Location: Faber, Rudy, 2000 @ d9a791364364 / faber_rudy_modified_version_2000.cellml

Author:
Catherine Lloyd <c.lloyd@auckland.ac.nz>
Date:
2009-10-07 13:45:44+13:00
Desc:
Tidied up the documentation to be consistent with the rest of the repository.
Permanent Source URI:
https://models.physiomeproject.org/workspace/faber_rudy_2000/rawfile/d9a791364364fcf9c6849eeb85a3de164a00c98d/faber_rudy_modified_version_2000.cellml

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This CellML file was generated on 31/07/2008 at 3:02:14 at p.m. using:

COR (0.9.31.915)
Copyright 2002-2008 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk

CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
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<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
  <articleinfo>
  <title>The Most Recent Verison of the Luo-Rudy Mammalian Ventricular Model II</title>
  <author>
    <firstname>Catherine</firstname>
          <surname>Lloyd</surname>
    <affiliation>
      <shortaffil>Auckland Bioengineering Institute</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
            This model has been curated and is known to run in PCEnv and COR to recreate the published results.  The units have been checked and are known to be consistent.  The CellML model has been based on a translation of the LRd07 Matlab code which can be downloaded from the Rudy lab website.  It is basically the Faber and Rudy 2000 model with the addition of a transient potassium current (Ito) and an updated Irel current.
          </para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>A subsequent pair of papers by Ching-hsing Luo and Yoram Rudy (1994a; 1994b) further developed the Luo-Rudy I model by addressing some of the issues which were not investigated in their original model.  In particular, the LR-II model incorporates a more thorough description of the processes which regulate intracellular calcium ion concentration and the movement of calcium ions through the cell and to and from the sarcoplasmic reticulum (see figure 1 below).
</para>

<para>
The complete original paper reference is cited below:
</para>

<para>
<ulink url="http://circres.ahajournals.org/cgi/content/abstract/74/6/1071">A Dynamic Model of the Cardiac Ventricular Action Potential - Simulations of Ionic Currents and Concentration Changes</ulink>, Ching-hsing Luo and Yoram Rudy, 1994, <ulink url="http://circres.ahajournals.org/">
            <emphasis>Circulation Research</emphasis>
          </ulink>, 74, 1071-1097.
</para>

<para>
Since the model was published in 1994, it has been updated several times, incorporating new experimental data taken from papers written by other authors.  These modifications have been considered in the model presented here.  To illustrate how the Luo-Rudy II dynamic model has been developed, see the sequence of diagrams.  Please note that the 1997 Shaw and Rudy model diagram is identical to the 1999 Viswanathan model diagram since the only difference between the two models is that the Viswanathan model introduces a second activation gate (X<subscript>s2</subscript>) into the formulation of I<subscript>Ks</subscript>.  In addition, the development of the Luo-Rudy II model has been documented by Yoram Rudy (To view this website, follow this link: <ulink url="http://rudylab.wustl.edu/research/cell/methodology/cellmodels/LRd/history.htm"> http://rudylab.wustl.edu/research/cell/methodology/cellmodels/LRd/history.htm</ulink>  
</para>

<informalfigure float="0" id="fig_cell_diagram_LR_II">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>cell diagram of the LR-II model showing ionic currents, pumps and exchangers within the sarcolemma and the sarcoplasmic reticulum</title>
    </objectinfo>
    <imagedata fileref="luo_1994.png"/>
  </imageobject>
</mediaobject>
<caption>A schematic diagram describing the current flows across the cell membrane that are captured in the original, 1994 Luo-Rudy II, dynamic model.</caption>
</informalfigure>

<informalfigure float="0" id="fig_cell_diagram_zeng">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>cell diagram of the zeng model showing ionic currents, pumps and exchangers within the sarcolemma and the sarcoplasmic reticulum</title>
    </objectinfo>
    <imagedata fileref="zeng_1995.png"/>
  </imageobject>
</mediaobject>
<caption>A schematic diagram showing the updated Luo-Rudy II, dynamic model.  In their 1995 ventricular model Zeng <emphasis>et al</emphasis> have included the slow and fast components of the delayed rectifier K<superscript>+</superscript> current, I<subscript>Kr</subscript> and I<subscript>Ks</subscript>.  A T-type Calcium channel (I<subscript>Ca(T)</subscript>) is also added.</caption>
</informalfigure>

<informalfigure float="0" id="fig_cell_diagram_shaw">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>cell diagram of the shaw and viswanathan models showing ionic currents, pumps and exchangers within the sarcolemma and the sarcoplasmic reticulum</title>
    </objectinfo>
    <imagedata fileref="shaw_1997.png"/>
  </imageobject>
</mediaobject>
<caption>
In their 1997 model Shaw and Rudy have built upon the 1995 Zeng <emphasis>et al</emphasis> version of the 1994 Luo-Rudy Dynamic Ventricular Model.  In addition to the slow and fast components of the delayed rectifier K<superscript>+</superscript> current, (I<subscript>Kr</subscript> and I<subscript>Ks</subscript>) and the  T-type Calcium channel (I<subscript>Ca(T)</subscript>), Shaw and Rudy have included an ATP-dependent potassium current (I<subscript>K(ATP)</subscript>) in their model.  In turn, Viswanathan <emphasis>et al</emphasis> develop this model to include two activation gates (X<subscript>s1</subscript> and X<subscript>s2</subscript>) into the formulation of I<subscript>Ks</subscript>.</caption>
</informalfigure>

<informalfigure float="0" id="fig_cell_diagram_faber">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>cell diagram of the shaw and viswanathan models showing ionic currents, pumps and exchangers within the sarcolemma and the sarcoplasmic reticulum</title>
    </objectinfo>
    <imagedata fileref="faber_2000.png"/>
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<caption>In this version of the 1994 Luo-Rudy Dynamic Ventricular Model, Faber and Rudy have built upon the 1999 Viswanathan model and they have added a sodium-dependent potassium current (I<subscript>K(Na)</subscript>).</caption>
</informalfigure>

<informalfigure float="0" id="fig_cell_diagram_LRd">
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  <imageobject>
    <objectinfo>
      <title>cell diagram</title>
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    <imagedata fileref="faber_2000_new.png"/>
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<caption>In this most recent version of the 1994 Luo-Rudy Dynamic Ventricular Model, the model has been extended to include a transient outward potassium current (I<subscript>to</subscript>) and also the eqautions for the I<subscript>rel</subscript> current have been updated.</caption>
</informalfigure>

<informalfigure float="0" id="state_diagram">
<mediaobject>
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    <objectinfo>
      <title>state diagram</title>
    </objectinfo>
    <imagedata fileref="livshitz_rudy_2007.png"/>
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<caption>In this model, Livshitz and Rudy have merged the Luo-Rudy dynamic (LRd) and Hund-Rudy dynamic
(HRd) models of mammalian ventricular AP.  This is a schematic diagram of the currents and the ion exchanges described by this merged model.</caption>
</informalfigure>

<para>
All the original paper references are cited below.  Note that the CellML model described here is not based on a single publication per se.  Rather, it is mainly based upon the 2000 Faber and Rudy model, with the addition of a transient outward potassium current (I<subscript>to</subscript>) and also the eqautions for the I<subscript>rel</subscript> current have been updated.  These modifications were based on the LRd07 Matlab code, which can be downloaded from the <ulink url="http://rudylab.wustl.edu/research/cell/methodology/cellmodels/HRd/HRd07.html">Rudy Research Lab website</ulink>
</para>

<para>
<ulink url="http://circres.ahajournals.org/cgi/content/abstract/77/1/140">Two Components of the Delayed Rectifier K<superscript>+</superscript> Current in Ventricular Myocytes of the Guinea Pig Type</ulink>, Jinglin Zeng, Kenneth R. Laurita, David S. Rosenbaum and Yoram Rudy, 1995, <ulink url="http://circres.ahajournals.org/">
            <emphasis>Circulation Research</emphasis>
          </ulink>, 77, 140-152.  (The <ulink url="http://circres.ahajournals.org/cgi/content/full/77/1/140">full text</ulink> version of the article is available for Journal Members on the Circulation Research website.)  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=7788872&amp;dopt=Abstract">PubMed ID: 7788872</ulink>  
</para>

