- Author:
- Shelley Fong <s.fong@auckland.ac.nz>
- Date:
- 2021-12-06 08:25:06+13:00
- Desc:
- Adding units submodule manually
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/705/rawfile/9f1753b7ba6c67dc1d2964813a1ed5f3322a73ce/parameter_finder/output/TEMP.cellml.txt
def model FCU_adenylylCyclase as
def import using "units_and_constants/units_BG.cellml" for
unit mM using unit mM;
unit fmol using unit fmol;
unit per_fmol using unit per_fmol;
unit J_per_mol using unit J_per_mol;
unit fmol_per_sec using unit fmol_per_sec;
unit C_per_mol using unit C_per_mol;
unit J_per_C using unit J_per_C;
unit microm3 using unit microm3;
unit fF using unit fF;
unit fC using unit fC;
unit fA using unit fA;
unit per_second using unit per_second;
unit millivolt using unit millivolt;
unit per_sec using unit per_sec;
unit J_per_K_per_mol using unit J_per_K_per_mol;
unit fmol_per_L using unit fmol_per_L;
unit fmol_per_L_per_sec using unit fmol_per_L_per_sec;
unit per_sec_per_fmol_per_L using unit per_sec_per_fmol_per_L;
unit uM using unit uM;
unit mM_per_sec using unit mM_per_sec;
unit uM_per_sec using unit uM_per_sec;
unit pL using unit pL;
unit m_to_u using unit m_to_u;
enddef;
def import using "units_and_constants/constants_BG.cellml" for
comp constants using comp constants;
enddef;
def import using "cAMP/BG_cAMP.cellml" for
comp cAMP using comp cAMP;
enddef;
def import using "GPCR_B1AR_reduced/BG_GPCR_B1AR_reduced.cellml" for
comp GPCR_B1AR_reduced using comp GPCR_B1AR_reduced;
enddef;
def import using "GPCR_M2_reduced/BG_GPCR_M2_reduced.cellml" for
comp GPCR_M2_reduced using comp GPCR_M2_reduced;
enddef;
def comp BG_parameters as
var kappa_1a: fmol_per_sec {init: 7.05076e+06, pub: out};
var kappa_1b: fmol_per_sec {init: 0.00147213, pub: out};
var kappa_2a: fmol_per_sec {init: 186465, pub: out};
var kappa_2b: fmol_per_sec {init: 0.0503158, pub: out};
var kappa_3a: fmol_per_sec {init: 2.50455e+08, pub: out};
var kappa_3b: fmol_per_sec {init: 2.91227e-17, pub: out};
var kappa_4a: fmol_per_sec {init: 30352.7, pub: out};
var kappa_4b: fmol_per_sec {init: 0.116741, pub: out};
var kappa_5: fmol_per_sec {init: 833.759, pub: out};
var kappa_6: fmol_per_sec {init: 4236.98, pub: out};
var kappa_7: fmol_per_sec {init: 569102, pub: out};
var kappa_GiAC: fmol_per_sec {init: 1052.47, pub: out};
var kappa_Rswitch_B1: fmol_per_sec {init: 93.1496, pub: out};
