- Author:
- David Nickerson <david.nickerson@gmail.com>
- Date:
- 2024-07-19 16:13:22+12:00
- Desc:
- fix typo in RST
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/b6e/rawfile/4007df6546726d49f979de277d4302a7d4785aaf/doc/README.rst
Introduction
============
In this exposure we provide the CellML_ model and associated SED-ML_ to demonstrate the use of in-browser simulation via the SPARC Portal.
The full content of the workspace is described below, but for this demonstration we collect the entire mathematical model in a single CellML_ file with an associated SED-ML_ for the simulation description.
The COMBINE Archive available from the button to the right contains the single CellML and SED-ML documents to be used in this demonstration.
Workspace
=========
This workspace illustrates how to connect multiscale models using the bond graph formalism.
The main CellML_ files in folder `models <models/>`_ are:
- `Cardiovascular model <models/cardiovascular.cellml>`_ encodes a cardiovascular system simplified from `Gee, Michelle M., et al.(2023)`_. The model follows the bond graph formalism.
- `Neural control model <models/neural_control.cellml>`_ encodes the neural control mechanism described in `Gee, Michelle M., et al.(2023)`_.
- `Cell action potential model <models/tentusscher_noble_noble_panfilov_2004_m.cellml>`_ encodes the M cell action potential model described in `ten Tusscher et al. (2004)`_
- `Combined model <models/Gee_whiz.cellml>`_ connects the M cell action potential model to the cardiovascular model via the tension model described in `HMT 1998`_
- the folder `CellMLV2 <models/CellMLV2>`_ includes `the flattened combined model using CellML version 2 <models/CellMLV2/Gee_whiz_flat.cellml>`_ and the associated SED-ML_ file.
.. _CellML: https://www.cellml.org/
.. _OpenCOR: https://opencor.ws/
.. _SED-ML: https://sed-ml.org
.. _`Gee, Michelle M., et al.(2023)`: https://doi.org/10.1002/aic.18033
.. _`ten Tusscher et al. (2004)`: https://doi.org/10.1152/ajpheart.00794.2003
.. _`HMT 1998`: https://doi.org/10.1016/s0079-6107(98)00013-3
