Location: Bhalla, Iyengar, 1999 @ 0d5503f0b7c7 / bhalla_iyengar_1999_a.cellml

Author:
pmr2.import <nobody@models.cellml.org>
Date:
2009-06-17 12:36:17+12:00
Desc:
committing version03 of bhalla_iyengar_1999
Permanent Source URI:
https://models.physiomeproject.org/workspace/bhalla_iyengar_1999/rawfile/0d5503f0b7c7a0d61be060bc4007999da50994eb/bhalla_iyengar_1999_a.cellml

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<!--
This CellML file was generated on 20/06/2007 at 12:39:18 at a.m. using:

COR (0.9.31.649)
Copyright 2002-2007 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk

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http://www.CellML.org/
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<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
  <articleinfo>
  <title>Emergent properties of networks of biological signaling pathways</title>
  <author>
    <firstname>Catherine</firstname>
          <surname>Lloyd</surname>
    <affiliation>
      <shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
            This version of the model describes the complete network of signalling pathways in the original publication.  This model is able to be solved but does not give the correct results as it is not connected to the other modules of the pathway. ValidateCellML verifies this model as valid CellML but detects unit inconsistencies.
    </para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>
In 1999 Upinder S. Bhalla and Ravi Iyengar published a paper discussing the emergent properties of signalling pathway networks.  To develop these networks, they modelled individual pathways and compared those results to previously published results before combining the individual pathways to create networks.  They only used mechanisms that had already been experimentally described when making connections between pathways.  The complete network of reaction pathways they modelled is shown in the figure below.
</para>

<para>
The complete original paper reference is cited below:
</para>

<para>
Emergent properties of networks of biological signaling pathways. Bhalla US, Iyengar R. <ulink url="http://www.sciencemag.org/">
            <emphasis>Science</emphasis>
          </ulink> 1999 Jan 15; 283(5400); 381-7.  (A <ulink url="http://www.sciencemag.org/cgi/content/full/283/5400/381">full text</ulink> version of the article is available to members on the <emphasis>Science</emphasis> website.)  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=9888852&amp;dopt=Abstract">PubMed ID: 9888852</ulink>
</para>


<informalfigure float="0" id="fig_pathway_diagram">
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    </objectinfo>
    <imagedata fileref="bhalla_model_1999.png"/>
  </imageobject>
</mediaobject>
<caption>A rendering of the complete signalling network.</caption>
</informalfigure>

</sect1>
</article>
</documentation>





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                        <ci>CaPLC</ci>
                        <ci>kbG1</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>CaGqPLC</ci>
                     <ci>kfG5</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <ci>CaGqPLC</ci>
                     </apply>
                     <ci>kbG4</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>CaPLC</ci>
                     <ci>Ga_GTP</ci>
                     <ci>kfG4</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>CaGqPLC</ci>
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            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <ci>GqPLC</ci>
                           <ci>Ca</ci>
                           <ci>kfG3</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>CaGqPLC</ci>
                           <ci>kbG3</ci>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>CaPLC</ci>
                        <ci>Ga_GTP</ci>
                        <ci>kfG4</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>CaGqPLC</ci>
                     <ci>kbG4</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>CaGqPLC</ci>
                  <ci>kfG5</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>GEF_inact</ci>
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            <apply>
               <minus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>PKA</ci>
                     <ci>VmaxB1</ci>
                     <ci>GEF</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>kmB1</ci>
                     <ci>GEF</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>kfB2</ci>
                  <ci>GEF_inact</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>GEF</ci>
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            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <plus/>
                                    <apply>
                                       <divide/>
                                       <apply>
                                          <times/>
                                          <ci>PKA</ci>
                                          <ci>VmaxB1</ci>
                                          <ci>GEF</ci>
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                                       <apply>
                                          <plus/>
                                          <ci>kmB1</ci>
                                          <ci>GEF</ci>
                                       </apply>
                                    </apply>
                                    <apply>
                                       <divide/>
                                       <apply>
                                          <times/>
                                          <ci>PKC</ci>
                                          <ci>VmaxB6</ci>
                                          <ci>GEF</ci>
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                                       <apply>
                                          <plus/>
                                          <apply>
                                             <times/>
                                             <ci>kmB6</ci>
                                             <apply>
                                                <plus/>
                                                <ci>one</ci>
                                                <apply>
                                                   <divide/>
                                                   <ci>GAP</ci>
                                                   <ci>kmB3</ci>
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                                                <apply>
                                                   <divide/>
                                                   <ci>Ng</ci>
                                                   <ci>kmM7</ci>
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                                                <apply>
                                                   <divide/>
                                                   <ci>Raf</ci>
                                                   <ci>kmH1</ci>
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                                                <apply>
                                                   <divide/>
                                                   <ci>NgCaM</ci>
                                                   <ci>kmM8</ci>
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                                             </apply>
                                          </apply>
                                          <ci>GEF</ci>
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                                    </apply>
                                 </apply>
                                 <apply>
                                    <times/>
                                    <ci>kfB2</ci>
                                    <ci>GEF_inact</ci>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>kfB7</ci>
                                 <ci>GEF_star</ci>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <ci>kfB5</ci>
                           <ci>Ca4CAM</ci>
                           <ci>GEF</ci>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>kbB5</ci>
                        <ci>CaM_GEF</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kfB8</ci>
                     <ci>GEF</ci>
                     <ci>Gbg</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>kbB8</ci>
                  <ci>Gbg_GEF</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>CaM_GEF</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <ci>kbB5</ci>
                  </apply>
                  <ci>CaM_GEF</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>kfB5</ci>
                  <ci>GEF</ci>
                  <ci>Ca4CAM</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>Ca4CAM</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <ci>kbB5</ci>
                           </apply>
                           <ci>CaM_GEF</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>kfB5</ci>
                           <ci>GEF</ci>
                           <ci>Ca4CAM</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Ca</ci>
                     <ci>Ca3CaM</ci>
                     <ci>kfM3</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>kbM3</ci>
                  <ci>Ca4CAM</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>Gbg_GEF</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <ci>kfB8</ci>
                     </apply>
                     <ci>GEF</ci>
                     <ci>Gbg</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kbB8</ci>
                     <ci>Gbg_GEF</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>GEF_star</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>PKC</ci>
                     <ci>VmaxB6</ci>
                     <ci>GEF</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>kmB6</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
                           <apply>
                              <divide/>
                              <ci>GAP</ci>
                              <ci>kmB3</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>Ng</ci>
                              <ci>kmM7</ci>
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                           <apply>
                              <divide/>
                              <ci>Raf</ci>
                              <ci>kmH1</ci>
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                           <apply>
