Location: FCU_cardiac_pH @ cc50e57955e5 / FCU_cardiac_pH_pH_regulation.cellml

Author:
Shelley Fong <sfon036@UoA.auckland.ac.nz>
Date:
2022-07-13 16:00:34+12:00
Desc:
Moving channel states into main environment from individual submodule components
Permanent Source URI:
https://models.physiomeproject.org/workspace/885/rawfile/cc50e57955e59c98e8a98a55eb222cdef43c75ff/FCU_cardiac_pH_pH_regulation.cellml

<?xml version='1.0' encoding='UTF-8'?>
<model name="FCU_cardiac_pH" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
    <import xlink:href="units_and_constants/units_BG.cellml">
        <units name="mM" units_ref="mM"/>
        <units name="fmol" units_ref="fmol"/>
        <units name="per_fmol" units_ref="per_fmol"/>
        <units name="J_per_mol" units_ref="J_per_mol"/>
        <units name="fmol_per_sec" units_ref="fmol_per_sec"/>
        <units name="C_per_mol" units_ref="C_per_mol"/>
        <units name="J_per_C" units_ref="J_per_C"/>
        <units name="microm3" units_ref="microm3"/>
        <units name="fF" units_ref="fF"/>
        <units name="fC" units_ref="fC"/>
        <units name="fA" units_ref="fA"/>
        <units name="per_second" units_ref="per_second"/>
        <units name="millivolt" units_ref="millivolt"/>
        <units name="per_sec" units_ref="per_sec"/>
        <units name="J_per_K_per_mol" units_ref="J_per_K_per_mol"/>
        <units name="fmol_per_L" units_ref="fmol_per_L"/>
        <units name="fmol_per_L_per_sec" units_ref="fmol_per_L_per_sec"/>
        <units name="per_sec_per_fmol_per_L" units_ref="per_sec_per_fmol_per_L"/>
        <units name="uM" units_ref="uM"/>
        <units name="mM_per_sec" units_ref="mM_per_sec"/>
        <units name="uM_per_sec" units_ref="uM_per_sec"/>
        <units name="pL" units_ref="pL"/>
        <units name="m_to_u" units_ref="m_to_u"/>
    </import>
    <import xlink:href="units_and_constants/constants_BG.cellml">
        <component component_ref="constants" name="constants"/>
    </import>
    <import xlink:href="AE/BG_AE.cellml">
        <component component_ref="AE" name="AE"/>
    </import>
    <import xlink:href="CHE/BG_CHE.cellml">
        <component component_ref="CHE" name="CHE"/>
    </import>
    <import xlink:href="CO2_hyd/BG_CO2_hyd.cellml">
        <component component_ref="CO2_hyd" name="CO2_hyd"/>
    </import>
    <import xlink:href="NBC/BG_NBC.cellml">
        <component component_ref="NBC" name="NBC"/>
    </import>
    <import xlink:href="NHE/BG_NHE.cellml">
        <component component_ref="NHE" name="NHE"/>
    </import>
    <import xlink:href="pH_B1/BG_pH_B1.cellml">
        <component component_ref="pH_B1" name="pH_B1"/>
    </import>
    <import xlink:href="pH_B2/BG_pH_B2.cellml">
        <component component_ref="pH_B2" name="pH_B2"/>
    </import>
    <component name="BG_parameters">
        <variable initial_value="16989.7" name="kappa_R61_AE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="9.95603e+09" name="kappa_R12_AE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="3.34396e+12" name="kappa_R23_AE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="124813" name="kappa_R34_AE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="3.53951e+12" name="kappa_R45_AE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="5.65383e+09" name="kappa_R56_AE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1.51752e-30" name="kappa_R61_pHi_AE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="3.89362e-30" name="kappa_R12_pHi_AE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1.01232e-29" name="kappa_R23_pHi_AE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1.09142e-29" name="kappa_R34_pHi_AE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1.17671e-29" name="kappa_R45_pHi_AE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="4.25377e-30" name="kappa_R56_pHi_AE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="2.47392e+17" name="kappa_R61_pHo_AE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="6.34754e+17" name="kappa_R12_pHo_AE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1.65032e+18" name="kappa_R23_pHo_AE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1.77928e+18" name="kappa_R34_pHo_AE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1.91832e+18" name="kappa_R45_pHo_AE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="6.93467e+17" name="kappa_R56_pHo_AE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="2.66006" name="kappa_R61_CHE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.00948314" name="kappa_R12_CHE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="894374" name="kappa_R23_CHE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.00338371" name="kappa_R34_CHE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="5.20571e+07" name="kappa_R45_CHE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="551967" name="kappa_R56_CHE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="4.07921e-08" name="kappa_Re_CO2hyd" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.00115162" name="kappa_R61_NBC" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1773.83" name="kappa_R12_NBC" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.951701" name="kappa_R23_NBC" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.110974" name="kappa_R34_NBC" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.0103641" name="kappa_R45_NBC" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="184.891" name="kappa_R56_NBC" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="7.65077e+19" name="kappa_R61_pHi_NBC" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1.15584e+20" name="kappa_R12_pHi_NBC" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="6.96298e+20" name="kappa_R23_pHi_NBC" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="2.70285e+20" name="kappa_R34_pHi_NBC" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1.45878e+19" name="kappa_R45_pHi_NBC" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="2.48755e+19" name="kappa_R56_pHi_NBC" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1.79055e-16" name="kappa_R61_pHo_NBC" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="2.70508e-16" name="kappa_R12_pHo_NBC" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1.62959e-15" name="kappa_R23_pHo_NBC" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="6.32563e-16" name="kappa_R34_pHo_NBC" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="3.41407e-17" name="kappa_R45_pHo_NBC" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="5.82174e-17" name="kappa_R56_pHo_NBC" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="2.72703e-10" name="kappa_R61_NHE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="8.07856e-12" name="kappa_R12_NHE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.0305301" name="kappa_R23_NHE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="3.45577e-10" name="kappa_R34_NHE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.00928252" name="kappa_R45_NHE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="4.57222e-12" name="kappa_R56_NHE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1.86088e+17" name="kappa_R61_pHi_NHE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="2.63374e+17" name="kappa_R12_pHi_NHE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="6.56887e+17" name="kappa_R23_pHi_NHE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1.05958e+18" name="kappa_R34_pHi_NHE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="4.1238e+17" name="kappa_R45_pHi_NHE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1.80633e+17" name="kappa_R56_pHi_NHE" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1.21945e-08" name="kappa_Re_B1" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0" name="kappa_Re_B2" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.173797" name="K_HCO3_i" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.344362" name="K_HCO3_o" public_interface="out" units="per_fmol"/>
        <variable initial_value="3.00818e-05" name="K_Cl_i" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.000182919" name="K_Cl_o" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.00536147" name="K_S1_AE" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.000871028" name="K_S2_AE" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.000793158" name="K_S3_AE" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.000749338" name="K_S4_AE" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.000682347" name="K_S5_AE" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.00573416" name="K_S6_AE" public_interface="out" units="per_fmol"/>
        <variable initial_value="3.74048e+06" name="K_H_i" public_interface="out" units="per_fmol"/>
        <variable initial_value="1.86796e+07" name="K_H_o" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.00283707" name="K_OH_i" public_interface="out" units="per_fmol"/>
        <variable initial_value="17251.5" name="K_OH_o" public_interface="out" units="per_fmol"/>
        <variable initial_value="25.3323" name="K_S1_CHE" public_interface="out" units="per_fmol"/>
        <variable initial_value="3256.68" name="K_S2_CHE" public_interface="out" units="per_fmol"/>
        <variable initial_value="5424.75" name="K_S3_CHE" public_interface="out" units="per_fmol"/>
        <variable initial_value="93.2005" name="K_S4_CHE" public_interface="out" units="per_fmol"/>
        <variable initial_value="46.3947" name="K_S5_CHE" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.434702" name="K_S6_CHE" public_interface="out" units="per_fmol"/>
        <variable initial_value="3.17169e+12" name="K_CO2_i" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.000964254" name="K_Na_i" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.00165864" name="K_Na_o" public_interface="out" units="per_fmol"/>
        <variable initial_value="4620.34" name="K_S1_NBC" public_interface="out" units="per_fmol"/>
        <variable initial_value="2900.41" name="K_S2_NBC" public_interface="out" units="per_fmol"/>
        <variable initial_value="127.315" name="K_S3_NBC" public_interface="out" units="per_fmol"/>
        <variable initial_value="19248.9" name="K_S4_NBC" public_interface="out" units="per_fmol"/>
        <variable initial_value="43706.1" name="K_S5_NBC" public_interface="out" units="per_fmol"/>
        <variable initial_value="6619.78" name="K_S6_NBC" public_interface="out" units="per_fmol"/>
