Location: FCU_cardiacAP_Pan @ 87841eaa9b1c / LCC_channel.cellml
- Author:
- Shelley Fong <s.fong@auckland.ac.nz>
- Date:
- 2022-02-16 14:51:03+13:00
- Desc:
- With major fixes to main code and inclusion of Ca buffers. Results now reproduce Pan AP
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/81b/rawfile/87841eaa9b1cb1829c9503ef28b45a0ada9b7e32/LCC_channel.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="cardiac_AP_LCC_only" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#">
<units name="J_per_K_per_mol">
<unit units="joule"/>
<unit exponent="-1" units="kelvin"/>
<unit exponent="-1" units="mole"/>
</units>
<units name="C_per_mol">
<unit units="coulomb"/>
<unit exponent="-1" units="mole"/>
</units>
<units name="fF">
<unit prefix="femto" units="farad"/>
</units>
<units name="fmol">
<unit prefix="femto" units="mole"/>
</units>
<units name="per_fmol">
<unit exponent="-1" units="fmol"/>
</units>
<units name="fmol_per_sec">
<unit units="fmol"/>
<unit exponent="-1" units="second"/>
</units>
<units name="fC">
<unit prefix="femto" units="coulomb"/>
</units>
<units name="fA">
<unit prefix="femto" units="ampere"/>
</units>
<units name="J_per_mol">
<unit units="joule"/>
<unit exponent="-1" units="mole"/>
</units>
<component name="environment">
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<variable initial_value="310" name="T" public_interface="out" units="kelvin"/>
<variable initial_value="96485" name="F" public_interface="out" units="C_per_mol"/>
<variable initial_value="153400" name="C_m" public_interface="out" units="fF"/>
<variable initial_value="9.3276" name="x_Cae_init" units="fmol"/>
<variable initial_value="0.00456" name="x_Cai_init" units="fmol"/>
<variable initial_value="27.9828" name="x_Ke_init" units="fmol"/>
<variable initial_value="5510" name="x_Ki_init" units="fmol"/>
<variable initial_value="3.6989e-07" name="x_S000_LCC_init" units="fmol"/>
<variable initial_value="7.3239e-05" name="x_S010_LCC_init" units="fmol"/>
<variable initial_value="3.6989e-07" name="x_S020_LCC_init" units="fmol"/>
<variable initial_value="3.7363e-09" name="x_S100_LCC_init" units="fmol"/>
<variable initial_value="7.3979e-07" name="x_S110_LCC_init" units="fmol"/>
<variable initial_value="3.7363e-09" name="x_S120_LCC_init" units="fmol"/>
<variable initial_value="4.1099e-08" name="x_S001_LCC_init" units="fmol"/>
<variable initial_value="8.1377e-06" name="x_S011_LCC_init" units="fmol"/>
<variable initial_value="4.1099e-08" name="x_S021_LCC_init" units="fmol"/>
<variable initial_value="4.1514e-10" name="x_S101_LCC_init" units="fmol"/>
<variable initial_value="8.2199e-08" name="x_S111_LCC_init" units="fmol"/>
<variable initial_value="4.1514e-10" name="x_S121_LCC_init" units="fmol"/>
<variable name="x_Cae_mLCC" public_interface="in" units="fmol"/>
<variable name="x_Cae" public_interface="out" units="fmol"/>
<variable name="x_Cai_mLCC" public_interface="in" units="fmol"/>
<variable name="x_Cai" public_interface="out" units="fmol"/>
<variable name="x_Ke_mLCC" public_interface="in" units="fmol"/>
<variable name="x_Ke" public_interface="out" units="fmol"/>
<variable name="x_Ki_mLCC" public_interface="in" units="fmol"/>
<variable name="x_Ki" public_interface="out" units="fmol"/>
<variable name="x_S000_LCC_mLCC" public_interface="in" units="fmol"/>
<variable name="x_S000_LCC" public_interface="out" units="fmol"/>
<variable name="x_S010_LCC_mLCC" public_interface="in" units="fmol"/>
<variable name="x_S010_LCC" public_interface="out" units="fmol"/>
<variable name="x_S020_LCC_mLCC" public_interface="in" units="fmol"/>
<variable name="x_S020_LCC" public_interface="out" units="fmol"/>
<variable name="x_S100_LCC_mLCC" public_interface="in" units="fmol"/>
<variable name="x_S100_LCC" public_interface="out" units="fmol"/>
<variable name="x_S110_LCC_mLCC" public_interface="in" units="fmol"/>
<variable name="x_S110_LCC" public_interface="out" units="fmol"/>
<variable name="x_S120_LCC_mLCC" public_interface="in" units="fmol"/>
<variable name="x_S120_LCC" public_interface="out" units="fmol"/>
<variable name="x_S001_LCC_mLCC" public_interface="in" units="fmol"/>
<variable name="x_S001_LCC" public_interface="out" units="fmol"/>
<variable name="x_S011_LCC_mLCC" public_interface="in" units="fmol"/>
<variable name="x_S011_LCC" public_interface="out" units="fmol"/>
<variable name="x_S021_LCC_mLCC" public_interface="in" units="fmol"/>
<variable name="x_S021_LCC" public_interface="out" units="fmol"/>
<variable name="x_S101_LCC_mLCC" public_interface="in" units="fmol"/>
<variable name="x_S101_LCC" public_interface="out" units="fmol"/>
<variable name="x_S111_LCC_mLCC" public_interface="in" units="fmol"/>
<variable name="x_S111_LCC" public_interface="out" units="fmol"/>
