- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2022-05-13 11:56:11+12:00
- Desc:
- Fixing equations
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/857/rawfile/764c22a661800aa2d3173388426c3b88d31ebc80/yang_sGC.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="sGC_activation" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#">
<units name="per_microM_per_s">
<unit exponent="-1.0" units="micromolar"/>
<unit units="per_s"/>
</units>
<units name="micromolar">
<unit exponent="-1.0" units="litre"/>
<unit prefix="micro" units="mole"/>
</units>
<units name="per_s">
<unit exponent="-1.0" units="second"/>
</units>
<units name="millivolt">
<unit prefix="milli" units="volt"/>
</units>
<units name="per_nM_per_s">
<unit exponent="-1.0" units="nanomolar"/>
<unit units="per_s"/>
</units>
<units name="microM_per_s">
<unit units="micromolar"/>
<unit units="per_s"/>
</units>
<units name="nanomolar">
<unit prefix="nano" units="mole"/>
<unit exponent="-1.0" units="litre"/>
</units>
<units name="nm_per_s">
<unit units="per_s"/>
<unit units="nanomolar"/>
</units>
<component name="environment">
<variable name="time" public_interface="in" units="second"/>
<variable name="E_b" public_interface="in" units="dimensionless"/>
<variable name="E_6c" public_interface="in" units="dimensionless"/>
<variable name="E_5c" public_interface="in" units="dimensionless"/>
<variable initial_value="0.011" name="K_4" public_interface="out" units="per_s"/>
<variable name="m" public_interface="in" units="dimensionless"/>
<variable initial_value="0" name="sGC_activation" public_interface="out" units="micromolar"/>
</component>
<component name="sGC_activation">
<variable initial_value="1" name="E_b" public_interface="out" units="dimensionless"/>
<variable initial_value="0" name="E_6c" public_interface="out" units="dimensionless"/>
<variable initial_value="0" name="E_5c" public_interface="out" units="dimensionless"/>
<variable initial_value="2" name="k_1" units="per_nM_per_s"/>
<variable initial_value="100" name="k_m1" units="per_s"/>
<variable initial_value="0.1" name="k_2" units="per_s"/>
<variable initial_value="0.003" name="k_3" units="per_nM_per_s"/>
<variable name="k_4" units="per_s"/>
<variable initial_value="220" name="NO" units="nanomolar"/>
<variable initial_value="3" name="J_no" units="nm_per_s"/>
<variable initial_value="0.01" name="k_dno" units="per_s"/>
<variable initial_value="0.011" name="K_4" public_interface="out" units="per_s"/>
<variable initial_value="2" name="m" public_interface="out" units="dimensionless"/>
<variable name="cGMP" public_interface="in" units="micromolar"/>
<variable name="E0" units="dimensionless"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>E_b</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<ci>k_1</ci>
</apply>
<ci>E_b</ci>
<ci>NO</ci>
</apply>
<apply>
<times/>
<ci>k_m1</ci>
<ci>E_6c</ci>
</apply>
<apply>
<times/>
<ci>k_4</ci>
<ci>E_5c</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>E_6c</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>k_1</ci>
<ci>E_b</ci>
<ci>NO</ci>
</apply>
<apply>
<times/>
<ci>k_m1</ci>
<ci>E_6c</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_2</ci>
<ci>E_6c</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_3</ci>
<ci>E_6c</ci>
<ci>NO</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>E_5c</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>k_3</ci>
<ci>E_6c</ci>
<ci>NO</ci>
</apply>
<apply>
<times/>
<ci>k_2</ci>
<ci>E_6c</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_4</ci>
<ci>E_5c</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_4</ci>
<apply>
<times/>
<ci>K_4</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>cGMP</ci>
<cn cellml:units="micromolar">1</cn>
</apply>
<ci>m</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>NO</ci>
</apply>
<apply>
<minus/>
<ci>J_no</ci>
<apply>
<times/>
<ci>k_dno</ci>
<ci>NO</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E0</ci>
<apply>
<plus/>
<ci>E_b</ci>
<ci>E_6c</ci>
<ci>E_5c</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="environment" component_2="sGC_activation"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="E_b" variable_2="E_b"/>
<map_variables variable_1="E_5c" variable_2="E_5c"/>
<map_variables variable_1="E_6c" variable_2="E_6c"/>
<map_variables variable_1="K_4" variable_2="K_4"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="sGC_activation" variable_2="sGC_activation"/>
</connection>
</model>