<para>
<ulink url="http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6T14-3R37WSS-17&amp;_user=140507&amp;_coverDate=08%2F31%2F1997&amp;_alid=185463716&amp;_rdoc=1&amp;_fmt=summary&amp;_orig=search&amp;_qd=1&amp;_cdi=4880&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000011498&amp;_version=1&amp;_urlVersion=0&amp;_userid=140507&amp;md5=ad03ef8fddd6cc6d11f8484e421991f2">Electrophysiological effects of acute myocardial ischemia: a theoretical study of altered cell excitability and action potential duration</ulink>, Robin M. Shaw and Yoram Rudy, 1997, <ulink url="http://www.sciencedirect.com/science?_ob=JournalURL&amp;_cdi=4880&amp;_auth=y&amp;_acct=C000011498&amp;_version=1&amp;_urlVersion=0&amp;_userid=140507&amp;md5=845774525765eaf31dec5d2fc2a614f6">
            <emphasis>Cardiovascular Research</emphasis>
          </ulink>, 35, 256-272.  <ulink url="http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6T14-3R37WSS-17&amp;_coverDate=08%2F31%2F1997&amp;_alid=185463716&amp;_rdoc=1&amp;_fmt=&amp;_orig=search&amp;_qd=1&amp;_cdi=4880&amp;_sort=d&amp;view=c&amp;_acct=C000011498&amp;_version=1&amp;_urlVersion=0&amp;_userid=140507&amp;md5=2b061b7dec7050a8c72e2eba382d5e97">Full text</ulink> and PDF versions of the article are available to subscribers on the Science Direct website.  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=9349389&amp;dopt=Abstract">PubMed ID: 9349389</ulink>    
</para>

<para>
<ulink url="http://circ.ahajournals.org/cgi/content/abstract/99/18/2466">Effects of I<subscript>Kr</subscript> and I<subscript>Ks</subscript> Heterogeneity on Action Potential Duration and Its Rate Dependence: A Simulation Study</ulink>, Prakash C. Viswanathan, BE; Robin M. Shaw, PhD; and Yoram Rudy, PhD, 1999, <ulink url="http://circ.ahajournals.org/">
            <emphasis>Circulation</emphasis>
          </ulink>, 99, 2466-2474.  (<ulink url="http://www.circ.ahajournals.org/cgi/content/full/99/18/2466">Full text</ulink> and <ulink url="http://www.circ.ahajournals.org/cgi/reprint/99/18/2466.pdf">PDF</ulink> versions of the article are available for Journal Members on the Circulation website.)  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=10318671&amp;dopt=Abstract">PubMed ID: 10318671</ulink>      
</para>

<para>
<ulink url="http://www.biophysj.org/cgi/content/abstract/78/5/2392">Action Potential and Contractility in [Na<superscript>+</superscript>]<subscript>i</subscript> Overloaded Cardiac Myocytes</ulink>, Gregory M. Faber and Yoram Rudy, 2000, <ulink url="http://www.biophysj.org/">
            <emphasis>Biophysical Journal</emphasis>
          </ulink>, 78, 2392-2404.  (<ulink url="http://www.biophysj.org/cgi/content/full/78/5/2392">Full text</ulink> and <ulink url="http://www.biophysj.org/cgi/reprint/78/5/2392.pdf">PDF</ulink> versions of the article are available for Journal Members on the Biophysical Journal website.)  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=10777735&amp;dopt=Abstract">PubMed ID: 10777735</ulink>   
</para>

<para>
<ulink url="http://ajpheart.physiology.org/cgi/content/abstract/292/6/H2854">Regulation of Ca2+ and electrical alternans in cardiac myocytes: role of CAMKII and repolarizing currents</ulink>, Leonid M. Livshitz and Yoram Rudy, 2007, <ulink url="http://ajpheart.physiology.org/">
            <emphasis>American Journal of Physiology: Heart and Circulatory Physiology</emphasis>
          </ulink>, 292, H2854-H2866. (<ulink url="http://ajpheart.physiology.org/cgi/content/full/292/6/H2854"> Full text</ulink> and <ulink url="http://ajpheart.physiology.org/cgi/reprint/292/6/H2854">PDF</ulink> versions of this article are available to subscribers on the <emphasis>American Journal of Physiology: Heart and Circulatory Physiology</emphasis> website).  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=17277017&amp;dopt=Abstract">PubMed ID: 17277017</ulink>
</para>