                              <divide/>
                              <ci>NgCaM</ci>
                              <ci>kmM8</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>GEF</ci>
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               </apply>
               <apply>
                  <times/>
                  <ci>kfB7</ci>
                  <ci>GEF_star</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>CaM</ci>
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            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <ci>kfM1</ci>
                           <ci>Ca</ci>
                           <ci>Ca</ci>
                           <ci>CaM</ci>
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                        <apply>
                           <times/>
                           <ci>kbM1</ci>
                           <ci>Ca2CaM</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
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                        <times/>
                        <ci>kfM4</ci>
                        <ci>Ng</ci>
                        <ci>CaM</ci>
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                     <apply>
                        <times/>
                        <ci>kbM4</ci>
                        <ci>NgCaM</ci>
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                  </apply>
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               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>NgCaM</ci>
                     <ci>PKC</ci>
                     <ci>VmaxM8</ci>
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                  <apply>
                     <plus/>
                     <ci>NgCaM</ci>
                     <ci>kmM8</ci>
                  </apply>
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            </apply>
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         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>NgCaM</ci>
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            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kfM4</ci>
                     <ci>Ng</ci>
                     <ci>CaM</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kbM4</ci>
                     <ci>NgCaM</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>NgCaM</ci>
                     <ci>PKC</ci>
                     <ci>VmaxM8</ci>
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                  <apply>
                     <plus/>
                     <ci>NgCaM</ci>
                     <apply>
                        <times/>
                        <ci>kmM8</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
                           <apply>
                              <divide/>
                              <ci>GAP</ci>
                              <ci>kmB3</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>GEF</ci>
                              <ci>kmB6</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>Raf</ci>
                              <ci>kmH1</ci>
                           </apply>
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                              <divide/>
                              <ci>Ng</ci>
                              <ci>kmM7</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>Ca2CaM</ci>
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            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kfM1</ci>
                     <ci>Ca</ci>
                     <ci>Ca</ci>
                     <ci>CaM</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kbM1</ci>
                     <ci>Ca2CaM</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
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                     <times/>
                     <ci>Ca</ci>
                     <ci>Ca2CaM</ci>
                     <ci>kfM2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kbM2</ci>
                     <ci>Ca3CaM</ci>
                  </apply>
               </apply>
            </apply>
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         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>Ca3CaM</ci>
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            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>Ca</ci>
                     <ci>Ca2CaM</ci>
                     <ci>kfM2</ci>
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                  <apply>
                     <times/>
                     <ci>kbM2</ci>
                     <ci>Ca3CaM</ci>
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               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>Ca</ci>
                     <ci>Ca3CaM</ci>
                     <ci>kfM3</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kbM3</ci>
                     <ci>Ca4CAM</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>Ng_star</ci>
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            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>NgCaM</ci>
                           <ci>PKC</ci>
                           <ci>VmaxM8</ci>
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                        <apply>
                           <plus/>
                           <ci>NgCaM</ci>
                           <apply>
                              <times/>
                              <ci>kmM8</ci>
                              <apply>
                                 <plus/>
                                 <ci>one</ci>
                                 <apply>
                                    <divide/>
                                    <ci>GAP</ci>
                                    <ci>kmB3</ci>
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                                 <apply>
                                    <divide/>
                                    <ci>GEF</ci>
                                    <ci>kmB6</ci>
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                                 <apply>
                                    <divide/>
                                    <ci>Raf</ci>
                                    <ci>kmH1</ci>
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                                 <apply>
                                    <divide/>
                                    <ci>Ng</ci>
                                    <ci>kmM7</ci>
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                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>kfM6</ci>
                        <ci>Ng_star</ci>
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                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>VmaxM5</ci>
                        <ci>Ng_star</ci>
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                     <apply>
                        <plus/>
                        <ci>Ng_star</ci>
                        <ci>kmM5</ci>
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                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>Ng</ci>
                     <ci>PKC</ci>
                     <ci>VmaxM7</ci>
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                  <apply>
                     <plus/>
                     <ci>Ng</ci>
                     <apply>
                        <times/>
                        <ci>kmM7</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
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                              <divide/>
                              <ci>GAP</ci>
                              <ci>kmB3</ci>
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                              <divide/>
                              <ci>GEF</ci>
                              <ci>kmB6</ci>
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                           <apply>
                              <divide/>
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                              <divide/>
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            <eq/>
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               <diff/>
               <bvar>
                  <ci>t</ci>
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               <ci>Ng</ci>
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               <minus/>
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                  <plus/>
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                     <times/>
                     <ci>kfM6</ci>
                     <ci>Ng_star</ci>
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                     <divide/>
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                        <times/>
                        <ci>VmaxM5</ci>
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                        <plus/>
                        <ci>Ng_star</ci>
                        <ci>kmM5</ci>
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                  </apply>
               </apply>
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                  <divide/>
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                     <times/>
                     <ci>Ng</ci>
                     <ci>PKC</ci>
                     <ci>VmaxM7</ci>
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                  <apply>
                     <plus/>
                     <ci>Ng</ci>
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                        <times/>
                        <ci>kmM7</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
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                              <divide/>
                              <ci>GAP</ci>
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                              <divide/>
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                              <divide/>
                              <ci>Raf</ci>
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                              <divide/>
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                              <ci>kmM8</ci>
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                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="B_Model_Modules">
      <variable units="s" public_interface="in" name="t"/>
      <variable units="um" public_interface="in" name="GEF_star"/>
      <variable units="um" public_interface="in" name="Gbg_GEF"/>
      <variable units="um" public_interface="in" name="CaM_GEF"/>