var kappa_LRswitch_B1: fmol_per_sec {init: 0.00202063, pub: out};
var kappa_C_B1: fmol_per_sec {init: 1459.71, pub: out};
var kappa_R_B1: fmol_per_sec {init: 31664.5, pub: out};
var kappa_L_B1: fmol_per_sec {init: 0.00057588, pub: out};
var kappa_Act1_Gs: fmol_per_sec {init: 0.00326844, pub: out};
var kappa_Act2_Gs: fmol_per_sec {init: 37.7371, pub: out};
var kappa_Hyd_Gs: fmol_per_sec {init: 0.0787034, pub: out};
var kappa_Reassoc_Gs: fmol_per_sec {init: 0.00156706, pub: out};
var kappa_InternR_B1: fmol_per_sec {init: 0.00130092, pub: out};
var kappa_InternLR_B1: fmol_per_sec {init: 15.0203, pub: out};
var kappa_Rswitch_M2: fmol_per_sec {init: 271.765, pub: out};
var kappa_LRswitch_M2: fmol_per_sec {init: 0.0101296, pub: out};
var kappa_C_M2: fmol_per_sec {init: 7036.75, pub: out};
var kappa_R_M2: fmol_per_sec {init: 262283, pub: out};
var kappa_L_M2: fmol_per_sec {init: 0.111426, pub: out};
var kappa_Act1_Gi: fmol_per_sec {init: 0.00270806, pub: out};
var kappa_Act2_Gi: fmol_per_sec {init: 1.32138, pub: out};
var kappa_Hyd_Gi: fmol_per_sec {init: 0.48875, pub: out};
var kappa_Reassoc_Gi: fmol_per_sec {init: 0.00258927, pub: out};
var kappa_InternR_M2: fmol_per_sec {init: 0.000652343, pub: out};
var kappa_InternLR_M2: fmol_per_sec {init: 0.318306, pub: out};
var K_ATP: per_fmol {init: 6.60544e-05, pub: out};
var K_cAMP: per_fmol {init: 0.0166528, pub: out};
var K_AC: per_fmol {init: 1.68744, pub: out};
var K_AC_ATP: per_fmol {init: 3.94935, pub: out};
var K_Gsa_GTP_AC: per_fmol {init: 6.86096, pub: out};
var K_Gsa_GTP_AC_ATP: per_fmol {init: 4.91084, pub: out};
var K_FSK_AC: per_fmol {init: 0.0510801, pub: out};
var K_FSK_AC_ATP: per_fmol {init: 0.0998184, pub: out};
var K_PDE: per_fmol {init: 1.67186, pub: out};
var K_PDE_cAMP: per_fmol {init: 1.24505, pub: out};
var K_five_AMP: per_fmol {init: 0.0166528, pub: out};
var K_IBMX: per_fmol {init: 0.020208, pub: out};
var K_PDEinh: per_fmol {init: 34.8659, pub: out};
var K_Gsa_GTP: per_fmol {init: 0.295487, pub: out};
var K_FSK: per_fmol {init: 1.99992e-05, pub: out};
var K_Gia_GTP: per_fmol {init: 0.0475823, pub: out};
var K_ACinh: per_fmol {init: 27.6205, pub: out};
var K_PPi: per_fmol {init: 0.000115307, pub: out};
var K_RB1_inactive: per_fmol {init: 3.12076, pub: out};
var K_L_RB1_inactive: per_fmol {init: 143865, pub: out};
var K_LB1: per_fmol {init: 4702.09, pub: out};
var K_RB1: per_fmol {init: 0.0312076, pub: out};
