- Author:
- Leyla <lnor300>
- Date:
- 2022-09-28 16:08:33+13:00
- Desc:
- ..
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/919/rawfile/3affededfd25a44594b79661e39fb68801515613/NKCC/INKCC.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="INKCC" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../Common/units.cellml">
<units name="current_units" units_ref="current_units"/>
<units name="voltage_units" units_ref="voltage_units"/>
<units name="time_units" units_ref="time_units"/>
<units name="conductance_units" units_ref="conductance_units"/>
<units name="millimolar" units_ref="millimolar"/>
<units name="Inverse_Voltage_units" units_ref="Inverse_Voltage_units"/>
</import>
<component name="m_Na_SM">
<variable name="Vm_SM" public_interface="in" units="voltage_units"/>
<variable name="m_inf_Na" units="dimensionless"/>
<variable name="tau_m_Na" units="time_units"/>
<variable initial_value="0.005" name="m_Na_SM" public_interface="out" units="dimensionless"/>
<variable name="time" public_interface="in" units="time_units"/>
<variable name="T_correction_Na" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>m_inf_Na</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm_SM</ci>
<cn cellml:units="voltage_units">47</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="voltage_units">4.8</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_m_Na</ci>
<apply>
<times/>
<ci>T_correction_Na</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>Vm_SM</ci>
<apply>
<minus/>
<cn cellml:units="Inverse_Voltage_units">0.017</cn>
</apply>
<cn cellml:units="time_units">1</cn>
</apply>
<cn cellml:units="time_units">0.440</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m_Na_SM</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>m_inf_Na</ci>
<ci>m_Na_SM</ci>
</apply>
<ci>tau_m_Na</ci>
</apply>
</apply>
</math>
</component>
<component name="h_Na_SM">
<variable name="Vm_SM" public_interface="in" units="voltage_units"/>
<variable name="h_inf_Na" units="dimensionless"/>
<variable name="tau_h_Na" units="time_units"/>
<variable initial_value="0.05787" name="h_Na_SM" public_interface="out" units="dimensionless"/>
<variable name="time" public_interface="in" units="time_units"/>
<variable name="T_correction_Na" private_interface="none" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>h_inf_Na</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm_SM</ci>
<cn cellml:units="voltage_units">78</cn>
</apply>
<cn cellml:units="voltage_units">3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_h_Na</ci>
<apply>
<times/>
<ci>T_correction_Na</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>Vm_SM</ci>
<apply>
<minus/>
<cn cellml:units="Inverse_Voltage_units">0.25</cn>
</apply>
<cn cellml:units="time_units">1</cn>
</apply>
<cn cellml:units="time_units">5.50</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>h_Na_SM</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>h_inf_Na</ci>
<ci>h_Na_SM</ci>
</apply>
<ci>tau_h_Na</ci>
</apply>
</apply>
</math>
</component>
<component name="I_Na_SM">
<variable name="I_Na_SM" private_interface="out" public_interface="out" units="current_units"/>
<variable name="E_Na" units="voltage_units"/>
<variable initial_value="3" name="G_max_Na_SM" units="conductance_units"/>
<variable name="Vm_SM" private_interface="out" public_interface="in" units="voltage_units"/>
<variable name="h_Na_SM" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="m_Na_SM" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="RToF" public_interface="in" units="voltage_units"/>
<variable name="Na_o" private_interface="out" public_interface="in" units="millimolar"/>
<variable name="Na_i" private_interface="out" public_interface="in" units="millimolar"/>
<variable name="T_correction_Na" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="time" private_interface="out" public_interface="in" units="time_units"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Na_o</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_Na_SM</ci>
<apply>
<times/>
<ci>G_max_Na_SM</ci>
<ci>h_Na_SM</ci>
<ci>m_Na_SM</ci>
<apply>
<minus/>
<ci>Vm_SM</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="h_Na_SM" component_2="I_Na_SM"/>
<map_variables variable_1="Vm_SM" variable_2="Vm_SM"/>
<map_variables variable_1="h_Na_SM" variable_2="h_Na_SM"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="T_correction_Na" variable_2="T_correction_Na"/>
</connection>
<connection>
<map_components component_1="m_Na_SM" component_2="I_Na_SM"/>
<map_variables variable_1="Vm_SM" variable_2="Vm_SM"/>
<map_variables variable_1="m_Na_SM" variable_2="m_Na_SM"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="T_correction_Na" variable_2="T_correction_Na"/>
</connection>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="I_Na_SM">
<component_ref component="h_Na_SM"/>
<component_ref component="m_Na_SM"/>
</component_ref>
</group>
</model>