<variable name="x_S121_LCC_mLCC" public_interface="in" units="fmol"/>
<variable name="x_S121_LCC" public_interface="out" units="fmol"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>x_Cae</ci>
<apply>
<plus/>
<ci>x_Cae_init</ci>
<ci>x_Cae_mLCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>x_Cai</ci>
<apply>
<plus/>
<ci>x_Cai_init</ci>
<ci>x_Cai_mLCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>x_Ke</ci>
<apply>
<plus/>
<ci>x_Ke_init</ci>
<ci>x_Ke_mLCC</ci>
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<eq/>
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<plus/>
<ci>x_Ki_init</ci>
<ci>x_Ki_mLCC</ci>
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<apply>
<eq/>
<ci>x_S000_LCC</ci>
<apply>
<plus/>
<ci>x_S000_LCC_init</ci>
<ci>x_S000_LCC_mLCC</ci>
</apply>
</apply>
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<eq/>
<ci>x_S010_LCC</ci>
<apply>
<plus/>
<ci>x_S010_LCC_init</ci>
<ci>x_S010_LCC_mLCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>x_S020_LCC</ci>
<apply>
<plus/>
<ci>x_S020_LCC_init</ci>
<ci>x_S020_LCC_mLCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>x_S100_LCC</ci>
<apply>
<plus/>
<ci>x_S100_LCC_init</ci>
<ci>x_S100_LCC_mLCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>x_S110_LCC</ci>
<apply>
<plus/>
<ci>x_S110_LCC_init</ci>
<ci>x_S110_LCC_mLCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>x_S120_LCC</ci>
<apply>
<plus/>
<ci>x_S120_LCC_init</ci>
<ci>x_S120_LCC_mLCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>x_S001_LCC</ci>
<apply>
<plus/>
<ci>x_S001_LCC_init</ci>
<ci>x_S001_LCC_mLCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>x_S011_LCC</ci>
<apply>
<plus/>
<ci>x_S011_LCC_init</ci>
<ci>x_S011_LCC_mLCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>x_S021_LCC</ci>
<apply>
<plus/>
<ci>x_S021_LCC_init</ci>
<ci>x_S021_LCC_mLCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>x_S101_LCC</ci>
<apply>
<plus/>
<ci>x_S101_LCC_init</ci>
<ci>x_S101_LCC_mLCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>x_S111_LCC</ci>
<apply>
<plus/>
<ci>x_S111_LCC_init</ci>
<ci>x_S111_LCC_mLCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>x_S121_LCC</ci>
<apply>
<plus/>
<ci>x_S121_LCC_init</ci>
<ci>x_S121_LCC_mLCC</ci>
</apply>
</apply>
</math>
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<variable name="q_mem_mLCC" public_interface="in" units="fC"/>
<variable name="q_mem" public_interface="out" units="fC"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>q_mem</ci>
<apply>
<plus/>
<ci>q_mem_init</ci>
<ci>q_mem_mLCC</ci>
</apply>
</apply>
</math>
</component>
<component name="LCC_parameters">
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<variable initial_value="1565.0581" name="K_001_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="53.3957" name="K_010_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="63435.6844" name="K_011_LCC" public_interface="out" units="per_fmol"/>
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<variable initial_value="33923.3476" name="K_021_LCC" public_interface="out" units="per_fmol"/>
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<variable initial_value="10.7528" name="K_110_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="12774.6463" name="K_111_LCC" public_interface="out" units="per_fmol"/>
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<variable initial_value="6831.4667" name="K_121_LCC" public_interface="out" units="per_fmol"/>
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<variable initial_value="0.022218" name="K_Cai" public_interface="out" units="per_fmol"/>
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<variable initial_value="0.0080926" name="K_Ki" public_interface="out" units="per_fmol"/>
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<variable initial_value="369.4994" name="kappa_d000" public_interface="out" units="fmol_per_sec"/>
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<variable initial_value="2627.333" name="kappa_fCa01" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="4913.0371" name="kappa_fCa02" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="528814.1044" name="kappa_fCa10" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="13046.6757" name="kappa_fCa11" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="24396.9083" name="kappa_fCa12" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="2" name="zCa" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="zK" public_interface="out" units="dimensionless"/>
<variable initial_value="2.1404" name="z_fd" public_interface="out" units="dimensionless"/>
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<variable initial_value="0.72162" name="z_ff2" public_interface="out" units="dimensionless"/>