var K_Gs: per_fmol {init: 0.185505, pub: out};
var K_RB1_Gs: per_fmol {init: 6.57187, pub: out};
var K_L_RB1: per_fmol {init: 0.00143865, pub: out};
var K_L_RB1_Gs: per_fmol {init: 0.000569194, pub: out};
var K_Gsbetagamma: per_fmol {init: 9.19376, pub: out};
var K_Gsa_GDP: per_fmol {init: 70.9724, pub: out};
var K_GTP: per_fmol {init: 0.629469, pub: out};
var K_GDP: per_fmol {init: 5.92518e-07, pub: out};
var K_Pi: per_fmol {init: 1.51286e-06, pub: out};
var K_RB1_tag: per_fmol {init: 1.35735, pub: out};
var K_L_RB1_tag: per_fmol {init: 0.000117561, pub: out};
var K_RB1_GRKArr: per_fmol {init: 0.00223456, pub: out};
var K_L_RB1_GRKArr: per_fmol {init: 1.93537e-07, pub: out};
var K_GRKArr: per_fmol {init: 4785.64, pub: out};
var K_RM2_inactive: per_fmol {init: 1.06966, pub: out};
var K_L_RM2_inactive: per_fmol {init: 28697.8, pub: out};
var K_LM2: per_fmol {init: 70.9007, pub: out};
var K_RM2: per_fmol {init: 0.0106966, pub: out};
var K_Gi: per_fmol {init: 0.11227, pub: out};
var K_RM2_Gi: per_fmol {init: 1.23934, pub: out};
var K_L_RM2: per_fmol {init: 0.000286978, pub: out};
var K_L_RM2_Gi: per_fmol {init: 0.00253994, pub: out};
var K_Gibetagamma: per_fmol {init: 34.5537, pub: out};
var K_Gia_GDP: per_fmol {init: 11.4287, pub: out};
var K_RM2_tag: per_fmol {init: 2.70687, pub: out};
var K_L_RM2_tag: per_fmol {init: 0.00554752, pub: out};
var K_RM2_GRKArr: per_fmol {init: 0.00445621, pub: out};
var K_L_RM2_GRKArr: per_fmol {init: 9.13266e-06, pub: out};
enddef;
def comp environment as
var time: second {pub: out};
var vol_myo: pL {init: 34.4, pub: out};
var freq: dimensionless {init: 500};
// stimulus
// ramp UP and ramp DOWN
var stimSt: second {init: 3.5e-4};
var stimDur: second {init: 0.25e-4};
var tRamp: second {init: 1.8e-4};
var stimMag: fmol {init: 1e1};
var stimHolding: fmol {init: 1e-5};
var m: fmol_per_sec;
m = stimMag/tRamp;
q_L_B1_init = sel
case (time < stimSt) and (time > stimSt-tRamp):
stimHolding+m*(time-stimSt+tRamp);
case (time >= stimSt) and (time < stimSt+stimDur):
stimMag+stimHolding;
case (time < stimSt+tRamp+stimDur) and (time >= stimSt+stimDur):
stimHolding+-m*(time-stimSt-tRamp-stimDur);
otherwise:
stimHolding;
endsel;
var q_ATP_init: fmol {init: 1e-888};
var q_cAMP_init: fmol {init: 1e-888};
var q_AC_init: fmol {init: 1e-888};
var q_AC_ATP_init: fmol {init: 1e-888};
var q_Gsa_GTP_AC_init: fmol {init: 1e-888};
var q_Gsa_GTP_AC_ATP_init: fmol {init: 1e-888};
