- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-08-20 13:26:17+12:00
- Desc:
- Change picture
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/b9f/rawfile/7db836d2459e07c2a673dba04580cb932972b344/exposure/exposure_frontpage.rst
About
====================
Landing page for the sarcoplasmic/endoplasmic calcium ATPase (**SERCA**).
..
Other name for these proteins: Ca\ :math:`{^2}`:math:`{^+}`\ **pump**
Its major function is to transport calcium from the cytosol into the sarcoplasmic reticulum in muscle cells. This action is coupled with the hydrolysis of ATP.
Pictures
===================
.. figure:: exposure/ATP2A1.png
:width: 50%
:align: center
:alt: serca_pic
Fig. 1. Structure of the ATP2A1 protein, rendered from PDB structure
Subfamilies
===================
The following list contains the known subfamilies of SERCA pump.
.. csv-table:: Variants within the human species
:header: "Channel name", "Alias", Gene, Structure
:widths: 7,7,7,7
SERCA1, ATP2A1, `Uniprot 1 <https://www.uniprot.org/uniprotkb/O14983/entry>`_, `SMR 1 <https://swissmodel.expasy.org/repository/uniprot/O14983?csm=C8F33809B56FDDEE>`_
SERCA2, ATP2A2, `Uniprot 2 <https://www.uniprot.org/uniprotkb/P16615/entry>`_, `PDB 2 <https://www.ebi.ac.uk/pdbe-srv/view/entry/5ZTF>`_
SERCA3, ATP2A3, `Uniprot 3 <https://www.uniprot.org/uniprotkb/Q93084/entry>`_, `SMR 3 <https://swissmodel.expasy.org/repository/uniprot/Q93084?csm=44E9F1FBF41FE36A>`_
Literature
===================
.. csv-table:: For further reading
:header: "Title", "Author"
:widths: 30, 15
"`A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources <https://doi.org/10.1113/JP278739>`_", "Kernik et al."
"`A thermodynamic framework for modelling membrane transporters <https://arxiv.org/abs/1806.04341>`_", "Pan et al."
Existing models
===================
.. csv-table:: Link to other PMR workspaces or exposures
:header: "Title", "Author"
:widths: 30, 15
"`BG_SERCA <https://models.physiomeproject.org/workspace/7a5>`_", "S Fong"
"`Transporter_thermodynamics^ <https://github.com/uomsystemsbiology/transporter_thermodynamics>`_", "Pan et al."
"`Bond graph modelling of the cardiac action potential: Implications for drift and non-unique steady states <https://github.com/uomsystemsbiology/bond_graph_cardiac_AP>`_", "M Pan et al."
"`A Thermodynamic Model of the Cardiac Sarcoplasmic/Endoplasmic Ca(2+) (SERCA) Pump: the three-state SERCA model* <https://models.physiomeproject.org/exposure/d3bde1a45f3b2778875a6a446618e336/tran_smith_loiselle_crampin_2009.cellml/view>`_", "Tran et al."
Models denoted by [*] are not in bond graph form.
Models denoted by [^] are part of a whole cell model.
..
Other annotations
..
===================