<variable initial_value="4.2933" name="z_ff3" public_interface="out" units="dimensionless"/>
<variable initial_value="2" name="z_rCa" public_interface="out" units="dimensionless"/>
<variable initial_value="-2.1404" name="z_rd" public_interface="out" units="dimensionless"/>
<variable initial_value="1.8993" name="z_rf1" public_interface="out" units="dimensionless"/>
<variable initial_value="-0.52288" name="z_rf2" public_interface="out" units="dimensionless"/>
<variable initial_value="0" name="z_rf3" public_interface="out" units="dimensionless"/>
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<component name="LCC_channel">
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<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable name="C_m" public_interface="in" units="fF"/>
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<variable name="K_001_LCC" public_interface="in" units="per_fmol"/>
<variable name="K_010_LCC" public_interface="in" units="per_fmol"/>
<variable name="K_011_LCC" public_interface="in" units="per_fmol"/>
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<variable name="K_021_LCC" public_interface="in" units="per_fmol"/>
<variable name="K_100_LCC" public_interface="in" units="per_fmol"/>
<variable name="K_101_LCC" public_interface="in" units="per_fmol"/>
<variable name="K_110_LCC" public_interface="in" units="per_fmol"/>
<variable name="K_111_LCC" public_interface="in" units="per_fmol"/>
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<variable name="K_121_LCC" public_interface="in" units="per_fmol"/>
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<variable name="kappa_LCC_Ca1" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_LCC_Ca2" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_LCC_K1" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_LCC_K2" public_interface="in" units="fmol_per_sec"/>
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<variable name="kappa_d011" public_interface="in" units="fmol_per_sec"/>
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<variable name="kappa_d021" public_interface="in" units="fmol_per_sec"/>
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<variable name="kappa_f1_100" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_f1_101" public_interface="in" units="fmol_per_sec"/>
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<variable name="kappa_fCa02" public_interface="in" units="fmol_per_sec"/>
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<variable name="mu_Cai" units="J_per_mol"/>
<variable name="mu_Ke" units="J_per_mol"/>
<variable name="mu_Ki" units="J_per_mol"/>
<variable name="mu_S000_LCC" units="J_per_mol"/>
<variable name="mu_S010_LCC" units="J_per_mol"/>
<variable name="mu_S020_LCC" units="J_per_mol"/>
<variable name="mu_S100_LCC" units="J_per_mol"/>
<variable name="mu_S110_LCC" units="J_per_mol"/>
<variable name="mu_S120_LCC" units="J_per_mol"/>
<variable name="mu_S001_LCC" units="J_per_mol"/>
<variable name="mu_S011_LCC" units="J_per_mol"/>
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<ci>kappa_f1_001</ci>
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<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_f1_001</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_f1_001</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f1_100</ci>
<apply>
<times/>
<ci>kappa_f1_100</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_f1_100</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_f1_100</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f1_101</ci>
<apply>
<times/>
<ci>kappa_f1_101</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_f1_101</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_f1_101</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f2_000</ci>
<apply>
<times/>
<ci>kappa_f2_000</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_f2_000</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_f2_000</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f2_001</ci>
<apply>
<times/>
<ci>kappa_f2_001</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_f2_001</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_f2_001</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f2_100</ci>
<apply>
<times/>
<ci>kappa_f2_100</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_f2_100</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_f2_100</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f2_101</ci>
<apply>
<times/>
<ci>kappa_f2_101</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_f2_101</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_f2_101</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f3_010</ci>
<apply>
<times/>