var q_FSK_AC_init: fmol {init: 1e-888};
var q_FSK_AC_ATP_init: fmol {init: 1e-888};
var q_PDE_init: fmol {init: 1e-888};
var q_PDE_cAMP_init: fmol {init: 1e-888};
var q_five_AMP_init: fmol {init: 1e-888};
var q_IBMX_init: fmol {init: 1e-888};
var q_PDEinh_init: fmol {init: 1e-888};
var q_Gsa_GTP_init: fmol {init: 1e-888};
var q_FSK_init: fmol {init: 1e-888};
var q_Gia_GTP_init: fmol {init: 1e-888};
var q_ACinh_init: fmol {init: 1e-888};
var q_PPi_init: fmol {init: 1e-888};
var q_RB1_inactive_init: fmol {init: 1e-888};
var q_L_RB1_inactive_init: fmol {init: 1e-888};
var q_LB1_init: fmol {init: 1e-888};
var q_RB1_init: fmol {init: 1e-888};
var q_Gs_init: fmol {init: 1e-888};
var q_RB1_Gs_init: fmol {init: 1e-888};
var q_L_RB1_init: fmol {init: 1e-888};
var q_L_RB1_Gs_init: fmol {init: 1e-888};
var q_Gsbetagamma_init: fmol {init: 1e-888};
var q_Gsa_GDP_init: fmol {init: 1e-888};
var q_GTP_init: fmol {init: 1e-888};
var q_GDP_init: fmol {init: 1e-888};
var q_Pi_init: fmol {init: 1e-888};
var q_RB1_tag_init: fmol {init: 1e-888};
var q_L_RB1_tag_init: fmol {init: 1e-888};
var q_RB1_GRKArr_init: fmol {init: 1e-888};
var q_L_RB1_GRKArr_init: fmol {init: 1e-888};
var q_GRKArr_init: fmol {init: 1e-888};
var q_RM2_inactive_init: fmol {init: 1e-888};
var q_L_RM2_inactive_init: fmol {init: 1e-888};
var q_LM2_init: fmol {init: 1e-888};
var q_RM2_init: fmol {init: 1e-888};
var q_Gi_init: fmol {init: 1e-888};
var q_RM2_Gi_init: fmol {init: 1e-888};
var q_L_RM2_init: fmol {init: 1e-888};
var q_L_RM2_Gi_init: fmol {init: 1e-888};
var q_Gibetagamma_init: fmol {init: 1e-888};
var q_Gia_GDP_init: fmol {init: 1e-888};
var q_RM2_tag_init: fmol {init: 1e-888};
var q_L_RM2_tag_init: fmol {init: 1e-888};
var q_RM2_GRKArr_init: fmol {init: 1e-888};
var q_L_RM2_GRKArr_init: fmol {init: 1e-888};
// mass conservation checks
var LB1_T: fmol;
var RB1_T: fmol;
var Gs_T: fmol;
var adenosine_T: fmol;
LB1_T = q_LB1+q_L_RB1_Gs+q_L_RB1+q_L_RB1_aby+q_L_RB1_aby_T;
RB1_T = q_RB1+q_RB1_Gs+q_L_RB1+q_L_RB1_Gs+q_RB1_aby+q_RB1_aby_T+q_L_RB1_aby+q_L_RB1_aby_T;
Gs_T = q_Gs+q_RB1_Gs+q_L_RB1_Gs+q_Gsa_GTP+q_Gsa_GDP+q_RB1_aby+q_RB1_aby_T+q_L_RB1_aby+q_L_RB1_aby_T;
adenosine_T = q_cAMP+q_PDE_cAMP+q_five_AMP+q_ATP+q_AC_ATP+q_Gsa_GTP_AC_ATP+q_FSK_AC_ATP;
// Global value
var q_ATP: fmol {pub: out};
var q_cAMP: fmol {pub: out};
var q_AC: fmol {pub: out};
var q_AC_ATP: fmol {pub: out};
