- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-08-09 14:35:07+12:00
- Desc:
- adding untidied annotations
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/b80/rawfile/870f1deb789671572afc2d781489d992c14613d7/exposure/exposure_frontpage.rst
About
====================
Landing page for the delayed rectifier potassium channel, of both rapid (Kr) and slow (Ks) variants (**Kr** and **Ks**).
Other name for this protein: **Kv**, **KCNx** (x denotes letter from A to H)
Kv is thought to be tetrameric - made of four units of the pore-forming, alpha subunit protein. This is assembled with one or more units of the regulatory beta subunit. There may be other subunits that control channel gating.
Pictures
===================
.. figure:: exposure/K_channel_wikipedia.png
:width: 100%
:align: center
:alt: Kr_pic
Fig. 1. Schematic of delayed rectifier potassium channel action (purple channel), transferring potassium ions (purple triangles) from the extracellular fluid into the cell cytosol.
Subfamilies
===================
The following list contains a portion of all 12 subfamilies that fall under the Kv group. This portion pertains to the delayed rectifier current only.
.. csv-table:: Variants within the human species
:header: "Channel name", "Alias", "x", "Subunit", "Binds", "Current", Gene, Structure
:widths: 7, 10, 7, 7, 8, 8, 7, 7
"Kv1.x", "KCNAx", "1", "alpha", " ", " ", `Uniprot KCNA1 <https://www.uniprot.org/Uniprot Kb/Q09470/entry>`_, `SMR KCNA1 <https://swissmodel.expasy.org/repository/uniprot/Q09470?csm=0A1B1AB87BCDDEBA>`_
" ", " ", "2 ", "alpha", " ", "Kr", `Uniprot KCNA2 <https://www.uniprot.org/Uniprot Kb/Q28293/entry>`_, `SMR KCNA2 <https://swissmodel.expasy.org/repository/uniprot/Q28293?csm=394FDA7D04CA8EC8>`_
" ", " ", "3 ", "alpha", " ", " ", `Uniprot KCNA3 <https://www.uniprot.org/Uniprot Kb/P22001/entry>`_, `PDB KCNA3 <https://www.ebi.ac.uk/pdbe-srv/view/entry/4BGC>`_
" ", " ", "5 ", "alpha", " ", " ", `Uniprot KCNA5 <https://www.uniprot.org/Uniprot Kb/P22460/entry>`_, `SMR KCNA5 <https://swissmodel.expasy.org/repository/uniprot/P22460?csm=A5B02B27F8396E3D>`_
" ", " ", "6 ", "alpha", " ", " ", `Uniprot KCNA6 <https://www.uniprot.org/Uniprot Kb/P17658/entry>`_, `SMR KCNA6 <https://swissmodel.expasy.org/repository/uniprot/P17658?csm=CFF0710A1F9CD69F>`_
" ", " ", "7 ", "alpha", " ", " ", `Uniprot KCNA7 <https://www.uniprot.org/Uniprot Kb/Q96RP8/entry>`_, `SMR KCNA7 <https://swissmodel.expasy.org/repository/uniprot/Q96RP8?csm=EF9980CF54D52FB8>`_
"Kv2.x", "KCNBx", "1", "alpha", " ", "Ks", `Uniprot KCNB1 <https://www.uniprot.org/Uniprot Kb/Q14721/entry>`_, `PDB KCNB1 <https://pdbe-kb.org/proteins/Q14721>`_
" ", " ", "2 ", "alpha ", " ", " ", `Uniprot KCNB2 <https://www.uniprot.org/Uniprot Kb/Q92953/entry>`_, `SMR KCNB2 <https://swissmodel.expasy.org/repository/uniprot/Q92953?csm=2261D7D6280CF81A>`_
