- Author:
- Shelley Fong <s.fong@auckland.ac.nz>
- Date:
- 2022-04-20 11:21:33+12:00
- Desc:
- storing gate particle number in comp environment
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/828/rawfile/7f4a0a947226d62246af5497cec3a3d315050674/BG_NCX.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="cardiac_AP_NCX_only" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="units_and_constants/units_BG.cellml">
<units name="mM" units_ref="mM"/>
<units name="fmol" units_ref="fmol"/>
<units name="per_fmol" units_ref="per_fmol"/>
<units name="J_per_mol" units_ref="J_per_mol"/>
<units name="fmol_per_sec" units_ref="fmol_per_sec"/>
<units name="C_per_mol" units_ref="C_per_mol"/>
<units name="J_per_C" units_ref="J_per_C"/>
<units name="J_per_K_per_mol" units_ref="J_per_K_per_mol"/>
<units name="fF" units_ref="fF"/>
<units name="fC" units_ref="fC"/>
<units name="fA" units_ref="fA"/>
</import>
<component name="environment">
<variable initial_value="0" name="t" public_interface="out" units="second"/>
<variable initial_value="8.314" name="R" public_interface="out" units="J_per_K_per_mol"/>
<variable initial_value="310" name="T" public_interface="out" units="kelvin"/>
<variable initial_value="96485" name="F" public_interface="out" units="C_per_mol"/>
<variable initial_value="153400" name="C_m" public_interface="out" units="fF"/>
<variable initial_value="9.3276" name="q_Ca_o" public_interface="out" units="fmol"/>
<variable initial_value="0.00456" name="q_Ca_i" public_interface="out" units="fmol"/>
<variable initial_value="725.48" name="q_Na_o" public_interface="out" units="fmol"/>
<variable initial_value="380" name="q_Na_i" public_interface="out" units="fmol"/>
<variable initial_value="0.000103509" name="q_P1_NCX" public_interface="out" units="fmol"/>
<variable initial_value="0.000103509" name="q_P2_NCX" public_interface="out" units="fmol"/>
<variable initial_value="0.000103509" name="q_P3_NCX" public_interface="out" units="fmol"/>
<variable initial_value="0.000103509" name="q_P4_NCX" public_interface="out" units="fmol"/>
<variable initial_value="0.000103509" name="q_P5_NCX" public_interface="out" units="fmol"/>
<variable initial_value="0.000103509" name="q_P6_NCX" public_interface="out" units="fmol"/>
<variable name="v_Ca_o_NCX" public_interface="in" units="fmol_per_sec"/>
<variable name="v_Ca_i_NCX" public_interface="in" units="fmol_per_sec"/>
<variable name="v_Na_o_NCX" public_interface="in" units="fmol_per_sec"/>
<variable name="v_Na_i_NCX" public_interface="in" units="fmol_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
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<ci>t</ci>
</bvar>
<ci>q_Ca_o</ci>
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</apply>
<apply>
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<diff/>
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<ci>t</ci>
</bvar>
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<apply>
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<diff/>
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<ci>t</ci>
</bvar>
<ci>q_Na_i</ci>
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</apply>
</math>
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<variable name="I_mem_NCX" public_interface="in" units="fA"/>
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</bvar>
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</apply>
<ci>I_mem_NCX</ci>
</apply>
</math>
</component>
<component name="NCX_parameters">
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<variable initial_value="407.3479" name="K_2_NCX" public_interface="out" units="per_fmol"/>
<variable initial_value="22191.7214" name="K_3_NCX" public_interface="out" units="per_fmol"/>
<variable initial_value="119580.5289" name="K_4_NCX" public_interface="out" units="per_fmol"/>