var q_Gsa_GTP_AC: fmol {pub: out};
var q_Gsa_GTP_AC_ATP: fmol {pub: out};
var q_FSK_AC: fmol {pub: out};
var q_FSK_AC_ATP: fmol {pub: out};
var q_PDE: fmol {pub: out};
var q_PDE_cAMP: fmol {pub: out};
var q_five_AMP: fmol {pub: out};
var q_IBMX: fmol {pub: out};
var q_PDEinh: fmol {pub: out};
var q_Gsa_GTP: fmol {pub: out};
var q_FSK: fmol {pub: out};
var q_Gia_GTP: fmol {pub: out};
var q_ACinh: fmol {pub: out};
var q_PPi: fmol {pub: out};
var q_RB1_inactive: fmol {pub: out};
var q_L_RB1_inactive: fmol {pub: out};
var q_LB1: fmol {pub: out};
var q_RB1: fmol {pub: out};
var q_Gs: fmol {pub: out};
var q_RB1_Gs: fmol {pub: out};
var q_L_RB1: fmol {pub: out};
var q_L_RB1_Gs: fmol {pub: out};
var q_Gsbetagamma: fmol {pub: out};
var q_Gsa_GDP: fmol {pub: out};
var q_GTP: fmol {pub: out};
var q_GDP: fmol {pub: out};
var q_Pi: fmol {pub: out};
var q_RB1_tag: fmol {pub: out};
var q_L_RB1_tag: fmol {pub: out};
var q_RB1_GRKArr: fmol {pub: out};
var q_L_RB1_GRKArr: fmol {pub: out};
var q_GRKArr: fmol {pub: out};
var q_RM2_inactive: fmol {pub: out};
var q_L_RM2_inactive: fmol {pub: out};
var q_LM2: fmol {pub: out};
var q_RM2: fmol {pub: out};
var q_Gi: fmol {pub: out};
var q_RM2_Gi: fmol {pub: out};
var q_L_RM2: fmol {pub: out};
var q_L_RM2_Gi: fmol {pub: out};
var q_Gibetagamma: fmol {pub: out};
var q_Gia_GDP: fmol {pub: out};
var q_RM2_tag: fmol {pub: out};
var q_L_RM2_tag: fmol {pub: out};
var q_RM2_GRKArr: fmol {pub: out};
var q_L_RM2_GRKArr: fmol {pub: out};
// cAMP imports
var q_ATP_mcAMP: fmol {pub: in};
var q_cAMP_mcAMP: fmol {pub: in};
var q_AC_mcAMP: fmol {pub: in};
var q_AC_ATP_mcAMP: fmol {pub: in};
var q_Gsa_GTP_AC_mcAMP: fmol {pub: in};
var q_Gsa_GTP_AC_ATP_mcAMP: fmol {pub: in};
var q_FSK_AC_mcAMP: fmol {pub: in};
var q_FSK_AC_ATP_mcAMP: fmol {pub: in};
var q_PDE_mcAMP: fmol {pub: in};
var q_PDE_cAMP_mcAMP: fmol {pub: in};
var q_five_AMP_mcAMP: fmol {pub: in};
var q_IBMX_mcAMP: fmol {pub: in};
var q_PDEinh_mcAMP: fmol {pub: in};
var q_Gsa_GTP_mcAMP: fmol {pub: in};
var q_FSK_mcAMP: fmol {pub: in};
var q_Gia_GTP_mcAMP: fmol {pub: in};
var q_ACinh_mcAMP: fmol {pub: in};
var q_PPi_mcAMP: fmol {pub: in};
// GPCR_B1AR_reduced imports
var q_RB1_inactive_mGPCR_B1AR_reduced: fmol {pub: in};
var q_L_RB1_inactive_mGPCR_B1AR_reduced: fmol {pub: in};
var q_LB1_mGPCR_B1AR_reduced: fmol {pub: in};
var q_RB1_mGPCR_B1AR_reduced: fmol {pub: in};