"Kv3.x", "KCNCx", "1", alpha, " ", " ", `Uniprot KCNC1 <https://www.uniprot.org/Uniprot Kb/P48547/entry>`_, `PDB KCNC1 <https://www.ebi.ac.uk/pdbe-srv/view/entry/7PHH>`_
" ", " ", "2", "alpha", " ", " ", `Uniprot KCNC2<https://www.uniprot.org/Uniprot Kb/Q96PR1/entry>`_, `SMR KCNC2 <https://swissmodel.expasy.org/repository/uniprot/Q96PR1?csm=211CAF8395A58C5D>`_
" ", " ", "3", "alpha", " ", " ", `Uniprot KCNC3<https://www.uniprot.org/Uniprot Kb/Q14003/entry>`_, `SMR KCNC3 <https://swissmodel.expasy.org/repository/uniprot/Q14003?csm=B44306B850DFD797>`_
" ", " ", "4", "alpha", " ", " ", `Uniprot KCNC4<https://www.uniprot.org/Uniprot Kb/Q03721/entry>`_, `PDB KCNC4 <https://www.ebi.ac.uk/pdbe-srv/view/entry/1B4G>`_
"Kv6.x", "KCNGx", "1", alpha, " ", "Ks", `Uniprot KCNG1 <https://www.uniprot.org/Uniprot Kb/Q9UIX4/entry>`_, `SMR KCNG1 <https://swissmodel.expasy.org/repository/uniprot/Q9UIX4?csm=A002F1C0EF2FBDC5>`_
" ", " ", "2", "alpha ", " ", "Ks", `Uniprot KCNG2 <https://www.uniprot.org/Uniprot Kb/Q9UJ96/entry>`_, `SMR KCNG2 <https://www.uniprot.org/database?query=(name:SMR)&direct>`_
" ", " ", "3", "alpha ", " ", "Ks", `Uniprot KCNG3 <https://www.uniprot.org/Uniprot Kb/Q8TAE7/entry>`_, `SMR KCNG3 <https://www.uniprot.org/Uniprot Kb/Q8TAE7/entry>`_
" ", " ", "4", "alpha ", " ", "Ks", `Uniprot KCNG4 <https://www.uniprot.org/Uniprot Kb/Q8TDN1/entry>`_, `SMR KCNG4 <https://swissmodel.expasy.org/repository/uniprot/Q8TDN1?csm=E5BBA354931AB0A4>`_
"Kv9.x", "KCNSx", "1", alpha, " ", "Ks", `Uniprot KCNS1 <https://www.uniprot.org/Uniprot Kb/Q96KK3/entry>`_, `SMR KCNS1 <https://swissmodel.expasy.org/repository/uniprot/Q96KK3?csm=00F0E415E3A68C91>`_
" ", " ", "2", "alpha", " ", "Ks", `Uniprot KCNS2 <https://www.uniprot.org/Uniprot Kb/Q9ULS6/entry>`_, `SMR KCNS2 <https://swissmodel.expasy.org/repository/uniprot/O35174?csm=C7AD7AA3AE312B2C>`_
" ", " ", "3", "alpha", " ", "Ks", `Uniprot KCNS3 <https://www.uniprot.org/Uniprot Kb/Q9BQ31/entry>`_, `SMR KCNS3 <https://swissmodel.expasy.org/repository/uniprot/Q9BQ31?csm=FFE02CA3DCA50185>`_
"Kv7.x", "KCNQx", "1", "alpha", " ", "Ks", `Uniprot KCNQ1 <https://www.uniprot.org/Uniprot Kb/P51787/entry>`_, `PDB KCNQ1 <https://www.ebi.ac.uk/pdbe-srv/view/entry/3BJ4>`_
" ", " ", "2", "alpha", " ", " ", `Uniprot KCNQ2<https://www.uniprot.org/Uniprot Kb/O43526/entry>`_, `EMD KCNQ2 <https://www.ebi.ac.uk/emdb/EMD-30443>`_
" ", " ", "3", "alpha", " ", " ", `Uniprot KCNQ3<https://www.uniprot.org/Uniprot Kb/O43525/entry>`_, `PDB KCNQ3 <https://pdbe-kb.org/proteins/O43525>`_
" ", " ", "4", "alpha", " ", " ", `Uniprot KCNQ4<https://www.uniprot.org/Uniprot Kb/P56696/entry>`_, `PDB KCNQ4 <https://pdbe-kb.org/proteins/P56696>`_
" ", " ", "5", "alpha", " ", " ", `Uniprot KCNQ5<https://www.uniprot.org/Uniprot Kb/Q9NR82/entry>`_, `PDB KCNQ5 <https://www.ebi.ac.uk/pdbe-srv/view/entry/6B8Q>`_
"Kv10.x", "KCNHx", "1", "alpha", " ", " ", `Uniprot KCNH1 <https://www.uniprot.org/Uniprot Kb/O95259/entry>`_, `PDB KCNH1 <https://www.ebi.ac.uk/pdbe-srv/view/entry/5J7E>`_