</sect1>
</article>
</documentation>

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         </apply>
      </math>
   </component>
   <component name="fast_sodium_current_m_gate">
      <variable units="dimensionless" public_interface="out" name="m" initial_value="0.001513296212"/>
      <variable units="per_ms" name="alpha_m"/>
      <variable units="per_ms" name="beta_m"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="millivolt" name="E0_m"/>
      <variable units="ms" public_interface="in" name="time"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E0_m</ci>
            <apply>
               <plus/>
               <ci>V</ci>
               <cn cellml:units="millivolt">47.13</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_m</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn cellml:units="per_millivolt_ms">0.32</cn>
                  <ci>E0_m</ci>
               </apply>
               <apply>
                  <minus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn cellml:units="per_millivolt">0.1</cn>
                        </apply>
                        <ci>E0_m</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_m</ci>
            <apply>
               <times/>
               <cn cellml:units="per_ms">0.08</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <ci>V</ci>
                     </apply>
                     <cn cellml:units="millivolt">11</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>m</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_m</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>m</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_m</ci>
                  <ci>m</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="fast_sodium_current_h_gate">
      <variable units="dimensionless" public_interface="out" name="h" initial_value="0.985318710339"/>
      <variable units="per_ms" name="alpha_h"/>
      <variable units="per_ms" name="beta_h"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="ms" public_interface="in" name="time"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_h</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <cn cellml:units="per_ms">0.135</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <cn cellml:units="millivolt">80</cn>
                              <ci>V</ci>
                           </apply>
                           <apply>
                              <minus/>
                              <cn cellml:units="millivolt">6.8</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn cellml:units="per_ms">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_h</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_ms">3.56</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn cellml:units="per_millivolt">0.079</cn>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn cellml:units="per_ms">310000</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn cellml:units="per_millivolt">0.35</cn>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <cn cellml:units="per_ms">1</cn>
                     <apply>
                        <times/>
                        <cn cellml:units="dimensionless">0.13</cn>
                        <apply>
                           <plus/>
                           <cn cellml:units="dimensionless">1</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">10.66</cn>
                                 </apply>
                                 <apply>
                                    <minus/>
                                    <cn cellml:units="millivolt">11.1</cn>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>h</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_h</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>h</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_h</ci>
                  <ci>h</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="fast_sodium_current_j_gate">
      <variable units="dimensionless" public_interface="out" name="j" initial_value="0.990731711845"/>
      <variable units="per_ms" name="alpha_j"/>
      <variable units="per_ms" name="beta_j"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="ms" public_interface="in" name="time"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_j</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <apply>
                                 <times/>
                                 <cn cellml:units="per_millivolt_ms">127140</cn>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <times/>
                                       <cn cellml:units="per_millivolt">0.2444</cn>
                                       <ci>V</ci>
                                    </apply>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <cn cellml:units="per_millivolt_ms">3.474e-5</cn>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <times/>
                                       <apply>
                                          <minus/>
                                          <cn cellml:units="per_millivolt">0.04391</cn>
                                       </apply>
                                       <ci>V</ci>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">37.78</cn>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn cellml:units="per_millivolt">0.311</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">79.23</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn cellml:units="per_ms">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_j</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_ms">0.1212</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_millivolt">0.01052</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_millivolt">0.1378</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">40.14</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_ms">0.3</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_millivolt">2.535e-7</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_millivolt">0.1</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">32</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>j</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_j</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>j</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_j</ci>
                  <ci>j</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel">
      <variable units="microA_per_microF" public_interface="out" name="i_Ca_L"/>
      <variable units="microA_per_microF" public_interface="out" name="i_CaCa"/>
      <variable units="microA_per_microF" public_interface="out" name="i_CaK"/>
      <variable units="microA_per_microF" public_interface="out" name="i_CaNa"/>
      <variable units="dimensionless" public_interface="out" name="gamma_Nai" initial_value="0.75"/>
      <variable units="dimensionless" public_interface="out" name="gamma_Nao" initial_value="0.75"/>
      <variable units="dimensionless" public_interface="out" name="gamma_Ki" initial_value="0.75"/>
      <variable units="dimensionless" public_interface="out" name="gamma_Ko" initial_value="0.75"/>
      <variable units="dimensionless" name="gamma_Cai" initial_value="1"/>
      <variable units="dimensionless" name="gamma_Cao" initial_value="0.341"/>
      <variable units="microA_per_microF" name="I_CaCa"/>
      <variable units="microA_per_microF" name="I_CaK"/>
      <variable units="microA_per_microF" name="I_CaNa"/>
      <variable units="litre_per_farad_millisecond" name="P_Ca" initial_value="0.00054"/>
      <variable units="litre_per_farad_millisecond" name="P_Na" initial_value="6.75e-7"/>
      <variable units="litre_per_farad_millisecond" name="P_K" initial_value="1.93e-7"/>
      <variable units="ms" public_interface="in" private_interface="out" name="time"/>
      <variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
      <variable units="millimolar" public_interface="in" private_interface="out" name="Cai"/>
      <variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
      <variable units="kelvin" public_interface="in" name="T"/>
      <variable units="coulomb_per_mole" public_interface="in" name="F"/>
      <variable units="millimolar" public_interface="in" name="Cao"/>
      <variable units="millimolar" public_interface="in" name="Nao"/>
      <variable units="millimolar" public_interface="in" name="Ko"/>
      <variable units="millimolar" public_interface="in" name="Nai"/>
      <variable units="millimolar" public_interface="in" name="Ki"/>
      <variable units="dimensionless" private_interface="in" name="d"/>
      <variable units="dimensionless" private_interface="in" name="f"/>
      <variable units="dimensionless" private_interface="in" name="f_Ca"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>I_CaCa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_Ca</ci>
                        <apply>
                           <power/>
                           <cn cellml:units="dimensionless">2</cn>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Cai</ci>
                        <ci>Cai</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn cellml:units="dimensionless">2</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Cao</ci>
                        <ci>Cao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">2</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_CaNa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_Na</ci>
                        <apply>
                           <power/>
                           <cn cellml:units="dimensionless">1</cn>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Nai</ci>
                        <ci>Nai</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn cellml:units="dimensionless">1</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Nao</ci>
                        <ci>Nao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">1</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_CaK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_K</ci>
                        <apply>
                           <power/>
                           <cn cellml:units="dimensionless">1</cn>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Ki</ci>
                        <ci>Ki</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn cellml:units="dimensionless">1</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Ko</ci>
                        <ci>Ko</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">1</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaCa</ci>
            <apply>
               <times/>
               <ci>d</ci>
               <ci>f</ci>
               <ci>f_Ca</ci>
               <ci>I_CaCa</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaNa</ci>
            <apply>
               <times/>
               <ci>d</ci>
               <ci>f</ci>
               <ci>f_Ca</ci>
               <ci>I_CaNa</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaK</ci>
            <apply>
               <times/>
               <ci>d</ci>
               <ci>f</ci>
               <ci>f_Ca</ci>
               <ci>I_CaK</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_L</ci>
            <apply>
               <plus/>
               <ci>i_CaCa</ci>
               <ci>i_CaK</ci>
               <ci>i_CaNa</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_d_gate">
      <variable units="dimensionless" public_interface="out" name="d" initial_value="0.000005906564"/>
      <variable units="per_ms" name="alpha_d"/>
      <variable units="per_ms" name="beta_d"/>
      <variable units="dimensionless" name="d_infinity"/>
      <variable units="ms" name="tau_d"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="ms" public_interface="in" name="time"/>
      <variable units="millivolt" name="E0_d"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E0_d</ci>
            <apply>
               <plus/>
               <ci>V</ci>
               <cn cellml:units="millivolt">10</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>d_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>E0_d</ci>
                        </apply>
                        <cn cellml:units="millivolt">6.24</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_d</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn cellml:units="ms">1</cn>
                  <ci>d_infinity</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>E0_d</ci>
                           </apply>
                           <cn cellml:units="millivolt">6.24</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <cn cellml:units="per_millivolt">0.035</cn>
                  <ci>E0_d</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_d</ci>
            <apply>
               <divide/>
               <ci>d_infinity</ci>
               <ci>tau_d</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_d</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <ci>d_infinity</ci>
