Location: A Quantitative Model of Gastric Smooth Muscle Cellular Activation @ d240a295f3b9 / Istim / Istim.cellml
- Author:
- Leyla <lnor300>
- Date:
- 2022-09-28 15:32:13+13:00
- Desc:
- ..
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/919/rawfile/d240a295f3b924c79033a0da95a7b33466b386e4/Istim/Istim.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="Istim" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../common/units.cellml">
<units name="current_units" units_ref="current_units"/>
<units name="voltage_units" units_ref="voltage_units"/>
<units name="time_units" units_ref="time_units"/>
<units name="conductance_units" units_ref="conductance_units"/>
<units name="rate_constants_units" units_ref="rate_constants_units"/>
</import>
<component name="I_stim">
<variable name="time" public_interface="in" units="time_units"/>
<variable name="local_time" units="time_units"/>
<variable initial_value="20000" name="period" units="time_units"/>
<variable name="stim_start" units="time_units"/>
<variable initial_value="59" name="delta_VICC" units="voltage_units"/>
<variable name="Gcouple" public_interface="in" units="conductance_units"/>
<variable initial_value="98" name="t_ICCpeak" units="time_units"/>
<variable initial_value="7582" name="t_ICCplateau" units="time_units"/>
<variable initial_value="10000" name="t_ICC_stimulus" units="time_units"/>
<variable initial_value="37.25" name="V_decay" units="voltage_units"/>
<variable name="I_stim" public_interface="out" units="current_units"/>
<variable initial_value="0" name="m" public_interface="out" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<cn cellml:units="rate_constants_units">1</cn>
</apply>
<apply>
<eq/>
<ci>stim_start</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>period</ci>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<apply>
<and/>
<apply>
<gt/>
<ci>time</ci>
<apply>
<times/>
<ci>period</ci>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
<apply>
<leq/>
<ci>time</ci>
<apply>
<times/>
<ci>period</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</piece>
<piece>
<apply>
<times/>
<ci>period</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
<apply>
<and/>
<apply>
<gt/>
<ci>time</ci>
<apply>
<times/>
<ci>period</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<leq/>
<ci>time</ci>
<apply>
<times/>
<ci>period</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
</apply>
</piece>
<piece>
<apply>
<times/>
<ci>period</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
<apply>
<and/>
<apply>
<gt/>
<ci>time</ci>
<apply>
<times/>
<ci>period</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
<apply>
<leq/>
<ci>time</ci>
<apply>
<times/>
<ci>period</ci>
<cn cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
</apply>
</piece>
<piece>
<apply>
<times/>
<ci>period</ci>
<cn cellml:units="dimensionless">4.0</cn>
</apply>
<apply>
<and/>
<apply>
<gt/>
<ci>time</ci>
<apply>
<times/>
<ci>period</ci>
<cn cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
<apply>
<leq/>
<ci>time</ci>
<apply>
<times/>
<ci>period</ci>
<cn cellml:units="dimensionless">5.0</cn>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="time_units">0.0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>local_time</ci>
<apply>
<minus/>
<ci>time</ci>
<apply>
<plus/>
<ci>stim_start</ci>
<ci>t_ICCpeak</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_stim</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>Gcouple</ci>
<ci>delta_VICC</ci>
</apply>
<apply>
<lt/>
<ci>local_time</ci>
<ci>t_ICCpeak</ci>
</apply>
</piece>
<piece>
<apply>
<divide/>
<apply>
<times/>
<ci>Gcouple</ci>
<ci>delta_VICC</ci>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>local_time</ci>
<cn cellml:units="time_units">8000</cn>
</apply>
<cn cellml:units="time_units">1000</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<geq/>
<ci>local_time</ci>
<ci>t_ICCpeak</ci>
</apply>
<apply>
<leq/>
<ci>local_time</ci>
<ci>t_ICCplateau</ci>
</apply>
</apply>
</piece>
<piece>
<apply>
<divide/>
<apply>
<times/>
<ci>Gcouple</ci>
<ci>V_decay</ci>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>local_time</ci>
<cn cellml:units="time_units">8000</cn>
</apply>
<cn cellml:units="time_units">150</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<gt/>
<ci>local_time</ci>
<ci>t_ICCplateau</ci>
</apply>
<apply>
<lt/>
<ci>local_time</ci>
<ci>t_ICC_stimulus</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="current_units">0.0</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
</model>