<variable initial_value="10363474.1803" name="K_5_NCX" public_interface="out" units="per_fmol"/>
<variable initial_value="199.44" name="K_6_NCX" public_interface="out" units="per_fmol"/>
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<variable initial_value="0.022218" name="K_Ca_i" public_interface="out" units="per_fmol"/>
<variable initial_value="0.017678" name="K_Na_o" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0024108" name="K_Na_i" public_interface="out" units="per_fmol"/>
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<variable initial_value="6834.2872" name="kappa_3_NCX" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="21141816.1231" name="kappa_4_NCX" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="256862.245" name="kappa_5_NCX" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1.7753" name="kappa_6_NCX" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="3" name="nNa_o_NCX" public_interface="out" units="dimensionless"/>
<variable initial_value="3" name="nNa_i_NCX" public_interface="out" units="dimensionless"/>
<variable initial_value="-0.55679" name="zf_NCX" public_interface="out" units="dimensionless"/>
<variable initial_value="0.44321" name="zr_NCX" public_interface="out" units="dimensionless"/>
</component>
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<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable name="C_m" public_interface="in" units="fF"/>
<variable name="K_1_NCX" public_interface="in" units="per_fmol"/>
<variable name="K_2_NCX" public_interface="in" units="per_fmol"/>
<variable name="K_3_NCX" public_interface="in" units="per_fmol"/>
<variable name="K_4_NCX" public_interface="in" units="per_fmol"/>
<variable name="K_5_NCX" public_interface="in" units="per_fmol"/>
<variable name="K_6_NCX" public_interface="in" units="per_fmol"/>
<variable name="K_Ca_o" public_interface="in" units="per_fmol"/>
<variable name="K_Ca_i" public_interface="in" units="per_fmol"/>
<variable name="K_Na_o" public_interface="in" units="per_fmol"/>
<variable name="K_Na_i" public_interface="in" units="per_fmol"/>
<variable name="kappa_1_NCX" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_2_NCX" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_3_NCX" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_4_NCX" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_5_NCX" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_6_NCX" public_interface="in" units="fmol_per_sec"/>
<variable name="nNa_o_NCX" public_interface="in" units="dimensionless"/>
<variable name="nNa_i_NCX" public_interface="in" units="dimensionless"/>
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<variable name="zr_NCX" public_interface="in" units="dimensionless"/>
<variable name="q_Ca_o" public_interface="in" units="fmol"/>
<variable name="q_Ca_i" public_interface="in" units="fmol"/>
<variable name="q_Na_o" public_interface="in" units="fmol"/>
<variable name="q_Na_i" public_interface="in" units="fmol"/>
<variable name="q_P1_NCX" public_interface="in" units="fmol"/>
<variable name="q_P2_NCX" public_interface="in" units="fmol"/>
<variable name="q_P3_NCX" public_interface="in" units="fmol"/>
<variable name="q_P4_NCX" public_interface="in" units="fmol"/>
<variable name="q_P5_NCX" public_interface="in" units="fmol"/>
<variable name="q_P6_NCX" public_interface="in" units="fmol"/>
<variable name="q_mem" public_interface="in" units="fC"/>
<variable name="mu_Ca_o" units="J_per_mol"/>
<variable name="mu_Ca_i" units="J_per_mol"/>
<variable name="mu_Na_o" units="J_per_mol"/>
<variable name="mu_Na_i" units="J_per_mol"/>
<variable name="mu_P1_NCX" units="J_per_mol"/>
<variable name="mu_P2_NCX" units="J_per_mol"/>
<variable name="mu_P3_NCX" units="J_per_mol"/>
<variable name="mu_P4_NCX" units="J_per_mol"/>
<variable name="mu_P5_NCX" units="J_per_mol"/>
<variable name="mu_P6_NCX" units="J_per_mol"/>