<ci>kappa_f3_010</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_f3_010</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_f3_010</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f3_011</ci>
<apply>
<times/>
<ci>kappa_f3_011</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_f3_011</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_f3_011</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f3_110</ci>
<apply>
<times/>
<ci>kappa_f3_110</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_f3_110</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_f3_110</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f3_111</ci>
<apply>
<times/>
<ci>kappa_f3_111</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_f3_111</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_f3_111</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_fCa00</ci>
<apply>
<times/>
<ci>kappa_fCa00</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_fCa00</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_fCa00</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_fCa01</ci>
<apply>
<times/>
<ci>kappa_fCa01</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_fCa01</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_fCa01</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_fCa02</ci>
<apply>
<times/>
<ci>kappa_fCa02</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_fCa02</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_fCa02</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_fCa10</ci>
<apply>
<times/>
<ci>kappa_fCa10</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_fCa10</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_fCa10</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_fCa11</ci>
<apply>
<times/>
<ci>kappa_fCa11</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_fCa11</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_fCa11</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_fCa12</ci>
<apply>
<times/>
<ci>kappa_fCa12</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_fCa12</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_fCa12</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_LCC_Ca1</ci>
<apply>
<plus/>
<ci>mu_Cai</ci>
<apply>
<times/>
<ci>zCa</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
<ci>mu_S111_LCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_LCC_Ca2</ci>
<apply>
<plus/>
<ci>mu_Cai</ci>
<apply>
<times/>
<ci>zCa</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
<ci>mu_S121_LCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_LCC_K1</ci>
<apply>
<plus/>
<ci>mu_Ki</ci>
<apply>
<times/>
<ci>zK</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
<ci>mu_S111_LCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_LCC_K2</ci>
<apply>
<plus/>
<ci>mu_Ki</ci>
<apply>
<times/>
<ci>zK</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
<ci>mu_S121_LCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_d000</ci>
<apply>
<plus/>
<ci>mu_S000_LCC</ci>
<apply>
<times/>
<ci>z_fd</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_d001</ci>
<apply>
<plus/>
<ci>mu_S001_LCC</ci>
<apply>
<times/>
<ci>z_fd</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_d010</ci>
<apply>
<plus/>
<ci>mu_S010_LCC</ci>
<apply>
<times/>
<ci>z_fd</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_d011</ci>
<apply>
<plus/>
<ci>mu_S011_LCC</ci>
<apply>
<times/>
<ci>z_fd</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_d020</ci>
<apply>
<plus/>
<ci>mu_S020_LCC</ci>
<apply>
<times/>
<ci>z_fd</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_d021</ci>
<apply>
<plus/>
<ci>mu_S021_LCC</ci>
<apply>
<times/>
<ci>z_fd</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_f1_000</ci>
<apply>
<plus/>
<ci>mu_S000_LCC</ci>
<apply>
<times/>
<ci>z_ff1</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_f1_001</ci>
<apply>
<plus/>
<ci>mu_S001_LCC</ci>
<apply>
<times/>
<ci>z_ff1</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_f1_100</ci>
<apply>
<plus/>
<ci>mu_S100_LCC</ci>
<apply>
<times/>
<ci>z_ff1</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_f1_101</ci>
<apply>
<plus/>
<ci>mu_S101_LCC</ci>
<apply>
<times/>
<ci>z_ff1</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_f2_000</ci>
<apply>
<plus/>
<ci>mu_S000_LCC</ci>
<apply>
<times/>
<ci>z_ff2</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_f2_001</ci>
<apply>
<plus/>
<ci>mu_S001_LCC</ci>
<apply>
<times/>
<ci>z_ff2</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_f2_100</ci>
<apply>
<plus/>
<ci>mu_S100_LCC</ci>
<apply>
<times/>
<ci>z_ff2</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_f2_101</ci>
<apply>
<plus/>
<ci>mu_S101_LCC</ci>
<apply>
<times/>
<ci>z_ff2</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_f3_010</ci>
<apply>
<plus/>