      <variable units="um" public_interface="in" name="PKC"/>
      <variable units="um" public_interface="in" name="SHCstar_SOS_GRB2"/>
      <variable units="um" public_interface="in" name="MAPK_star"/>
      <variable units="um" public_interface="in" name="NgCaM"/>
      <variable units="um" public_interface="in" name="GEF"/>
      <variable units="um" public_interface="in" name="Ng"/>
      <variable units="um" public_interface="in" name="SOS"/>
      <variable units="um" public_interface="in" name="MAPKK_star_star"/>
      <variable units="um" public_interface="in" name="MAPKK_star"/>
      <variable units="um" public_interface="out" name="Raf_star" initial_value="0"/>
      <variable units="um" public_interface="out" name="GAP" initial_value="0.002"/>
      <variable units="um" public_interface="out" name="Raf" initial_value="0.2"/>
      <variable units="um" public_interface="out" name="GTPRasRaf_star" initial_value="0"/>
      <variable units="um" public_interface="out" name="Raf_star_star" initial_value="0"/>
      <variable units="um" name="GTP_RAS" initial_value="0"/>
      <variable units="um" name="GDP_RAS" initial_value="0.2"/>
      <variable units="um" name="GAPstar" initial_value="0"/>
      <variable units="um" name="PP2A" initial_value="0.224"/>
      <variable units="dimensionless" name="one" initial_value="1"/>
      <variable units="per_s" name="kfB12" initial_value="0.0001"/>
      <variable units="per_s" name="kbB12" initial_value="0"/>
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      <variable units="um" name="kmB10" initial_value="0.50505"/>
      <variable units="per_s" name="VmaxB10" initial_value="0.02"/>
      <variable units="um" name="kmB11" initial_value="0.50505"/>
      <variable units="per_s" name="VmaxB11" initial_value="0.02"/>
      <variable units="um" name="kmB13" initial_value="1.0104"/>
      <variable units="per_s" name="VmaxB13" initial_value="10"/>
      <variable units="per_s" name="kfB4" initial_value="0.1"/>
      <variable units="per_s" name="kbB4" initial_value="0"/>
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      <variable units="per_s" name="VmaxB3" initial_value="4"/>
      <variable units="um" name="kmA7" initial_value="0.50505"/>
      <variable units="per_s" name="VmaxA7" initial_value="0.02"/>
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      <variable units="per_s" name="kbH5" initial_value="0.5"/>
      <variable units="um" name="kmH1" initial_value="66.666666667"/>
      <variable units="um" name="kmH2" initial_value="25.64166667"/>
      <variable units="um" name="kmH3" initial_value="15.6565"/>
      <variable units="um" name="kmH4" initial_value="15.6565"/>
      <variable units="per_s" name="VmaxH1" initial_value="4"/>
      <variable units="per_s" name="VmaxH2" initial_value="10"/>
      <variable units="per_s" name="VmaxH3" initial_value="6"/>
      <variable units="per_s" name="VmaxH4" initial_value="6"/>
      <variable units="um" name="kmM8" initial_value="28.595"/>
      <variable units="um" name="kmB6" initial_value="3.33333333333"/>
      <variable units="um" name="kmM7" initial_value="28.626667"/>
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      <variable units="um" name="kmH8" initial_value="15.6565"/>
      <variable units="um" name="kmH9" initial_value="15.6565"/>
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               <diff/>
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                  <ci>t</ci>
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                  <minus/>
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                        <minus/>
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                                 <minus/>
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                              <ci>GTP_RAS</ci>
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                        </apply>
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                           <times/>
                           <ci>kfB12</ci>
                           <ci>GTP_RAS</ci>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>GEF_star</ci>
                           <ci>VmaxB10</ci>
                           <ci>GDP_RAS</ci>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>kmB10</ci>
                           <ci>GDP_RAS</ci>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>Gbg_GEF</ci>
                           <ci>VmaxB11</ci>
                           <ci>GDP_RAS</ci>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>kmB11</ci>
                           <ci>GDP_RAS</ci>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>CaM_GEF</ci>
                           <ci>VmaxB9</ci>
                           <ci>GDP_RAS</ci>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>kmB9</ci>
                           <ci>GDP_RAS</ci>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>SHCstar_SOS_GRB2</ci>
                           <ci>VmaxA7</ci>
                           <ci>GDP_RAS</ci>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>kmA7</ci>
                           <ci>GDP_RAS</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>GTP_RAS</ci>
                     <ci>Raf_star</ci>
                     <ci>kfH5</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>GTPRasRaf_star</ci>
                  <ci>kbH5</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>GDP_RAS</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>GAP</ci>
                              </apply>
                              <ci>VmaxB13</ci>
                              <ci>GTP_RAS</ci>
                           </apply>
                           <apply>
                              <plus/>
                              <ci>kmB13</ci>
                              <ci>GTP_RAS</ci>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <ci>kfB12</ci>
                           <ci>GTP_RAS</ci>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>GEF_star</ci>
                           <ci>VmaxB10</ci>
                           <ci>GDP_RAS</ci>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>kmB10</ci>
                           <ci>GDP_RAS</ci>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>Gbg_GEF</ci>
                           <ci>VmaxB11</ci>
                           <ci>GDP_RAS</ci>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>kmB11</ci>
                           <ci>GDP_RAS</ci>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>CaM_GEF</ci>
                           <ci>VmaxB9</ci>
                           <ci>GDP_RAS</ci>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>kmB9</ci>
                           <ci>GDP_RAS</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>SHCstar_SOS_GRB2</ci>
                     <ci>VmaxA7</ci>
                     <ci>GDP_RAS</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>kmA7</ci>
                     <ci>GDP_RAS</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>GAP</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <ci>PKC</ci>
                     </apply>
                     <ci>VmaxB3</ci>
                     <ci>GAP</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>kmB3</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
                           <apply>
                              <divide/>
                              <ci>Raf</ci>
                              <ci>kmH1</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>GEF</ci>
                              <ci>kmB6</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>Ng</ci>
                              <ci>kmM7</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>NgCaM</ci>
                              <ci>kmM8</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>GAP</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>kfB4</ci>
                  <ci>GAPstar</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>GAPstar</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>PKC</ci>
                     <ci>VmaxB3</ci>
                     <ci>GAP</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>kmB3</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
                           <apply>
                              <divide/>
                              <ci>Raf</ci>
                              <ci>kmH1</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>GEF</ci>
                              <ci>kmB6</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>Ng</ci>
                              <ci>kmM7</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>NgCaM</ci>
                              <ci>kmM8</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>GAP</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>kfB4</ci>
                  <ci>GAPstar</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>GTPRasRaf_star</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>GTP_RAS</ci>
                  <ci>Raf_star</ci>
                  <ci>kfH5</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>GTPRasRaf_star</ci>
                  <ci>kbH5</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>Raf</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <ci>PKC</ci>
                     </apply>
                     <ci>Raf</ci>
                     <ci>VmaxH1</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>kmH1</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
                           <apply>
                              <divide/>
                              <ci>GAP</ci>
                              <ci>kmB3</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>GEF</ci>
                              <ci>kmB6</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>Ng</ci>
                              <ci>kmM7</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>NgCaM</ci>
                              <ci>kmM8</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>Raf</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>Raf_star</ci>
                     <ci>PP2A</ci>
                     <ci>VmaxH3</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>kmH3</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
                           <apply>
                              <divide/>
                              <ci>Raf_star_star</ci>
                              <ci>kmH4</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>MAPKK_star_star</ci>
                              <ci>kmH9</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>MAPKK_star</ci>
