Location: BG_Ks @ ef4b8640984c / BG_Ks.cellml

Author:
Shelley Fong <s.fong@auckland.ac.nz>
Date:
2022-04-08 14:02:01+12:00
Desc:
Fitting to kinetic hybrid model of LRd + Kernik
Permanent Source URI:
https://models.physiomeproject.org/workspace/82d/rawfile/ef4b8640984c620ac0534355377346919cffdeb6/BG_Ks.cellml

<?xml version='1.0' encoding='UTF-8'?>
<!-- slow delayed rectifier (potassium) 1
 gate variables
 S_Ks00: xs_10 xs_20
 S_Ks01: xs_11 xs_20
 S_Ks10: xs_10 xs_21
 S_Ks11: xs_11 xs_21
 gate variable transitions
 xs1: a to b
 xs2: c to d
 xs3: a to c
 xs4: b to d-->
<model name="BG_Ks_model" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
    <import xlink:href="units_and_constants/units_BG.cellml">
        <units name="mM" units_ref="mM"/>
        <units name="fmol" units_ref="fmol"/>
        <units name="per_fmol" units_ref="per_fmol"/>
        <units name="J_per_mol" units_ref="J_per_mol"/>
        <units name="J_per_K_per_mol" units_ref="J_per_K_per_mol"/>
        <units name="fmol_per_sec" units_ref="fmol_per_sec"/>
        <units name="C_per_mol" units_ref="C_per_mol"/>
        <units name="J_per_C" units_ref="J_per_C"/>
        <units name="fF" units_ref="fF"/>
        <units name="fC" units_ref="fC"/>
        <units name="fA" units_ref="fA"/>
    </import>
    <component name="environment">
        <variable name="time" public_interface="out" units="second"/>
        <variable initial_value="153400" name="C_m" public_interface="out" units="fF"/>
        <variable initial_value="27.9828" name="q_K_o" public_interface="out" units="fmol"/>
        <variable initial_value="5510" name="q_K_i" public_interface="out" units="fmol"/>
        <variable initial_value="-8.5e4" name="q_mem" public_interface="out" units="fC"/>
        <variable name="Vmem" units="volt"/>
        <variable initial_value="8.31" name="R" public_interface="out" units="J_per_K_per_mol"/>
        <variable initial_value="310" name="T" public_interface="out" units="kelvin"/>
        <variable initial_value="96500" name="F" public_interface="out" units="C_per_mol"/>
        <variable name="v_Ks" public_interface="in" units="fmol_per_sec"/>
        <variable name="I_mem_Ks" public_interface="in" units="fA"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_K_i</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_Ks</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_K_o</ci>
                </apply>
                <ci>v_Ks</ci>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_mem</ci>
                </apply>
                <ci>I_mem_Ks</ci>
            </apply>
            <apply>
                <eq/>
                <ci>Vmem</ci>
                <apply>
                    <divide/>
                    <ci>q_mem</ci>
                    <ci>C_m</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Ks_parameters">
        <variable initial_value="562.081" name="kappa_Ks" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.0131575" name="kappa_xs1" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.0469146" name="kappa_xs2" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.0131575" name="kappa_xs3" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.0469146" name="kappa_xs4" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.689193" name="K_K_i" public_interface="out" units="per_fmol"/>
        <variable initial_value="4.57511" name="K_K_o" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.0885882" name="K_S_Ks00" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.0248451" name="K_S_Ks01" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.0248451" name="K_S_Ks10" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.00696797" name="K_S_Ks11" public_interface="out" units="per_fmol"/>
        <variable initial_value="1" name="zK" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.000400323747581994" name="z_xs_f" public_interface="out" units="dimensionless"/>
        <variable initial_value="-1.41544821457997" name="z_xs_r" public_interface="out" units="dimensionless"/>
    </component>
    <component name="Ks">
        <variable name="t" private_interface="out" public_interface="in" units="second"/>
        <variable name="R" public_interface="in" units="J_per_K_per_mol"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <variable name="F" private_interface="out" public_interface="in" units="C_per_mol"/>
        <variable name="C_m" public_interface="in" units="fF"/>
        <!-- Parameters-->
        <!-- overall ion permeability (GHK) is kappa_{ion}-->
        <variable name="kappa_Ks" public_interface="in" units="fmol_per_sec"/>
        <variable name="K_K_o" public_interface="in" units="per_fmol"/>
        <variable name="K_K_i" public_interface="in" units="per_fmol"/>
        <!-- state variables-->
        <variable name="q_K_i" public_interface="in" units="fmol"/>
        <variable name="q_K_o" public_interface="in" units="fmol"/>
        <variable name="q_mem" public_interface="in" units="fC"/>
        <variable name="v_Ks" public_interface="out" units="fmol_per_sec"/>
        <variable name="I_mem_Ks" public_interface="out" units="fA"/>
        <variable name="u_K_i" units="J_per_mol"/>
        <variable name="u_K_o" units="J_per_mol"/>
        <variable name="V_mem" private_interface="out" units="J_per_C"/>
        <variable name="Am_Ks" units="J_per_mol"/>