               </apply>
               <ci>tau_d</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>d</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_d</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>d</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_d</ci>
                  <ci>d</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_f_gate">
      <variable units="dimensionless" public_interface="out" name="f" initial_value="0.999390880784"/>
      <variable units="per_ms" name="alpha_f"/>
      <variable units="per_ms" name="beta_f"/>
      <variable units="dimensionless" name="f_infinity"/>
      <variable units="ms" name="tau_f"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="ms" public_interface="in" name="time"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>f_infinity</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">32</cn>
                           </apply>
                           <cn cellml:units="millivolt">8</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn cellml:units="dimensionless">0.6</cn>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <cn cellml:units="millivolt">50</cn>
                              <ci>V</ci>
                           </apply>
                           <cn cellml:units="millivolt">20</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_f</ci>
            <apply>
               <divide/>
               <cn cellml:units="ms">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">0.0197</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <minus/>
                           <apply>
                              <power/>
                              <apply>
                                 <times/>
                                 <cn cellml:units="per_millivolt">0.0337</cn>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">10</cn>
                                 </apply>
                              </apply>
                              <cn cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">0.02</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_f</ci>
            <apply>
               <divide/>
               <ci>f_infinity</ci>
               <ci>tau_f</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_f</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <ci>f_infinity</ci>
               </apply>
               <ci>tau_f</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_f</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>f</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_f</ci>
                  <ci>f</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_f_Ca_gate">
      <variable units="dimensionless" public_interface="out" name="f_Ca"/>
      <variable units="millimolar" name="Km_Ca" initial_value="0.0006"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="millimolar" public_interface="in" name="Cai"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>f_Ca</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>Cai</ci>
                     <ci>Km_Ca</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="T_type_Ca_channel">
      <variable units="microA_per_microF" public_interface="out" name="i_Ca_T"/>
      <variable units="milliS_per_microF" name="g_CaT" initial_value="0.05"/>
      <variable units="millivolt" public_interface="in" name="E_Ca"/>
      <variable units="ms" public_interface="in" private_interface="out" name="time"/>
      <variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
      <variable units="dimensionless" private_interface="in" name="b"/>
      <variable units="dimensionless" private_interface="in" name="g"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ca_T</ci>
            <apply>
               <times/>
               <ci>g_CaT</ci>
               <ci>b</ci>
               <ci>b</ci>
               <ci>g</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ca</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="T_type_Ca_channel_b_gate">
      <variable units="dimensionless" public_interface="out" name="b" initial_value="0.001378275288"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="ms" public_interface="in" name="time"/>
      <variable units="dimensionless" name="b_inf"/>
      <variable units="ms" name="tau_b"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>b_inf</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">14</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="millivolt">10.8</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_b</ci>
            <apply>
               <plus/>
               <cn cellml:units="ms">3.7</cn>
               <apply>
                  <divide/>
                  <cn cellml:units="ms">6.1</cn>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">25</cn>
                           </apply>
                           <cn cellml:units="millivolt">4.5</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>b</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>b_inf</ci>
                  <ci>b</ci>
               </apply>
               <ci>tau_b</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="T_type_Ca_channel_g_gate">
      <variable units="dimensionless" public_interface="out" name="g" initial_value="0.988597502434"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="ms" public_interface="in" name="time"/>
      <variable units="dimensionless" name="g_inf"/>
      <variable units="ms" name="tau_g"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_inf</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">60</cn>
                        </apply>
                        <cn cellml:units="millivolt">5.6</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_g</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn cellml:units="ms_per_millivolt">0.875</cn>
                        </apply>
                        <ci>V</ci>
                     </apply>
                     <cn cellml:units="ms">12</cn>
                  </apply>
                  <apply>
                     <leq/>
                     <ci>V</ci>
                     <cn cellml:units="millivolt">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <cn cellml:units="ms">12</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>g</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>g_inf</ci>
                  <ci>g</ci>
               </apply>
               <ci>tau_g</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="rapid_delayed_rectifier_potassium_current">
      <variable units="microA_per_microF" public_interface="out" name="i_Kr"/>
      <variable units="milliS_per_microF" name="g_Kr"/>
      <variable units="milliS_per_microF" name="G_Kr" initial_value="0.02614"/>
      <variable units="dimensionless" name="Rect"/>
      <variable units="millivolt" public_interface="in" name="E_K"/>
      <variable units="ms" public_interface="in" private_interface="out" name="time"/>
      <variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
      <variable units="millimolar" public_interface="in" name="Ko"/>
      <variable units="dimensionless" private_interface="in" name="xr"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_Kr</ci>
            <apply>
               <times/>
               <ci>G_Kr</ci>
               <apply>
                  <root/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn cellml:units="millimolar">5.4</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Rect</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">9</cn>
                        </apply>
                        <cn cellml:units="millivolt">22.4</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Kr</ci>
            <apply>
               <times/>
               <ci>g_Kr</ci>
               <ci>xr</ci>
               <ci>Rect</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="rapid_delayed_rectifier_potassium_current_xr_gate">
      <variable units="dimensionless" public_interface="out" name="xr" initial_value="0.000207067204"/>
      <variable units="dimensionless" name="xr_infinity"/>
      <variable units="ms" name="tau_xr"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="ms" public_interface="in" name="time"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>xr_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">21.5</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="millivolt">7.5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xr</ci>
            <apply>
               <divide/>
               <cn cellml:units="ms">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_millivolt">0.00138</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">14.2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_millivolt">0.123</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">14.2</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_millivolt">0.00061</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">38.9</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn cellml:units="per_millivolt">0.145</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">38.9</cn>
                              </apply>
                           </apply>
                        </apply>
                        <cn cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xr</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xr_infinity</ci>
                  <ci>xr</ci>
               </apply>
               <ci>tau_xr</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_delayed_rectifier_potassium_current">
      <variable units="microA_per_microF" public_interface="out" name="i_Ks"/>
      <variable units="milliS_per_microF" name="g_Ks"/>
      <variable units="milliS_per_microF" name="G_Ks" initial_value="0.433"/>
      <variable units="millivolt" name="E_Ks"/>
      <variable units="dimensionless" name="PNaK" initial_value="0.01833"/>
      <variable units="ms" public_interface="in" private_interface="out" name="time"/>
      <variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
      <variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
      <variable units="kelvin" public_interface="in" name="T"/>
      <variable units="coulomb_per_mole" public_interface="in" name="F"/>
      <variable units="millimolar" public_interface="in" name="Ko"/>
      <variable units="millimolar" public_interface="in" name="Ki"/>
      <variable units="millimolar" public_interface="in" name="Nao"/>
      <variable units="millimolar" public_interface="in" name="Nai"/>
      <variable units="millimolar" public_interface="in" name="Cai"/>
      <variable units="dimensionless" private_interface="in" name="xs1"/>
      <variable units="dimensionless" private_interface="in" name="xs2"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_Ks</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <ci>Ko</ci>
                        <apply>
                           <times/>
                           <ci>PNaK</ci>
                           <ci>Nao</ci>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>Ki</ci>
                        <apply>
                           <times/>
                           <ci>PNaK</ci>
                           <ci>Nai</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>g_Ks</ci>
            <apply>
               <times/>
               <ci>G_Ks</ci>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <cn cellml:units="dimensionless">0.6</cn>
                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <cn cellml:units="millimolar">3.8e-5</cn>
                              <ci>Cai</ci>
                           </apply>
                           <cn cellml:units="dimensionless">1.4</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ks</ci>
            <apply>
               <times/>
               <ci>g_Ks</ci>
               <ci>xs1</ci>
               <ci>xs2</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ks</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_delayed_rectifier_potassium_current_xs1_gate">
      <variable units="dimensionless" public_interface="out" name="xs1" initial_value="0.007136102382"/>
      <variable units="dimensionless" name="xs1_infinity"/>
      <variable units="ms" name="tau_xs1"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="ms" public_interface="in" name="time"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>xs1_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">1.5</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="millivolt">16.7</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xs1</ci>
            <apply>
               <divide/>
               <cn cellml:units="ms">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_millivolt">7.19e-5</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_millivolt">0.148</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_millivolt">0.000131</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn cellml:units="per_millivolt">0.0687</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                        <cn cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xs1</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xs1_infinity</ci>
