time_dependent_volume_receptor_adaptation">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#time_dependent_volume_receptor_adaptation">
<rdf:value>
VR3, VR4, and VR5:
Series of blocks to provide autoresetting of the volume receptors back
toward zero with time. The degree of reset is the variable (AHY), and
the time constant for resetting is the variable (AH11).
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#VR3_to_VR5">
<rdf:value>
VR3, VR4, and VR5:
Series of blocks to provide autoresetting of the volume receptors back
toward zero with time. The degree of reset is the variable (AHY), and
the time constant for resetting is the variable (AH11).
</rdf:value>
</rdf:Description>
</rdf:RDF>
<!-- Inputs from other components -->
<variable name="AHZ" units="dimensionless" private_interface="none" public_interface="in"/>
<variable name="AHY_init" units="dimensionless" private_interface="none" public_interface="in"/>
<variable name="time" units="minute" private_interface="none" public_interface="in"/>
<!-- Outputs to other components -->
<variable name="AHY" initial_value="AHY_init" units="dimensionless" private_interface="none" public_interface="out"/>
<!-- Parameters from parameter_file -->
<variable name="AH11" units="minute" private_interface="none" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="VR3_to_VR5">
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>AHY</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>AHZ</ci>
<ci>AHY</ci>
</apply>
<ci>AH11</ci>
</apply>
</apply>
</math>
</component>
<!-- STATE VARIABLES INITIAL VALUE -->
<connection>
<map_components component_1="time_dependent_volume_receptor_adaptation" component_2="state_variables"/>
<map_variables variable_1="AHY_init" variable_2="AHY_init"/>
</connection>
<!-- INPUT CONNECTIONS -->
<connection>
<map_components component_1="time_dependent_volume_receptor_adaptation" component_2="effect_of_pressure_on_volume_receptors"/>
<map_variables variable_1="AHZ" variable_2="AHZ"/>
</connection>
<connection>
<map_components component_1="time_dependent_volume_receptor_adaptation" component_2="volume_receptors"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<!-- PARAMETER CONNECTIONS -->
<connection>
<map_components component_1="time_dependent_volume_receptor_adaptation" component_2="parameter_values"/>
<map_variables variable_1="AH11" variable_2="AH11"/>
</connection>
<!-- ======================================== TOTAL VOLUME NERVOUS FEEDBACK ============================================= -->
<component name="total_volume_nervous_feedback"
cmeta:id="total_volume_nervous_feedback">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#total_volume_nervous_feedback">
<rdf:value>
VR6:
The final degree of effect of the volume nervous feedback mechanism is
the output from block VR6 (AH7).
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#VR6">
<rdf:value>
VR6:
The final degree of effect of the volume nervous feedback mechanism is
the output from block VR6 (AH7).
</rdf:value>
</rdf:Description>
</rdf:RDF>
<!-- Inputs from other components -->
<variable name="AHZ" units="dimensionless" private_interface="none" public_interface="in"/>
<variable name="AHY" units="dimensionless" private_interface="none" public_interface="in"/>
<!-- Outputs to other components -->
<variable cmeta:id="total_volume_nervous_feedback_AH7"
name="AH7" units="dimensionless" private_interface="none" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="VR6">
<eq/>
<ci>AH7</ci>
<apply>
<minus/>
<ci>AHZ</ci>
<ci>AHY</ci>
</apply>
</apply>
</math>
</component>
<!-- INPUT CONNECTIONS -->
<connection>
<map_components component_1="total_volume_nervous_feedback" component_2="effect_of_pressure_on_volume_receptors"/>
<map_variables variable_1="AHZ" variable_2="AHZ"/>
</connection>
<connection>
<map_components component_1="total_volume_nervous_feedback" component_2="time_dependent_volume_receptor_adaptation"/>
<map_variables variable_1="AHY" variable_2="AHY"/>
</connection>
<!-- ======================================== VOLUME EFFECT ON ARTERIES ============================================= -->
<component name="volume_effect_on_arteries"
cmeta:id="volume_effect_on_arteries">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#volume_effect_on_arteries">
<rdf:value>
VR7 and VR8:
Sensitivity control for the volume receptor nervous feedback effect on the
non-muscle arterial resistance. The output multiplier effect for feedback
to the arteries is the variable (ATRRFB) and the sensitivity controller is
the variable (ATRFBM).