        <variable name="Af_Ks" units="J_per_mol"/>
        <variable name="Ar_Ks" units="J_per_mol"/>
        <variable name="zK" public_interface="in" units="dimensionless"/>
        <!-- Conservation laws-->
        <!-- Constitutive relations - Convention: positive flow from inside to outside-->
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>Am_Ks</ci>
                <apply>
                    <times/>
                    <ci>zK</ci>
                    <ci>F</ci>
                    <ci>V_mem</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>u_K_i</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_K_i</ci>
                            <ci>q_K_i</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>u_K_o</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_K_o</ci>
                            <ci>q_K_o</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Af_Ks</ci>
                <apply>
                    <plus/>
                    <ci>mu_S_Ks11</ci>
                    <ci>u_K_i</ci>
                    <ci>Am_Ks</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Ar_Ks</ci>
                <apply>
                    <plus/>
                    <ci>mu_S_Ks11</ci>
                    <ci>u_K_o</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_Ks</ci>
                <piecewise>
                    <piece>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">1</cn>
                            <ci>kappa_Ks</ci>
                            <apply>
                                <minus/>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <divide/>
                                        <ci>Af_Ks</ci>
                                        <apply>
                                            <times/>
                                            <ci>R</ci>
                                            <ci>T</ci>
                                        </apply>
                                    </apply>
                                </apply>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <divide/>
                                        <ci>Ar_Ks</ci>
                                        <apply>
                                            <times/>
                                            <ci>R</ci>
                                            <ci>T</ci>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <eq/>
                            <ci>Am_Ks</ci>
                            <cn cellml:units="J_per_mol">0</cn>
                        </apply>
                    </piece>
                    <otherwise>
                        <apply>
                            <times/>
                            <apply>
                                <divide/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <times/>
                                        <cn cellml:units="dimensionless">1</cn>
                                        <ci>kappa_Ks</ci>
                                        <ci>Am_Ks</ci>
                                    </apply>
                                    <apply>
                                        <times/>
                                        <ci>R</ci>
                                        <ci>T</ci>
                                    </apply>
                                </apply>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <exp/>
                                        <apply>
                                            <divide/>
                                            <ci>Am_Ks</ci>
                                            <apply>
                                                <times/>
                                                <ci>R</ci>
                                                <ci>T</ci>
                                            </apply>
                                        </apply>
                                    </apply>
                                    <cn cellml:units="dimensionless">1</cn>
                                </apply>
                            </apply>
                            <apply>
                                <minus/>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <divide/>
                                        <ci>Af_Ks</ci>
                                        <apply>
                                            <times/>
                                            <ci>R</ci>
                                            <ci>T</ci>
                                        </apply>
                                    </apply>
                                </apply>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <divide/>
                                        <ci>Ar_Ks</ci>
                                        <apply>
                                            <times/>
                                            <ci>R</ci>
                                            <ci>T</ci>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <ci>V_mem</ci>
                <apply>
                    <divide/>
                    <ci>q_mem</ci>
                    <ci>C_m</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_mem_Ks</ci>
                <apply>
                    <times/>
                    <ci>F</ci>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <ci>zK</ci>
