- Author:
- Leyla <lnor300>
- Date:
- 2022-09-28 14:18:41+13:00
- Desc:
- ..
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/916/rawfile/afe0649a295b268b0f453c56ea726d6a4019a340/Simulations/Experiment_Vm.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="experiment_Vm" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../Common/units.cellml">
<units name="flux" units_ref="flux"/>
<units name="micromolar" units_ref="micromolar"/>
<units name="picoampere" units_ref="picoampere"/>
<units name="micromolar_coulomb" units_ref="micromolar_coulomb"/>
<units name="picofarad" units_ref="picofarad"/>
<units name="per_micromolar" units_ref="per_micromolar"/>
<units name="per_micromolar2" units_ref="per_micromolar2"/>
<units name="first_order_rate_constant" units_ref="first_order_rate_constant"/>
<units name="picosiemens" units_ref="picosiemens"/>
<units name="attojoule_per_zeptomole_kelvin" units_ref="attojoule_per_zeptomole_kelvin"/>
<units name="femtocoulomb_per_zeptomole" units_ref="femtocoulomb_per_zeptomole"/>
<units name="millivolt" units_ref="millivolt"/>
</import>
<import xlink:href="../Common/environment.cellml">
<component component_ref="environment" name="environment"/>
</import>
<import xlink:href="../Common/parameters.cellml">
<component component_ref="model_parameters" name="model_parameters"/>
</import>
<import xlink:href="../Common/parameters.cellml">
<component component_ref="model_initials" name="model_initials"/>
</import>
<import xlink:href="../Components/Ca_Intracellular_Flux(J_S1S2)/J_S1S2.cellml">
<component component_ref="JS1S2" name="JS1S2"/>
</import>
<import xlink:href="../Components/IPR3(J_IPR3)/J_IPR3.cellml">
<component component_ref="JIPR" name="JIPR"/>
</import>
<import xlink:href="../Components/MCU(J_MCU)/J_MCU.cellml">
<component component_ref="JMCU" name="JMCU"/>
</import>
<import xlink:href="../Components/Ca_Na_Exchanger(J_NCX)/J_NCX.cellml">
<component component_ref="JNCX" name="JNCX"/>
</import>
<import xlink:href="../Components/SERCA/J_SERCA.cellml">
<component component_ref="JSERCA" name="JSERCA"/>
</import>
<import xlink:href="../Components/CMT(Ca_MT)/Ca_MT.cellml">
<component component_ref="CMT" name="CMT"/>
</import>
<import xlink:href="../Components/NS1/N_S1.cellml">
<component component_ref="NS1" name="NS1"/>
</import>
<import xlink:href="../Components/CER(Ca_ER)/Ca_ER.cellml">
<component component_ref="CER" name="CER"/>
</import>
<import xlink:href="../Components/Ca_Cytosolic_Subspace1(Ca_S1)/Ca_S1.cellml">
<component component_ref="CS1" name="CS1"/>
</import>
<import xlink:href="../Components/Ca_Cytosolic_Subspace2(Ca_S2)/Ca_S2.cellml">
<component component_ref="CS2" name="CS2"/>
</import>
<import xlink:href="../Components/Ca_PM/Ca_PM.cellml">
<component component_ref="I_PM" name="I_PM"/>
</import>
<import xlink:href="../Components/CICR(ICa)/ICa.cellml">
<component component_ref="I_Ca" name="I_Ca"/>
</import>
<import xlink:href="../Components/NSCC_Ca/INSCC_Ca.cellml">
<component component_ref="I_NSCC_Ca" name="I_NSCC_Ca"/>
</import>
<import xlink:href="../Components/NSCC_Na/INSCC_Na.cellml">
<component component_ref="I_NSCC_Na" name="I_NSCC_Na"/>
</import>
<import xlink:href="../Components/Outward_Na_Pump(I_Na_P)/I_Na_P.cellml">
<component component_ref="I_Na" name="I_Na"/>
</import>
<import xlink:href="../Components/Membrane_Vm/Membrane_voltage.cellml">
<component component_ref="Vm" name="Vm"/>
</import>
<connection>
<map_components component_1="Vm" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="JS1S2" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="JNCX" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_PM" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_Ca" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="JMCU" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="CS1" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="CS2" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="CER" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="CMT" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="NS1" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="JIPR" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Vm" component_2="CS1"/>
<map_variables variable_1="I_iCa" variable_2="I_iCa"/>
<map_variables variable_1="CS1" variable_2="CS1"/>
</connection>
<connection>
<map_components component_1="Vm" component_2="NS1"/>
<map_variables variable_1="I_iNa" variable_2="I_iNa"/>
<map_variables variable_1="NS1" variable_2="NS1"/>
