- Author:
- Leyla <lnor300>
- Date:
- 2022-09-28 15:32:13+13:00
- Desc:
- ..
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/919/rawfile/d240a295f3b924c79033a0da95a7b33466b386e4/NSCC/INSCC.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model cmeta:id="Non_Selective_Cation_Channel" name="INSCC" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../common/units.cellml">
<units name="current_units" units_ref="current_units"/>
<units name="voltage_units" units_ref="voltage_units"/>
<units name="time_units" units_ref="time_units"/>
<units name="conductance_units" units_ref="conductance_units"/>
<units name="millimolar" units_ref="millimolar"/>
</import>
<component name="m_NSCC_SM">
<variable name="Vm_SM" public_interface="in" units="voltage_units"/>
<variable name="m_inf_NSCC_SM" units="dimensionless"/>
<variable name="tau_m_NSCC_SM" units="time_units"/>
<variable initial_value="0.0" name="m_NSCC_SM" public_interface="out" units="dimensionless"/>
<variable name="time" public_interface="in" units="time_units"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>m_inf_NSCC_SM</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm_SM</ci>
<cn cellml:units="voltage_units">25.0</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="voltage_units">20</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_m_NSCC_SM</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm_SM</ci>
<cn cellml:units="voltage_units">66</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="voltage_units">26</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="time_units">150</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m_NSCC_SM</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>m_inf_NSCC_SM</ci>
<ci>m_NSCC_SM</ci>
</apply>
<ci>tau_m_NSCC_SM</ci>
</apply>
</apply>
</math>
</component>
<component name="I_NSCC_SM">
<variable name="I_NSCC_SM" private_interface="out" public_interface="out" units="current_units"/>
<variable initial_value="-28" name="E_NSCC" units="voltage_units"/>
<variable initial_value="50" name="G_max_NSCC_SM" units="conductance_units"/>
<variable name="Vm_SM" private_interface="out" public_interface="in" units="voltage_units"/>
<variable name="Ca_i" public_interface="in" units="millimolar"/>
<variable name="Ach" public_interface="in" units="millimolar"/>
<variable name="m_NSCC_SM" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="f_ca_NSCC_SM" public_interface="out" units="dimensionless"/>
<variable name="rach_NSCC_SM" public_interface="out" units="dimensionless"/>
<variable name="RToF" public_interface="in" units="voltage_units"/>
<variable name="time" private_interface="out" public_interface="in" units="time_units"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_ca_NSCC_SM</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca_i</ci>
<cn cellml:units="millimolar">0.0002</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>rach_NSCC_SM</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<divide/>
<cn cellml:units="millimolar">0.01</cn>
<ci>Ach</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NSCC_SM</ci>
<apply>
<times/>
<ci>G_max_NSCC_SM</ci>
<ci>m_NSCC_SM</ci>
<ci>f_ca_NSCC_SM</ci>
<ci>rach_NSCC_SM</ci>
<apply>
<minus/>
<ci>Vm_SM</ci>
<ci>E_NSCC</ci>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="m_NSCC_SM" component_2="I_NSCC_SM"/>
<map_variables variable_1="Vm_SM" variable_2="Vm_SM"/>
<map_variables variable_1="m_NSCC_SM" variable_2="m_NSCC_SM"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="I_NSCC_SM">
<component_ref component="m_NSCC_SM"/>
</component_ref>
</group>
</model>