        <variable initial_value="4.70821e+09" name="K_S1_NHE" public_interface="out" units="per_fmol"/>
        <variable initial_value="4.1237e+09" name="K_S2_NHE" public_interface="out" units="per_fmol"/>
        <variable initial_value="7.5687e+08" name="K_S3_NHE" public_interface="out" units="per_fmol"/>
        <variable initial_value="1.58488e+09" name="K_S4_NHE" public_interface="out" units="per_fmol"/>
        <variable initial_value="4.99686e+09" name="K_S5_NHE" public_interface="out" units="per_fmol"/>
        <variable initial_value="8.26036e+09" name="K_S6_NHE" public_interface="out" units="per_fmol"/>
        <variable initial_value="8.271e-06" name="K_B1" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.000107117" name="K_HB1" public_interface="out" units="per_fmol"/>
        <variable initial_value="1e-6" name="K_B2" public_interface="out" units="per_fmol"/>
        <variable initial_value="1e-6" name="K_HB2" public_interface="out" units="per_fmol"/>
    </component>
    <component name="environment">
        <variable name="time" public_interface="out" units="second"/>
        <variable initial_value="509.2" name="q_HCO3_i" public_interface="out" units="fmol"/>
        <variable initial_value="122.2952" name="q_HCO3_o" public_interface="out" units="fmol"/>
        <variable initial_value="824.6" name="q_Cl_i" public_interface="out" units="fmol"/>
        <variable initial_value="725.48" name="q_Cl_o" public_interface="out" units="fmol"/>
        <variable initial_value="5.36764E-06" name="q_OH_i" public_interface="out" units="fmol"/>
        <variable initial_value="1.30166E-06" name="q_OH_o" public_interface="out" units="fmol"/>
        <variable initial_value="481.46" name="q_Na_i" public_interface="out" units="fmol"/>
        <variable initial_value="725.48" name="q_Na_o" public_interface="out" units="fmol"/>
        <variable initial_value="2.69019E-06" name="q_H_i" public_interface="out" units="fmol"/>
        <variable initial_value="2.06299E-07" name="q_H_o" public_interface="out" units="fmol"/>
        <variable initial_value="3199.6" name="q_B1" public_interface="out" units="fmol"/>
        <variable initial_value="1e-12" name="q_HB1" public_interface="out" units="fmol"/>
        <variable initial_value="1117.2" name="q_B2" public_interface="out" units="fmol"/>
        <variable initial_value="1e-12" name="q_HB2" public_interface="out" units="fmol"/>
        <variable initial_value="46.968" name="q_CO2_i" public_interface="out" units="fmol"/>
        <!-- AE imports-->
        <variable name="v_R61_AE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R12_AE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R23_AE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R34_AE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R45_AE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R56_AE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R61_pHi_AE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R12_pHi_AE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R23_pHi_AE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R34_pHi_AE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R45_pHi_AE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R56_pHi_AE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R61_pHo_AE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R12_pHo_AE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R23_pHo_AE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R34_pHo_AE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R45_pHo_AE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R56_pHo_AE" public_interface="in" units="fmol_per_sec"/>
        <variable name="ni_AE" public_interface="in" units="dimensionless"/>
        <variable name="no_AE" public_interface="in" units="dimensionless"/>
        <!-- CHE imports-->
        <variable name="v_R61_CHE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R12_CHE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R23_CHE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R34_CHE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R45_CHE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R56_CHE" public_interface="in" units="fmol_per_sec"/>
        <!-- CO2_hyd imports-->
        <variable name="v_Re_CO2hyd" public_interface="in" units="fmol_per_sec"/>
        <!-- NBC imports-->
        <variable name="v_R61_NBC" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R12_NBC" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R23_NBC" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R34_NBC" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R45_NBC" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R56_NBC" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R61_pHi_NBC" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R12_pHi_NBC" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R23_pHi_NBC" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R34_pHi_NBC" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R45_pHi_NBC" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R56_pHi_NBC" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R61_pHo_NBC" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R12_pHo_NBC" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R23_pHo_NBC" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R34_pHo_NBC" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R45_pHo_NBC" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R56_pHo_NBC" public_interface="in" units="fmol_per_sec"/>