</connection>
<connection>
<map_components component_1="Vm" component_2="CS2"/>
<map_variables variable_1="CS2" variable_2="CS2"/>
</connection>
<connection>
<map_components component_1="Vm" component_2="JIPR"/>
<map_variables variable_1="JIPR" variable_2="JIPR"/>
</connection>
<connection>
<map_components component_1="Vm" component_2="JMCU"/>
<map_variables variable_1="JMCU" variable_2="JMCU"/>
</connection>
<connection>
<map_components component_1="Vm" component_2="JNCX"/>
<map_variables variable_1="JNCX" variable_2="JNCX"/>
</connection>
<connection>
<map_components component_1="Vm" component_2="JS1S2"/>
<map_variables variable_1="JS1S2" variable_2="JS1S2"/>
</connection>
<connection>
<map_components component_1="Vm" component_2="JSERCA"/>
<map_variables variable_1="JSERCA" variable_2="JSERCA"/>
</connection>
<connection>
<map_components component_1="JS1S2" component_2="CS1"/>
<map_variables variable_1="CS1" variable_2="CS1"/>
<map_variables variable_1="JS1S2" variable_2="JS1S2"/>
</connection>
<connection>
<map_components component_1="JNCX" component_2="CS1"/>
<map_variables variable_1="JNCX" variable_2="JNCX"/>
</connection>
<connection>
<map_components component_1="I_PM" component_2="CS1"/>
<map_variables variable_1="CS1" variable_2="CS1"/>
</connection>
<connection>
<map_components component_1="JSERCA" component_2="CS1"/>
<map_variables variable_1="CS1" variable_2="CS1"/>
<map_variables variable_1="JSERCA" variable_2="JSERCA"/>
</connection>
<connection>
<map_components component_1="I_NSCC_Ca" component_2="CS1"/>
<map_variables variable_1="CS1" variable_2="CS1"/>
</connection>
<connection>
<map_components component_1="I_NSCC_Na" component_2="CS1"/>
<map_variables variable_1="CS1" variable_2="CS1"/>
</connection>
<connection>
<map_components component_1="model_parameters" component_2="CS1"/>
<map_variables variable_1="delta_s" variable_2="delta_s"/>
<map_variables variable_1="gamma_MT" variable_2="gamma_MT"/>
<map_variables variable_1="gamma_S1" variable_2="gamma_S1"/>
<map_variables variable_1="gamma_ER" variable_2="gamma_ER"/>
</connection>
<connection>
<map_components component_1="model_initials" component_2="CS1"/>
<map_variables variable_1="CS1_initial" variable_2="CS1_initial"/>
</connection>
<connection>
<map_components component_1="JS1S2" component_2="CS2"/>
<map_variables variable_1="CS2" variable_2="CS2"/>
<map_variables variable_1="JS1S2" variable_2="JS1S2"/>
</connection>
<connection>
<map_components component_1="JMCU" component_2="CS2"/>
<map_variables variable_1="CS2" variable_2="CS2"/>
<map_variables variable_1="JMCU" variable_2="JMCU"/>
</connection>
<connection>
<map_components component_1="JIPR" component_2="CS2"/>
<map_variables variable_1="CS2" variable_2="CS2"/>
<map_variables variable_1="JIPR" variable_2="JIPR"/>
</connection>
<connection>
<map_components component_1="JIPR" component_2="model_parameters"/>
<map_variables variable_1="P" variable_2="P"/>
</connection>
<connection>
<map_components component_1="model_parameters" component_2="CS2"/>
<map_variables variable_1="gamma_MT" variable_2="gamma_MT"/>
<map_variables variable_1="gamma_S1" variable_2="gamma_S1"/>
<map_variables variable_1="gamma_S2" variable_2="gamma_S2"/>
<map_variables variable_1="gamma_ER" variable_2="gamma_ER"/>
</connection>
<connection>
<map_components component_1="model_initials" component_2="CS2"/>
<map_variables variable_1="CS2_initial" variable_2="CS2_initial"/>
</connection>
<connection>
<map_components component_1="JSERCA" component_2="CER"/>
<map_variables variable_1="CER" variable_2="CER"/>
<map_variables variable_1="JSERCA" variable_2="JSERCA"/>
</connection>
<connection>
<map_components component_1="JIPR" component_2="CER"/>
<map_variables variable_1="CER" variable_2="CER"/>
<map_variables variable_1="JIPR" variable_2="JIPR"/>
</connection>
<connection>
<map_components component_1="JNCX" component_2="CMT"/>
<map_variables variable_1="CMT" variable_2="CMT"/>
<map_variables variable_1="JNCX" variable_2="JNCX"/>
</connection>
<connection>
<map_components component_1="JMCU" component_2="CMT"/>
<map_variables variable_1="CMT" variable_2="CMT"/>
<map_variables variable_1="JMCU" variable_2="JMCU"/>
</connection>
<connection>
<map_components component_1="model_parameters" component_2="NS1"/>
<map_variables variable_1="delta_s" variable_2="delta_s"/>
</connection>
<connection>
<map_components component_1="Vm" component_2="I_Ca"/>
<map_variables variable_1="I_Ca" variable_2="I_Ca"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="Vm" component_2="I_PM"/>
