- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-07-09 10:30:26+12:00
- Desc:
- First init to models
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/b7e/rawfile/072f58a20fb1971973e5e20c73ccb2e96d00a372/exposure/exposure_frontpage.rst
About
====================
Landing page for the voltage-gated sodium potassium channel (**fastNa**).
Other names for this protein: **NaV1.1** to **1.9**
The fastNa channel is thought to be made of one type of pore-forming alpha subunit, modulated by one or more beta subunits.
Subfamilies
===================
.. csv-table:: Variants within the human species
:header: "Gene", "Protein"
:widths: 7, 15
"`SCN1A <https://www.uniprot.org/uniprotkb/P35498/entry>`_", "Sodium channel protein type 1 subunit alpha"
"`SCN2A <https://www.uniprot.org/uniprotkb/Q99250/entry>`_", "Sodium channel protein type 2 subunit alpha"
"`SCN3A <https://www.uniprot.org/uniprotkb/Q9NY46/entry>`_", "Sodium channel protein type 3 subunit alpha"
"`SCN4A <https://www.uniprot.org/uniprotkb/P35499/entry>`_", "Sodium channel protein type 4 subunit alpha"
"`SCN5A <https://www.uniprot.org/uniprotkb/Q14524/entry>`_", "Sodium channel protein type 5 subunit alpha"
"`SCN8A <https://www.uniprot.org/uniprotkb/Q9UQD0/entry>`_", "Sodium channel protein type 8 subunit alpha"
"`SCN9A <https://www.uniprot.org/uniprotkb/Q15858/entry>`_", "Sodium channel protein type 9 subunit alpha"
"`SCNAA <https://www.uniprot.org/uniprotkb/Q9Y5Y9/entry>`_", "Sodium channel protein type 10 subunit alpha"
"`SCNBA <https://www.uniprot.org/uniprotkb/Q9UI33/entry>`_", "Sodium channel protein type 11 subunit alpha"
"`SCN1B <https://www.uniprot.org/uniprotkb/Q07699/entry>`_", "Sodium channel subunit beta-1"
"`SCN2B <https://www.uniprot.org/uniprotkb/O60939/entry>`_", "Sodium channel subunit beta-2"
"`SCN3B <https://www.uniprot.org/uniprotkb/Q9NY72/entry>`_", "Sodium channel subunit beta-3"
"`SCN4B <https://www.uniprot.org/uniprotkb/Q8IWT1/entry>`_", "Sodium channel subunit beta-4"
The link to the annotation (Uniprot) is provided in the first column.
Pictures
===================
Insert
Literature
===================
.. csv-table:: For further reading
:header: "Title", "Author"
:widths: 30, 15
"`A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources <https://doi.org/10.1113/JP278739>`_", "Kernik et al."
"`Bond graph modelling of the cardiac action potential: Implications for drift and non-unique steady states <https://doi.org/10.1098/rspa.2018.0106>`_", "Pan et al."
Existing models
===================
.. csv-table:: Link to other model workspaces or exposures
:header: "Title", "Author"
:widths: 30, 15
"`BG_fast_Na <https://models.physiomeproject.org/workspace/826>`_", "S Fong"
"`Bond graph modelling of the cardiac action potential: Implications for drift and non-unique steady states^ <https://github.com/uomsystemsbiology/bond_graph_cardiac_AP>`_", "M Pan et al."
Models denoted by [*] are not in bond graph form.
Models denoted by [^] are part of a whole cell model.