<ci>mu_S010_LCC</ci>
<apply>
<times/>
<ci>z_ff3</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_f3_011</ci>
<apply>
<plus/>
<ci>mu_S011_LCC</ci>
<apply>
<times/>
<ci>z_ff3</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_f3_110</ci>
<apply>
<plus/>
<ci>mu_S110_LCC</ci>
<apply>
<times/>
<ci>z_ff3</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_f3_111</ci>
<apply>
<plus/>
<ci>mu_S111_LCC</ci>
<apply>
<times/>
<ci>z_ff3</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_fCa00</ci>
<ci>mu_S000_LCC</ci>
</apply>
<apply>
<eq/>
<ci>Af_fCa01</ci>
<ci>mu_S010_LCC</ci>
</apply>
<apply>
<eq/>
<ci>Af_fCa02</ci>
<ci>mu_S020_LCC</ci>
</apply>
<apply>
<eq/>
<ci>Af_fCa10</ci>
<ci>mu_S100_LCC</ci>
</apply>
<apply>
<eq/>
<ci>Af_fCa11</ci>
<ci>mu_S110_LCC</ci>
</apply>
<apply>
<eq/>
<ci>Af_fCa12</ci>
<ci>mu_S120_LCC</ci>
</apply>
<apply>
<eq/>
<ci>Am_LCC_Ca1</ci>
<apply>
<times/>
<ci>zCa</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Am_LCC_Ca2</ci>
<apply>
<times/>
<ci>zCa</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Am_LCC_K1</ci>
<apply>
<times/>
<ci>zK</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Am_LCC_K2</ci>
<apply>
<times/>
<ci>zK</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_LCC_Ca1</ci>
<apply>
<plus/>
<ci>mu_Cae</ci>
<ci>mu_S111_LCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_LCC_Ca2</ci>
<apply>
<plus/>
<ci>mu_Cae</ci>
<ci>mu_S121_LCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_LCC_K1</ci>
<apply>
<plus/>
<ci>mu_Ke</ci>
<ci>mu_S111_LCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_LCC_K2</ci>
<apply>
<plus/>
<ci>mu_Ke</ci>
<ci>mu_S121_LCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_d000</ci>
<apply>
<plus/>
<ci>mu_S100_LCC</ci>
<apply>
<times/>
<ci>z_rd</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_d001</ci>
<apply>
<plus/>
<ci>mu_S101_LCC</ci>
<apply>
<times/>
<ci>z_rd</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_d010</ci>
<apply>
<plus/>
<ci>mu_S110_LCC</ci>
<apply>
<times/>
<ci>z_rd</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_d011</ci>
<apply>
<plus/>
<ci>mu_S111_LCC</ci>
<apply>
<times/>
<ci>z_rd</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_d020</ci>
<apply>
<plus/>
<ci>mu_S120_LCC</ci>
<apply>
<times/>
<ci>z_rd</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_d021</ci>
<apply>
<plus/>
<ci>mu_S121_LCC</ci>
<apply>
<times/>
<ci>z_rd</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_f1_000</ci>
<apply>
<plus/>
<ci>mu_S010_LCC</ci>
<apply>
<times/>
<ci>z_rf1</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_f1_001</ci>
<apply>
<plus/>
<ci>mu_S011_LCC</ci>
<apply>
<times/>
<ci>z_rf1</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_f1_100</ci>
<apply>
<plus/>
<ci>mu_S110_LCC</ci>
<apply>
<times/>
<ci>z_rf1</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_f1_101</ci>
<apply>
<plus/>
<ci>mu_S111_LCC</ci>
<apply>
<times/>
<ci>z_rf1</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_f2_000</ci>
<apply>
<plus/>
<ci>mu_S020_LCC</ci>
<apply>
<times/>
<ci>z_rf2</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_f2_001</ci>
<apply>
<plus/>
<ci>mu_S021_LCC</ci>
<apply>
<times/>
<ci>z_rf2</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_f2_100</ci>
<apply>
<plus/>
<ci>mu_S120_LCC</ci>
<apply>
<times/>
<ci>z_rf2</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_f2_101</ci>
<apply>
<plus/>
<ci>mu_S121_LCC</ci>
<apply>
<times/>
<ci>z_rf2</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_f3_010</ci>
<apply>
<plus/>
<ci>mu_S020_LCC</ci>
<apply>
<times/>
<ci>z_rf3</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_f3_011</ci>
<apply>
<plus/>
<ci>mu_S021_LCC</ci>
<apply>
<times/>
<ci>z_rf3</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_f3_110</ci>
<apply>
<plus/>
<ci>mu_S120_LCC</ci>
<apply>
<times/>
<ci>z_rf3</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_f3_111</ci>
<apply>
<plus/>
<ci>mu_S121_LCC</ci>
<apply>
<times/>
<ci>z_rf3</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_fCa00</ci>
<apply>
<plus/>
<ci>mu_S001_LCC</ci>
<apply>
<times/>
<ci>z_rCa</ci>
<ci>mu_Cai</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_fCa01</ci>
<apply>
<plus/>
<ci>mu_S011_LCC</ci>
<apply>
<times/>
<ci>z_rCa</ci>
<ci>mu_Cai</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_fCa02</ci>
<apply>
<plus/>
<ci>mu_S021_LCC</ci>
<apply>
<times/>
<ci>z_rCa</ci>
<ci>mu_Cai</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_fCa10</ci>
<apply>
<plus/>
<ci>mu_S101_LCC</ci>
<apply>
<times/>
<ci>z_rCa</ci>
<ci>mu_Cai</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_fCa11</ci>
<apply>
<plus/>
<ci>mu_S111_LCC</ci>
<apply>
<times/>
<ci>z_rCa</ci>
<ci>mu_Cai</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_fCa12</ci>
