Location: BG_Ca_leak @ 3027d789e7b5 / parameter_finder / output / TEMP.cellml.txt

Author:

Shelley Fong <s.fong@auckland.ac.nz>

Date:

2022-04-28 11:07:01+12:00

Desc:

Updating with Kernik stuff

Permanent Source URI:

https://models.physiomeproject.org/workspace/835/rawfile/3027d789e7b520983200af71015fd49f6c3851eb/parameter_finder/output/TEMP.cellml.txt

def model individual_Ca_leak as
 def import using "units_and_constants/units_BG.cellml" for
        unit mM using unit mM;
unit fmol using unit fmol;
unit per_fmol using unit per_fmol;
        unit J_per_mol using unit J_per_mol;
unit fmol_per_sec using unit fmol_per_sec;
        unit C_per_mol using unit C_per_mol;
  unit J_per_C using unit J_per_C;
        unit microm3 using unit microm3;
  unit fF using unit fF;
        unit fC using unit fC;
  unit fA using unit fA;
        unit per_second using unit per_second;
  unit millivolt using unit millivolt;
        unit per_sec using unit per_sec;
  unit J_per_K_per_mol using unit J_per_K_per_mol;
        unit fmol_per_L using unit fmol_per_L;
  unit fmol_per_L_per_sec using unit fmol_per_L_per_sec;
        unit per_sec_per_fmol_per_L using unit per_sec_per_fmol_per_L;
  unit uM using unit uM;
        unit mM_per_sec using unit mM_per_sec;
  unit uM_per_sec using unit uM_per_sec;
        unit pL using unit pL;
  unit m_to_u using unit m_to_u;
 enddef;
def import using "units_and_constants/constants_BG.cellml" for
            comp constants using comp constants;
enddef;

    def comp environment as
    var time: second {pub: out};
    // initial values
var q_Ca_SR: fmol {init: 1e-888, pub: out};
var q_Ca_i: fmol {init: 1e-888, pub: out};
// From submodule
var v_leak: fmol_per_sec {pub: in};
ode(q_Ca_SR, time) = vvv;
ode(q_Ca_i, time) = vvv;
enddef;

def comp Ca_leak_parameters as
var kappa_leak: fmol_per_sec {init: 0.000136798, pub: out};
var K_Ca_SR: per_fmol {init: 0.052543, pub: out};
var K_Ca_i: per_fmol {init: 0.00315258, pub: out};
enddef;
def comp Ca_leak as
        var time: second {pub: in};
        var R: J_per_K_per_mol {pub: in};
        var T: kelvin {pub: in};
        // parameters
var kappa_leak: fmol_per_sec {pub: in};
var K_Ca_SR: per_fmol {pub: in};
var K_Ca_i: per_fmol {pub: in};
// Input from global environment
var q_Ca_SR: fmol {pub: in};
var q_Ca_i: fmol {pub: in};
// Constitutive parameters
var mu_Ca_SR: J_per_mol;
var mu_Ca_i: J_per_mol;
var v_leak: fmol_per_sec {pub: out};
mu_Ca_SR = R*T*ln(K_Ca_SR*q_Ca_SR);
mu_Ca_i = R*T*ln(K_Ca_i*q_Ca_i);
v_leak = ppp;
enddef;
def map between environment and Ca_leak for
vars time and time;
vars q_Ca_SR and q_Ca_SR;
vars q_Ca_i and q_Ca_i;
vars v_leak and v_leak;
enddef;
def map between Ca_leak and Ca_leak_parameters for
vars kappa_leak and kappa_leak;
vars K_Ca_SR and K_Ca_SR;
vars K_Ca_i and K_Ca_i;
enddef;
def map between constants and Ca_leak for
vars R and R;
 vars T and T;
enddef;
enddef;