                  <ci>xs1</ci>
               </apply>
               <ci>tau_xs1</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_delayed_rectifier_potassium_current_xs2_gate">
      <variable units="dimensionless" public_interface="out" name="xs2" initial_value="0.039518996812"/>
      <variable units="dimensionless" name="xs2_infinity"/>
      <variable units="ms" name="tau_xs2"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="ms" public_interface="in" name="time"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>xs2_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">1.5</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="millivolt">16.7</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xs2</ci>
            <apply>
               <divide/>
               <cn cellml:units="ms">4</cn>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_millivolt">7.19e-5</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_millivolt">0.148</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_millivolt">0.000131</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn cellml:units="per_millivolt">0.0687</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                        <cn cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xs2</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xs2_infinity</ci>
                  <ci>xs2</ci>
               </apply>
               <ci>tau_xs2</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="ATP_sensitive_potassium_current">
      <variable units="microA_per_microF" public_interface="out" name="i_K_ATP"/>
      <variable units="milliS_per_microF" name="g_K_ATP"/>
      <variable units="dimensionless" name="i_K_ATP_on" initial_value="1"/>
      <variable units="dimensionless" name="nATP" initial_value="0.24"/>
      <variable units="dimensionless" name="nicholsarea" initial_value="5e-5"/>
      <variable units="millimolar" name="ATPi" initial_value="3"/>
      <variable units="dimensionless" name="hATP" initial_value="2"/>
      <variable units="millimolar" name="kATP" initial_value="0.00025"/>
      <variable units="dimensionless" name="pATP"/>
      <variable units="milliS_per_microF" name="GKbaraATP"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="millimolar" public_interface="in" name="Ko"/>
      <variable units="millivolt" public_interface="in" name="E_K"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_K_ATP</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>i_K_ATP_on</ci>
                  <cn cellml:units="milliS_per_microF">0.000193</cn>
               </apply>
               <ci>nicholsarea</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pATP</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>ATPi</ci>
                        <ci>kATP</ci>
                     </apply>
                     <ci>hATP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>GKbaraATP</ci>
            <apply>
               <times/>
               <ci>g_K_ATP</ci>
               <ci>pATP</ci>
               <apply>
                  <power/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn cellml:units="millimolar">4</cn>
                  </apply>
                  <ci>nATP</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_K_ATP</ci>
            <apply>
               <times/>
               <ci>GKbaraATP</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_current">
      <variable units="microA_per_microF" public_interface="out" name="i_to"/>
      <variable units="milliS_per_microF" name="g_to"/>
      <variable units="millivolt" public_interface="in" name="E_K"/>
      <variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
      <variable units="ms" public_interface="in" private_interface="out" name="time"/>
      <variable units="dimensionless" name="rvdv"/>
      <variable units="dimensionless" private_interface="in" name="zdv"/>
      <variable units="dimensionless" private_interface="in" name="ydv"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_to</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">0</cn>
               <cn cellml:units="milliS_per_microF">0.5</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>rvdv</ci>
            <apply>
               <exp/>
               <apply>
                  <divide/>
                  <ci>V</ci>
                  <cn cellml:units="millivolt">100</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_to</ci>
            <apply>
               <times/>
               <ci>g_to</ci>
               <apply>
                  <power/>
                  <ci>zdv</ci>
                  <cn cellml:units="dimensionless">3</cn>
               </apply>
               <ci>ydv</ci>
               <ci>rvdv</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_current_zdv_gate">
      <variable units="dimensionless" public_interface="out" name="zdv" initial_value="0.014537782303"/>
      <variable units="per_ms" name="alpha_zdv"/>
      <variable units="per_ms" name="beta_zdv"/>
      <variable units="ms" name="tau_zdv"/>
      <variable units="dimensionless" name="zdv_ss"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="ms" public_interface="in" name="time"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_zdv</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn cellml:units="per_ms">10</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">40</cn>
                        </apply>
                        <cn cellml:units="millivolt">25</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">40</cn>
                        </apply>
                        <cn cellml:units="millivolt">25</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_zdv</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn cellml:units="per_ms">10</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">90</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="millivolt">25</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">90</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="millivolt">25</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_zdv</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_zdv</ci>
                  <ci>beta_zdv</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>zdv_ss</ci>
            <apply>
               <divide/>
               <ci>alpha_zdv</ci>
               <apply>
                  <plus/>
                  <ci>alpha_zdv</ci>
                  <ci>beta_zdv</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>zdv</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>zdv_ss</ci>
                  <ci>zdv</ci>
               </apply>
               <ci>tau_zdv</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_current_ydv_gate">
      <variable units="dimensionless" public_interface="out" name="ydv" initial_value="0.99993940527"/>
      <variable units="per_ms" name="alpha_ydv"/>
      <variable units="per_ms" name="beta_ydv"/>
      <variable units="ms" name="tau_ydv"/>
      <variable units="dimensionless" name="ydv_ss"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="ms" public_interface="in" name="time"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_ydv</ci>
            <apply>
               <divide/>
               <cn cellml:units="per_ms">0.015</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">60</cn>
                        </apply>
                        <cn cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_ydv</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn cellml:units="per_ms">0.1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">25</cn>
                        </apply>
                        <cn cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">25</cn>
                        </apply>
                        <cn cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_ydv</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_ydv</ci>
                  <ci>beta_ydv</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ydv_ss</ci>
            <apply>
               <divide/>
               <ci>alpha_ydv</ci>
               <apply>
                  <plus/>
                  <ci>alpha_ydv</ci>
                  <ci>beta_ydv</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ydv</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>ydv_ss</ci>
                  <ci>ydv</ci>
               </apply>
               <ci>tau_ydv</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="time_independent_potassium_current">
      <variable units="microA_per_microF" public_interface="out" name="i_K1"/>
      <variable units="millivolt" public_interface="out" private_interface="out" name="E_K"/>
      <variable units="milliS_per_microF" name="g_K1"/>
      <variable units="milliS_per_microF" name="G_K1" initial_value="0.75"/>
      <variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
      <variable units="millimolar" public_interface="in" name="Ko"/>
      <variable units="millimolar" public_interface="in" name="Ki"/>
      <variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
      <variable units="kelvin" public_interface="in" name="T"/>
      <variable units="coulomb_per_mole" public_interface="in" name="F"/>
      <variable units="dimensionless" private_interface="in" name="K1_infinity"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_K1</ci>
            <apply>
               <times/>
               <ci>G_K1</ci>
               <apply>
                  <root/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn cellml:units="millimolar">5.4</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>E_K</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <ci>Ki</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_K1</ci>
            <apply>
               <times/>
               <ci>g_K1</ci>
               <ci>K1_infinity</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="time_independent_potassium_current_K1_gate">
      <variable units="dimensionless" public_interface="out" name="K1_infinity"/>
      <variable units="per_ms" name="alpha_K1"/>
      <variable units="per_ms" name="beta_K1"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="millivolt" public_interface="in" name="E_K"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_K1</ci>
            <apply>
               <divide/>
               <cn cellml:units="per_ms">1.02</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_millivolt">0.2385</cn>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <ci>E_K</ci>
                           </apply>
                           <cn cellml:units="millivolt">59.215</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_K1</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn cellml:units="per_ms">1</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <cn cellml:units="dimensionless">0.49124</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn cellml:units="per_millivolt">0.08032</cn>
                              <apply>
                                 <plus/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <ci>E_K</ci>
                                 </apply>
                                 <cn cellml:units="millivolt">5.476</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <cn cellml:units="per_millivolt">0.06175</cn>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <ci>E_K</ci>
                              </apply>
                              <cn cellml:units="millivolt">594.31</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn cellml:units="per_millivolt">0.5143</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <ci>E_K</ci>
                           </apply>
                           <cn cellml:units="millivolt">4.753</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>K1_infinity</ci>
            <apply>
               <divide/>
               <ci>alpha_K1</ci>
               <apply>
                  <plus/>
                  <ci>alpha_K1</ci>
                  <ci>beta_K1</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="plateau_potassium_current">
      <variable units="microA_per_microF" public_interface="out" name="i_Kp"/>
      <variable units="milliS_per_microF" name="g_Kp" initial_value="0.00552"/>
      <variable units="dimensionless" name="Kp"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="millivolt" public_interface="in" name="E_K"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Kp</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn cellml:units="millivolt">7.488</cn>
                           <ci>V</ci>
                        </apply>