                              <ci>kmH8</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>Raf_star</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>Raf_star</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>PKC</ci>
                           <ci>Raf</ci>
                           <ci>VmaxH1</ci>
                        </apply>
                        <apply>
                           <plus/>
                           <apply>
                              <times/>
                              <ci>kmH1</ci>
                              <apply>
                                 <plus/>
                                 <ci>one</ci>
                                 <apply>
                                    <divide/>
                                    <ci>GAP</ci>
                                    <ci>kmB3</ci>
                                 </apply>
                                 <apply>
                                    <divide/>
                                    <ci>GEF</ci>
                                    <ci>kmB6</ci>
                                 </apply>
                                 <apply>
                                    <divide/>
                                    <ci>Ng</ci>
                                    <ci>kmM7</ci>
                                 </apply>
                                 <apply>
                                    <divide/>
                                    <ci>NgCaM</ci>
                                    <ci>kmM8</ci>
                                 </apply>
                              </apply>
                           </apply>
                           <ci>Raf</ci>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>Raf_star</ci>
                           <ci>PP2A</ci>
                           <ci>VmaxH3</ci>
                        </apply>
                        <apply>
                           <plus/>
                           <apply>
                              <times/>
                              <ci>kmH3</ci>
                              <apply>
                                 <plus/>
                                 <ci>one</ci>
                                 <apply>
                                    <divide/>
                                    <ci>Raf_star_star</ci>
                                    <ci>kmH4</ci>
                                 </apply>
                                 <apply>
                                    <divide/>
                                    <ci>MAPKK_star_star</ci>
                                    <ci>kmH9</ci>
                                 </apply>
                                 <apply>
                                    <divide/>
                                    <ci>MAPKK_star</ci>
                                    <ci>kmH8</ci>
                                 </apply>
                              </apply>
                           </apply>
                           <ci>Raf_star</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Raf_star</ci>
                        <ci>MAPK_star</ci>
                        <ci>VmaxH2</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <ci>kmH2</ci>
                           <apply>
                              <plus/>
                              <ci>one</ci>
                              <apply>
                                 <divide/>
                                 <ci>SOS</ci>
                                 <ci>kmA9</ci>
                              </apply>
                           </apply>
                        </apply>
                        <ci>Raf_star</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>Raf_star_star</ci>
                     <ci>PP2A</ci>
                     <ci>VmaxH4</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>kmH4</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
                           <apply>
                              <divide/>
                              <ci>Raf_star</ci>
                              <ci>kmH3</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>MAPKK_star_star</ci>
                              <ci>kmH9</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>MAPKK_star</ci>
                              <ci>kmH8</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>Raf_star_star</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>Raf_star_star</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>Raf_star</ci>
                     <ci>MAPK_star</ci>
                     <ci>VmaxH2</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>kmH2</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
                           <apply>
                              <divide/>
                              <ci>SOS</ci>
                              <ci>kmA9</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>Raf_star</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>Raf_star_star</ci>
                     <ci>PP2A</ci>
                     <ci>VmaxH4</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>kmH4</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
                           <apply>
                              <divide/>
                              <ci>Raf_star</ci>
                              <ci>kmH3</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>MAPKK_star_star</ci>
                              <ci>kmH9</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>MAPKK_star</ci>
                              <ci>kmH8</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>Raf_star_star</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="H_Model_Module_MAPKK">
      <variable units="s" public_interface="in" name="t"/>
      <variable units="um" public_interface="in" name="GTPRasRaf_star"/>
      <variable units="um" public_interface="in" name="Raf_star"/>
      <variable units="um" public_interface="in" name="Raf_star_star"/>
      <variable units="um" public_interface="out" name="MAPKK_star" initial_value="0"/>
      <variable units="um" public_interface="out" name="MAPKK_star_star" initial_value="0"/>
      <variable units="um" name="MAPKK" initial_value="0.18"/>
      <variable units="um" name="PP2A" initial_value="0.224"/>
      <variable units="dimensionless" name="one" initial_value="1"/>
      <variable units="um" name="kmH6" initial_value="0.159091667"/>
      <variable units="um" name="kmH7" initial_value="0.159091667"/>
      <variable units="um" name="kmH8" initial_value="15.6565"/>
      <variable units="um" name="kmH9" initial_value="15.6565"/>
      <variable units="per_s" name="VmaxH6" initial_value="0.105"/>
      <variable units="per_s" name="VmaxH7" initial_value="0.105"/>
      <variable units="per_s" name="VmaxH8" initial_value="6"/>
      <variable units="per_s" name="VmaxH9" initial_value="6"/>
      <variable units="um" name="kmH3" initial_value="15.6565"/>
      <variable units="um" name="kmH4" initial_value="15.6565"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>MAPKK</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <ci>MAPKK</ci>
                     </apply>
                     <ci>VmaxH6</ci>
                     <ci>GTPRasRaf_star</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>kmH6</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
                           <apply>
                              <divide/>
                              <ci>MAPKK_star</ci>
                              <ci>kmH7</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>MAPKK</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>MAPKK_star</ci>
                     <ci>VmaxH8</ci>
                     <ci>PP2A</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>kmH8</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
                           <apply>
                              <divide/>
                              <ci>Raf_star</ci>
                              <ci>kmH3</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>Raf_star_star</ci>
                              <ci>kmH4</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>MAPKK_star_star</ci>
                              <ci>kmH9</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>MAPKK_star</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>MAPKK_star</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>MAPKK</ci>
                           <ci>VmaxH6</ci>
                           <ci>GTPRasRaf_star</ci>
                        </apply>
                        <apply>
                           <plus/>
                           <apply>
                              <times/>
                              <ci>kmH6</ci>
                              <apply>
                                 <plus/>
                                 <ci>one</ci>
                                 <apply>
                                    <divide/>
                                    <ci>MAPKK_star</ci>
                                    <ci>kmH7</ci>
                                 </apply>
                              </apply>
                           </apply>
                           <ci>MAPKK</ci>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>MAPKK_star</ci>
                           <ci>VmaxH8</ci>
                           <ci>PP2A</ci>
                        </apply>
                        <apply>
                           <plus/>
                           <apply>
                              <times/>
                              <ci>kmH8</ci>
                              <apply>
                                 <plus/>
                                 <ci>one</ci>
                                 <apply>
                                    <divide/>
                                    <ci>Raf_star</ci>
                                    <ci>kmH3</ci>
                                 </apply>
                                 <apply>
                                    <divide/>
                                    <ci>Raf_star_star</ci>
                                    <ci>kmH4</ci>
                                 </apply>
                                 <apply>
                                    <divide/>
                                    <ci>MAPKK_star_star</ci>
                                    <ci>kmH9</ci>
                                 </apply>
                              </apply>
                           </apply>
                           <ci>MAPKK_star</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>MAPKK_star</ci>
                        <ci>VmaxH7</ci>
