- Author:
- Leyla <lnor300>
- Date:
- 2022-09-28 14:24:20+13:00
- Desc:
- Adding the modular version of Corrias_Buist_2007 model on PMR.
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/919/rawfile/a09d10b0432dd07dcdf441dcc6476bf932d840dc/Vm_SMC/Experiment_Vm_SMC.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="experiment_Vm_SM" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../common/units.cellml">
<units name="time_units" units_ref="time_units"/>
<units name="millimolar" units_ref="millimolar"/>
<units name="R_units" units_ref="R_units"/>
<units name="F_units" units_ref="F_units"/>
<units name="capacitance_units" units_ref="capacitance_units"/>
<units name="Temperature_units" units_ref="Temperature_units"/>
<units name="conductance_units" units_ref="conductance_units"/>
<units name="Inverse_Voltage_units" units_ref="Inverse_Voltage_units"/>
<units name="voltage_units" units_ref="voltage_units"/>
<units name="current_units" units_ref="current_units"/>
<units name="volume_units" units_ref="volume_units"/>
<units name="millimolar_per_millisecond" units_ref="millimolar_per_millisecond"/>
</import>
<import xlink:href="../Common/environment.cellml">
<component component_ref="environment" name="environment"/>
</import>
<import xlink:href="../Common/parameters.cellml">
<component component_ref="parameter_values" name="parameter_values"/>
<component component_ref="Gap_junction" name="Gap_junction"/>
<component component_ref="Neural_input" name="Neural_input"/>
</import>
<import xlink:href="../A_type_K/IBK.cellml">
<component component_ref="I_BK_SM" name="I_BK_SM"/>
</import>
<import xlink:href="../Background_K/Ibk.cellml">
<component component_ref="I_bk_SM" name="I_bk_SM"/>
</import>
<import xlink:href="../CaNa_Exchanger/CaNa_Exchanger.cellml">
<component component_ref="J_CaSR_SM" name="J_CaSR_SM"/>
</import>
<import xlink:href="../Istim/Istim.cellml">
<component component_ref="I_stim" name="I_stim"/>
</import>
<import xlink:href="../Vm_SMC/Vm_SMC.cellml">
<component component_ref="SM_Membrane" name="SM_Membrane"/>
</import>
<import xlink:href="../Delayed_Rectifier/Ikr.cellml">
<component component_ref="I_kr_SM" name="I_kr_SM"/>
</import>
<import xlink:href="../L_type_Ca/ICa_L.cellml">
<component component_ref="I_Ltype_SM" name="I_Ltype_SM"/>
</import>
<import xlink:href="../NKCC/INKCC.cellml">
<component component_ref="I_Na_SM" name="I_Na_SM"/>
</import>
<import xlink:href="../NSCC/INSCC.cellml">
<component component_ref="I_NSCC_SM" name="I_NSCC_SM"/>
</import>
<import xlink:href="../Potasium_channel/Ika.cellml">
<component component_ref="I_ka_SM" name="I_ka_SM"/>
</import>
<import xlink:href="../T_type_Ca/ICa_T.cellml">
<component component_ref="I_LVA_SM" name="I_LVA_SM"/>
</import>
<connection>
<map_components component_1="I_BK_SM" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_bk_SM" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_stim" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="SM_Membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_kr_SM" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_Ltype_SM" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="J_CaSR_SM" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_NSCC_SM" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_ka_SM" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_LVA_SM" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_Na_SM" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_Na_SM" component_2="SM_Membrane"/>
<map_variables variable_1="Vm_SM" variable_2="Vm_SM"/>
<map_variables variable_1="I_Na_SM" variable_2="I_Na_SM"/>
</connection>
<connection>
<map_components component_1="parameter_values" component_2="I_Na_SM"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
<map_variables variable_1="T_correction_Na" variable_2="T_correction_Na"/>
</connection>
<connection>
<map_components component_1="I_Ltype_SM" component_2="SM_Membrane"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Vm_SM" variable_2="Vm_SM"/>
<map_variables variable_1="I_Ltype_SM" variable_2="I_Ltype_SM"/>
<map_variables variable_1="d_Ltype_SM" variable_2="d_Ltype_SM"/>
<map_variables variable_1="f_Ltype_SM" variable_2="f_Ltype_SM"/>
</connection>
<connection>
<map_components component_1="parameter_values" component_2="I_Ltype_SM"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="T_correction_Ca" variable_2="T_correction_Ca"/>
</connection>
<connection>
<map_components component_1="I_kr_SM" component_2="SM_Membrane"/>
<map_variables variable_1="Vm_SM" variable_2="Vm_SM"/>
<map_variables variable_1="I_kr_SM" variable_2="I_kr_SM"/>
<map_variables variable_1="xr1_SM" variable_2="xr1_SM"/>
<map_variables variable_1="xr2_SM" variable_2="xr2_SM"/>
</connection>
<connection>
<map_components component_1="I_kr_SM" component_2="parameter_values"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
<map_variables variable_1="T_correction_K" variable_2="T_correction_K"/>
</connection>
<connection>
<map_components component_1="I_ka_SM" component_2="SM_Membrane"/>
<map_variables variable_1="Vm_SM" variable_2="Vm_SM"/>
<map_variables variable_1="I_ka_SM" variable_2="I_ka_SM"/>
<map_variables variable_1="xa1_SM" variable_2="xa1_SM"/>
<map_variables variable_1="xa2_SM" variable_2="xa2_SM"/>