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#VR7_and_VR8">
<rdf:value>
VR7 and VR8:
Sensitivity control for the volume receptor nervous feedback effect on the
non-muscle arterial resistance. The output multiplier effect for feedback
to the arteries is the variable (ATRRFB) and the sensitivity controller is
the variable (ATRFBM).
</rdf:value>
</rdf:Description>
</rdf:RDF>
<!-- Inputs from other components -->
<variable name="AH7" units="dimensionless" private_interface="none" public_interface="in"/>
<!-- Outputs to other components -->
<variable cmeta:id="volume_effect_on_arteries_ATRRFB"
name="ATRRFB" units="dimensionless" private_interface="none" public_interface="out"/>
<!-- Parameters from parameter_file -->
<variable name="ATRFBM" units="dimensionless" private_interface="none" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="VR7_and_VR8">
<eq/>
<ci>ATRRFB</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>AH7</ci>
<ci>ATRFBM</ci>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</math>
</component>
<!-- INPUT CONNECTIONS -->
<connection>
<map_components component_1="volume_effect_on_arteries" component_2="total_volume_nervous_feedback"/>
<map_variables variable_1="AH7" variable_2="AH7"/>
</connection>
<!-- PARAMETER CONNECTIONS -->
<connection>
<map_components component_1="volume_effect_on_arteries" component_2="parameter_values"/>
<map_variables variable_1="ATRFBM" variable_2="ATRFBM"/>
</connection>
<!-- ======================================== VOLUME EFFECT ON UNSTRESSED VENOUS VOLUME ============================================= -->
<component name="volume_effect_on_unstressed_venous_volume"
cmeta:id="volume_effect_on_unstressed_venous_volume">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#volume_effect_on_unstressed_venous_volume">
<rdf:value>
VR9:
Sensitivity control for volume receptor feedback to the venous system.
The output of Block 9 (ATRVFB) controls V0 of the venous tree. The sensitivity
controller is the variable (ATRVM).
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#VR9">
<rdf:value>
VR9:
Sensitivity control for volume receptor feedback to the venous system.
The output of Block 9 (ATRVFB) controls V0 of the venous tree. The sensitivity
controller is the variable (ATRVM).
</rdf:value>
</rdf:Description>
</rdf:RDF>
<!-- Inputs from other components -->
<variable name="AH7" units="dimensionless" private_interface="none" public_interface="in"/>
<!-- Outputs to other components -->
<variable cmeta:id="volume_effect_on_unstressed_venous_volume_ATRVFB"
name="ATRVFB" units="litre" private_interface="none" public_interface="out"/>
<!-- Parameters from parameter_file -->
<variable name="ATRVM" units="litre" private_interface="none" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="VR9">
<eq/>
<ci>ATRVFB</ci>
<apply>
<times/>
<ci>AH7</ci>
<ci>ATRVM</ci>
</apply>
</apply>
</math>
</component>
<!-- INPUT CONNECTIONS -->
<connection>
<map_components component_1="volume_effect_on_unstressed_venous_volume" component_2="total_volume_nervous_feedback"/>
<map_variables variable_1="AH7" variable_2="AH7"/>
</connection>
<!-- PARAMETER CONNECTIONS -->
<connection>
<map_components component_1="volume_effect_on_unstressed_venous_volume" component_2="parameter_values"/>
<map_variables variable_1="ATRVM" variable_2="ATRVM"/>
</connection>
<!-- ============================================================ GROUPING =============================================================== -->
<group>
<relationship_ref relationship="containment"/>
<component_ref component="volume_receptors">
<component_ref component="effect_of_pressure_on_volume_receptors"/>
<component_ref component="time_dependent_volume_receptor_adaptation"/>
<component_ref component="total_volume_nervous_feedback"/>
<component_ref component="volume_effect_on_arteries"/>
<component_ref component="volume_effect_on_unstressed_venous_volume"/>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="volume_receptors">
<component_ref component="parameter_values"/>
<component_ref component="state_variables"/>
<component_ref component="effect_of_pressure_on_volume_receptors"/>
<component_ref component="time_dependent_volume_receptor_adaptation"/>
<component_ref component="total_volume_nervous_feedback"/>
<component_ref component="volume_effect_on_arteries"/>
<component_ref component="volume_effect_on_unstressed_venous_volume"/>
</component_ref>
</group>
</model>