                        <ci>GTPRasRaf_star</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <ci>kmH7</ci>
                           <apply>
                              <plus/>
                              <ci>one</ci>
                              <apply>
                                 <divide/>
                                 <ci>MAPKK</ci>
                                 <ci>kmH6</ci>
                              </apply>
                           </apply>
                        </apply>
                        <ci>MAPKK_star</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>MAPKK_star_star</ci>
                     <ci>VmaxH9</ci>
                     <ci>PP2A</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>kmH9</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
                           <apply>
                              <divide/>
                              <ci>Raf_star</ci>
                              <ci>kmH3</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>Raf_star_star</ci>
                              <ci>kmH4</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>MAPKK_star</ci>
                              <ci>kmH8</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>MAPKK_star_star</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>MAPKK_star_star</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>MAPKK_star</ci>
                     <ci>VmaxH7</ci>
                     <ci>GTPRasRaf_star</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>kmH7</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
                           <apply>
                              <divide/>
                              <ci>MAPKK</ci>
                              <ci>kmH6</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>MAPKK_star</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>MAPKK_star_star</ci>
                     <ci>VmaxH9</ci>
                     <ci>PP2A</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>kmH9</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
                           <apply>
                              <divide/>
                              <ci>Raf_star</ci>
                              <ci>kmH3</ci>
                           </apply>
                           <apply>
                              <divide/>
                              <ci>Raf_star_star</ci>
                              <ci>kmH4</ci>
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                           <apply>
                              <divide/>
                              <ci>MAPKK_star</ci>
                              <ci>kmH8</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>MAPKK_star_star</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="H_Model_Module_MAPK">
      <variable units="s" public_interface="in" name="t"/>
      <variable units="um" public_interface="in" name="MAPKK_star_star"/>
      <variable units="um" public_interface="out" name="MAPK_star" initial_value="0"/>
      <variable units="um" public_interface="out" name="MAPK" initial_value="0.36"/>
      <variable units="um" name="MAPK_tyr" initial_value="0"/>
      <variable units="um" name="MKP1" initial_value="0.032"/>
      <variable units="dimensionless" name="one" initial_value="1"/>
      <variable units="um" name="kmH10" initial_value="0.046296667"/>
      <variable units="um" name="kmH11" initial_value="0.046296667"/>
      <variable units="um" name="kmH12" initial_value="0.066666667"/>
      <variable units="um" name="kmH13" initial_value="0.066666667"/>
      <variable units="per_s" name="VmaxH10" initial_value="0.15"/>
      <variable units="per_s" name="VmaxH11" initial_value="0.15"/>
      <variable units="per_s" name="VmaxH12" initial_value="1"/>
      <variable units="per_s" name="VmaxH13" initial_value="1"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>MAPK</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <ci>MAPK</ci>
                     </apply>
                     <ci>VmaxH10</ci>
                     <ci>MAPKK_star_star</ci>
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                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>kmH10</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
                           <apply>
                              <divide/>
                              <ci>MAPK_tyr</ci>
                              <ci>kmH11</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>MAPK</ci>
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               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>MAPK_tyr</ci>
                     <ci>VmaxH12</ci>
                     <ci>MKP1</ci>
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                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>kmH12</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
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                              <divide/>
                              <ci>MAPK_star</ci>
                              <ci>kmH13</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>MAPK_tyr</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>MAPK_tyr</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>MAPK</ci>
                           <ci>VmaxH10</ci>
                           <ci>MAPKK_star_star</ci>
                        </apply>
                        <apply>
                           <plus/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <ci>kmH10</ci>
                                 <ci>MAPK_tyr</ci>
                              </apply>
                              <ci>kmH11</ci>
                           </apply>
                           <ci>MAPK</ci>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>MAPK_tyr</ci>
                           <ci>VmaxH12</ci>
                           <ci>MKP1</ci>
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                        <apply>
                           <plus/>
                           <apply>
                              <times/>
                              <ci>kmH12</ci>
                              <apply>
                                 <plus/>
                                 <ci>one</ci>
                                 <apply>
                                    <divide/>
                                    <ci>MAPK_star</ci>
                                    <ci>kmH13</ci>
                                 </apply>
                              </apply>
                           </apply>
                           <ci>MAPK_tyr</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>MAPK_tyr</ci>
                        <ci>VmaxH11</ci>
                        <ci>MAPKK_star_star</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <ci>kmH11</ci>
                           <apply>
                              <plus/>
                              <ci>one</ci>
                              <apply>
                                 <divide/>
                                 <ci>MAPK_tyr</ci>
                                 <ci>kmH12</ci>
                              </apply>
                           </apply>
                        </apply>
                        <ci>MAPK_tyr</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>MAPK_star</ci>
                     <ci>VmaxH13</ci>
                     <ci>MKP1</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>kmH13</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
                           <apply>
                              <divide/>
                              <ci>MAPK_tyr</ci>
                              <ci>kmH12</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>MAPK_star</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>MAPK_star</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>MAPK_tyr</ci>
                     <ci>VmaxH11</ci>
                     <ci>MAPKK_star_star</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>kmH11</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
                           <apply>
                              <divide/>
                              <ci>MAPK</ci>
                              <ci>kmH10</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>MAPK_tyr</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>MAPK_star</ci>
                     <ci>VmaxH13</ci>
                     <ci>MKP1</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>kmH13</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
                           <apply>
                              <divide/>
                              <ci>MAPK_tyr</ci>
                              <ci>kmH12</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>MAPK_star</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="A_Model_Module_SHC">
      <variable units="s" public_interface="in" name="t"/>
      <variable units="um" public_interface="in" name="EGF_EGFR"/>
      <variable units="um" public_interface="in" name="MAPK_star"/>
      <variable units="um" public_interface="in" name="Raf_star"/>
      <variable units="um" public_interface="in" name="CaPLCg"/>
      <variable units="um" public_interface="out" name="SOS" initial_value="0.1"/>
      <variable units="um" public_interface="out" name="SHCstar_SOS_GRB2" initial_value="0"/>
      <variable units="um" public_interface="out" name="SHC" initial_value="0.5"/>
      <variable units="um" name="SHCstar" initial_value="0"/>
      <variable units="um" name="SOSstar_GRB2" initial_value="0"/>
      <variable units="um" name="SOS_GRB2" initial_value="0"/>
      <variable units="um" name="GRB2" initial_value="1"/>
      <variable units="um" name="SOSstar" initial_value="0"/>
      <variable units="dimensionless" name="one" initial_value="1"/>
      <variable units="um" name="kmA3" initial_value="0.83333333333"/>
      <variable units="per_s" name="kfA4" initial_value="0.0016667"/>
      <variable units="per_s" name="kbA4" initial_value="0"/>
      <variable units="per_um_s" name="kfA5" initial_value="0.000000041667"/>
      <variable units="per_s" name="kbA5" initial_value="0.0168"/>
      <variable units="per_um_s" name="kfA6" initial_value="0.0000008333"/>
      <variable units="per_s" name="kbA6" initial_value="0.1"/>
      <variable units="per_s" name="kfA8" initial_value="0.001"/>
      <variable units="per_s" name="kbA8" initial_value="0"/>
      <variable units="per_um_s" name="kfA10" initial_value="0.000000041667"/>
      <variable units="per_s" name="kbA10" initial_value="0.0168"/>
      <variable units="um" name="kmA7" initial_value="0.40404"/>
      <variable units="um" name="kmA9" initial_value="2.564166667"/>