                            </apply>
                            <ci>v_Ks</ci>
                        </apply>
                        <apply>
                            <times/>
                            <apply>
                                <plus/>
                                <ci>v_xs1</ci>
                                <ci>v_xs2</ci>
                                <ci>v_xs3</ci>
                                <ci>v_xs4</ci>
                            </apply>
                            <apply>
                                <minus/>
                                <ci>z_xs_r</ci>
                                <ci>z_xs_f</ci>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
        <!-- GATE
 channel states variables
        xs00
        xs01
        xs10
        xs11-->
        <variable name="v_S_Ks00" units="fmol_per_sec"/>
        <variable name="v_S_Ks01" units="fmol_per_sec"/>
        <variable name="v_S_Ks10" units="fmol_per_sec"/>
        <variable name="v_S_Ks11" units="fmol_per_sec"/>
        <!-- gate variable transitions
 R1: 00 to 01
 R2: 10 to 11
 R3: 00 to 10
 R4: 01 to 11-->
        <variable name="v_xs1" units="fmol_per_sec"/>
        <variable name="v_xs2" units="fmol_per_sec"/>
        <variable name="v_xs3" units="fmol_per_sec"/>
        <variable name="v_xs4" units="fmol_per_sec"/>
        <variable name="mu_S_Ks00" units="J_per_mol"/>
        <variable name="mu_S_Ks01" units="J_per_mol"/>
        <variable name="mu_S_Ks10" units="J_per_mol"/>
        <variable name="mu_S_Ks11" units="J_per_mol"/>
        <!-- forward/reverse affinities at each reaction-->
        <variable name="Af_xs1" units="J_per_mol"/>
        <variable name="Ar_xs1" units="J_per_mol"/>
        <variable name="Af_xs2" units="J_per_mol"/>
        <variable name="Ar_xs2" units="J_per_mol"/>
        <variable name="Af_xs3" units="J_per_mol"/>
        <variable name="Ar_xs3" units="J_per_mol"/>
        <variable name="Af_xs4" units="J_per_mol"/>
        <variable name="Ar_xs4" units="J_per_mol"/>
        <!-- gating variables-->
        <variable name="kappa_xs1" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_xs2" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_xs3" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_xs4" public_interface="in" units="fmol_per_sec"/>
        <variable name="K_S_Ks00" public_interface="in" units="per_fmol"/>
        <variable name="K_S_Ks01" public_interface="in" units="per_fmol"/>
        <variable name="K_S_Ks10" public_interface="in" units="per_fmol"/>
        <variable name="K_S_Ks11" public_interface="in" units="per_fmol"/>
        <variable name="z_xs_f" public_interface="in" units="dimensionless"/>
        <variable name="z_xs_r" public_interface="in" units="dimensionless"/>
        <variable initial_value="0.999997" name="q_S_Ks00" units="fmol"/>
        <variable initial_value="1e-6" name="q_S_Ks01" units="fmol"/>
        <variable initial_value="1e-6" name="q_S_Ks10" units="fmol"/>
        <variable initial_value="1e-6" name="q_S_Ks11" units="fmol"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>Af_xs1</ci>
                <apply>
                    <plus/>
                    <ci>mu_S_Ks00</ci>
                    <apply>
                        <times/>
                        <ci>z_xs_f</ci>
                        <ci>F</ci>
                        <ci>V_mem</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Ar_xs1</ci>
                <apply>
                    <plus/>
                    <ci>mu_S_Ks01</ci>
                    <apply>
                        <times/>
                        <ci>z_xs_r</ci>
                        <ci>F</ci>
                        <ci>V_mem</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Af_xs2</ci>
                <apply>
                    <plus/>
                    <ci>mu_S_Ks10</ci>
                    <apply>
                        <times/>
                        <ci>z_xs_f</ci>
                        <ci>F</ci>
                        <ci>V_mem</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Ar_xs2</ci>
                <apply>
                    <plus/>
                    <ci>mu_S_Ks11</ci>
                    <apply>
                        <times/>
                        <ci>z_xs_r</ci>
                        <ci>F</ci>
                        <ci>V_mem</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Af_xs3</ci>
                <apply>
                    <plus/>
                    <ci>mu_S_Ks00</ci>
                    <apply>
                        <times/>
                        <ci>z_xs_f</ci>
                        <ci>F</ci>
                        <ci>V_mem</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Ar_xs3</ci>
                <apply>
                    <plus/>
                    <ci>mu_S_Ks10</ci>
                    <apply>
                        <times/>
                        <ci>z_xs_r</ci>
                        <ci>F</ci>
                        <ci>V_mem</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Af_xs4</ci>
                <apply>
                    <plus/>
                    <ci>mu_S_Ks01</ci>
                    <apply>
                        <times/>
                        <ci>z_xs_f</ci>
                        <ci>F</ci>
