- Author:
- Weiwei Ai <wai484@aucklanduni.ac.nz>
- Date:
- 2024-05-27 15:41:10+12:00
- Desc:
- Update readme file
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/b65/rawfile/b7ec0e1728a7d93333c64719ad8e2ef696837d3f/doc/README.rst
Energy-based bond graph models of glucose transport with SLC transporters
===========================================================================
We present the parameterized bond graph models for facilitated diffusion with
SLC2A2 (GLUT2)
and electrogenic cotransport with SLC5A1 (SGLT1) transporters. The bond graphs
are placed are in the folders <Facilitated transporter>
and <Electrogenic cotransporter>, respectively.
Facilitated transporter
===========================
The main CellML_ files are:
- `The bond graph model of GLUT2 <Facilitated transporter/GLUT2_BG.cellml>`_ parameterized to `Lowe and Walmsley (1986)`_,
- `The steady-state model derived from the bond graph GLUT2 with the variation of intracellular concentration of glucose <Facilitated transporter/GLUT2_ss_io.cellml>`_,
- `The steady-state model derived from the bond graph GLUT2 with the variation of extracellular concentration of glucose <Facilitated transporter/GLUT2_ss_oi.cellml>`_,
- `The steady-state kinetic models <Facilitated transporter/GLUT2_kinetic.cellml>`_ in `Lowe and Walmsley (1986)`_,
- `The parameter file of the bond graph model GLUT2 <Facilitated transporter/params_BG.cellml>`_ ,
- `The unit definition file for GLUT2 <Facilitated transporter/units.cellml>`_.
Electrogenic cotransporter
===========================
The main CellML_ files are:
- `The bond graph model of SGLT1 <Electrogenic cotransporter/SGLT1_BG.cellml>`_ parameterized to `Parent et al (1992)`_,
- `The bond graph model of SGLT1 with fast binding/unbinding parameters <Electrogenic cotransporter/SGLT1_BG_fast.cellml>`_,
- `The steady-state model derived from the bond graph SGLT1 <Electrogenic cotransporter/SGLT1_ss.cellml>`_ ,
- `The steady-state model derived from the bond graph SGLT1 with fast binding/unbinding parameters <Electrogenic cotransporter/SGLT1_ss_fast.cellml>`_ ,
- `The parameter file for the bond graph model SGLT1 <Electrogenic cotransporter/params_BG.cellml>`_ ,
- `The parameter file for the bond graph model SGLT1 with fast binding/unbinding parameters <Electrogenic cotransporter/params_BG_fast.cellml>`_,
- `The unit definition file for SGLT1 <Electrogenic cotransporter/units.cellml>`_ .
The corresponding SED-ML_ files can be used to run simulations in OpenCOR_.
.. _CellML: https://www.cellml.org/
.. _OpenCOR: https://opencor.ws/
.. _SED-ML: https://sed-ml.org
.. _`Lowe and Walmsley (1986)`: https://doi.org/10.1016/0005-2736(86)90342-1
.. _`Parent et al (1992)`: https://doi.org/10.1007/BF00235798