      <variable units="per_s" name="VmaxA7" initial_value="0.02"/>
      <variable units="per_s" name="VmaxA3" initial_value="0.2"/>
      <variable units="per_s" name="VmaxA9" initial_value="10"/>
      <variable units="um" name="kmH2" initial_value="25.64166667"/>
      <variable units="um" name="kmF4" initial_value="0.33333333333"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>SHCstar</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <minus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>EGF_EGFR</ci>
                           <ci>VmaxA3</ci>
                           <ci>SHC</ci>
                        </apply>
                        <apply>
                           <plus/>
                           <apply>
                              <times/>
                              <ci>kmA3</ci>
                              <apply>
                                 <plus/>
                                 <ci>one</ci>
                                 <apply>
                                    <divide/>
                                    <ci>CaPLCg</ci>
                                    <ci>kmF4</ci>
                                 </apply>
                              </apply>
                           </apply>
                           <ci>SHC</ci>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>kfA6</ci>
                        <ci>SHCstar</ci>
                        <ci>SOS_GRB2</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kbA6</ci>
                     <ci>SHCstar_SOS_GRB2</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>kfA4</ci>
                  <ci>SHCstar</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>SHC</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kfA4</ci>
                     <ci>SHCstar</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kbA4</ci>
                     <ci>SHC</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>EGF_EGFR</ci>
                     <ci>VmaxA3</ci>
                     <ci>SHC</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>kmA3</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
                           <apply>
                              <divide/>
                              <ci>CaPLCg</ci>
                              <ci>kmF4</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>SHC</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>SHCstar_SOS_GRB2</ci>
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            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kfA6</ci>
                  <ci>SHCstar</ci>
                  <ci>SOS_GRB2</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>kbA6</ci>
                  <ci>SHCstar_SOS_GRB2</ci>
               </apply>
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         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>SOS_GRB2</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>kfA6</ci>
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                        <ci>SHCstar</ci>
                        <ci>SOS_GRB2</ci>
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                     <apply>
                        <times/>
                        <ci>kbA6</ci>
                        <ci>SHCstar_SOS_GRB2</ci>
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                  </apply>
                  <apply>
                     <times/>
                     <ci>kbA5</ci>
                     <ci>SOS_GRB2</ci>
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               </apply>
               <apply>
                  <times/>
                  <ci>kfA5</ci>
                  <ci>SOS</ci>
                  <ci>GRB2</ci>
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         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>SOS</ci>
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            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <minus/>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <ci>kfA8</ci>
                           <ci>SOSstar</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>kbA8</ci>
                           <ci>SOS</ci>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>MAPK_star</ci>
                           <ci>VmaxA9</ci>
                           <ci>SOS</ci>
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                        <apply>
                           <plus/>
                           <apply>
                              <times/>
                              <ci>kmA9</ci>
                              <apply>
                                 <plus/>
                                 <ci>one</ci>
                                 <apply>
                                    <divide/>
                                    <ci>Raf_star</ci>
                                    <ci>kmH2</ci>
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                              </apply>
                           </apply>
                           <ci>SOS</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kbA5</ci>
                     <ci>SOS_GRB2</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>kfA5</ci>
                  <ci>SOS</ci>
                  <ci>GRB2</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
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               <ci>SOSstar</ci>
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            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>kfA8</ci>
                        </apply>
                        <ci>SOSstar</ci>
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                     <apply>
                        <times/>
                        <ci>kbA8</ci>
                        <ci>SOS</ci>
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                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>MAPK_star</ci>
                           <ci>VmaxA9</ci>
                           <ci>SOS</ci>
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                        <apply>
                           <plus/>
                           <apply>
                              <times/>
                              <ci>kmA9</ci>
                              <apply>
                                 <plus/>
                                 <ci>one</ci>
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                                    <divide/>
                                    <ci>Raf_star</ci>
                                    <ci>kmH2</ci>
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                              </apply>
                           </apply>
                           <ci>SOS</ci>
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                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kfA10</ci>
                     <ci>SOSstar</ci>
                     <ci>GRB2</ci>
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               </apply>
               <apply>
                  <times/>
                  <ci>kbA10</ci>
                  <ci>SOSstar_GRB2</ci>
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         <apply>
            <eq/>
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               <bvar>
                  <ci>t</ci>
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               <ci>SOSstar_GRB2</ci>
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            <apply>
               <minus/>
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                  <times/>
                  <ci>kfA10</ci>
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                  <ci>GRB2</ci>
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               <apply>
                  <times/>
                  <ci>kbA10</ci>
                  <ci>SOSstar_GRB2</ci>
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         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
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               <ci>GRB2</ci>
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            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
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                        <times/>
                        <ci>kbA5</ci>
                        <ci>SOS_GRB2</ci>
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                     <apply>
                        <times/>
                        <ci>kfA5</ci>
                        <ci>SOS</ci>
                        <ci>GRB2</ci>
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                  <apply>
                     <times/>
                     <ci>kfA10</ci>
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                     <ci>GRB2</ci>
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               <apply>
                  <times/>
                  <ci>kbA10</ci>
                  <ci>SOSstar_GRB2</ci>
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         </apply>
      </math>
   </component>
   <component name="A_Model_Module_EGFR">
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      <variable units="um" public_interface="out" name="EGF_EGFR" initial_value="0"/>
      <variable units="um" name="EGF_EGFR_INTERNAL" initial_value="0"/>
      <variable units="um" name="EGF" initial_value="166.67"/>
      <variable units="um" name="EGFR" initial_value="0.16667"/>
      <variable units="per_um_s" name="kfA1" initial_value="0.000007"/>
      <variable units="per_s" name="kbA1" initial_value="0.25"/>
      <variable units="per_s" name="kfA2" initial_value="0.002"/>
      <variable units="per_s" name="kbA2" initial_value="0.00033"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>EGF</ci>
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            <apply>
               <plus/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <ci>kfA1</ci>
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                  <ci>EGF</ci>
                  <ci>EGFR</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>kbA1</ci>
                  <ci>EGF_EGFR</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
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               <diff/>
               <bvar>
                  <ci>t</ci>
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               <ci>EGFR</ci>
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            <apply>
               <plus/>
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                  <times/>
                  <apply>