<apply>
<plus/>
<ci>mu_S121_LCC</ci>
<apply>
<times/>
<ci>z_rCa</ci>
<ci>mu_Cai</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_Cae</ci>
<apply>
<plus/>
<ci>v_LCC_Ca2</ci>
<ci>v_LCC_Ca1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_Cai</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>z_rCa</ci>
<ci>v_fCa10</ci>
</apply>
<apply>
<times/>
<ci>z_rCa</ci>
<ci>v_fCa11</ci>
</apply>
<apply>
<times/>
<ci>z_rCa</ci>
<ci>v_fCa02</ci>
</apply>
<apply>
<times/>
<ci>z_rCa</ci>
<ci>v_fCa01</ci>
</apply>
<apply>
<times/>
<ci>z_rCa</ci>
<ci>v_fCa00</ci>
</apply>
<apply>
<times/>
<ci>z_rCa</ci>
<ci>v_fCa12</ci>
</apply>
</apply>
<ci>v_LCC_Ca1</ci>
</apply>
<ci>v_LCC_Ca2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_Ke</ci>
<apply>
<plus/>
<ci>v_LCC_K2</ci>
<ci>v_LCC_K1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_Ki</ci>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_LCC_K1</ci>
</apply>
<ci>v_LCC_K2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S000_LCC</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_d000</ci>
</apply>
<ci>v_f1_000</ci>
</apply>
<ci>v_f2_000</ci>
</apply>
<ci>v_fCa00</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S001_LCC</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_d001</ci>
</apply>
<ci>v_f1_001</ci>
</apply>
<ci>v_f2_001</ci>
</apply>
<apply>
<minus/>
<ci>v_fCa00</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S010_LCC</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_d010</ci>
</apply>
<ci>v_f1_000</ci>
</apply>
<ci>v_fCa01</ci>
</apply>
<ci>v_f3_010</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S011_LCC</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_d011</ci>
</apply>
<ci>v_f1_001</ci>
</apply>
<apply>
<minus/>
<ci>v_fCa01</ci>
</apply>
</apply>
<ci>v_f3_011</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S020_LCC</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_d020</ci>
</apply>
<ci>v_f2_000</ci>
</apply>
<ci>v_fCa02</ci>
</apply>
<ci>v_f3_010</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S021_LCC</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_d021</ci>
</apply>
<ci>v_f2_001</ci>
</apply>
<apply>
<minus/>
<ci>v_fCa02</ci>
</apply>
</apply>
<ci>v_f3_011</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S100_LCC</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_f2_100</ci>
</apply>
<ci>v_d000</ci>
</apply>
<ci>v_f1_100</ci>
</apply>
<ci>v_fCa10</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S101_LCC</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_f2_101</ci>
</apply>
<ci>v_d001</ci>
</apply>
<ci>v_f1_101</ci>
</apply>
<apply>
<minus/>
<ci>v_fCa10</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S110_LCC</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>v_f1_100</ci>
<ci>v_d010</ci>
</apply>
<ci>v_fCa11</ci>
</apply>
<ci>v_f3_110</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S111_LCC</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>v_f1_101</ci>
<ci>v_d011</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_fCa11</ci>
</apply>
<ci>v_LCC_Ca1</ci>
</apply>
<ci>v_LCC_Ca1</ci>
</apply>
<ci>v_LCC_K1</ci>
</apply>
<ci>v_LCC_K1</ci>
</apply>
</apply>
<ci>v_f3_111</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S120_LCC</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>v_f2_100</ci>
<ci>v_d020</ci>
</apply>
<ci>v_fCa12</ci>
</apply>
<ci>v_f3_110</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S121_LCC</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>v_f2_101</ci>
<ci>v_d021</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_fCa12</ci>
</apply>
<ci>v_LCC_Ca2</ci>
</apply>
<ci>v_LCC_Ca2</ci>
</apply>
<ci>v_LCC_K2</ci>
</apply>
<ci>v_LCC_K2</ci>
</apply>
</apply>
<ci>v_f3_111</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_LCC_Ca1</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>kappa_LCC_Ca1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_LCC_Ca1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_LCC_Ca1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Am_LCC_Ca1</ci>
<cn cellml:units="J_per_mol">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>kappa_LCC_Ca1</ci>
<ci>Am_LCC_Ca1</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Am_LCC_Ca1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_LCC_Ca1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_LCC_Ca1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>v_LCC_Ca2</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>kappa_LCC_Ca2</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_LCC_Ca2</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_LCC_Ca2</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Am_LCC_Ca2</ci>