" ", " ", "2", "alpha", " ", "Kr", `Uniprot KCNH2 <https://www.uniprot.org/Uniprot Kb/Q12809/entry>`_, `PDB KCNH2 <https://www.ebi.ac.uk/pdbe-srv/view/entry/1BYW>`_
"-", "KCNEx", "1", "beta", KCNQ1, "Ks", `Uniprot KCNE1 <https://www.uniprot.org/Uniprot Kb/P15382/entry>`_, `PDB KCNE1 <https://www.ebi.ac.uk/pdbe-srv/view/entry/2K21>`_
"-", " ", "2", "beta", " ", "Kr", `Uniprot KCNE2<https://www.uniprot.org/Uniprot Kb/Q9Y6J6/entry>`_, `PDB KCNE2 <https://www.ebi.ac.uk/pdbe-srv/view/entry/2M0Q>`_
"-", " ", "3", "beta", "KCNB1", "Ks", `Uniprot KCNE3 <https://www.uniprot.org/Uniprot Kb/Q9Y6H6/entry>`_, `PDB KCNE3 <https://www.ebi.ac.uk/pdbe-srv/view/entry/2NDJ>`_
Blank spaces: unknowns
Known associates of Kr: KCNA2, KCNH2, KCNE2
Known associates of Ks: KCNB1, KCNE1 (with KCNQ1), KCNE3 (with KCNB1), KCNG1-4 (Kv6.x), KCNS1-3, KCIP4 (with KCND2)
Literature
===================
.. csv-table:: For further reading
:header: "Title", "Author"
:widths: 30, 15
"`A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources <https://doi.org/10.1113/JP278739>`_", "Kernik et al."
Existing models
===================
.. csv-table:: Link to other PMR workspaces or exposures
:header: "Title", "Author"
:widths: 30, 15
"`BG_KR <https://models.physiomeproject.org/workspace/82c>`_", "S Fong"
"`BG_Ks <https://models.physiomeproject.org/workspace/82d>`_", "S Fong"
"`Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death*^ <https://models.physiomeproject.org/e/514>`_", "C Clancy and Y Rudy"
"`Bond graph modelling of the cardiac action potential: Implications for drift and non-unique steady states^ <https://github.com/uomsystemsbiology/bond_graph_cardiac_AP>`_", "M Pan et al."
"`A Model of the Ventricular Cardiac Action Potential - Depolarisation, Repolarisation and Their Interaction*^ <https://models.physiomeproject.org/exposure/2d2ce7737b42a4f72d6bf8b67f6eb5a2>`_", "C Luo and Y Rudy"
Models denoted by [*] are not in bond graph form.
Models denoted by [^] are part of a whole cell model.
Other annotations
===================
.. csv-table::
:header: "Item", "Database"
:widths: 30, 15
"KCNE1 `PDB <>", "`PDB <> <https://www.rcsb.org/`PDB <>/2K21>`_"
"KCNE2 `PDB <>", "`PDB <> <https://www.rcsb.org/`PDB <>/2M0Q>`_"
"KCNE3 `PDB <>", "`PDB <> <https://www.rcsb.org/`PDB <>/2NDJ>`_"
"KCNE1 protein", "`Uniprot <> 1 <https://www.uniprot.org/Uniprot Kb/P15382/entry>`_"
"KCNE2 protein", "`Uniprot <> 2 <https://www.uniprot.org/Uniprot Kb/Q9Y6J6/entry>`_"
"KCNE3 protein", "`Uniprot <> 3 <https://www.uniprot.org/Uniprot Kb/Q9Y6H6/entry>`_"
"m", "n"
"Voltage gated potassium channel subunits Kv1-12", "Reactome <https://reactome.org/content/detail/R-HSA-1296098>`_" "Protein activity", "``Uniprot <> ontology <https://www.ebi.ac.uk/QuickGO/term/GO:0005251>`_"
"Hierarchy of Kv channels", "`Interpro <https://www.ebi.ac.uk/interpro/entry/InterPro/IPR003968/>`_"