        <variable name="ni_NBC" public_interface="in" units="dimensionless"/>
        <variable name="no_NBC" public_interface="in" units="dimensionless"/>
        <!-- NHE imports-->
        <variable name="v_R61_NHE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R12_NHE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R23_NHE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R34_NHE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R45_NHE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R56_NHE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R61_pHi_NHE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R12_pHi_NHE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R23_pHi_NHE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R34_pHi_NHE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R45_pHi_NHE" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_R56_pHi_NHE" public_interface="in" units="fmol_per_sec"/>
        <variable name="ni_NHE" public_interface="in" units="dimensionless"/>
        <!-- pH_B1 imports-->
        <variable name="v_Re_B1" public_interface="in" units="fmol_per_sec"/>
        <!-- pH_B2 imports-->
        <variable name="v_Re_B2" public_interface="in" units="fmol_per_sec"/>
        <variable name="dH_idt_NBC" units="fmol_per_sec"/>
        <variable name="dH_idt_NHE" units="fmol_per_sec"/>
        <variable name="dH_idt_AE" units="fmol_per_sec"/>
        <variable name="dH_odt_NBC" units="fmol_per_sec"/>
        <variable name="dH_odt_AE" units="fmol_per_sec"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>dH_idt_NBC</ci>
                <apply>
                    <times/>
                    <ci>ni_NBC</ci>
                    <apply>
                        <plus/>
                        <ci>v_R61_pHi_NBC</ci>
                        <ci>v_R12_pHi_NBC</ci>
                        <ci>v_R23_pHi_NBC</ci>
                        <ci>v_R34_pHi_NBC</ci>
                        <ci>v_R45_pHi_NBC</ci>
                        <ci>v_R56_pHi_NBC</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>dH_odt_NBC</ci>
                <apply>
                    <times/>
                    <apply>
                        <minus/>
                        <ci>no_NBC</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>v_R61_pHo_NBC</ci>
                        <ci>v_R12_pHo_NBC</ci>
                        <ci>v_R23_pHo_NBC</ci>
                        <ci>v_R34_pHo_NBC</ci>
                        <ci>v_R45_pHo_NBC</ci>
                        <ci>v_R56_pHo_NBC</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>dH_idt_AE</ci>
                <apply>
                    <times/>
                    <apply>
                        <minus/>
                        <ci>ni_AE</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>v_R61_pHi_AE</ci>
                        <ci>v_R12_pHi_AE</ci>
                        <ci>v_R23_pHi_AE</ci>
                        <ci>v_R34_pHi_AE</ci>
                        <ci>v_R45_pHi_AE</ci>
                        <ci>v_R56_pHi_AE</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>dH_odt_AE</ci>
                <apply>
                    <times/>
                    <ci>no_AE</ci>
                    <apply>
                        <plus/>
                        <ci>v_R61_pHo_AE</ci>
                        <ci>v_R12_pHo_AE</ci>
                        <ci>v_R23_pHo_AE</ci>
                        <ci>v_R34_pHo_AE</ci>
                        <ci>v_R45_pHo_AE</ci>
                        <ci>v_R56_pHo_AE</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>dH_idt_NHE</ci>
                <apply>
                    <times/>
                    <ci>ni_NHE</ci>
                    <apply>
                        <plus/>
                        <ci>v_R61_pHi_NHE</ci>
                        <ci>v_R12_pHi_NHE</ci>
                        <ci>v_R23_pHi_NHE</ci>
                        <ci>v_R34_pHi_NHE</ci>
                        <ci>v_R45_pHi_NHE</ci>
                        <ci>v_R56_pHi_NHE</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_HCO3_i</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <minus/>
                        <ci>v_R56_AE</ci>
                    </apply>
                    <ci>v_R45_NBC</ci>
                    <ci>v_Re_CO2hyd</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_HCO3_o</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_R12_AE</ci>
                    <ci>v_R23_NBC</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_Cl_i</ci>
                </apply>
                <apply>
                    <plus/>
                    <ci>v_R45_AE</ci>
                    <ci>v_R45_CHE</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_Cl_o</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <ci>v_R23_AE</ci>