<cn cellml:units="J_per_mol">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>kappa_LCC_Ca2</ci>
<ci>Am_LCC_Ca2</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Am_LCC_Ca2</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_LCC_Ca2</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_LCC_Ca2</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>v_LCC_K1</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>kappa_LCC_K1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_LCC_K1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_LCC_K1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Am_LCC_K1</ci>
<cn cellml:units="J_per_mol">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>kappa_LCC_K1</ci>
<ci>Am_LCC_K1</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Am_LCC_K1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_LCC_K1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_LCC_K1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>v_LCC_K2</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>kappa_LCC_K2</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_LCC_K2</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_LCC_K2</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Am_LCC_K2</ci>
<cn cellml:units="J_per_mol">0</cn>
</apply>
</piece>
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<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>kappa_LCC_K2</ci>
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</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
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<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Am_LCC_K2</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
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</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_LCC_K2</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_LCC_K2</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>x_Cae</ci>
</apply>
<ci>v_Cae</ci>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>x_Cai</ci>
</apply>
<ci>v_Cai</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>x_Ke</ci>
</apply>
<ci>v_Ke</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>x_Ki</ci>
</apply>
<ci>v_Ki</ci>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>x_S000_LCC</ci>
</apply>
<ci>v_S000_LCC</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>x_S010_LCC</ci>
</apply>
<ci>v_S010_LCC</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>x_S020_LCC</ci>
</apply>
<ci>v_S020_LCC</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>x_S100_LCC</ci>
</apply>
<ci>v_S100_LCC</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>x_S110_LCC</ci>
</apply>
<ci>v_S110_LCC</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>x_S120_LCC</ci>
</apply>
<ci>v_S120_LCC</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>x_S001_LCC</ci>
</apply>
<ci>v_S001_LCC</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>x_S011_LCC</ci>
</apply>
<ci>v_S011_LCC</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>x_S021_LCC</ci>
</apply>
<ci>v_S021_LCC</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>x_S101_LCC</ci>
</apply>
<ci>v_S101_LCC</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>x_S111_LCC</ci>
</apply>
<ci>v_S111_LCC</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>x_S121_LCC</ci>
</apply>
<ci>v_S121_LCC</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_mem</ci>
</apply>
<ci>I_mem</ci>
</apply>
</math>
</component>
<connection>
<map_components component_1="LCC_channel" component_2="LCC_parameters"/>
<map_variables variable_1="K_000_LCC" variable_2="K_000_LCC"/>
<map_variables variable_1="K_001_LCC" variable_2="K_001_LCC"/>
<map_variables variable_1="K_010_LCC" variable_2="K_010_LCC"/>
<map_variables variable_1="K_011_LCC" variable_2="K_011_LCC"/>
<map_variables variable_1="K_020_LCC" variable_2="K_020_LCC"/>
<map_variables variable_1="K_021_LCC" variable_2="K_021_LCC"/>
<map_variables variable_1="K_100_LCC" variable_2="K_100_LCC"/>
<map_variables variable_1="K_101_LCC" variable_2="K_101_LCC"/>
<map_variables variable_1="K_110_LCC" variable_2="K_110_LCC"/>
<map_variables variable_1="K_111_LCC" variable_2="K_111_LCC"/>
<map_variables variable_1="K_120_LCC" variable_2="K_120_LCC"/>
<map_variables variable_1="K_121_LCC" variable_2="K_121_LCC"/>
<map_variables variable_1="K_Cae" variable_2="K_Cae"/>
<map_variables variable_1="K_Cai" variable_2="K_Cai"/>
<map_variables variable_1="K_Ke" variable_2="K_Ke"/>
<map_variables variable_1="K_Ki" variable_2="K_Ki"/>
<map_variables variable_1="kappa_LCC_Ca1" variable_2="kappa_LCC_Ca1"/>
<map_variables variable_1="kappa_LCC_Ca2" variable_2="kappa_LCC_Ca2"/>
<map_variables variable_1="kappa_LCC_K1" variable_2="kappa_LCC_K1"/>