                        <ci>V_mem</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Ar_xs4</ci>
                <apply>
                    <plus/>
                    <ci>mu_S_Ks11</ci>
                    <apply>
                        <times/>
                        <ci>z_xs_r</ci>
                        <ci>F</ci>
                        <ci>V_mem</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_xs1</ci>
                <apply>
                    <times/>
                    <ci>kappa_xs1</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>Af_xs1</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>Ar_xs1</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_xs2</ci>
                <apply>
                    <times/>
                    <ci>kappa_xs2</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>Af_xs2</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>Ar_xs2</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_xs3</ci>
                <apply>
                    <times/>
                    <ci>kappa_xs3</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>Af_xs3</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>Ar_xs3</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_xs4</ci>
                <apply>
                    <times/>
                    <ci>kappa_xs4</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>Af_xs4</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>Ar_xs4</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_S_Ks00</ci>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <ci>v_xs1</ci>
                    </apply>
                    <ci>v_xs3</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_S_Ks01</ci>
                <apply>
                    <minus/>
                    <ci>v_xs1</ci>
                    <ci>v_xs4</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_S_Ks10</ci>
                <apply>
                    <minus/>
                    <ci>v_xs3</ci>
                    <ci>v_xs2</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_S_Ks11</ci>
                <apply>
                    <plus/>
                    <ci>v_xs2</ci>
                    <ci>v_xs4</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_S_Ks00</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_S_Ks00</ci>
                            <ci>q_S_Ks00</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_S_Ks01</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_S_Ks01</ci>
                            <ci>q_S_Ks01</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_S_Ks10</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_S_Ks10</ci>
                            <ci>q_S_Ks10</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_S_Ks11</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_S_Ks11</ci>
                            <ci>q_S_Ks11</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>t</ci>
                    </bvar>
                    <ci>q_S_Ks00</ci>
                </apply>
                <ci>v_S_Ks00</ci>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>t</ci>
                    </bvar>
                    <ci>q_S_Ks01</ci>
                </apply>
                <ci>v_S_Ks01</ci>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>t</ci>
                    </bvar>
                    <ci>q_S_Ks10</ci>
                </apply>
                <ci>v_S_Ks10</ci>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>t</ci>
                    </bvar>
                    <ci>q_S_Ks11</ci>
                </apply>
                <ci>v_S_Ks11</ci>
            </apply>
        </math>
    </component>
    <connection>
        <map_components component_1="environment" component_2="Ks"/>
        <map_variables variable_1="time" variable_2="t"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
        <map_variables variable_1="F" variable_2="F"/>
        <map_variables variable_1="q_K_i" variable_2="q_K_i"/>
        <map_variables variable_1="q_K_o" variable_2="q_K_o"/>
        <map_variables variable_1="q_mem" variable_2="q_mem"/>
        <map_variables variable_1="C_m" variable_2="C_m"/>
        <map_variables variable_1="v_Ks" variable_2="v_Ks"/>
        <map_variables variable_1="I_mem_Ks" variable_2="I_mem_Ks"/>
    </connection>
    <connection>
        <map_components component_1="Ks" component_2="Ks_parameters"/>
        <map_variables variable_1="kappa_Ks" variable_2="kappa_Ks"/>
        <map_variables variable_1="K_K_o" variable_2="K_K_o"/>
        <map_variables variable_1="K_K_i" variable_2="K_K_i"/>
        <map_variables variable_1="kappa_xs1" variable_2="kappa_xs1"/>
        <map_variables variable_1="kappa_xs2" variable_2="kappa_xs2"/>
        <map_variables variable_1="kappa_xs3" variable_2="kappa_xs3"/>
        <map_variables variable_1="kappa_xs4" variable_2="kappa_xs4"/>
        <map_variables variable_1="K_S_Ks00" variable_2="K_S_Ks00"/>
        <map_variables variable_1="K_S_Ks01" variable_2="K_S_Ks01"/>
        <map_variables variable_1="K_S_Ks10" variable_2="K_S_Ks10"/>
        <map_variables variable_1="K_S_Ks11" variable_2="K_S_Ks11"/>
        <map_variables variable_1="z_xs_f" variable_2="z_xs_f"/>
        <map_variables variable_1="z_xs_r" variable_2="z_xs_r"/>
        <map_variables variable_1="zK" variable_2="zK"/>
    </connection>
</model>