Location: Ryanodine receptor knowledge page @ 0fe38b38cbb9 / exposure / exposure_frontpage.rst

Author:
Shelley Fong <sfon036@UoA.auckland.ac.nz>
Date:
2024-08-26 10:17:36+12:00
Desc:
Init
Permanent Source URI:
https://models.physiomeproject.org/workspace/bb8/rawfile/0fe38b38cbb98564268a9374f9268a342f052745/exposure/exposure_frontpage.rst

About
====================

Landing page for the ryanodine receptor (**Ryr**). 
   
Its major function is to create calcium-induced calcium release (CICR): the channel mediates the release of calcium from the sarcoplasmic reticulum into the cytosol, leading to the triggering of muscle contraction following depolarization of T-tubules in the same cell.

Pictures
===================

.. figure:: exposure/RYR2_protein.png
   :width: 50%
   :align: center
   :alt: ryr2
   
   Fig. 1. Visualisation of the Ryr2 protein


Subfamilies
===================
The following list contains the known isoforms of Ryr.

.. csv-table:: Variants within the human species
   :header: "Channel name", "Organ", Gene, Structure
   :widths: 7,7,7,7

   RYR1, Skeletal, `Uniprot 1 <https://www.uniprot.org/uniprotkb/P21817/entry>`_, `PDB 1 <https://www.ebi.ac.uk/pdbe-srv/view/entry/6UHI>`_
   RYR2, Cardiac, `Uniprot 2 <https://www.uniprot.org/uniprotkb/Q92736/entry>`_, `PDB 2 <https://www.ebi.ac.uk/pdbe-srv/view/entry/4JKQ>`_
   RYR3, Brain, `Uniprot 3 <https://www.uniprot.org/uniprotkb/Q15413/entry>`_, `PDB 3 <https://www.ebi.ac.uk/pdbe-srv/view/entry/4ERV>`_

Column 'Organ' refers to the site where the isoform primarily exists.


Literature
===================

.. csv-table:: For further reading
   :header: "Title", "Author"
   :widths: 30, 15   
   
   "`Local Control Models of Cardiac Excitation-Contraction Coupling A Possible Role for Allosteric Interactions between Ryanodine Receptors <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10051521&dopt=Abstract>`_", "Stern et al."  
   "`Cardiac Ca2+ Dynamics: The Roles of Ryanodine Receptor Adaptation and Sarcoplasmic Reticulum Load <https://doi.org/10.1016/S0006-3495(98)77832-4>`_", "Jafri et al."   

Existing models 
===================

.. csv-table:: Link to other PMR workspaces or exposures
   :header: "Title", "Author"
   :widths: 30, 15
   
   "`BG_pCa <https://models.physiomeproject.org/workspace/833>`_", "S Fong" 
   "`Local Control Models of Cardiac Excitation-Contraction Coupling A Possible Role for Allosteric Interactions between Ryanodine Receptors* <https://models.physiomeproject.org/exposure/b060fdbcfae8c7d85e595c24d36ab11b>`_", "Stern et al."   
   
   
Models denoted by [*] are not in bond graph form.
Models denoted by [^] are part of a whole cell model.


..
   Other annotations
   
..
   ===================