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<variable name="v_Na_o_NCX" public_interface="out" units="fmol_per_sec"/>
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<eq/>
<ci>v_P2_NCX</ci>
<apply>
<minus/>
<ci>v_r1</ci>
<ci>v_r2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_P3_NCX</ci>
<apply>
<minus/>
<ci>v_r2</ci>
<ci>v_r3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_P4_NCX</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_r4</ci>
</apply>
<ci>v_r3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_P5_NCX</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_r5</ci>
</apply>
<ci>v_r4</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_P6_NCX</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_r6</ci>
</apply>
<ci>v_r5</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_P1_NCX</ci>
</apply>
<ci>v_P1_NCX</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_P2_NCX</ci>
</apply>
<ci>v_P2_NCX</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_P3_NCX</ci>
</apply>
<ci>v_P3_NCX</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_P4_NCX</ci>
</apply>
<ci>v_P4_NCX</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_P5_NCX</ci>
</apply>
<ci>v_P5_NCX</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_P6_NCX</ci>
</apply>
<ci>v_P6_NCX</ci>
</apply>
</math>
</component>
<connection>
<map_components component_1="NCX" component_2="NCX_parameters"/>
<map_variables variable_1="K_1_NCX" variable_2="K_1_NCX"/>
<map_variables variable_1="K_2_NCX" variable_2="K_2_NCX"/>
<map_variables variable_1="K_3_NCX" variable_2="K_3_NCX"/>
<map_variables variable_1="K_4_NCX" variable_2="K_4_NCX"/>
<map_variables variable_1="K_5_NCX" variable_2="K_5_NCX"/>
<map_variables variable_1="K_6_NCX" variable_2="K_6_NCX"/>
<map_variables variable_1="K_Ca_o" variable_2="K_Ca_o"/>
<map_variables variable_1="K_Ca_i" variable_2="K_Ca_i"/>
<map_variables variable_1="K_Na_o" variable_2="K_Na_o"/>
<map_variables variable_1="K_Na_i" variable_2="K_Na_i"/>
<map_variables variable_1="kappa_1_NCX" variable_2="kappa_1_NCX"/>
<map_variables variable_1="kappa_2_NCX" variable_2="kappa_2_NCX"/>
<map_variables variable_1="kappa_3_NCX" variable_2="kappa_3_NCX"/>
<map_variables variable_1="kappa_4_NCX" variable_2="kappa_4_NCX"/>
<map_variables variable_1="kappa_5_NCX" variable_2="kappa_5_NCX"/>
<map_variables variable_1="kappa_6_NCX" variable_2="kappa_6_NCX"/>
<map_variables variable_1="nNa_o_NCX" variable_2="nNa_o_NCX"/>
<map_variables variable_1="nNa_i_NCX" variable_2="nNa_i_NCX"/>
<map_variables variable_1="zf_NCX" variable_2="zf_NCX"/>
<map_variables variable_1="zr_NCX" variable_2="zr_NCX"/>
</connection>
<connection>
<map_components component_1="NCX" component_2="environment"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="C_m" variable_2="C_m"/>
<map_variables variable_1="q_Ca_o" variable_2="q_Ca_o"/>
<map_variables variable_1="q_Ca_i" variable_2="q_Ca_i"/>
<map_variables variable_1="q_Na_o" variable_2="q_Na_o"/>
<map_variables variable_1="q_Na_i" variable_2="q_Na_i"/>
<map_variables variable_1="q_P1_NCX" variable_2="q_P1_NCX"/>
<map_variables variable_1="q_P2_NCX" variable_2="q_P2_NCX"/>
<map_variables variable_1="q_P3_NCX" variable_2="q_P3_NCX"/>
<map_variables variable_1="q_P4_NCX" variable_2="q_P4_NCX"/>
<map_variables variable_1="q_P5_NCX" variable_2="q_P5_NCX"/>
<map_variables variable_1="q_P6_NCX" variable_2="q_P6_NCX"/>
<map_variables variable_1="v_Ca_o_NCX" variable_2="v_Ca_o_NCX"/>
<map_variables variable_1="v_Ca_i_NCX" variable_2="v_Ca_i_NCX"/>
<map_variables variable_1="v_Na_o_NCX" variable_2="v_Na_o_NCX"/>
<map_variables variable_1="v_Na_i_NCX" variable_2="v_Na_i_NCX"/>
<map_variables variable_1="q_mem" variable_2="q_mem"/>
<map_variables variable_1="I_mem_NCX" variable_2="I_mem_NCX"/>
</connection>
</model>