                        <cn cellml:units="millivolt">5.98</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Kp</ci>
            <apply>
               <times/>
               <ci>g_Kp</ci>
               <ci>Kp</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_activated_potassium_current">
      <variable units="microA_per_microF" public_interface="out" name="i_K_Na"/>
      <variable units="milliS_per_microF" name="g_K_Na" initial_value="0.12848"/>
      <variable units="dimensionless" name="nKNa" initial_value="2.8"/>
      <variable units="dimensionless" name="pona"/>
      <variable units="dimensionless" name="pov"/>
      <variable units="millimolar" name="kdKNa" initial_value="66"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="millimolar" public_interface="in" name="Nai"/>
      <variable units="millivolt" public_interface="in" name="E_K"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>pona</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">0.85</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>kdKNa</ci>
                        <ci>Nai</ci>
                     </apply>
                     <ci>nKNa</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pov</ci>
            <apply>
               <minus/>
               <cn cellml:units="dimensionless">0.8</cn>
               <apply>
                  <divide/>
                  <cn cellml:units="dimensionless">0.65</cn>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">125</cn>
                           </apply>
                           <cn cellml:units="millivolt">15</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_K_Na</ci>
            <apply>
               <times/>
               <ci>g_K_Na</ci>
               <ci>pona</ci>
               <ci>pov</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sarcolemmal_calcium_pump">
      <variable units="microA_per_microF" public_interface="out" name="i_p_Ca"/>
      <variable units="millimolar" name="K_mpCa" initial_value="0.0005"/>
      <variable units="microA_per_microF" name="I_pCa" initial_value="1.15"/>
      <variable units="millimolar" public_interface="in" name="Cai"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_p_Ca</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_pCa</ci>
                  <ci>Cai</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>K_mpCa</ci>
                  <ci>Cai</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_background_current">
      <variable units="microA_per_microF" public_interface="out" name="i_Na_b"/>
      <variable units="milliS_per_microF" name="g_Nab" initial_value="0.004"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="millivolt" public_interface="in" name="E_Na"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Na_b</ci>
            <apply>
               <times/>
               <ci>g_Nab</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Na</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="calcium_background_current">
      <variable units="microA_per_microF" public_interface="out" name="i_Ca_b"/>
      <variable units="milliS_per_microF" name="g_Cab" initial_value="0.003016"/>
      <variable units="millivolt" public_interface="out" name="E_Ca"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
      <variable units="kelvin" public_interface="in" name="T"/>
      <variable units="coulomb_per_mole" public_interface="in" name="F"/>
      <variable units="millimolar" public_interface="in" name="Cai"/>
      <variable units="millimolar" public_interface="in" name="Cao"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_Ca</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">2</cn>
                     <ci>F</ci>
                  </apply>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Cao</ci>
                     <ci>Cai</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_b</ci>
            <apply>
               <times/>
               <ci>g_Cab</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ca</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_potassium_pump">
      <variable units="microA_per_microF" public_interface="out" name="i_NaK"/>
      <variable units="microA_per_microF" name="I_NaK" initial_value="2.25"/>
      <variable units="dimensionless" name="f_NaK"/>
      <variable units="millimolar" name="K_mNai" initial_value="10"/>
      <variable units="millimolar" name="K_mKo" initial_value="1.5"/>
      <variable units="dimensionless" name="sigma"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
      <variable units="kelvin" public_interface="in" name="T"/>
      <variable units="coulomb_per_mole" public_interface="in" name="F"/>
      <variable units="millimolar" public_interface="in" name="Nai"/>
      <variable units="millimolar" public_interface="in" name="Nao"/>
      <variable units="millimolar" public_interface="in" name="Ko"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>sigma</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn cellml:units="dimensionless">1</cn>
                  <cn cellml:units="dimensionless">7</cn>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>Nao</ci>
                        <cn cellml:units="millimolar">67.3</cn>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>f_NaK</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">0.1245</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="dimensionless">0.1</cn>
                              </apply>
                              <ci>V</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">0.0365</cn>
                     <ci>sigma</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                              </apply>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_NaK</ci>
            <apply>
               <divide/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>I_NaK</ci>
                     <ci>f_NaK</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>K_mNai</ci>
                           <ci>Nai</ci>
                        </apply>
                        <cn cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>K_mKo</ci>
                     <ci>Ko</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="non_specific_calcium_activated_current">
      <variable units="microA_per_microF" public_interface="out" name="i_ns_Ca"/>
      <variable units="microA_per_microF" public_interface="out" name="i_ns_Na"/>
      <variable units="microA_per_microF" public_interface="out" name="i_ns_K"/>
      <variable units="litre_per_farad_millisecond" name="P_ns_Ca"/>
      <variable units="dimensionless" public_interface="in" name="gamma_Nai"/>
      <variable units="dimensionless" public_interface="in" name="gamma_Nao"/>
      <variable units="dimensionless" public_interface="in" name="gamma_Ki"/>
      <variable units="dimensionless" public_interface="in" name="gamma_Ko"/>
      <variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
      <variable units="kelvin" public_interface="in" name="T"/>
      <variable units="coulomb_per_mole" public_interface="in" name="F"/>
      <variable units="millimolar" public_interface="in" name="Cao"/>
      <variable units="millimolar" public_interface="in" name="Nao"/>
      <variable units="millimolar" public_interface="in" name="Ko"/>
      <variable units="millimolar" public_interface="in" name="Nai"/>
      <variable units="millimolar" public_interface="in" name="Ki"/>
      <variable units="microA_per_microF" name="I_ns_Na"/>
      <variable units="microA_per_microF" name="I_ns_K"/>
      <variable units="millimolar" name="K_m_ns_Ca" initial_value="0.0012"/>
      <variable units="ms" public_interface="in" name="time"/>
      <variable units="millimolar" public_interface="in" name="Cai"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>P_ns_Ca</ci>
            <cn cellml:units="litre_per_farad_millisecond">1.75e-7</cn>
         </apply>
         <apply>
            <eq/>
            <ci>I_ns_Na</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_ns_Ca</ci>
                        <apply>
                           <power/>
                           <cn cellml:units="dimensionless">1</cn>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Nai</ci>
                        <ci>Nai</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn cellml:units="dimensionless">1</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Nao</ci>
                        <ci>Nao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">1</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_ns_K</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_ns_Ca</ci>
                        <apply>
                           <power/>
                           <cn cellml:units="dimensionless">1</cn>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Ki</ci>
                        <ci>Ki</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn cellml:units="dimensionless">1</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Ko</ci>
                        <ci>Ko</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">1</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_ns_Na</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_ns_Na</ci>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>K_m_ns_Ca</ci>
                        <ci>Cai</ci>
                     </apply>
                     <cn cellml:units="dimensionless">3</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_ns_K</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_ns_K</ci>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>K_m_ns_Ca</ci>
                        <ci>Cai</ci>
                     </apply>
                     <cn cellml:units="dimensionless">3</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_ns_Ca</ci>
            <apply>
               <plus/>
               <ci>i_ns_Na</ci>
               <ci>i_ns_K</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Na_Ca_exchanger">
      <variable units="microA_per_microF" public_interface="out" name="i_NaCa"/>
      <variable units="microA_per_microF" name="c1" initial_value="0.00025"/>
      <variable units="dimensionless" name="c2" initial_value="0.0001"/>
      <variable units="dimensionless" name="gamma" initial_value="0.15"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
      <variable units="kelvin" public_interface="in" name="T"/>
      <variable units="coulomb_per_mole" public_interface="in" name="F"/>
      <variable units="millimolar" public_interface="in" name="Nai"/>
      <variable units="millimolar" public_interface="in" name="Nao"/>
      <variable units="millimolar" public_interface="in" name="Cai"/>
      <variable units="millimolar" public_interface="in" name="Cao"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaCa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>c1</ci>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <ci>gamma</ci>
                              <cn cellml:units="dimensionless">1</cn>
                           </apply>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <power/>
                           <ci>Nai</ci>
                           <cn cellml:units="dimensionless">3</cn>
                        </apply>
                        <ci>Cao</ci>
                     </apply>
                     <apply>
                        <times/>
                        <apply>
                           <power/>
                           <ci>Nao</ci>
                           <cn cellml:units="dimensionless">3</cn>
                        </apply>
                        <ci>Cai</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="millimolar4">1</cn>
                  <apply>
                     <times/>
                     <ci>c2</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>gamma</ci>
                                 <cn cellml:units="dimensionless">1</cn>
                              </apply>
                              <ci>V</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <times/>
                                    <ci>V</ci>
                                    <ci>F</ci>
                                 </apply>
                                 <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                 </apply>
                              </apply>
                           </apply>
                           <apply>
                              <power/>
                              <ci>Nai</ci>
                              <cn cellml:units="dimensionless">3</cn>
                           </apply>
                           <ci>Cao</ci>
                        </apply>
                        <apply>
                           <times/>
                           <apply>
                              <power/>
                              <ci>Nao</ci>
                              <cn cellml:units="dimensionless">3</cn>
                           </apply>