                    </apply>
                    <ci>v_R23_CHE</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_Na_i</ci>
                </apply>
                <apply>
                    <plus/>
                    <ci>v_R56_NBC</ci>
                    <ci>v_R45_NHE</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_Na_o</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <ci>v_R12_NBC</ci>
                    </apply>
                    <ci>v_R23_NHE</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_OH_i</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_R56_CHE</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_OH_o</ci>
                </apply>
                <ci>v_R12_CHE</ci>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_H_i</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <minus/>
                        <apply>
                            <minus/>
                            <apply>
                                <minus/>
                                <ci>v_R56_NHE</ci>
                            </apply>
                            <ci>v_Re_B1</ci>
                        </apply>
                        <ci>v_Re_B2</ci>
                    </apply>
                    <ci>v_Re_CO2hyd</ci>
                    <ci>dH_idt_NBC</ci>
                    <ci>dH_idt_NHE</ci>
                    <ci>dH_idt_AE</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_H_o</ci>
                </apply>
                <apply>
                    <plus/>
                    <ci>v_R12_NHE</ci>
                    <ci>dH_odt_NBC</ci>
                    <ci>dH_odt_AE</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_B1</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_Re_B1</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_HB1</ci>
                </apply>
                <ci>v_Re_B1</ci>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_B2</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_Re_B2</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_HB2</ci>
                </apply>
                <ci>v_Re_B2</ci>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_CO2_i</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_Re_CO2hyd</ci>
                </apply>
            </apply>
        </math>
        <variable name="pH_i" units="dimensionless"/>
        <variable name="pH_o" units="dimensionless"/>
        <variable name="cH_i" units="mM"/>
        <variable name="cH_o" units="mM"/>
        <variable initial_value="38" name="w_i" units="pL"/>
        <variable initial_value="5.182" name="w_o" units="pL"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>cH_i</ci>
                <apply>
                    <divide/>
                    <ci>q_H_i</ci>
                    <ci>w_i</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>cH_o</ci>
                <apply>
                    <divide/>
                    <ci>q_H_o</ci>
                    <ci>w_o</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>pH_i</ci>
                <apply>
                    <minus/>
                    <apply>
                        <log/>
                        <ci>cH_i</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>pH_o</ci>
                <apply>
                    <minus/>
                    <apply>
                        <log/>
                        <ci>cH_o</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <connection>
        <map_components component_1="environment" component_2="AE"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="q_HCO3_i" variable_2="q_HCO3_i"/>
        <map_variables variable_1="q_HCO3_o" variable_2="q_HCO3_o"/>
        <map_variables variable_1="q_Cl_i" variable_2="q_Cl_i"/>
        <map_variables variable_1="q_Cl_o" variable_2="q_Cl_o"/>
        <map_variables variable_1="q_H_i" variable_2="q_H_i"/>
        <map_variables variable_1="q_H_o" variable_2="q_H_o"/>
        <map_variables variable_1="v_R61_AE" variable_2="v_R61_AE"/>
        <map_variables variable_1="v_R12_AE" variable_2="v_R12_AE"/>
        <map_variables variable_1="v_R23_AE" variable_2="v_R23_AE"/>
        <map_variables variable_1="v_R34_AE" variable_2="v_R34_AE"/>
        <map_variables variable_1="v_R45_AE" variable_2="v_R45_AE"/>
        <map_variables variable_1="v_R56_AE" variable_2="v_R56_AE"/>
        <map_variables variable_1="v_R61_pHi_AE" variable_2="v_R61_pHi_AE"/>
        <map_variables variable_1="v_R12_pHi_AE" variable_2="v_R12_pHi_AE"/>
        <map_variables variable_1="v_R23_pHi_AE" variable_2="v_R23_pHi_AE"/>
        <map_variables variable_1="v_R34_pHi_AE" variable_2="v_R34_pHi_AE"/>
        <map_variables variable_1="v_R45_pHi_AE" variable_2="v_R45_pHi_AE"/>
        <map_variables variable_1="v_R56_pHi_AE" variable_2="v_R56_pHi_AE"/>
        <map_variables variable_1="v_R61_pHo_AE" variable_2="v_R61_pHo_AE"/>
        <map_variables variable_1="v_R12_pHo_AE" variable_2="v_R12_pHo_AE"/>
        <map_variables variable_1="v_R23_pHo_AE" variable_2="v_R23_pHo_AE"/>
        <map_variables variable_1="v_R34_pHo_AE" variable_2="v_R34_pHo_AE"/>
        <map_variables variable_1="v_R45_pHo_AE" variable_2="v_R45_pHo_AE"/>
