- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2022-07-12 17:11:03+12:00
- Desc:
- Change the stimulation protocol to double pulse with conditioning; add steady state equations
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/8af/rawfile/113b9d7fbcebee0427016d8f7d9b5b181656ab2e/Components/buildsrc/MWC_10_test.txt
def model MWC_10_test as
def import using "../cellLib/Components/units.cellml" for
unit mV using unit mV;
unit ms using unit ms;
unit per_ms using unit per_ms;
enddef;
def import using "../Components/MWC_10.cellml" for
comp MWC_10 using comp MWC_10;
enddef;
def import using "../Components/Para.cellml" for
comp Para using comp Para;
enddef;
def import using "../cellLib/Protocols/Patch_clamp_protocol.cellml" for
comp dPulse_protocol_ms using comp dPulse_protocol_ms;
enddef;
def import using "../cellLib/Components/time.cellml" for
comp time using comp time_ms;
enddef;
def comp output_10 as
var P_o: dimensionless {pub: in};
var Q: dimensionless {pub: in};
var P_ss: dimensionless {pub: in};
var Q_ss: dimensionless {pub: in};
var t: ms {pub: in};
var V: mV {pub: in};
var dQ: per_ms {pub: in};
var C_0: dimensionless {pub: in};
var C_1: dimensionless {pub: in};
var C_2: dimensionless {pub: in};
var C_3: dimensionless {pub: in};
var C_4: dimensionless {pub: in};
var O_0: dimensionless {pub: in};
var O_1: dimensionless {pub: in};
var O_2: dimensionless {pub: in};
var O_3: dimensionless {pub: in};
var O_4: dimensionless {pub: in};
enddef;
def comp clamp_para as
var t_ss: ms {init: 100, pub: out};
var V_actHolding: mV {init: -80, pub: out};
var t_act: ms {init: 100, pub: out};
var V_actTest: mV {init: -40, pub: out};
var t_cd: ms {init: 10, pub: out};
var T_cd: ms {init: 100, pub: out};
var V_cd: mV {init: 20, pub: out};
enddef;
def comp free_para_10 as
var K: mV {init: 4.5, pub: out};
var k_L: per_ms {init: 0.002, pub: out};
var k_Lminus: per_ms {init: 900, pub: out};
var f: dimensionless {init: 0.175, pub: out};
var V0: mV {init: -20, pub: out};
var C0_init: dimensionless {init: 0.922136731, pub: out};
var C1_init: dimensionless {init: 0.075497647, pub: out};
var C2_init: dimensionless {init: 0.002317952, pub: out};
var C3_init: dimensionless {init: 3.16E-05, pub: out};
var C4_init: dimensionless {init: 1.61E-07, pub: out};
var O0_init: dimensionless {init: 2.05E-06, pub: out};
var O1_init: dimensionless {init: 5.48E-06, pub: out};
var O2_init: dimensionless {init: 5.49E-06, pub: out};
var O3_init: dimensionless {init: 2.45E-06, pub: out};
var O4_init: dimensionless {init: 4.07E-07, pub: out};
enddef;
def map between MWC_10 and output_10 for
vars C_0 and C_0;
vars C_1 and C_1;
vars C_2 and C_2;
vars C_3 and C_3;
vars C_4 and C_4;
vars O_0 and O_0;
vars O_1 and O_1;
vars O_2 and O_2;
vars O_3 and O_3;
vars O_4 and O_4;
vars P_ss and P_ss;
vars Q_ss and Q_ss;
vars P_o and P_o;
vars Q and Q;
vars dQ and dQ;
enddef;
def map between MWC_10 and free_para_10 for
vars C0_init and C0_init;
vars C1_init and C1_init;
vars C2_init and C2_init;
vars C3_init and C3_init;
vars C4_init and C4_init;
vars O0_init and O0_init;
vars O1_init and O1_init;
vars O2_init and O2_init;
vars O3_init and O3_init;
vars O4_init and O4_init;
vars K and K;
vars k_L and k_L;
vars k_Lminus and k_Lminus;
vars f and f;
vars V0 and V0;
enddef;
def map between MWC_10 and Para for
vars alpha and alpha;
vars C1_i and C1_i;
vars C2_i and C2_i;
vars C3_i and C3_i;
vars O1_i and O1_i;
vars O2_i and O2_i;
vars O3_i and O3_i;
enddef;
def map between MWC_10 and dPulse_protocol_ms for
vars V and V;
enddef;
def map between MWC_10 and time for
vars t and time;
enddef;
def map between output_10 and dPulse_protocol_ms for
vars V and V;
enddef;
def map between output_10 and time for
vars t and time;
enddef;
def map between clamp_para and dPulse_protocol_ms for
vars t_ss and t_ss;
vars V_actHolding and V_actHolding;
vars t_act and t_act;
vars V_actTest and V_actTest;
vars t_cd and t_cd;
vars T_cd and T_cd;
vars V_cd and V_cd;
enddef;
def map between dPulse_protocol_ms and time for
vars time and time;
enddef;
enddef;
