- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-08-06 10:09:20+12:00
- Desc:
- Fix typo
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/b7e/rawfile/7dceafc62286c12dec79898fca963a7b1758a1eb/exposure/exposure_frontpage.rst
About
====================
Landing page for the voltage-gated sodium potassium channel (**fastNa**).
Other names for this protein: **NaV1.1** to **1.9**
The fastNa channel is thought to be made of one type of pore-forming alpha subunit, modulated by one or more beta subunits.
Subfamilies
===================
.. csv-table:: Variants within the human species
:header: "Name", "Abbrev", "Gene", "Structure"
:widths: 25, 7, 15, 15
"Sodium channel protein type 1 subunit alpha", "SCN1A", "`SCN1A (Uniprot) <https://www.uniprot.org/uniprotkb/P35498/entry>`_", "`SCN1A (PDB) <https://www.rcsb.org/structure/7DTD>`_"
"Sodium channel protein type 2 subunit alpha", "SCN2A", "`SCN2A (Uniprot) <https://www.uniprot.org/uniprotkb/Q99250/entry>`_", "`SCN2A (PDB) <https://www.ebi.ac.uk/pdbe/entry/pdb/2KAV>`_"
"Sodium channel protein type 3 subunit alpha", "SCN3A", "`SCN3A (Uniprot) <https://www.uniprot.org/uniprotkb/Q9NY46/entry>`_", "`SCN3A (PDB) <https://www.ebi.ac.uk/pdbe-srv/view/entry/7W77>`_"
"Sodium channel protein type 4 subunit alpha", "SCN4A", "`SCN4A (Uniprot) <https://www.uniprot.org/uniprotkb/P35499/entry>`_", "`SCN4A (PDB) <https://www.ebi.ac.uk/pdbe-srv/view/entry/6AGF>`_"
"Sodium channel protein type 5 subunit alpha", "SCN5A", "`SCN5A (Uniprot) <https://www.uniprot.org/uniprotkb/Q14524/entry>`_", "`SCN5A (PDB) <https://www.ebi.ac.uk/pdbe-srv/view/entry/2KBI>`_"
"Sodium channel protein type 8 subunit alpha", "SCN8A", "`SCN8A (Uniprot) <https://www.uniprot.org/uniprotkb/Q9UQD0/entry>`_", "`SCN8A (PDB) <https://www.ebi.ac.uk/pdbe-srv/view/entry/8FHD>`_"
"Sodium channel protein type 9 subunit alpha", "SCN9A", "`SCN9A (Uniprot) <https://www.uniprot.org/uniprotkb/Q15858/entry>`_", "`SCN9A (AlphaFold) <https://alphafold.ebi.ac.uk/entry/Q15858>`_"
"Sodium channel protein type 10 subunit alpha", "SCNAA", "`SCNAA (Uniprot) <https://www.uniprot.org/uniprotkb/Q9Y5Y9/entry>`_", "`SCNAA (PDB) <https://www.ebi.ac.uk/pdbe-srv/view/entry/7WE4>`_"
"Sodium channel protein type 11 subunit alpha", "SCNBA", "`SCNBA (Uniprot) <https://www.uniprot.org/uniprotkb/Q9UI33/entry>`_", "`SCNBA (AlphaFold) <https://alphafold.ebi.ac.uk/entry/Q9UI33>`_"
"Sodium channel subunit beta-1", "SCN1B", "`SCN1B (Uniprot) <https://www.uniprot.org/uniprotkb/Q07699/entry>`_", "`SCN1B (AlphaFold) <https://alphafold.ebi.ac.uk/entry/Q07699>`_"
"Sodium channel subunit beta-2", "SCN2B", "`SCN2B (Uniprot) <https://www.uniprot.org/uniprotkb/O60939/entry>`_", "`SCN2B (PDB) <https://www.ebi.ac.uk/pdbe/entry/pdb/5FDY>`_"
"Sodium channel subunit beta-3", "SCN3B", "`SCN3B (Uniprot) <https://www.uniprot.org/uniprotkb/Q9NY72/entry>`_", "`SCN3B (PDB) <https://www.ebi.ac.uk/pdbe/entry/pdb/4L1D>`_"
"Sodium channel subunit beta-4", "SCN4B", "`SCN4B (Uniprot) <https://www.uniprot.org/uniprotkb/Q8IWT1/entry>`_", "`SCN4B (PDB) <https://www.ebi.ac.uk/pdbe/entry/pdb/4MZ2>`_"
The link to the annotation (Uniprot) is provided in the first column.
Pictures
===================
.. figure:: exposure/Na_channel_wikipedia.png
:width: 100%
:align: center
:alt: fast_Na_pic
Fig. 1. Schematic of sodium channel (C) action, transferring sodium ions from the extracellular fluid into the cell.
|
Literature
===================
.. csv-table:: For further reading
:header: "Title", "Author"
:widths: 30, 15
"`A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources <https://doi.org/10.1113/JP278739>`_", "Kernik et al."
"`Bond graph modelling of the cardiac action potential: Implications for drift and non-unique steady states <https://doi.org/10.1098/rspa.2018.0106>`_", "Pan et al."
Existing models
===================
.. csv-table:: Link to other model workspaces or exposures
:header: "Title", "Author"
:widths: 30, 15
"`BG_fast_Na <https://models.physiomeproject.org/workspace/826>`_", "S Fong"
"`Bond graph modelling of the cardiac action potential: Implications for drift and non-unique steady states^ <https://github.com/uomsystemsbiology/bond_graph_cardiac_AP>`_", "M Pan et al."
"`A Model of the Ventricular Cardiac Action Potential - Depolarisation, Repolarisation and Their Interaction*^ <https://models.physiomeproject.org/exposure/2d2ce7737b42a4f72d6bf8b67f6eb5a2>`_", "C Luo and Y Rudy"
Models denoted by [*] are not in bond graph form.
Models denoted by [^] are part of a whole cell model.
Other annotations
===================
.. csv-table::
:header: "Item", "Database"
:widths: 17, 15
"Family of Na channels, alpha subunit", "`Alpha (Interpro) <https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001696/>`_"
"Family of Na channels, beta subunit", "`Beta (Interpro) <https://www.ebi.ac.uk/interpro/entry/InterPro/IPR027098/>`_"
"Cellular component", "`Gene Ontology <https://www.ebi.ac.uk/QuickGO/term/GO:0001518>`_"
"Gene activity", "`Gene Ontology (activity) <https://www.ebi.ac.uk/QuickGO/term/GO:0086006>`_"
