- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-07-09 14:36:46+12:00
- Desc:
- Init
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/b80/rawfile/d83b26314314258a07f4cf94c31fa3dbe5d7f570/exposure/exposure_frontpage.rst
About
====================
Landing page for the rapid delayed rectifier potassium channel (**Kr**).
Other names for this protein **Kv**, **Name2**
Kr is thought to be KCNE1 and/or KCNE2 assembled with KCNH2/HERG proteins.
Subfamilies
===================
KCNA (Kv1.x), KCNB (Kv2.x), ...
Pictures
===================
Insert
Literature
===================
.. csv-table:: For further reading
:header: "Title", "Author"
:widths: 30, 15
"`A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources <https://doi.org/10.1113/JP278739>`_", "Kernik et al."
Existing models
===================
.. csv-table:: Link to other PMR workspaces or exposures
:header: "Title", "Author"
:widths: 30, 15
"`BG_Kr <https://models.physiomeproject.org/workspace/82c>`_", "S Fong"
"`Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death*^ <https://models.physiomeproject.org/e/514>`_", "C Clancy and Y Rudy"
"`Bond graph modelling of the cardiac action potential: Implications for drift and non-unique steady states^ <https://github.com/uomsystemsbiology/bond_graph_cardiac_AP>`_", "M Pan et al."
Models denoted by [*] are not in bond graph form.
Models denoted by [^] are part of a whole cell model.
Annotations
===================
.. csv-table::
:header: "Item", "Database"
:widths: 30, 15
"KCNE1 structure", "`PDB <https://www.rcsb.org/structure/2K21>`_"
"KCNE2 structure", "`AlphaFold <https://alphafold.ebi.ac.uk/entry/Q9Y6J6>`_"
"KCNE1 protein", "`Uniprot 1 <https://www.uniprot.org/uniprotkb/P15382/entry>`_"
"KCNE2 protein", "`Uniprot 2 <https://www.uniprot.org/uniprotkb/Q9Y6J6/entry>`_"
"Protein activity", "Gene ontology <https://www.ebi.ac.uk/QuickGO/term/GO:0005251>`_"
"Hierarchy of Kv channels", "`Interpro <https://www.ebi.ac.uk/interpro/entry/InterPro/IPR003968/>`_"