        <map_variables variable_1="v_R56_pHo_AE" variable_2="v_R56_pHo_AE"/>
        <map_variables variable_1="ni_AE" variable_2="ni"/>
        <map_variables variable_1="no_AE" variable_2="no"/>
    </connection>
    <connection>
        <map_components component_1="environment" component_2="CHE"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="q_OH_i" variable_2="q_OH_i"/>
        <map_variables variable_1="q_OH_o" variable_2="q_OH_o"/>
        <map_variables variable_1="q_Cl_i" variable_2="q_Cl_i"/>
        <map_variables variable_1="q_Cl_o" variable_2="q_Cl_o"/>
        <map_variables variable_1="v_R61_CHE" variable_2="v_R61_CHE"/>
        <map_variables variable_1="v_R12_CHE" variable_2="v_R12_CHE"/>
        <map_variables variable_1="v_R23_CHE" variable_2="v_R23_CHE"/>
        <map_variables variable_1="v_R34_CHE" variable_2="v_R34_CHE"/>
        <map_variables variable_1="v_R45_CHE" variable_2="v_R45_CHE"/>
        <map_variables variable_1="v_R56_CHE" variable_2="v_R56_CHE"/>
    </connection>
    <connection>
        <map_components component_1="environment" component_2="CO2_hyd"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="q_CO2_i" variable_2="q_CO2_i"/>
        <map_variables variable_1="q_HCO3_i" variable_2="q_HCO3_i"/>
        <map_variables variable_1="q_H_i" variable_2="q_H_i"/>
        <map_variables variable_1="v_Re_CO2hyd" variable_2="v_Re_CO2hyd"/>
    </connection>
    <connection>
        <map_components component_1="environment" component_2="NBC"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="q_Na_i" variable_2="q_Na_i"/>
        <map_variables variable_1="q_Na_o" variable_2="q_Na_o"/>
        <map_variables variable_1="q_HCO3_i" variable_2="q_HCO3_i"/>
        <map_variables variable_1="q_HCO3_o" variable_2="q_HCO3_o"/>
        <map_variables variable_1="q_H_i" variable_2="q_H_i"/>
        <map_variables variable_1="q_H_o" variable_2="q_H_o"/>
        <map_variables variable_1="v_R61_NBC" variable_2="v_R61_NBC"/>
        <map_variables variable_1="v_R12_NBC" variable_2="v_R12_NBC"/>
        <map_variables variable_1="v_R23_NBC" variable_2="v_R23_NBC"/>
        <map_variables variable_1="v_R34_NBC" variable_2="v_R34_NBC"/>
        <map_variables variable_1="v_R45_NBC" variable_2="v_R45_NBC"/>
        <map_variables variable_1="v_R56_NBC" variable_2="v_R56_NBC"/>
        <map_variables variable_1="v_R61_pHi_NBC" variable_2="v_R61_pHi_NBC"/>
        <map_variables variable_1="v_R12_pHi_NBC" variable_2="v_R12_pHi_NBC"/>
        <map_variables variable_1="v_R23_pHi_NBC" variable_2="v_R23_pHi_NBC"/>
        <map_variables variable_1="v_R34_pHi_NBC" variable_2="v_R34_pHi_NBC"/>
        <map_variables variable_1="v_R45_pHi_NBC" variable_2="v_R45_pHi_NBC"/>
        <map_variables variable_1="v_R56_pHi_NBC" variable_2="v_R56_pHi_NBC"/>
        <map_variables variable_1="v_R61_pHo_NBC" variable_2="v_R61_pHo_NBC"/>
        <map_variables variable_1="v_R12_pHo_NBC" variable_2="v_R12_pHo_NBC"/>
        <map_variables variable_1="v_R23_pHo_NBC" variable_2="v_R23_pHo_NBC"/>
        <map_variables variable_1="v_R34_pHo_NBC" variable_2="v_R34_pHo_NBC"/>
        <map_variables variable_1="v_R45_pHo_NBC" variable_2="v_R45_pHo_NBC"/>
        <map_variables variable_1="v_R56_pHo_NBC" variable_2="v_R56_pHo_NBC"/>
        <map_variables variable_1="ni_NBC" variable_2="ni"/>
        <map_variables variable_1="no_NBC" variable_2="no"/>
    </connection>
    <connection>
        <map_components component_1="environment" component_2="NHE"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="q_H_i" variable_2="q_H_i"/>
        <map_variables variable_1="q_H_o" variable_2="q_H_o"/>
        <map_variables variable_1="q_Na_i" variable_2="q_Na_i"/>
        <map_variables variable_1="q_Na_o" variable_2="q_Na_o"/>
        <map_variables variable_1="v_R61_NHE" variable_2="v_R61_NHE"/>
        <map_variables variable_1="v_R12_NHE" variable_2="v_R12_NHE"/>
        <map_variables variable_1="v_R23_NHE" variable_2="v_R23_NHE"/>
        <map_variables variable_1="v_R34_NHE" variable_2="v_R34_NHE"/>
        <map_variables variable_1="v_R45_NHE" variable_2="v_R45_NHE"/>
        <map_variables variable_1="v_R56_NHE" variable_2="v_R56_NHE"/>
        <map_variables variable_1="v_R61_pHi_NHE" variable_2="v_R61_pHi_NHE"/>
        <map_variables variable_1="v_R12_pHi_NHE" variable_2="v_R12_pHi_NHE"/>
        <map_variables variable_1="v_R23_pHi_NHE" variable_2="v_R23_pHi_NHE"/>
        <map_variables variable_1="v_R34_pHi_NHE" variable_2="v_R34_pHi_NHE"/>
        <map_variables variable_1="v_R45_pHi_NHE" variable_2="v_R45_pHi_NHE"/>
        <map_variables variable_1="v_R56_pHi_NHE" variable_2="v_R56_pHi_NHE"/>
        <map_variables variable_1="ni_NHE" variable_2="ni"/>
    </connection>
    <connection>
        <map_components component_1="environment" component_2="pH_B1"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="q_H_i" variable_2="q_H_i"/>
        <map_variables variable_1="q_B1" variable_2="q_B1"/>
        <map_variables variable_1="q_HB1" variable_2="q_HB1"/>
        <map_variables variable_1="v_Re_B1" variable_2="v_Re_B1"/>
    </connection>
    <connection>