var q_Gs_mGPCR_B1AR_reduced: fmol {pub: in};
var q_RB1_Gs_mGPCR_B1AR_reduced: fmol {pub: in};
var q_L_RB1_mGPCR_B1AR_reduced: fmol {pub: in};
var q_L_RB1_Gs_mGPCR_B1AR_reduced: fmol {pub: in};
var q_Gsa_GTP_mGPCR_B1AR_reduced: fmol {pub: in};
var q_Gsbetagamma_mGPCR_B1AR_reduced: fmol {pub: in};
var q_Gsa_GDP_mGPCR_B1AR_reduced: fmol {pub: in};
var q_GTP_mGPCR_B1AR_reduced: fmol {pub: in};
var q_GDP_mGPCR_B1AR_reduced: fmol {pub: in};
var q_Pi_mGPCR_B1AR_reduced: fmol {pub: in};
var q_RB1_tag_mGPCR_B1AR_reduced: fmol {pub: in};
var q_L_RB1_tag_mGPCR_B1AR_reduced: fmol {pub: in};
var q_RB1_GRKArr_mGPCR_B1AR_reduced: fmol {pub: in};
var q_L_RB1_GRKArr_mGPCR_B1AR_reduced: fmol {pub: in};
var q_GRKArr_mGPCR_B1AR_reduced: fmol {pub: in};
// GPCR_M2_reduced imports
var q_RM2_inactive_mGPCR_M2_reduced: fmol {pub: in};
var q_L_RM2_inactive_mGPCR_M2_reduced: fmol {pub: in};
var q_LM2_mGPCR_M2_reduced: fmol {pub: in};
var q_RM2_mGPCR_M2_reduced: fmol {pub: in};
var q_Gi_mGPCR_M2_reduced: fmol {pub: in};
var q_RM2_Gi_mGPCR_M2_reduced: fmol {pub: in};
var q_L_RM2_mGPCR_M2_reduced: fmol {pub: in};
var q_L_RM2_Gi_mGPCR_M2_reduced: fmol {pub: in};
var q_Gia_GTP_mGPCR_M2_reduced: fmol {pub: in};
var q_Gibetagamma_mGPCR_M2_reduced: fmol {pub: in};
var q_Gia_GDP_mGPCR_M2_reduced: fmol {pub: in};
var q_GTP_mGPCR_M2_reduced: fmol {pub: in};
var q_GDP_mGPCR_M2_reduced: fmol {pub: in};
var q_Pi_mGPCR_M2_reduced: fmol {pub: in};
var q_RM2_tag_mGPCR_M2_reduced: fmol {pub: in};
var q_L_RM2_tag_mGPCR_M2_reduced: fmol {pub: in};
var q_RM2_GRKArr_mGPCR_M2_reduced: fmol {pub: in};
var q_L_RM2_GRKArr_mGPCR_M2_reduced: fmol {pub: in};
var q_GRKArr_mGPCR_M2_reduced: fmol {pub: in};
q_ATP = q_ATP_init + q_ATP_mcAMP ;
q_cAMP = q_cAMP_init + q_cAMP_mcAMP ;
q_AC = q_AC_init + q_AC_mcAMP ;
q_AC_ATP = q_AC_ATP_init + q_AC_ATP_mcAMP ;
q_Gsa_GTP_AC = q_Gsa_GTP_AC_init + q_Gsa_GTP_AC_mcAMP ;
q_Gsa_GTP_AC_ATP = q_Gsa_GTP_AC_ATP_init + q_Gsa_GTP_AC_ATP_mcAMP ;
q_FSK_AC = q_FSK_AC_init + q_FSK_AC_mcAMP ;
q_FSK_AC_ATP = q_FSK_AC_ATP_init + q_FSK_AC_ATP_mcAMP ;
q_PDE = q_PDE_init + q_PDE_mcAMP ;
q_PDE_cAMP = q_PDE_cAMP_init + q_PDE_cAMP_mcAMP ;
q_five_AMP = q_five_AMP_init + q_five_AMP_mcAMP ;
q_IBMX = q_IBMX_init + q_IBMX_mcAMP ;
q_PDEinh = q_PDEinh_init + q_PDEinh_mcAMP ;
q_Gsa_GTP = q_Gsa_GTP_init + q_Gsa_GTP_mcAMP + q_Gsa_GTP_mGPCR_B1AR_reduced ;
q_FSK = q_FSK_init + q_FSK_mcAMP ;