                     <minus/>
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                  <ci>EGF</ci>
                  <ci>EGFR</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>kbA1</ci>
                  <ci>EGF_EGFR</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
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               <ci>EGF_EGFR</ci>
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            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>kfA1</ci>
                        <ci>EGF</ci>
                        <ci>EGFR</ci>
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                     <apply>
                        <times/>
                        <ci>kbA1</ci>
                        <ci>EGF_EGFR</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kfA2</ci>
                     <ci>EGF_EGFR</ci>
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               </apply>
               <apply>
                  <times/>
                  <ci>kbA2</ci>
                  <ci>EGF_EGFR_INTERNAL</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>EGF_EGFR_INTERNAL</ci>
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            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kfA2</ci>
                  <ci>EGF_EGFR</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>kbA2</ci>
                  <ci>EGF_EGFR_INTERNAL</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="F_Model_Module_PLC">
      <variable units="s" public_interface="in" name="t"/>
      <variable units="um" public_interface="in" name="EGF_EGFR"/>
      <variable units="um" public_interface="in" name="Ca"/>
      <variable units="um" public_interface="in" name="SHC"/>
      <variable units="um" public_interface="out" name="CaPLCg" initial_value="0"/>
      <variable units="um" public_interface="out" name="CaPLCg_star" initial_value="0"/>
      <variable units="um" name="PLCg" initial_value="0.82"/>
      <variable units="um" name="PLCg_star" initial_value="0"/>
      <variable units="per_um_s" name="kfF1" initial_value="0.0003"/>
      <variable units="per_s" name="kbF1" initial_value="10"/>
      <variable units="per_s" name="kfF3" initial_value="0.05"/>
      <variable units="per_um_s" name="kfF5" initial_value="0.00002"/>
      <variable units="per_s" name="kbF5" initial_value="10"/>
      <variable units="um" name="kmF4" initial_value="0.33333333333"/>
      <variable units="per_s" name="VmaxF4" initial_value="0.2"/>
      <variable units="um" name="kmA3" initial_value="0.83333333333"/>
      <variable units="dimensionless" name="one" initial_value="1"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>PLCg</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <ci>Ca</ci>
                  </apply>
                  <ci>PLCg</ci>
                  <ci>kfF1</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CaPLCg</ci>
                  <ci>kbF1</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>CaPLCg</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <ci>Ca</ci>
                           </apply>
                           <ci>PLCg</ci>
                           <ci>kfF1</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>CaPLCg</ci>
                           <ci>kbF1</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kfF3</ci>
                     <ci>CaPLCg_star</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>VmaxF4</ci>
                     <ci>EGF_EGFR</ci>
                     <ci>CaPLCg</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>kmF4</ci>
                        <apply>
                           <plus/>
                           <ci>one</ci>
                           <apply>
                              <divide/>
                              <ci>SHC</ci>
                              <ci>kmA3</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>CaPLCg</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>CaPLCg_star</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <minus/>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <ci>kfF3</ci>
                           <ci>CaPLCg_star</ci>
                        </apply>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <ci>VmaxF4</ci>
                              <ci>EGF_EGFR</ci>
                              <ci>CaPLCg</ci>
                           </apply>
                           <apply>
                              <plus/>
                              <ci>kmF4</ci>
                              <ci>CaPLCg</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Ca</ci>
                     <ci>PLCg_star</ci>
                     <ci>kfF5</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>kbF5</ci>
                  <ci>CaPLCg_star</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>PLCg_star</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <ci>Ca</ci>
                  </apply>
                  <ci>PLCg_star</ci>
                  <ci>kfF5</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>kbF5</ci>
                  <ci>CaPLCg_star</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="KEL_DAGIP3_Model_Modules">
      <variable units="s" public_interface="in" name="t"/>
      <variable units="um" public_interface="in" name="Ca"/>
      <variable units="um" public_interface="in" name="MAPK"/>
      <variable units="um" public_interface="in" name="CaPLCg"/>
      <variable units="um" public_interface="in" name="CaPLCg_star"/>
      <variable units="um" public_interface="in" name="CaPLC"/>
      <variable units="um" public_interface="in" name="CaGqPLC"/>
      <variable units="um" public_interface="out" name="PKC" initial_value="0"/>
      <variable units="um" name="PKC_i" initial_value="1"/>
      <variable units="um" name="DAGPKC" initial_value="0"/>
      <variable units="um" name="AADAGPKC" initial_value="0"/>
      <variable units="um" name="DAGCaPKC" initial_value="0"/>
      <variable units="um" name="CaPKC" initial_value="0"/>
      <variable units="um" name="AA" initial_value="0"/>
      <variable units="um" name="APC" initial_value="30"/>
      <variable units="um" name="PIP2_star" initial_value="2.5"/>
      <variable units="um" name="PLA2_cyt" initial_value="0.4"/>
      <variable units="um" name="PLA2_star" initial_value="0"/>
      <variable units="um" name="CaPLA2" initial_value="0"/>
      <variable units="um" name="PIP2CaPLA2" initial_value="0"/>
      <variable units="um" name="PIP2PLA2" initial_value="0"/>
      <variable units="um" name="DAGCaPLA2" initial_value="0"/>
      <variable units="um" name="CaPLA2_star" initial_value="0"/>
      <variable units="um" name="PIP2" initial_value="10"/>
      <variable units="um" name="DAG" initial_value="0"/>
      <variable units="um" name="IP3" initial_value="0"/>
      <variable units="um" name="Inositol" initial_value="0"/>
      <variable units="um" name="PC" initial_value="0"/>
      <variable units="per_s" name="kfK1" initial_value="1"/>
      <variable units="per_s" name="kbK1" initial_value="50"/>
      <variable units="per_um_s" name="kfK2" initial_value="0.0000000002"/>
      <variable units="per_s" name="kbK2" initial_value="0.1"/>
      <variable units="per_s" name="kfK3" initial_value="1.2705"/>
      <variable units="per_s" name="kbK3" initial_value="3.5026"/>
      <variable units="per_um_s" name="kfK4" initial_value="0.000000002"/>
      <variable units="per_s" name="kbK4" initial_value="0.1"/>
      <variable units="per_s" name="kfK5" initial_value="1"/>
      <variable units="per_s" name="kbK5" initial_value="0.1"/>
      <variable units="per_s" name="kfK6" initial_value="2"/>
      <variable units="per_s" name="kbK6" initial_value="0.2"/>
      <variable units="per_um_s" name="kfK7" initial_value="0.000001"/>
      <variable units="per_s" name="kbK7" initial_value="0.5"/>
      <variable units="per_um_s" name="kfK8" initial_value="0.000000013333"/>
      <variable units="per_s" name="kbK8" initial_value="8.6348"/>
      <variable units="per_um_s" name="kfK9" initial_value="0.000000001"/>
      <variable units="per_s" name="kbK9" initial_value="0.1"/>
      <variable units="per_um_s" name="kfK10" initial_value="0.00000003"/>
      <variable units="per_s" name="kbK10" initial_value="2"/>
      <variable units="per_um_s" name="kfE1" initial_value="0.000000002"/>
      <variable units="per_s" name="kbE1" initial_value="0.5"/>
      <variable units="per_um_s" name="kfE3" initial_value="0.00000016667"/>
      <variable units="per_s" name="kbE3" initial_value="0.1"/>
      <variable units="per_um_s" name="kfE5" initial_value="0.00000002"/>
      <variable units="per_s" name="kbE5" initial_value="0.1"/>
      <variable units="per_um_s" name="kfE7" initial_value="0.000000005"/>
      <variable units="per_s" name="kbE7" initial_value="4"/>
      <variable units="per_s" name="kfE10" initial_value="0.17"/>
      <variable units="per_s" name="kbE10" initial_value="0"/>
      <variable units="per_um_s" name="kfE11" initial_value="0.00001"/>
      <variable units="per_s" name="kbE11" initial_value="0.1"/>
      <variable units="um" name="kmE9" initial_value="25.64166667"/>
      <variable units="per_s" name="VmaxE9" initial_value="20"/>
      <variable units="per_s" name="kfE13" initial_value="0.4"/>
      <variable units="per_s" name="kbE13" initial_value="0"/>
      <variable units="um" name="kmE2" initial_value="20"/>
      <variable units="um" name="kmE4" initial_value="20"/>
      <variable units="um" name="kmE6" initial_value="20"/>
      <variable units="um" name="kmE8" initial_value="20"/>
      <variable units="um" name="kmE12" initial_value="20"/>
      <variable units="per_s" name="VmaxE2" initial_value="11.04"/>
      <variable units="per_s" name="VmaxE4" initial_value="5.4"/>
      <variable units="per_s" name="VmaxE6" initial_value="36"/>
      <variable units="per_s" name="VmaxE8" initial_value="60"/>
      <variable units="per_s" name="VmaxE12" initial_value="120"/>
      <variable units="um" name="kmF2" initial_value="97"/>
      <variable units="um" name="kmF6" initial_value="19.79166667"/>
      <variable units="per_s" name="VmaxF2" initial_value="14"/>
      <variable units="per_s" name="VmaxF6" initial_value="57"/>
      <variable units="per_s" name="kfG8" initial_value="0.15"/>
      <variable units="per_s" name="kfG9" initial_value="2.5"/>
      <variable units="um" name="kmG6" initial_value="5"/>
      <variable units="per_s" name="VmaxG6" initial_value="48"/>
      <variable units="um" name="kmG7" initial_value="19.84166667"/>
      <variable units="per_s" name="VmaxG7" initial_value="10"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>PKC_i</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <apply>