        <map_components component_1="environment" component_2="pH_B2"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="q_H_i" variable_2="q_H_i"/>
        <map_variables variable_1="q_B2" variable_2="q_B2"/>
        <map_variables variable_1="q_HB2" variable_2="q_HB2"/>
        <map_variables variable_1="v_Re_B2" variable_2="v_Re_B2"/>
    </connection>
    <connection>
        <map_components component_1="BG_parameters" component_2="AE"/>
        <map_variables variable_1="kappa_R61_AE" variable_2="kappa_R61_AE"/>
        <map_variables variable_1="kappa_R12_AE" variable_2="kappa_R12_AE"/>
        <map_variables variable_1="kappa_R23_AE" variable_2="kappa_R23_AE"/>
        <map_variables variable_1="kappa_R34_AE" variable_2="kappa_R34_AE"/>
        <map_variables variable_1="kappa_R45_AE" variable_2="kappa_R45_AE"/>
        <map_variables variable_1="kappa_R56_AE" variable_2="kappa_R56_AE"/>
        <map_variables variable_1="kappa_R61_pHi_AE" variable_2="kappa_R61_pHi_AE"/>
        <map_variables variable_1="kappa_R12_pHi_AE" variable_2="kappa_R12_pHi_AE"/>
        <map_variables variable_1="kappa_R23_pHi_AE" variable_2="kappa_R23_pHi_AE"/>
        <map_variables variable_1="kappa_R34_pHi_AE" variable_2="kappa_R34_pHi_AE"/>
        <map_variables variable_1="kappa_R45_pHi_AE" variable_2="kappa_R45_pHi_AE"/>
        <map_variables variable_1="kappa_R56_pHi_AE" variable_2="kappa_R56_pHi_AE"/>
        <map_variables variable_1="kappa_R61_pHo_AE" variable_2="kappa_R61_pHo_AE"/>
        <map_variables variable_1="kappa_R12_pHo_AE" variable_2="kappa_R12_pHo_AE"/>
        <map_variables variable_1="kappa_R23_pHo_AE" variable_2="kappa_R23_pHo_AE"/>
        <map_variables variable_1="kappa_R34_pHo_AE" variable_2="kappa_R34_pHo_AE"/>
        <map_variables variable_1="kappa_R45_pHo_AE" variable_2="kappa_R45_pHo_AE"/>
        <map_variables variable_1="kappa_R56_pHo_AE" variable_2="kappa_R56_pHo_AE"/>
        <map_variables variable_1="K_HCO3_i" variable_2="K_HCO3_i"/>
        <map_variables variable_1="K_HCO3_o" variable_2="K_HCO3_o"/>
        <map_variables variable_1="K_Cl_i" variable_2="K_Cl_i"/>
        <map_variables variable_1="K_Cl_o" variable_2="K_Cl_o"/>
        <map_variables variable_1="K_S1_AE" variable_2="K_S1_AE"/>
        <map_variables variable_1="K_S2_AE" variable_2="K_S2_AE"/>
        <map_variables variable_1="K_S3_AE" variable_2="K_S3_AE"/>
        <map_variables variable_1="K_S4_AE" variable_2="K_S4_AE"/>
        <map_variables variable_1="K_S5_AE" variable_2="K_S5_AE"/>
        <map_variables variable_1="K_S6_AE" variable_2="K_S6_AE"/>
        <map_variables variable_1="K_H_i" variable_2="K_H_i"/>
        <map_variables variable_1="K_H_o" variable_2="K_H_o"/>
    </connection>
    <connection>
        <map_components component_1="BG_parameters" component_2="CHE"/>
        <map_variables variable_1="kappa_R61_CHE" variable_2="kappa_R61_CHE"/>
        <map_variables variable_1="kappa_R12_CHE" variable_2="kappa_R12_CHE"/>
        <map_variables variable_1="kappa_R23_CHE" variable_2="kappa_R23_CHE"/>
        <map_variables variable_1="kappa_R34_CHE" variable_2="kappa_R34_CHE"/>
        <map_variables variable_1="kappa_R45_CHE" variable_2="kappa_R45_CHE"/>
        <map_variables variable_1="kappa_R56_CHE" variable_2="kappa_R56_CHE"/>
        <map_variables variable_1="K_OH_i" variable_2="K_OH_i"/>
        <map_variables variable_1="K_OH_o" variable_2="K_OH_o"/>
        <map_variables variable_1="K_Cl_i" variable_2="K_Cl_i"/>
        <map_variables variable_1="K_Cl_o" variable_2="K_Cl_o"/>
        <map_variables variable_1="K_S1_CHE" variable_2="K_S1_CHE"/>
        <map_variables variable_1="K_S2_CHE" variable_2="K_S2_CHE"/>
        <map_variables variable_1="K_S3_CHE" variable_2="K_S3_CHE"/>
        <map_variables variable_1="K_S4_CHE" variable_2="K_S4_CHE"/>
        <map_variables variable_1="K_S5_CHE" variable_2="K_S5_CHE"/>
        <map_variables variable_1="K_S6_CHE" variable_2="K_S6_CHE"/>
    </connection>
    <connection>
        <map_components component_1="BG_parameters" component_2="CO2_hyd"/>
        <map_variables variable_1="kappa_Re_CO2hyd" variable_2="kappa_Re_CO2hyd"/>
        <map_variables variable_1="K_CO2_i" variable_2="K_CO2_i"/>
        <map_variables variable_1="K_HCO3_i" variable_2="K_HCO3_i"/>
        <map_variables variable_1="K_H_i" variable_2="K_H_i"/>
    </connection>
    <connection>
        <map_components component_1="BG_parameters" component_2="NBC"/>
        <map_variables variable_1="kappa_R61_NBC" variable_2="kappa_R61_NBC"/>
        <map_variables variable_1="kappa_R12_NBC" variable_2="kappa_R12_NBC"/>
        <map_variables variable_1="kappa_R23_NBC" variable_2="kappa_R23_NBC"/>
        <map_variables variable_1="kappa_R34_NBC" variable_2="kappa_R34_NBC"/>
        <map_variables variable_1="kappa_R45_NBC" variable_2="kappa_R45_NBC"/>
        <map_variables variable_1="kappa_R56_NBC" variable_2="kappa_R56_NBC"/>
        <map_variables variable_1="kappa_R61_pHi_NBC" variable_2="kappa_R61_pHi_NBC"/>
        <map_variables variable_1="kappa_R12_pHi_NBC" variable_2="kappa_R12_pHi_NBC"/>
        <map_variables variable_1="kappa_R23_pHi_NBC" variable_2="kappa_R23_pHi_NBC"/>
