- Author:
- Shelley Fong <s.fong@auckland.ac.nz>
- Date:
- 2022-04-11 15:56:51+12:00
- Desc:
- Changing method of number of channels present. Guess density. Using SA of human iPSC for Kernik. Updating volumes
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/829/rawfile/79f3fe1243b62cc28c220fdbd93b1c4fe64dd159/BG_TRPN_buffer.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="cardiac_AP_TRPN_only" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="units_and_constants/units_BG.cellml">
<units name="fmol" units_ref="fmol"/>
<units name="per_fmol" units_ref="per_fmol"/>
<units name="J_per_mol" units_ref="J_per_mol"/>
<units name="fmol_per_sec" units_ref="fmol_per_sec"/>
<units name="C_per_mol" units_ref="C_per_mol"/>
<units name="J_per_C" units_ref="J_per_C"/>
<units name="fF" units_ref="fF"/>
<units name="fC" units_ref="fC"/>
<units name="fA" units_ref="fA"/>
<units name="per_second" units_ref="per_second"/>
<units name="per_sec" units_ref="per_sec"/>
<units name="J_per_K_per_mol" units_ref="J_per_K_per_mol"/>
<units name="fmol_per_L" units_ref="fmol_per_L"/>
<units name="fmol_per_L_per_sec" units_ref="fmol_per_L_per_sec"/>
<units name="per_sec_per_fmol_per_L" units_ref="per_sec_per_fmol_per_L"/>
<units name="pL" units_ref="pL"/>
</import>
<component name="environment">
<variable initial_value="0" name="t" public_interface="out" units="second"/>
<variable initial_value="8.314" name="R" public_interface="out" units="J_per_K_per_mol"/>
<variable initial_value="310" name="T" public_interface="out" units="kelvin"/>
<variable initial_value="96485" name="F" public_interface="out" units="C_per_mol"/>
<variable initial_value="153400" name="C_m" public_interface="out" units="fF"/>
<variable initial_value="0.00456" name="q_Ca_i" public_interface="out" units="fmol"/>
<variable initial_value="2.1452" name="q_TRPN" public_interface="out" units="fmol"/>
<variable initial_value="0.51484" name="q_TRPN_Ca" public_interface="out" units="fmol"/>
<variable name="v_b1" public_interface="in" units="fmol_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_TRPN</ci>
</apply>
<apply>
<minus/>
<ci>v_b1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_TRPN_Ca</ci>
</apply>
<ci>v_b1</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_Ca_i</ci>
</apply>
<apply>
<minus/>
<ci>v_b1</ci>
</apply>
</apply>
</math>
</component>
<component name="TRPN_parameters">
<variable initial_value="0.022218" name="K_Ca_i" public_interface="out" units="per_fmol"/>
<variable initial_value="37.1165" name="K_TRPN" public_interface="out" units="per_fmol"/>
<variable initial_value="0.015668" name="K_TRPN_Ca" public_interface="out" units="per_fmol"/>
<variable initial_value="839.7697" name="kappa_b1" public_interface="out" units="fmol_per_sec"/>
</component>
<component name="TRPN_buffer">
<variable name="t" public_interface="in" units="second"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="K_TRPN" public_interface="in" units="per_fmol"/>
<variable name="K_TRPN_Ca" public_interface="in" units="per_fmol"/>
<variable name="K_Ca_i" public_interface="in" units="per_fmol"/>
<variable name="kappa_b1" public_interface="in" units="fmol_per_sec"/>
<variable name="q_TRPN" public_interface="in" units="fmol"/>
<variable name="q_TRPN_Ca" public_interface="in" units="fmol"/>
<variable name="q_Ca_i" public_interface="in" units="fmol"/>
<variable name="mu_TRPN" units="J_per_mol"/>
<variable name="mu_TRPN_Ca" units="J_per_mol"/>
<variable name="mu_Ca_i" units="J_per_mol"/>
<variable name="Af_b1" units="J_per_mol"/>
<variable name="Ar_b1" units="J_per_mol"/>
<variable name="v_b1" public_interface="out" units="fmol_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>mu_TRPN</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_TRPN</ci>
<ci>q_TRPN</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_TRPN_Ca</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_TRPN_Ca</ci>
<ci>q_TRPN_Ca</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Ca_i</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Ca_i</ci>
<ci>q_Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_b1</ci>
<apply>
<times/>
<ci>kappa_b1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_b1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_b1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_b1</ci>
<apply>
<plus/>
<ci>mu_Ca_i</ci>
<ci>mu_TRPN</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_b1</ci>
<ci>mu_TRPN_Ca</ci>
</apply>
</math>
</component>
<connection>
<map_components component_1="TRPN_buffer" component_2="TRPN_parameters"/>
<map_variables variable_1="K_TRPN" variable_2="K_TRPN"/>
<map_variables variable_1="K_TRPN_Ca" variable_2="K_TRPN_Ca"/>
<map_variables variable_1="K_Ca_i" variable_2="K_Ca_i"/>
<map_variables variable_1="kappa_b1" variable_2="kappa_b1"/>
</connection>
<connection>
<map_components component_1="TRPN_buffer" component_2="environment"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="q_TRPN" variable_2="q_TRPN"/>
<map_variables variable_1="q_TRPN_Ca" variable_2="q_TRPN_Ca"/>
<map_variables variable_1="q_Ca_i" variable_2="q_Ca_i"/>
<map_variables variable_1="v_b1" variable_2="v_b1"/>
</connection>
</model>