<map_variables variable_1="kappa_LCC_K2" variable_2="kappa_LCC_K2"/>
<map_variables variable_1="kappa_d000" variable_2="kappa_d000"/>
<map_variables variable_1="kappa_d001" variable_2="kappa_d001"/>
<map_variables variable_1="kappa_d010" variable_2="kappa_d010"/>
<map_variables variable_1="kappa_d011" variable_2="kappa_d011"/>
<map_variables variable_1="kappa_d020" variable_2="kappa_d020"/>
<map_variables variable_1="kappa_d021" variable_2="kappa_d021"/>
<map_variables variable_1="kappa_f1_000" variable_2="kappa_f1_000"/>
<map_variables variable_1="kappa_f1_001" variable_2="kappa_f1_001"/>
<map_variables variable_1="kappa_f1_100" variable_2="kappa_f1_100"/>
<map_variables variable_1="kappa_f1_101" variable_2="kappa_f1_101"/>
<map_variables variable_1="kappa_f2_000" variable_2="kappa_f2_000"/>
<map_variables variable_1="kappa_f2_001" variable_2="kappa_f2_001"/>
<map_variables variable_1="kappa_f2_100" variable_2="kappa_f2_100"/>
<map_variables variable_1="kappa_f2_101" variable_2="kappa_f2_101"/>
<map_variables variable_1="kappa_f3_010" variable_2="kappa_f3_010"/>
<map_variables variable_1="kappa_f3_011" variable_2="kappa_f3_011"/>
<map_variables variable_1="kappa_f3_110" variable_2="kappa_f3_110"/>
<map_variables variable_1="kappa_f3_111" variable_2="kappa_f3_111"/>
<map_variables variable_1="kappa_fCa00" variable_2="kappa_fCa00"/>
<map_variables variable_1="kappa_fCa01" variable_2="kappa_fCa01"/>
<map_variables variable_1="kappa_fCa02" variable_2="kappa_fCa02"/>
<map_variables variable_1="kappa_fCa10" variable_2="kappa_fCa10"/>
<map_variables variable_1="kappa_fCa11" variable_2="kappa_fCa11"/>
<map_variables variable_1="kappa_fCa12" variable_2="kappa_fCa12"/>
<map_variables variable_1="zCa" variable_2="zCa"/>
<map_variables variable_1="zK" variable_2="zK"/>
<map_variables variable_1="z_fd" variable_2="z_fd"/>
<map_variables variable_1="z_ff1" variable_2="z_ff1"/>
<map_variables variable_1="z_ff2" variable_2="z_ff2"/>
<map_variables variable_1="z_ff3" variable_2="z_ff3"/>
<map_variables variable_1="z_rCa" variable_2="z_rCa"/>
<map_variables variable_1="z_rd" variable_2="z_rd"/>
<map_variables variable_1="z_rf1" variable_2="z_rf1"/>
<map_variables variable_1="z_rf2" variable_2="z_rf2"/>
<map_variables variable_1="z_rf3" variable_2="z_rf3"/>
</connection>
<connection>
<map_components component_1="LCC_channel" component_2="environment"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="C_m" variable_2="C_m"/>
<map_variables variable_1="x_Cae_global" variable_2="x_Cae"/>
<map_variables variable_1="x_Cae" variable_2="x_Cae_mLCC"/>
<map_variables variable_1="x_Cai_global" variable_2="x_Cai"/>
<map_variables variable_1="x_Cai" variable_2="x_Cai_mLCC"/>
<map_variables variable_1="x_Ke_global" variable_2="x_Ke"/>
<map_variables variable_1="x_Ke" variable_2="x_Ke_mLCC"/>
<map_variables variable_1="x_Ki_global" variable_2="x_Ki"/>
<map_variables variable_1="x_Ki" variable_2="x_Ki_mLCC"/>
<map_variables variable_1="x_S000_LCC_global" variable_2="x_S000_LCC"/>
<map_variables variable_1="x_S000_LCC" variable_2="x_S000_LCC_mLCC"/>
<map_variables variable_1="x_S010_LCC_global" variable_2="x_S010_LCC"/>
<map_variables variable_1="x_S010_LCC" variable_2="x_S010_LCC_mLCC"/>
<map_variables variable_1="x_S020_LCC_global" variable_2="x_S020_LCC"/>
<map_variables variable_1="x_S020_LCC" variable_2="x_S020_LCC_mLCC"/>
<map_variables variable_1="x_S100_LCC_global" variable_2="x_S100_LCC"/>
<map_variables variable_1="x_S100_LCC" variable_2="x_S100_LCC_mLCC"/>
<map_variables variable_1="x_S110_LCC_global" variable_2="x_S110_LCC"/>
<map_variables variable_1="x_S110_LCC" variable_2="x_S110_LCC_mLCC"/>
<map_variables variable_1="x_S120_LCC_global" variable_2="x_S120_LCC"/>
<map_variables variable_1="x_S120_LCC" variable_2="x_S120_LCC_mLCC"/>
<map_variables variable_1="x_S001_LCC_global" variable_2="x_S001_LCC"/>
<map_variables variable_1="x_S001_LCC" variable_2="x_S001_LCC_mLCC"/>
<map_variables variable_1="x_S011_LCC_global" variable_2="x_S011_LCC"/>
<map_variables variable_1="x_S011_LCC" variable_2="x_S011_LCC_mLCC"/>
<map_variables variable_1="x_S021_LCC_global" variable_2="x_S021_LCC"/>
<map_variables variable_1="x_S021_LCC" variable_2="x_S021_LCC_mLCC"/>
<map_variables variable_1="x_S101_LCC_global" variable_2="x_S101_LCC"/>
<map_variables variable_1="x_S101_LCC" variable_2="x_S101_LCC_mLCC"/>
<map_variables variable_1="x_S111_LCC_global" variable_2="x_S111_LCC"/>
<map_variables variable_1="x_S111_LCC" variable_2="x_S111_LCC_mLCC"/>
<map_variables variable_1="x_S121_LCC_global" variable_2="x_S121_LCC"/>
<map_variables variable_1="x_S121_LCC" variable_2="x_S121_LCC_mLCC"/>
<map_variables variable_1="q_mem_global" variable_2="q_mem"/>
<map_variables variable_1="q_mem" variable_2="q_mem_mLCC"/>
</connection>
</model>