- Author:
- Mike Cooling <m.cooling@auckland.ac.nz>
- Date:
- 2010-06-02 13:32:24+12:00
- Desc:
- Removed the sub-folder structure and pulling all three models into one folder, to avoid UI issues with the Repository.
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/cooling_hunter_crampin_2009/rawfile/00be32aed712c03ef96e6cd04f55cc5d219406c9/calcineurin_ShenProtocol.cellml
<?xml version="1.0" encoding="iso-8859-1"?>
<model
name="calcineurin"
cmeta:id="calcineurin"
xmlns="http://www.cellml.org/cellml/1.1#"
xmlns:cellml="http://www.cellml.org/cellml/1.1#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:RDF
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:bqs="http://www.cellml.org/bqs/1.0#"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#calcineurin">
<dc:creator rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Cooling</vCard:Family>
<vCard:Given>Michael</vCard:Given>
</vCard:N>
<vCard:EMAIL rdf:parseType="Resource">
<rdf:value>m.cooling@auckland.ac.nz</rdf:value>
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet" />
</vCard:EMAIL>
</dc:creator>
<dc:title>Cooling's calcineurin module for the Shen-derived protocol</dc:title>
</rdf:Description>
</rdf:RDF>
<!--
*******************************************************
*** U N I T S ***
*******************************************************
-->
<units name="s">
<unit units="second"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="nM">
<unit units="mole" prefix="nano"/>
<unit units="liter" exponent="-1"/>
</units>
<!--
*********************************************************
*** C O M P O N E N T S ***
*********************************************************
-->
<component name="calcineurin">
<variable name="t" units="s" public_interface="in"/>
<variable name="Ca" units="nM" public_interface="in"/>
<variable name="M" units="nM" initial_value="6000"/>
<variable name="Ntot" units="nM" initial_value="1000" public_interface="out"/>
<variable name="K_mN" units="nM" initial_value="535"/>
<variable name="n" units="dimensionless" initial_value="2.92"/>
<variable name="K_dN" units="nM" initial_value="1760"/>
<variable name="act_N" units="dimensionless"/>
<variable name="act_Napp" units="dimensionless" public_interface="out"/>
<variable name="tau_actN" units="s" initial_value="0.070059"/>
<variable name="tNinhib" units="s" initial_value="3600"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>act_N</ci>
<apply>
<divide/>
<apply>
<power/>
<ci>Ca</ci>
<ci>n</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>Ca</ci>
<ci>n</ci>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>K_mN</ci>
<ci>n</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>K_dN</ci>
<ci>M</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>act_Napp</ci>
<piecewise>
<piece>
<ci>act_N</ci>
<apply>
<lt/>
<ci>t</ci>
<ci>tNinhib</ci>
</apply>
</piece>
<piece>
<apply>
<times/>
<ci>act_N</ci>
<apply>
<power/>
<exponentiale/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>t</ci>
<ci>tNinhib</ci>
</apply>
</apply>
<ci>tau_actN</ci>
</apply>
</apply>
</apply>
<apply>
<geq/>
<ci>t</ci>
<ci>tNinhib</ci>
</apply>
</piece>
</piecewise>
</apply>
</math>
</component>
</model>
