Location: Deforming Heart @ 354032c95c17 / index.html
- Author:
- Dougal Cowan <devnull@localhost>
- Date:
- 2010-10-15 13:56:03+13:00
- Desc:
- Updated the RDF and HTML documentation with the correct citation.
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/deformingheart/rawfile/354032c95c173577039d0fbc6aeb80a088034317/index.html
Finite elasticity theory combined with finite element analysis provides the framework for analysing ventricular mechanics during the filling phase of the cardiac cycle, when cardiac cells are not actively contracting. The orthotropic properties of the passive tissue are described here by a polezero constitutive law, whose parameters are derived in part from a model of the underlying distributions of collagen fibres. These distributions are based on our observations of the fibroussheet laminar architecture of myocardial tissue. We illustrate the use of high order (cubic Hermite) basis functions in solving the Galerkin finite element stress equilibrium equations based on this orthotropic constitutive law and for incorporating the observed regional distributions of fibre and sheet orientations. Pressurevolume relations and 3D principal strains predicted by the model are compared with experimental observations. A model of active tissue properties, based on isolated muscle experiments, is also introduced in order to predict transmural distributions of 3D principal strains at the end of the contraction phase of the cardiac cycle. We end by offering a critique of the current model of ventricular mechanics and propose new challenges for future modellers.
![](https://models.physiomeproject.org/workspace/deformingheart/rawfile/354032c95c173577039d0fbc6aeb80a088034317/deforming_heart.png)
To launch the model, please select 'Zinc Viewer' under navigation on the right.