Location: Na channel knowledge page @ e3f245c10370 / exposure / exposure_frontpage.rst

Author:
Shelley Fong <sfon036@UoA.auckland.ac.nz>
Date:
2024-08-06 10:29:40+12:00
Desc:
Changing text
Permanent Source URI:
https://models.physiomeproject.org/workspace/b7e/rawfile/e3f245c10370bde9c465aa69494f85da50b0eb61/exposure/exposure_frontpage.rst

About
====================

Landing page for the voltage-gated sodium potassium channel (**fastNa**).
Other names for this protein: **NaV1.1** to **1.9**

The fastNa channel is thought to be made of one type of pore-forming alpha subunit, modulated by one or more beta subunits.


.. figure:: exposure/Na_channel_wikipedia.png
   :width: 100%
   :align: center
   :alt: fast_Na_pic

   Fig. 1. Schematic of sodium channel (C) action, transferring sodium ions (a) from the extracellular fluid into the cell cytosol.

|

Subfamilies
===================

.. csv-table:: Variants within the human species
   :header: "Name", "Abbrev", "Gene", "Structure"
   :widths: 25, 7, 15, 15

   "Sodium channel protein type 1 subunit alpha", "SCN1A",  "`SCN1A (Uniprot) <https://www.uniprot.org/uniprotkb/P35498/entry>`_",	"`SCN1A (PDB) <https://www.rcsb.org/structure/7DTD>`_"
   "Sodium channel protein type 2 subunit alpha", "SCN2A",  "`SCN2A (Uniprot) <https://www.uniprot.org/uniprotkb/Q99250/entry>`_",	"`SCN2A (PDB) <https://www.ebi.ac.uk/pdbe/entry/pdb/2KAV>`_"
   "Sodium channel protein type 3 subunit alpha", "SCN3A",  "`SCN3A (Uniprot) <https://www.uniprot.org/uniprotkb/Q9NY46/entry>`_",	"`SCN3A (PDB) <https://www.ebi.ac.uk/pdbe-srv/view/entry/7W77>`_"
   "Sodium channel protein type 4 subunit alpha", "SCN4A",  "`SCN4A (Uniprot) <https://www.uniprot.org/uniprotkb/P35499/entry>`_",	"`SCN4A (PDB) <https://www.ebi.ac.uk/pdbe-srv/view/entry/6AGF>`_"
   "Sodium channel protein type 5 subunit alpha", "SCN5A",  "`SCN5A (Uniprot) <https://www.uniprot.org/uniprotkb/Q14524/entry>`_",	"`SCN5A (PDB) <https://www.ebi.ac.uk/pdbe-srv/view/entry/2KBI>`_"
   "Sodium channel protein type 8 subunit alpha", "SCN8A",  "`SCN8A (Uniprot) <https://www.uniprot.org/uniprotkb/Q9UQD0/entry>`_",	"`SCN8A (PDB) <https://www.ebi.ac.uk/pdbe-srv/view/entry/8FHD>`_"
   "Sodium channel protein type 9 subunit alpha", "SCN9A",  "`SCN9A (Uniprot) <https://www.uniprot.org/uniprotkb/Q15858/entry>`_",	"`SCN9A (AlphaFold) <https://alphafold.ebi.ac.uk/entry/Q15858>`_"
   "Sodium channel protein type 10 subunit alpha", "SCNAA",	"`SCNAA (Uniprot) <https://www.uniprot.org/uniprotkb/Q9Y5Y9/entry>`_",	"`SCNAA (PDB) <https://www.ebi.ac.uk/pdbe-srv/view/entry/7WE4>`_"
   "Sodium channel protein type 11 subunit alpha",	"SCNBA", "`SCNBA (Uniprot) <https://www.uniprot.org/uniprotkb/Q9UI33/entry>`_",	"`SCNBA (AlphaFold) <https://alphafold.ebi.ac.uk/entry/Q9UI33>`_"
   "Sodium channel subunit beta-1", "SCN1B", "`SCN1B (Uniprot) <https://www.uniprot.org/uniprotkb/Q07699/entry>`_", "`SCN1B (AlphaFold) <https://alphafold.ebi.ac.uk/entry/Q07699>`_"
   "Sodium channel subunit beta-2", "SCN2B", "`SCN2B (Uniprot) <https://www.uniprot.org/uniprotkb/O60939/entry>`_", "`SCN2B (PDB) <https://www.ebi.ac.uk/pdbe/entry/pdb/5FDY>`_"
   "Sodium channel subunit beta-3", "SCN3B", "`SCN3B (Uniprot) <https://www.uniprot.org/uniprotkb/Q9NY72/entry>`_", "`SCN3B (PDB) <https://www.ebi.ac.uk/pdbe/entry/pdb/4L1D>`_"
   "Sodium channel subunit beta-4", "SCN4B", "`SCN4B (Uniprot) <https://www.uniprot.org/uniprotkb/Q8IWT1/entry>`_", "`SCN4B (PDB) <https://www.ebi.ac.uk/pdbe/entry/pdb/4MZ2>`_"



Literature
===================

.. csv-table:: For further reading
   :header: "Title", "Author"
   :widths: 30, 15   
   
   "`A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources <https://doi.org/10.1113/JP278739>`_", "Kernik et al."
   "`Bond graph modelling of the cardiac action potential: Implications for drift and non-unique steady states <https://doi.org/10.1098/rspa.2018.0106>`_", "Pan et al."


Existing models 
===================

.. csv-table:: Link to other model workspaces or exposures
   :header: "Title", "Author"
   :widths: 30, 15
   
   "`BG_fast_Na <https://models.physiomeproject.org/workspace/826>`_", "S Fong"
   "`Bond graph modelling of the cardiac action potential: Implications for drift and non-unique steady states^ <https://github.com/uomsystemsbiology/bond_graph_cardiac_AP>`_", "M Pan et al."
   "`A Model of the Ventricular Cardiac Action Potential - Depolarisation, Repolarisation and Their Interaction*^ <https://models.physiomeproject.org/exposure/2d2ce7737b42a4f72d6bf8b67f6eb5a2>`_", "C Luo and Y Rudy"
   
Models denoted by [*] are not in bond graph form.
Models denoted by [^] are part of a whole cell model.

Other annotations
===================

.. csv-table:: 
   :header: "Item", "Database"
   :widths: 17, 15
      
   "Family of Na channels, alpha subunit", "`Alpha (Interpro) <https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001696/>`_"
   "Family of Na channels, beta subunit", "`Beta (Interpro) <https://www.ebi.ac.uk/interpro/entry/InterPro/IPR027098/>`_"
   "Cellular component", "`Gene Ontology <https://www.ebi.ac.uk/QuickGO/term/GO:0001518>`_"
   "Gene activity", "`Gene Ontology (activity) <https://www.ebi.ac.uk/QuickGO/term/GO:0086006>`_"