<map_variables variable_1="I_PM" variable_2="I_PM"/>
</connection>
<connection>
<map_components component_1="Vm" component_2="CER"/>
<map_variables variable_1="CER" variable_2="CER"/>
</connection>
<connection>
<map_components component_1="Vm" component_2="CMT"/>
<map_variables variable_1="CMT" variable_2="CMT"/>
</connection>
<connection>
<map_components component_1="Vm" component_2="I_NSCC_Ca"/>
<map_variables variable_1="I_NSCC_Ca" variable_2="I_NSCC_Ca"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="model_parameters" component_2="I_NSCC_Ca"/>
<map_variables variable_1="hNSCC" variable_2="hNSCC"/>
<map_variables variable_1="ENSCC" variable_2="ENSCC"/>
<map_variables variable_1="KNSCC" variable_2="KNSCC"/>
</connection>
<connection>
<map_components component_1="Vm" component_2="I_Na"/>
<map_variables variable_1="I_Na" variable_2="I_Na"/>
</connection>
<connection>
<map_components component_1="Vm" component_2="I_NSCC_Na"/>
<map_variables variable_1="I_NSCC_Na" variable_2="I_NSCC_Na"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="model_parameters" component_2="I_NSCC_Na"/>
<map_variables variable_1="hNSCC" variable_2="hNSCC"/>
<map_variables variable_1="ENSCC" variable_2="ENSCC"/>
<map_variables variable_1="KNSCC" variable_2="KNSCC"/>
</connection>
<connection>
<map_components component_1="I_Ca" component_2="CS1"/>
<map_variables variable_1="CS1" variable_2="CS1"/>
</connection>
<connection>
<map_components component_1="model_parameters" component_2="I_Ca"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="CO" variable_2="CO"/>
</connection>
<connection>
<map_components component_1="I_Na" component_2="NS1"/>
<map_variables variable_1="NS1" variable_2="NS1"/>
</connection>
<component name="outputs">
<variable name="time" private_interface="out" public_interface="in" units="second"/>
<variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="I_iCa" private_interface="out" public_interface="in" units="picoampere"/>
<variable name="I_iNa" private_interface="out" public_interface="in" units="picoampere"/>
<variable name="I_Ca" private_interface="in" public_interface="out" units="picoampere"/>
<variable name="I_Na" private_interface="out" public_interface="in" units="picoampere"/>
<variable name="I_NSCC_Ca" private_interface="out" public_interface="in" units="picoampere"/>
<variable name="I_PM" private_interface="out" public_interface="in" units="picoampere"/>
<variable name="I_NSCC_Na" private_interface="out" public_interface="in" units="picoampere"/>
<variable name="CER" private_interface="out" public_interface="in" units="micromolar"/>
<variable name="NS1" private_interface="out" public_interface="in" units="micromolar"/>
<variable name="CMT" private_interface="out" public_interface="in" units="micromolar"/>
<variable name="CS1" private_interface="out" public_interface="in" units="micromolar"/>
<variable name="CS2" private_interface="out" public_interface="in" units="micromolar"/>
<variable name="JIPR" private_interface="out" public_interface="in" units="flux"/>
<variable name="JMCU" private_interface="out" public_interface="in" units="flux"/>
<variable name="JNCX" private_interface="out" public_interface="in" units="flux"/>
<variable name="JS1S2" private_interface="out" public_interface="in" units="flux"/>
<variable name="JSERCA" private_interface="out" public_interface="in" units="flux"/>
</component>
<connection>
<map_components component_1="outputs" component_2="Vm"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="I_iCa" variable_2="I_iCa"/>
<map_variables variable_1="I_iNa" variable_2="I_iNa"/>
<map_variables variable_1="I_Ca" variable_2="I_Ca"/>
<map_variables variable_1="I_Na" variable_2="I_Na"/>
<map_variables variable_1="I_PM" variable_2="I_PM"/>
<map_variables variable_1="I_NSCC_Ca" variable_2="I_NSCC_Ca"/>
<map_variables variable_1="I_NSCC_Na" variable_2="I_NSCC_Na"/>
<map_variables variable_1="CER" variable_2="CER"/>
<map_variables variable_1="NS1" variable_2="NS1"/>
<map_variables variable_1="CMT" variable_2="CMT"/>
<map_variables variable_1="CS1" variable_2="CS1"/>
<map_variables variable_1="CS2" variable_2="CS2"/>
<map_variables variable_1="JIPR" variable_2="JIPR"/>
<map_variables variable_1="JMCU" variable_2="JMCU"/>
<map_variables variable_1="JNCX" variable_2="JNCX"/>
<map_variables variable_1="JS1S2" variable_2="JS1S2"/>
<map_variables variable_1="JSERCA" variable_2="JSERCA"/>
</connection>
</model>