                                    <times/>
                                    <apply>
                                       <minus/>
                                       <ci>PKC_i</ci>
                                    </apply>
                                    <ci>kfK1</ci>
                                 </apply>
                                 <apply>
                                    <times/>
                                    <ci>PKC</ci>
                                    <ci>kbK1</ci>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>PKC_i</ci>
                                 <ci>AA</ci>
                                 <ci>kfK2</ci>
                              </apply>
                           </apply>
                           <apply>
                              <times/>
                              <ci>PKC</ci>
                              <ci>kbK2</ci>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <ci>PKC_i</ci>
                           <ci>DAG</ci>
                           <ci>kfK9</ci>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>DAGPKC</ci>
                        <ci>kbK9</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>PKC_i</ci>
                     <ci>Ca</ci>
                     <ci>kfK7</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>CaPKC</ci>
                  <ci>kbK7</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>DAGPKC</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>PKC_i</ci>
                        <ci>DAG</ci>
                        <ci>kfK9</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>DAGPKC</ci>
                        <ci>kbK9</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>DAGPKC</ci>
                     <ci>AA</ci>
                     <ci>kfK10</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>AADAGPKC</ci>
                  <ci>kbK10</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>AADAGPKC</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>DAGPKC</ci>
                        <ci>AA</ci>
                        <ci>kfK10</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>AADAGPKC</ci>
                        <ci>kbK10</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>AADAGPKC</ci>
                     <ci>kfK6</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>PKC</ci>
                  <ci>kbK6</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>CaPKC</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <times/>
                                    <ci>PKC_i</ci>
                                    <ci>Ca</ci>
                                    <ci>kfK7</ci>
                                 </apply>
                                 <apply>
                                    <times/>
                                    <ci>CaPKC</ci>
                                    <ci>kbK7</ci>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>CaPKC</ci>
                                 <ci>kfK3</ci>
                              </apply>
                           </apply>
                           <apply>
                              <times/>
                              <ci>PKC</ci>
                              <ci>kbK3</ci>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <ci>CaPKC</ci>
                           <ci>AA</ci>
                           <ci>kfK4</ci>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>PKC</ci>
                        <ci>kbK4</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>DAG</ci>
                     <ci>CaPKC</ci>
                     <ci>kfK8</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>DAGCaPKC</ci>
                  <ci>kbK8</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>DAGCaPKC</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>DAG</ci>
                        <ci>CaPKC</ci>
                        <ci>kfK8</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>DAGCaPKC</ci>
                        <ci>kbK8</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>DAGCaPKC</ci>
                     <ci>kfK5</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>PKC</ci>
                  <ci>kbK5</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>PKC</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <plus/>
                                    <apply>
                                       <minus/>
                                       <apply>
                                          <plus/>
                                          <apply>
                                             <minus/>
                                             <apply>
                                                <times/>
                                                <ci>PKC_i</ci>
                                                <ci>kfK1</ci>
                                             </apply>
                                             <apply>
                                                <times/>
                                                <ci>PKC</ci>
                                                <ci>kbK1</ci>
                                             </apply>
                                          </apply>
                                          <apply>
                                             <times/>
                                             <ci>PKC_i</ci>
                                             <ci>AA</ci>
                                             <ci>kfK2</ci>
                                          </apply>
                                       </apply>
                                       <apply>
                                          <times/>
                                          <ci>PKC</ci>
                                          <ci>kbK2</ci>
                                       </apply>
                                    </apply>
                                    <apply>
                                       <times/>
                                       <ci>CaPKC</ci>
                                       <ci>kfK3</ci>
                                    </apply>
                                 </apply>
                                 <apply>
                                    <times/>
                                    <ci>PKC</ci>
                                    <ci>kbK3</ci>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>CaPKC</ci>
                                 <ci>AA</ci>
                                 <ci>kfK4</ci>
                              </apply>
                           </apply>
                           <apply>
                              <times/>
                              <ci>PKC</ci>
                              <ci>kbK4</ci>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <ci>DAGCaPKC</ci>
                           <ci>kfK5</ci>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>PKC</ci>
                        <ci>kbK5</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>AADAGPKC</ci>
                     <ci>kfK6</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>PKC</ci>
                  <ci>kbK6</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>AA</ci>
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            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <apply>
                                    <times/>
                                    <apply>
                                       <minus/>
                                       <ci>PKC_i</ci>
                                    </apply>
                                    <ci>AA</ci>
                                    <ci>kfK2</ci>
                                 </apply>
                                 <apply>
                                    <times/>
                                    <ci>PKC</ci>
                                    <ci>kbK2</ci>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>CaPKC</ci>
                                 <ci>AA</ci>
                                 <ci>kfK4</ci>
                              </apply>
                           </apply>
                           <apply>
                              <times/>
                              <ci>PKC</ci>
                              <ci>kbK4</ci>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <ci>DAGPKC</ci>
                           <ci>AA</ci>
                           <ci>kfK10</ci>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>AADAGPKC</ci>
                        <ci>kbK10</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>AA</ci>
                     <ci>kfE13</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>CaPLA2_star</ci>
                     <ci>VmaxE12</ci>
                     <ci>APC</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>kmE12</ci>
                     <ci>APC</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>CaPLA2</ci>
                     <ci>VmaxE4</ci>
                     <ci>APC</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>kmE4</ci>
                     <ci>APC</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>DAGCaPLA2</ci>
                     <ci>VmaxE8</ci>
                     <ci>APC</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>kmE8</ci>
                     <ci>APC</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>PIP2CaPLA2</ci>
                     <ci>VmaxE6</ci>
                     <ci>APC</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>kmE6</ci>
                     <ci>APC</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>PIP2PLA2</ci>
                     <ci>VmaxE2</ci>
                     <ci>APC</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>kmE2</ci>
                     <ci>APC</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>t</ci>
               </bvar>
               <ci>PLA2_cyt</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <apply>
                           <minus/>
                           <apply>
                              <times/>
                              <ci>PLA2_star</ci>
                              <ci>kfE10</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>PIP2_star</ci>
                              <ci>PLA2_cyt</ci>
                              <ci>kfE1</ci>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <ci>PIP2PLA2</ci>
                           <ci>kbE1</ci>
                        </apply>
                     </apply>
                     <apply>
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