                           <ci>Cai</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="calcium_dynamics">
      <variable units="millimolar_per_ms" public_interface="in" name="i_rel"/>
      <variable units="millimolar_per_ms" public_interface="out" name="i_up"/>
      <variable units="millimolar_per_ms" public_interface="out" name="i_leak"/>
      <variable units="millimolar_per_ms" public_interface="out" name="i_tr"/>
      <variable units="ms" name="tau_tr" initial_value="120"/>
      <variable units="millimolar" name="CSQN_max" initial_value="10"/>
      <variable units="millimolar" name="K_mCSQN" initial_value="0.8"/>
      <variable units="millimolar" name="K_mup" initial_value="0.00092"/>
      <variable units="per_ms" name="K_leak"/>
      <variable units="millimolar_per_ms" name="I_up" initial_value="0.00875"/>
      <variable units="millimolar" name="Ca_NSR_max" initial_value="15"/>
      <variable units="ms" public_interface="in" name="time"/>
      <variable units="coulomb_per_mole" public_interface="in" name="F"/>
      <variable units="millimolar" public_interface="out" name="CaT" initial_value="0.01544711"/>
      <variable units="millimolar" public_interface="out" name="Cao" initial_value="1.8"/>
      <variable units="millimolar" public_interface="out" name="Ca_JSR"/>
      <variable units="millimolar" public_interface="out" name="JSR" initial_value="8.290468"/>
      <variable units="millimolar" public_interface="out" name="NSR" initial_value="1.516756041281"/>
      <variable units="millimolar" public_interface="out" name="Cai"/>
      <variable units="millimolar" public_interface="out" name="bjsr"/>
      <variable units="millimolar2" public_interface="out" name="cjsr"/>
      <variable units="millimolar" public_interface="out" name="bmyo"/>
      <variable units="millimolar2" public_interface="out" name="cmyo"/>
      <variable units="millimolar3" public_interface="out" name="dmyo"/>
      <variable units="micro_litre" public_interface="in" name="V_myo"/>
      <variable units="cm2" public_interface="in" name="A_cap"/>
      <variable units="micro_litre" public_interface="in" name="V_JSR"/>
      <variable units="micro_litre" public_interface="in" name="V_NSR"/>
      <variable units="microA_per_microF" public_interface="in" name="i_NaCa"/>
      <variable units="microA_per_microF" public_interface="in" name="i_CaCa"/>
      <variable units="microA_per_microF" public_interface="in" name="i_p_Ca"/>
      <variable units="microA_per_microF" public_interface="in" name="i_Ca_b"/>
      <variable units="microA_per_microF" public_interface="in" name="i_Ca_T"/>
      <variable units="millimolar" name="K_mTRPN" initial_value="0.0005"/>
      <variable units="millimolar" name="K_mCMDN" initial_value="0.00238"/>
      <variable units="millimolar" name="TRPN_max" initial_value="0.07"/>
      <variable units="millimolar" name="CMDN_max" initial_value="0.05"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>bjsr</ci>
            <apply>
               <plus/>
               <ci>CSQN_max</ci>
               <ci>K_mCSQN</ci>
               <apply>
                  <minus/>
                  <ci>JSR</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>cjsr</ci>
            <apply>
               <times/>
               <ci>K_mCSQN</ci>
               <ci>JSR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Ca_JSR</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <root/>
                     <apply>
                        <plus/>
                        <apply>
                           <power/>
                           <ci>bjsr</ci>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">4</cn>
                           <ci>cjsr</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>bjsr</ci>
               </apply>
               <cn cellml:units="dimensionless">2</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>bmyo</ci>
            <apply>
               <plus/>
               <ci>CMDN_max</ci>
               <ci>TRPN_max</ci>
               <ci>K_mCMDN</ci>
               <ci>K_mTRPN</ci>
               <apply>
                  <minus/>
                  <ci>CaT</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>cmyo</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>K_mCMDN</ci>
                  <ci>K_mTRPN</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>TRPN_max</ci>
                  <ci>K_mCMDN</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CMDN_max</ci>
                  <ci>K_mTRPN</ci>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <ci>CaT</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>K_mTRPN</ci>
                     <ci>K_mCMDN</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dmyo</ci>
            <apply>
               <times/>
               <apply>
                  <minus/>
                  <ci>K_mTRPN</ci>
               </apply>
               <ci>K_mCMDN</ci>
               <ci>CaT</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Cai</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <cn cellml:units="dimensionless">2</cn>
                     <cn cellml:units="dimensionless">3</cn>
                  </apply>
                  <apply>
                     <root/>
                     <apply>
                        <minus/>
                        <apply>
                           <power/>
                           <ci>bmyo</ci>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">3</cn>
                           <ci>cmyo</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <cos/>
                     <apply>
                        <divide/>
                        <apply>
                           <arccos/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">9</cn>
                                    <ci>bmyo</ci>
                                    <ci>cmyo</ci>
                                 </apply>
                                 <apply>
                                    <plus/>
                                    <apply>
                                       <times/>
                                       <cn cellml:units="dimensionless">2</cn>
                                       <apply>
                                          <power/>
                                          <ci>bmyo</ci>
                                          <cn cellml:units="dimensionless">3</cn>
                                       </apply>
                                    </apply>
                                    <apply>
                                       <times/>
                                       <cn cellml:units="dimensionless">27</cn>
                                       <ci>dmyo</ci>
                                    </apply>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <cn cellml:units="dimensionless">2</cn>
                                 <apply>
                                    <root/>
                                    <apply>
                                       <power/>
                                       <apply>
                                          <minus/>
                                          <apply>
                                             <power/>
                                             <ci>bmyo</ci>
                                             <cn cellml:units="dimensionless">2</cn>
                                          </apply>
                                          <apply>
                                             <times/>
                                             <cn cellml:units="dimensionless">3</cn>
                                             <ci>cmyo</ci>
                                          </apply>
                                       </apply>
                                       <cn cellml:units="dimensionless">3</cn>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <cn cellml:units="dimensionless">3</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <ci>bmyo</ci>
                  <cn cellml:units="dimensionless">3</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_up</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_up</ci>
                  <ci>Cai</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>Cai</ci>
                  <ci>K_mup</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>K_leak</ci>
            <apply>
               <divide/>
               <ci>I_up</ci>
               <ci>Ca_NSR_max</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_leak</ci>
            <apply>
               <times/>
               <ci>K_leak</ci>
               <ci>NSR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_tr</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>NSR</ci>
                  <ci>Ca_JSR</ci>
               </apply>
               <ci>tau_tr</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>JSR</ci>
            </apply>
            <apply>
               <minus/>
               <ci>i_tr</ci>
               <ci>i_rel</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>NSR</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>i_tr</ci>
                        </apply>
                        <ci>V_JSR</ci>
                     </apply>
                     <ci>V_NSR</ci>
                  </apply>
                  <ci>i_leak</ci>
               </apply>
               <ci>i_up</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CaT</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn cellml:units="microF_per_cm2">1</cn>
                     </apply>
                     <ci>A_cap</ci>
                     <apply>
                        <plus/>
                        <ci>i_CaCa</ci>
                        <ci>i_Ca_T</ci>
                        <ci>i_p_Ca</ci>
                        <ci>i_Ca_b</ci>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn cellml:units="dimensionless">2</cn>
                           </apply>
                           <ci>i_NaCa</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">2</cn>
                     <ci>V_myo</ci>
                     <ci>F</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>i_rel</ci>
                     <ci>V_JSR</ci>
                  </apply>
                  <ci>V_myo</ci>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <ci>i_leak</ci>
                        <ci>i_up</ci>
                     </apply>
                     <ci>V_NSR</ci>
                  </apply>
                  <ci>V_myo</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="CICR_current">
      <variable units="mM_per_millivolt_ms" name="kappa" initial_value="0.125"/>
      <variable units="ms" name="tau" initial_value="4.75"/>
      <variable units="millimolar" name="K_relss" initial_value="1"/>
      <variable units="dimensionless" name="qn" initial_value="9"/>
      <variable units="millimolar_per_mV" public_interface="out" name="alpha_rel"/>
      <variable units="ms" public_interface="out" name="tau_rel"/>
      <variable units="millimolar_per_ms" public_interface="out" name="I_relss"/>
      <variable units="millimolar_per_ms" public_interface="out" name="i_rel" initial_value="-0.000000000000000000474565"/>
      <variable units="microA_per_microF" public_interface="in" name="i_CaCa"/>
      <variable units="millimolar" public_interface="in" name="Ca_JSR"/>
      <variable units="ms" public_interface="in" name="time"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_rel</ci>
            <apply>
               <times/>
               <ci>kappa</ci>
               <ci>tau</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_relss</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>i_CaCa</ci>
                  <ci>alpha_rel</ci>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>K_relss</ci>
                        <ci>Ca_JSR</ci>
                     </apply>
                     <ci>qn</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_rel</ci>
            <apply>
               <divide/>
               <ci>tau</ci>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <cn cellml:units="millimolar">0.0123</cn>
                     <ci>Ca_JSR</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>i_rel</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>I_relss</ci>
                     <ci>i_rel</ci>
                  </apply>
               </apply>
               <ci>tau_rel</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="ionic_concentrations">
      <variable units="millimolar" public_interface="out" name="Nai" initial_value="10"/>
      <variable units="millimolar" public_interface="out" name="Nao" initial_value="140"/>
      <variable units="millimolar" public_interface="out" name="Ki" initial_value="144.473230653346"/>
      <variable units="millimolar" public_interface="out" name="Ko" initial_value="5.4"/>
      <variable units="cm2" public_interface="in" name="A_cap"/>
