- Author:
- Shelley Fong <s.fong@auckland.ac.nz>
- Date:
- 2022-05-05 12:39:54+12:00
- Desc:
- git submodule updated
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/822/rawfile/aa7c7bf60e546c6c01359afc25da594ae732e62f/BG_CMDN_buffer.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="cardiac_AP_CMDN_only" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="units_and_constants/units_BG.cellml">
<units name="fmol" units_ref="fmol"/>
<units name="per_fmol" units_ref="per_fmol"/>
<units name="J_per_mol" units_ref="J_per_mol"/>
<units name="fmol_per_sec" units_ref="fmol_per_sec"/>
<units name="C_per_mol" units_ref="C_per_mol"/>
<units name="J_per_C" units_ref="J_per_C"/>
<units name="fF" units_ref="fF"/>
<units name="fC" units_ref="fC"/>
<units name="fA" units_ref="fA"/>
<units name="per_second" units_ref="per_second"/>
<units name="per_sec" units_ref="per_sec"/>
<units name="J_per_K_per_mol" units_ref="J_per_K_per_mol"/>
<units name="fmol_per_L" units_ref="fmol_per_L"/>
<units name="fmol_per_L_per_sec" units_ref="fmol_per_L_per_sec"/>
<units name="per_sec_per_fmol_per_L" units_ref="per_sec_per_fmol_per_L"/>
<units name="pL" units_ref="pL"/>
</import>
<component name="environment">
<variable initial_value="0" name="t" public_interface="out" units="second"/>
<variable initial_value="8.314" name="R" public_interface="out" units="J_per_K_per_mol"/>
<variable initial_value="310" name="T" public_interface="out" units="kelvin"/>
<variable initial_value="96485" name="F" public_interface="out" units="C_per_mol"/>
<variable initial_value="153400" name="C_m" public_interface="out" units="fF"/>
<variable initial_value="0.00456" name="q_Ca_i" public_interface="out" units="fmol"/>
<variable initial_value="1.8088" name="q_CMDN" public_interface="out" units="fmol"/>
<variable initial_value="0.0912" name="q_CMDN_Ca" public_interface="out" units="fmol"/>
<variable name="v_b2" public_interface="in" units="fmol_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_CMDN</ci>
</apply>
<apply>
<minus/>
<ci>v_b2</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_CMDN_Ca</ci>
</apply>
<ci>v_b2</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_Ca_i</ci>
</apply>
<apply>
<minus/>
<ci>v_b2</ci>
</apply>
</apply>
</math>
</component>
<component name="CMDN_parameters">
<variable initial_value="22.0647" name="K_CMDN" public_interface="out" units="per_fmol"/>
<variable initial_value="0.044337" name="K_CMDN_Ca" public_interface="out" units="per_fmol"/>
<variable initial_value="0.022218" name="K_Ca_i" public_interface="out" units="per_fmol"/>
<variable initial_value="1412.6324" name="kappa_b2" public_interface="out" units="fmol_per_sec"/>
</component>
<component name="CMDN_buffer">
<variable name="t" public_interface="in" units="second"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="K_CMDN" public_interface="in" units="per_fmol"/>
<variable name="K_CMDN_Ca" public_interface="in" units="per_fmol"/>
<variable name="K_Ca_i" public_interface="in" units="per_fmol"/>
<variable name="kappa_b2" public_interface="in" units="fmol_per_sec"/>
<variable name="q_CMDN" public_interface="in" units="fmol"/>
<variable name="q_CMDN_Ca" public_interface="in" units="fmol"/>
<variable name="q_Ca_i" public_interface="in" units="fmol"/>
<variable name="mu_CMDN" units="J_per_mol"/>
<variable name="mu_CMDN_Ca" units="J_per_mol"/>
<variable name="mu_Ca_i" units="J_per_mol"/>
<variable name="Af_b2" units="J_per_mol"/>
<variable name="Ar_b2" units="J_per_mol"/>
<variable name="v_b2" public_interface="out" units="fmol_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Af_b2</ci>
<apply>
<plus/>
<ci>mu_Ca_i</ci>
<ci>mu_CMDN</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_b2</ci>
<ci>mu_CMDN_Ca</ci>
</apply>
<apply>
<eq/>
<ci>mu_CMDN</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_CMDN</ci>
<ci>q_CMDN</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_CMDN_Ca</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_CMDN_Ca</ci>
<ci>q_CMDN_Ca</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Ca_i</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Ca_i</ci>
<ci>q_Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_b2</ci>
<apply>
<times/>
<ci>kappa_b2</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_b2</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_b2</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="CMDN_buffer" component_2="CMDN_parameters"/>
<map_variables variable_1="K_CMDN" variable_2="K_CMDN"/>
<map_variables variable_1="K_CMDN_Ca" variable_2="K_CMDN_Ca"/>
<map_variables variable_1="K_Ca_i" variable_2="K_Ca_i"/>
<map_variables variable_1="kappa_b2" variable_2="kappa_b2"/>
</connection>
<connection>
<map_components component_1="CMDN_buffer" component_2="environment"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="q_CMDN" variable_2="q_CMDN"/>
<map_variables variable_1="q_CMDN_Ca" variable_2="q_CMDN_Ca"/>
<map_variables variable_1="q_Ca_i" variable_2="q_Ca_i"/>
<map_variables variable_1="v_b2" variable_2="v_b2"/>
</connection>
</model>
