- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-08-26 10:17:36+12:00
- Desc:
- Init
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/bb8/rawfile/0fe38b38cbb98564268a9374f9268a342f052745/exposure/exposure_frontpage.rst
About
====================
Landing page for the ryanodine receptor (**Ryr**).
Its major function is to create calcium-induced calcium release (CICR): the channel mediates the release of calcium from the sarcoplasmic reticulum into the cytosol, leading to the triggering of muscle contraction following depolarization of T-tubules in the same cell.
Pictures
===================
.. figure:: exposure/RYR2_protein.png
:width: 50%
:align: center
:alt: ryr2
Fig. 1. Visualisation of the Ryr2 protein
Subfamilies
===================
The following list contains the known isoforms of Ryr.
.. csv-table:: Variants within the human species
:header: "Channel name", "Organ", Gene, Structure
:widths: 7,7,7,7
RYR1, Skeletal, `Uniprot 1 <https://www.uniprot.org/uniprotkb/P21817/entry>`_, `PDB 1 <https://www.ebi.ac.uk/pdbe-srv/view/entry/6UHI>`_
RYR2, Cardiac, `Uniprot 2 <https://www.uniprot.org/uniprotkb/Q92736/entry>`_, `PDB 2 <https://www.ebi.ac.uk/pdbe-srv/view/entry/4JKQ>`_
RYR3, Brain, `Uniprot 3 <https://www.uniprot.org/uniprotkb/Q15413/entry>`_, `PDB 3 <https://www.ebi.ac.uk/pdbe-srv/view/entry/4ERV>`_
Column 'Organ' refers to the site where the isoform primarily exists.
Literature
===================
.. csv-table:: For further reading
:header: "Title", "Author"
:widths: 30, 15
"`Local Control Models of Cardiac Excitation-Contraction Coupling A Possible Role for Allosteric Interactions between Ryanodine Receptors <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10051521&dopt=Abstract>`_", "Stern et al."
"`Cardiac Ca2+ Dynamics: The Roles of Ryanodine Receptor Adaptation and Sarcoplasmic Reticulum Load <https://doi.org/10.1016/S0006-3495(98)77832-4>`_", "Jafri et al."
Existing models
===================
.. csv-table:: Link to other PMR workspaces or exposures
:header: "Title", "Author"
:widths: 30, 15
"`BG_pCa <https://models.physiomeproject.org/workspace/833>`_", "S Fong"
"`Local Control Models of Cardiac Excitation-Contraction Coupling A Possible Role for Allosteric Interactions between Ryanodine Receptors* <https://models.physiomeproject.org/exposure/b060fdbcfae8c7d85e595c24d36ab11b>`_", "Stern et al."
Models denoted by [*] are not in bond graph form.
Models denoted by [^] are part of a whole cell model.
..
Other annotations
..
===================