Annotations
===================
.. csv-table::
:header: "Item", "Database"
:widths: 17, 15
"Gene, type 1A", "`SCN1A (Uniprot) <https://www.uniprot.org/uniprotkb/P35498/entry>`_"
"Gene, type 2A", "`SCN2A (Uniprot) <https://www.uniprot.org/uniprotkb/Q99250/entry>`_"
"Gene, type 3A", "`SCN3A (Uniprot) <https://www.uniprot.org/uniprotkb/Q9NY46/entry>`_"
"Gene, type 4A", "`SCN4A (Uniprot) <https://www.uniprot.org/uniprotkb/P35499/entry>`_"
"Gene, type 5A", "`SCN5A (Uniprot) <https://www.uniprot.org/uniprotkb/Q14524/entry>`_"
"Gene, type 8A", "`SCN8A (Uniprot) <https://www.uniprot.org/uniprotkb/Q9UQD0/entry>`_"
"Gene, type 9A", "`SCN9A (Uniprot) <https://www.uniprot.org/uniprotkb/Q15858/entry>`_"
"Gene, type 10A", "`SCNAA (Uniprot) <https://www.uniprot.org/uniprotkb/Q9Y5Y9/entry>`_"
"Gene, type 11A", "`SCNBA (Uniprot) <https://www.uniprot.org/uniprotkb/Q9UI33/entry>`_"
"Gene, type 1B", "`SCN1B (Uniprot) <https://www.uniprot.org/uniprotkb/Q07699/entry>`_"
"Gene, type 2B", "`SCN2B (Uniprot) <https://www.uniprot.org/uniprotkb/O60939/entry>`_"
"Gene, type 3B", "`SCN3B (Uniprot) <https://www.uniprot.org/uniprotkb/Q9NY72/entry>`_"
"Gene, type 4B", "`SCN4B (Uniprot) <https://www.uniprot.org/uniprotkb/Q8IWT1/entry>`_"
"Structure, type 1A", "`SCN1A (PDB) <https://www.rcsb.org/structure/7DTD>`_"
"Structure, type 2A", "`SCN2A (PDB) <https://www.ebi.ac.uk/pdbe/entry/pdb/2KAV>`_"
"Structure, type 3A", "`SCN3A (PDB) <https://www.ebi.ac.uk/pdbe-srv/view/entry/7W77>`_"
"Structure, type 4A", "`SCN4A (PDB) <https://www.ebi.ac.uk/pdbe-srv/view/entry/6AGF>`_"
"Structure, type 5A", "`SCN5A (PDB) <https://www.ebi.ac.uk/pdbe-srv/view/entry/2KBI>`_"
"Structure, type 8A", "`SCN8A (PDB) <https://www.ebi.ac.uk/pdbe-srv/view/entry/8FHD>`_"
"Structure, type 9A", "`SCN9A (AlphaFold) <https://alphafold.ebi.ac.uk/entry/Q15858>`_"
"Structure, type 10A", "`SCNAA (PDB) <https://www.ebi.ac.uk/pdbe-srv/view/entry/7WE4>`_"
"Structure, type 11A", "`SCNBA (AlphaFold) <https://alphafold.ebi.ac.uk/entry/Q9UI33>`_"
"Structure, type 1B", "`SCN1B (AlphaFold) <https://alphafold.ebi.ac.uk/entry/Q07699>`_"
"Structure, type 2B", "`SCN2B (PDB) <https://www.ebi.ac.uk/pdbe/entry/pdb/5FDY>`_"
"Structure, type 3B", "`SCN3B (PDB) <https://www.ebi.ac.uk/pdbe/entry/pdb/4L1D>`_"
"Structure, type 4B", "`SCN4B (PDB) <https://www.ebi.ac.uk/pdbe/entry/pdb/4MZ2>`_"
"Family of Na channels, alpha subunit", "`Alpha (Interpro) <https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001696/>`_"
"Family of Na channels, beta subunit", "`Beta (Interpro) <https://www.ebi.ac.uk/interpro/entry/InterPro/IPR027098/>`_"
"Cellular component", "`Gene Ontology <https://www.ebi.ac.uk/QuickGO/term/GO:0001518>`_"
"Gene activity", "`Gene Ontology (activity) <https://www.ebi.ac.uk/QuickGO/term/GO:0086006>`_"