</connection>
<connection>
<map_components component_1="I_ka_SM" component_2="parameter_values"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
<map_variables variable_1="T_correction_K" variable_2="T_correction_K"/>
</connection>
<connection>
<map_components component_1="I_BK_SM" component_2="SM_Membrane"/>
<map_variables variable_1="Vm_SM" variable_2="Vm_SM"/>
<map_variables variable_1="I_BK_SM" variable_2="I_BK_SM"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="I_BK_SM" component_2="parameter_values"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
<map_variables variable_1="T_correction_BK" variable_2="T_correction_BK"/>
</connection>
<connection>
<map_components component_1="I_bk_SM" component_2="SM_Membrane"/>
<map_variables variable_1="Vm_SM" variable_2="Vm_SM"/>
<map_variables variable_1="I_bk_SM" variable_2="I_bk_SM"/>
</connection>
<connection>
<map_components component_1="I_bk_SM" component_2="parameter_values"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="I_NSCC_SM" component_2="SM_Membrane"/>
<map_variables variable_1="Vm_SM" variable_2="Vm_SM"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="I_NSCC_SM" variable_2="I_NSCC_SM"/>
<map_variables variable_1="m_NSCC_SM" variable_2="m_NSCC_SM"/>
</connection>
<connection>
<map_components component_1="I_NSCC_SM" component_2="parameter_values"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
</connection>
<connection>
<map_components component_1="I_LVA_SM" component_2="SM_Membrane"/>
<map_variables variable_1="Vm_SM" variable_2="Vm_SM"/>
<map_variables variable_1="I_LVA_SM" variable_2="I_LVA_SM"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="I_LVA_SM" component_2="parameter_values"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="T_correction_Ca" variable_2="T_correction_Ca"/>
</connection>
<connection>
<map_components component_1="Neural_input" component_2="I_NSCC_SM"/>
<map_variables variable_1="Ach" variable_2="Ach"/>
</connection>
<connection>
<map_components component_1="J_CaSR_SM" component_2="SM_Membrane"/>
<map_variables variable_1="J_CaSR_SM" variable_2="J_CaSR_SM"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="Gap_junction" component_2="I_stim"/>
<map_variables variable_1="Gcouple" variable_2="Gcouple"/>
</connection>
<connection>
<map_components component_1="SM_Membrane" component_2="I_stim"/>
<map_variables variable_1="I_stim" variable_2="I_stim"/>
</connection>
<connection>
<map_components component_1="SM_Membrane" component_2="parameter_values"/>
<map_variables variable_1="Vol_SM" variable_2="Vol_SM"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<component name="outputs">
<variable name="time" public_interface="in" units="time_units"/>
<variable name="Vm_SM" public_interface="in" units="voltage_units"/>
<variable name="Ca_i" public_interface="in" units="millimolar"/>
<variable name="I_Na_SM" public_interface="in" units="current_units"/>
<variable name="I_Ltype_SM" public_interface="in" units="current_units"/>
<variable name="d_Ltype_SM" public_interface="in" units="dimensionless"/>
<variable name="f_Ltype_SM" public_interface="in" units="dimensionless"/>
<variable name="I_kr_SM" public_interface="in" units="current_units"/>
<variable name="xr1_SM" public_interface="in" units="dimensionless"/>
<variable name="xr2_SM" public_interface="in" units="dimensionless"/>
<variable name="I_BK_SM" public_interface="in" units="current_units"/>
<variable name="I_ka_SM" public_interface="in" units="current_units"/>
<variable name="xa1_SM" public_interface="in" units="dimensionless"/>
<variable name="xa2_SM" public_interface="in" units="dimensionless"/>
<variable name="I_NSCC_SM" public_interface="in" units="current_units"/>
<variable name="m_NSCC_SM" public_interface="in" units="dimensionless"/>
<variable name="I_bk_SM" public_interface="in" units="current_units"/>
<variable name="J_CaSR_SM" public_interface="in" units="millimolar_per_millisecond"/>
<variable name="I_stim" public_interface="in" units="current_units"/>
</component>
<connection>
<map_components component_1="outputs" component_2="SM_Membrane"/>
<map_variables variable_1="Vm_SM" variable_2="Vm_SM"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="I_Na_SM" variable_2="I_Na_SM"/>
<map_variables variable_1="I_Ltype_SM" variable_2="I_Ltype_SM"/>
<map_variables variable_1="d_Ltype_SM" variable_2="d_Ltype_SM"/>
<map_variables variable_1="f_Ltype_SM" variable_2="f_Ltype_SM"/>
<map_variables variable_1="I_kr_SM" variable_2="I_kr_SM"/>
<map_variables variable_1="xr1_SM" variable_2="xr1_SM"/>
<map_variables variable_1="xr2_SM" variable_2="xr2_SM"/>
<map_variables variable_1="I_BK_SM" variable_2="I_BK_SM"/>
<map_variables variable_1="I_ka_SM" variable_2="I_ka_SM"/>
<map_variables variable_1="xa1_SM" variable_2="xa1_SM"/>
<map_variables variable_1="xa2_SM" variable_2="xa2_SM"/>
<map_variables variable_1="I_NSCC_SM" variable_2="I_NSCC_SM"/>
<map_variables variable_1="m_NSCC_SM" variable_2="m_NSCC_SM"/>
<map_variables variable_1="I_bk_SM" variable_2="I_bk_SM"/>
<map_variables variable_1="J_CaSR_SM" variable_2="J_CaSR_SM"/>
<map_variables variable_1="I_stim" variable_2="I_stim"/>
</connection>
<connection>
<map_components component_1="outputs" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
</model>