      <variable units="micro_litre" public_interface="in" name="V_myo"/>
      <variable units="ms" public_interface="in" name="time"/>
      <variable units="coulomb_per_mole" public_interface="in" name="F"/>
      <variable units="microA_per_microF" public_interface="in" name="i_Na"/>
      <variable units="microA_per_microF" public_interface="in" name="i_CaNa"/>
      <variable units="microA_per_microF" public_interface="in" name="i_Na_b"/>
      <variable units="microA_per_microF" public_interface="in" name="i_ns_Na"/>
      <variable units="microA_per_microF" public_interface="in" name="i_NaCa"/>
      <variable units="microA_per_microF" public_interface="in" name="i_NaK"/>
      <variable units="microA_per_microF" public_interface="in" name="i_CaK"/>
      <variable units="microA_per_microF" public_interface="in" name="i_Kr"/>
      <variable units="microA_per_microF" public_interface="in" name="i_Ks"/>
      <variable units="microA_per_microF" public_interface="in" name="i_K1"/>
      <variable units="microA_per_microF" public_interface="in" name="i_Kp"/>
      <variable units="microA_per_microF" public_interface="in" name="i_K_Na"/>
      <variable units="microA_per_microF" public_interface="in" name="i_ns_K"/>
      <variable units="microA_per_microF" public_interface="in" name="I_st"/>
      <variable units="microA_per_microF" public_interface="in" name="i_K_ATP"/>
      <variable units="microA_per_microF" public_interface="in" name="i_to"/>
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Nai</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <cn cellml:units="microF_per_cm2">1</cn>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>i_Na</ci>
                     <ci>i_CaNa</ci>
                     <ci>i_Na_b</ci>
                     <ci>i_ns_Na</ci>
                     <apply>
                        <times/>
                        <ci>i_NaCa</ci>
                        <cn cellml:units="dimensionless">3</cn>
                     </apply>
                     <apply>
                        <times/>
                        <ci>i_NaK</ci>
                        <cn cellml:units="dimensionless">3</cn>
                     </apply>
                  </apply>
                  <ci>A_cap</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>V_myo</ci>
                  <ci>F</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ki</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <cn cellml:units="microF_per_cm2">1</cn>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>I_st</ci>
                     <ci>i_CaK</ci>
                     <ci>i_Kr</ci>
                     <ci>i_Ks</ci>
                     <ci>i_K1</ci>
                     <ci>i_K_ATP</ci>
                     <ci>i_to</ci>
					 <ci>i_Kp</ci>
                     <ci>i_K_Na</ci>
                     <ci>i_ns_K</ci>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>i_NaK</ci>
                        </apply>
                        <cn cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
                  <ci>A_cap</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>V_myo</ci>
                  <ci>F</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="geometry">
      <variable units="mm" name="preplength" initial_value="0.1"/>
      <variable units="mm" name="radius" initial_value="0.011"/>
      <variable units="micro_litre" name="volume"/>
      <variable units="micro_litre" public_interface="out" name="V_myo"/>
      <variable units="micro_litre" public_interface="out" name="V_JSR"/>
      <variable units="micro_litre" public_interface="out" name="V_NSR"/>
      <variable units="cm2" public_interface="out" name="A_cap" initial_value="1.534e-4"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>volume</ci>
            <apply>
               <times/>
               <pi/>
               <ci>preplength</ci>
               <apply>
                  <power/>
                  <ci>radius</ci>
                  <cn cellml:units="dimensionless">2</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_myo</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">0.68</cn>
               <ci>volume</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_JSR</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">0.0048</cn>
               <ci>volume</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_NSR</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">0.0552</cn>
               <ci>volume</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transmembrane_currents"/>
   <component name="intracellular_currents"/>
   <component name="Ions_n_reversal_potentials"/>
   <group>
      <relationship_ref relationship="containment"/>
      <component_ref component="cell">
         <component_ref component="geometry"/>
         <component_ref component="transmembrane_currents">
            <component_ref component="fast_sodium_current">
               <component_ref component="fast_sodium_current_m_gate"/>
               <component_ref component="fast_sodium_current_h_gate"/>
               <component_ref component="fast_sodium_current_j_gate"/>
            </component_ref>
            <component_ref component="L_type_Ca_channel">
               <component_ref component="L_type_Ca_channel_d_gate"/>
               <component_ref component="L_type_Ca_channel_f_gate"/>
               <component_ref component="L_type_Ca_channel_f_Ca_gate"/>
            </component_ref>
            <component_ref component="T_type_Ca_channel">
               <component_ref component="T_type_Ca_channel_b_gate"/>
               <component_ref component="T_type_Ca_channel_g_gate"/>
            </component_ref>
            <component_ref component="rapid_delayed_rectifier_potassium_current">
               <component_ref component="rapid_delayed_rectifier_potassium_current_xr_gate"/>
            </component_ref>
            <component_ref component="slow_delayed_rectifier_potassium_current">
               <component_ref component="slow_delayed_rectifier_potassium_current_xs1_gate"/>
               <component_ref component="slow_delayed_rectifier_potassium_current_xs2_gate"/>
            </component_ref>
            <component_ref component="time_independent_potassium_current">
               <component_ref component="time_independent_potassium_current_K1_gate"/>
            </component_ref>
			<component_ref component="transient_outward_current">
               <component_ref component="transient_outward_current_zdv_gate"/>
               <component_ref component="transient_outward_current_ydv_gate"/>
            </component_ref>
            <component_ref component="Na_Ca_exchanger"/>
            <component_ref component="plateau_potassium_current"/>
            <component_ref component="sodium_activated_potassium_current"/>
            <component_ref component="ATP_sensitive_potassium_current"/>
			<component_ref component="sodium_background_current"/>
            <component_ref component="calcium_background_current"/>
            <component_ref component="sodium_potassium_pump"/>
            <component_ref component="non_specific_calcium_activated_current"/>
         </component_ref>
         <component_ref component="intracellular_currents">
            <component_ref component="sarcolemmal_calcium_pump"/>
         </component_ref>
         <component_ref component="Ions_n_reversal_potentials">
            <component_ref component="ionic_concentrations"/>
            <component_ref component="calcium_dynamics"/>
         </component_ref>
      </component_ref>
   </group>
   <group>
      <relationship_ref relationship="encapsulation"/>
      <component_ref component="fast_sodium_current">
         <component_ref component="fast_sodium_current_m_gate"/>
         <component_ref component="fast_sodium_current_h_gate"/>
         <component_ref component="fast_sodium_current_j_gate"/>
      </component_ref>
      <component_ref component="L_type_Ca_channel">
         <component_ref component="L_type_Ca_channel_d_gate"/>
         <component_ref component="L_type_Ca_channel_f_gate"/>
         <component_ref component="L_type_Ca_channel_f_Ca_gate"/>
      </component_ref>
      <component_ref component="T_type_Ca_channel">
         <component_ref component="T_type_Ca_channel_b_gate"/>
         <component_ref component="T_type_Ca_channel_g_gate"/>
      </component_ref>
      <component_ref component="rapid_delayed_rectifier_potassium_current">
         <component_ref component="rapid_delayed_rectifier_potassium_current_xr_gate"/>
      </component_ref>
      <component_ref component="slow_delayed_rectifier_potassium_current">
         <component_ref component="slow_delayed_rectifier_potassium_current_xs1_gate"/>
         <component_ref component="slow_delayed_rectifier_potassium_current_xs2_gate"/>
      </component_ref>
      <component_ref component="time_independent_potassium_current">
         <component_ref component="time_independent_potassium_current_K1_gate"/>
      </component_ref>
	  <component_ref component="transient_outward_current">
         <component_ref component="transient_outward_current_zdv_gate"/>
         <component_ref component="transient_outward_current_ydv_gate"/>
      </component_ref>
   </group>
   <connection>
      <map_components component_2="environment" component_1="cell"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="environment" component_1="fast_sodium_current"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="environment" component_1="L_type_Ca_channel"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="environment" component_1="T_type_Ca_channel"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="environment" component_1="rapid_delayed_rectifier_potassium_current"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="environment" component_1="transient_outward_current"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="environment" component_1="slow_delayed_rectifier_potassium_current"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="environment" component_1="non_specific_calcium_activated_current"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="environment" component_1="ionic_concentrations"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="environment" component_1="calcium_dynamics"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="environment" component_1="CICR_current"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="fast_sodium_current" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_Na" variable_1="i_Na"/>
      <map_variables variable_2="R" variable_1="R"/>
      <map_variables variable_2="T" variable_1="T"/>
      <map_variables variable_2="F" variable_1="F"/>
   </connection>
   <connection>
      <map_components component_2="L_type_Ca_channel" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_Ca_L" variable_1="i_Ca_L"/>
      <map_variables variable_2="R" variable_1="R"/>
      <map_variables variable_2="T" variable_1="T"/>
      <map_variables variable_2="F" variable_1="F"/>
   </connection>
   <connection>
      <map_components component_2="T_type_Ca_channel" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_Ca_T" variable_1="i_Ca_T"/>
   </connection>
   <connection>
      <map_components component_2="rapid_delayed_rectifier_potassium_current" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_Kr" variable_1="i_Kr"/>
   </connection>
   <connection>
      <map_components component_2="ATP_sensitive_potassium_current" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_K_ATP" variable_1="i_K_ATP"/>
   </connection>
   <connection>
      <map_components component_2="transient_outward_current" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_to" variable_1="i_to"/>
   </connection>
   <connection>
      <map_components component_2="slow_delayed_rectifier_potassium_current" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_Ks" variable_1="i_Ks"/>
      <map_variables variable_2="R" variable_1="R"/>
      <map_variables variable_2="T" variable_1="T"/>
      <map_variables variable_2="F" variable_1="F"/>
   </connection>
   <connection>
      <map_components component_2="sodium_activated_potassium_current" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_K_Na" variable_1="i_K_Na"/>
   </connection>
   <connection>
      <map_components component_2="Na_Ca_exchanger" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_NaCa" variable_1="i_NaCa"/>
      <map_variables variable_2="R" variable_1="R"/>
      <map_variables variable_2="T" variable_1="T"/>
      <map_variables variable_2="F" variable_1="F"/>
   </connection>
   <connection>
      <map_components component_2="time_independent_potassium_current" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_K1" variable_1="i_K1"/>
      <map_variables variable_2="R" variable_1="R"/>
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