        <map_variables variable_1="kappa_R34_pHi_NBC" variable_2="kappa_R34_pHi_NBC"/>
        <map_variables variable_1="kappa_R45_pHi_NBC" variable_2="kappa_R45_pHi_NBC"/>
        <map_variables variable_1="kappa_R56_pHi_NBC" variable_2="kappa_R56_pHi_NBC"/>
        <map_variables variable_1="kappa_R61_pHo_NBC" variable_2="kappa_R61_pHo_NBC"/>
        <map_variables variable_1="kappa_R12_pHo_NBC" variable_2="kappa_R12_pHo_NBC"/>
        <map_variables variable_1="kappa_R23_pHo_NBC" variable_2="kappa_R23_pHo_NBC"/>
        <map_variables variable_1="kappa_R34_pHo_NBC" variable_2="kappa_R34_pHo_NBC"/>
        <map_variables variable_1="kappa_R45_pHo_NBC" variable_2="kappa_R45_pHo_NBC"/>
        <map_variables variable_1="kappa_R56_pHo_NBC" variable_2="kappa_R56_pHo_NBC"/>
        <map_variables variable_1="K_Na_i" variable_2="K_Na_i"/>
        <map_variables variable_1="K_Na_o" variable_2="K_Na_o"/>
        <map_variables variable_1="K_HCO3_i" variable_2="K_HCO3_i"/>
        <map_variables variable_1="K_HCO3_o" variable_2="K_HCO3_o"/>
        <map_variables variable_1="K_S1_NBC" variable_2="K_S1_NBC"/>
        <map_variables variable_1="K_S2_NBC" variable_2="K_S2_NBC"/>
        <map_variables variable_1="K_S3_NBC" variable_2="K_S3_NBC"/>
        <map_variables variable_1="K_S4_NBC" variable_2="K_S4_NBC"/>
        <map_variables variable_1="K_S5_NBC" variable_2="K_S5_NBC"/>
        <map_variables variable_1="K_S6_NBC" variable_2="K_S6_NBC"/>
        <map_variables variable_1="K_H_i" variable_2="K_H_i"/>
        <map_variables variable_1="K_H_o" variable_2="K_H_o"/>
    </connection>
    <connection>
        <map_components component_1="BG_parameters" component_2="NHE"/>
        <map_variables variable_1="kappa_R61_NHE" variable_2="kappa_R61_NHE"/>
        <map_variables variable_1="kappa_R12_NHE" variable_2="kappa_R12_NHE"/>
        <map_variables variable_1="kappa_R23_NHE" variable_2="kappa_R23_NHE"/>
        <map_variables variable_1="kappa_R34_NHE" variable_2="kappa_R34_NHE"/>
        <map_variables variable_1="kappa_R45_NHE" variable_2="kappa_R45_NHE"/>
        <map_variables variable_1="kappa_R56_NHE" variable_2="kappa_R56_NHE"/>
        <map_variables variable_1="kappa_R61_pHi_NHE" variable_2="kappa_R61_pHi_NHE"/>
        <map_variables variable_1="kappa_R12_pHi_NHE" variable_2="kappa_R12_pHi_NHE"/>
        <map_variables variable_1="kappa_R23_pHi_NHE" variable_2="kappa_R23_pHi_NHE"/>
        <map_variables variable_1="kappa_R34_pHi_NHE" variable_2="kappa_R34_pHi_NHE"/>
        <map_variables variable_1="kappa_R45_pHi_NHE" variable_2="kappa_R45_pHi_NHE"/>
        <map_variables variable_1="kappa_R56_pHi_NHE" variable_2="kappa_R56_pHi_NHE"/>
        <map_variables variable_1="K_H_i" variable_2="K_H_i"/>
        <map_variables variable_1="K_H_o" variable_2="K_H_o"/>
        <map_variables variable_1="K_Na_i" variable_2="K_Na_i"/>
        <map_variables variable_1="K_Na_o" variable_2="K_Na_o"/>
        <map_variables variable_1="K_S1_NHE" variable_2="K_S1_NHE"/>
        <map_variables variable_1="K_S2_NHE" variable_2="K_S2_NHE"/>
        <map_variables variable_1="K_S3_NHE" variable_2="K_S3_NHE"/>
        <map_variables variable_1="K_S4_NHE" variable_2="K_S4_NHE"/>
        <map_variables variable_1="K_S5_NHE" variable_2="K_S5_NHE"/>
        <map_variables variable_1="K_S6_NHE" variable_2="K_S6_NHE"/>
    </connection>
    <connection>
        <map_components component_1="BG_parameters" component_2="pH_B1"/>
        <map_variables variable_1="kappa_Re_B1" variable_2="kappa_Re_B1"/>
        <map_variables variable_1="K_H_i" variable_2="K_H_i"/>
        <map_variables variable_1="K_B1" variable_2="K_B1"/>
        <map_variables variable_1="K_HB1" variable_2="K_HB1"/>
    </connection>
    <connection>
        <map_components component_1="BG_parameters" component_2="pH_B2"/>
        <map_variables variable_1="kappa_Re_B2" variable_2="kappa_Re_B2"/>
        <map_variables variable_1="K_H_i" variable_2="K_H_i"/>
        <map_variables variable_1="K_B2" variable_2="K_B2"/>
        <map_variables variable_1="K_HB2" variable_2="K_HB2"/>
    </connection>
    <connection>
        <map_components component_1="constants" component_2="AE"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
    </connection>
    <connection>
        <map_components component_1="constants" component_2="CHE"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
    </connection>
    <connection>
        <map_components component_1="constants" component_2="CO2_hyd"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
    </connection>
    <connection>
        <map_components component_1="constants" component_2="NBC"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
    </connection>
    <connection>
        <map_components component_1="constants" component_2="NHE"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
    </connection>
    <connection>
        <map_components component_1="constants" component_2="pH_B1"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
    </connection>
    <connection>
        <map_components component_1="constants" component_2="pH_B2"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
    </connection>
</model>