q_Gia_GTP = q_Gia_GTP_init + q_Gia_GTP_mcAMP + q_Gia_GTP_mGPCR_M2_reduced ;
q_ACinh = q_ACinh_init + q_ACinh_mcAMP ;
q_PPi = q_PPi_init + q_PPi_mcAMP ;
q_RB1_inactive = q_RB1_inactive_init + q_RB1_inactive_mGPCR_B1AR_reduced ;
q_L_RB1_inactive = q_L_RB1_inactive_init + q_L_RB1_inactive_mGPCR_B1AR_reduced ;
q_LB1 = q_LB1_init + q_LB1_mGPCR_B1AR_reduced ;
q_RB1 = q_RB1_init + q_RB1_mGPCR_B1AR_reduced ;
q_Gs = q_Gs_init + q_Gs_mGPCR_B1AR_reduced ;
q_RB1_Gs = q_RB1_Gs_init + q_RB1_Gs_mGPCR_B1AR_reduced ;
q_L_RB1 = q_L_RB1_init + q_L_RB1_mGPCR_B1AR_reduced ;
q_L_RB1_Gs = q_L_RB1_Gs_init + q_L_RB1_Gs_mGPCR_B1AR_reduced ;
q_Gsbetagamma = q_Gsbetagamma_init + q_Gsbetagamma_mGPCR_B1AR_reduced ;
q_Gsa_GDP = q_Gsa_GDP_init + q_Gsa_GDP_mGPCR_B1AR_reduced ;
q_GTP = q_GTP_init + q_GTP_mGPCR_B1AR_reduced + q_GTP_mGPCR_M2_reduced ;
q_GDP = q_GDP_init + q_GDP_mGPCR_B1AR_reduced + q_GDP_mGPCR_M2_reduced ;
q_Pi = q_Pi_init + q_Pi_mGPCR_B1AR_reduced + q_Pi_mGPCR_M2_reduced ;
q_RB1_tag = q_RB1_tag_init + q_RB1_tag_mGPCR_B1AR_reduced ;
q_L_RB1_tag = q_L_RB1_tag_init + q_L_RB1_tag_mGPCR_B1AR_reduced ;
q_RB1_GRKArr = q_RB1_GRKArr_init + q_RB1_GRKArr_mGPCR_B1AR_reduced ;
q_L_RB1_GRKArr = q_L_RB1_GRKArr_init + q_L_RB1_GRKArr_mGPCR_B1AR_reduced ;
q_GRKArr = q_GRKArr_init + q_GRKArr_mGPCR_B1AR_reduced + q_GRKArr_mGPCR_M2_reduced ;
q_RM2_inactive = q_RM2_inactive_init + q_RM2_inactive_mGPCR_M2_reduced ;
q_L_RM2_inactive = q_L_RM2_inactive_init + q_L_RM2_inactive_mGPCR_M2_reduced ;
q_LM2 = q_LM2_init + q_LM2_mGPCR_M2_reduced ;
q_RM2 = q_RM2_init + q_RM2_mGPCR_M2_reduced ;
q_Gi = q_Gi_init + q_Gi_mGPCR_M2_reduced ;
q_RM2_Gi = q_RM2_Gi_init + q_RM2_Gi_mGPCR_M2_reduced ;
q_L_RM2 = q_L_RM2_init + q_L_RM2_mGPCR_M2_reduced ;
q_L_RM2_Gi = q_L_RM2_Gi_init + q_L_RM2_Gi_mGPCR_M2_reduced ;
q_Gibetagamma = q_Gibetagamma_init + q_Gibetagamma_mGPCR_M2_reduced ;
q_Gia_GDP = q_Gia_GDP_init + q_Gia_GDP_mGPCR_M2_reduced ;
q_RM2_tag = q_RM2_tag_init + q_RM2_tag_mGPCR_M2_reduced ;
q_L_RM2_tag = q_L_RM2_tag_init + q_L_RM2_tag_mGPCR_M2_reduced ;
q_RM2_GRKArr = q_RM2_GRKArr_init + q_RM2_GRKArr_mGPCR_M2_reduced ;
q_L_RM2_GRKArr = q_L_RM2_GRKArr_init + q_L_RM2_GRKArr_mGPCR_M2_reduced ;
enddef;
def map between environment and cAMP for
vars time and time;
vars q_ATP_mcAMP and q_ATP;
vars q_ATP and q_ATP_global;
vars q_cAMP_mcAMP and q_cAMP;
vars q_cAMP and q_cAMP_global;
vars q_AC_mcAMP and q_AC;
vars q_AC and q_AC_global;
vars q_AC_ATP_mcAMP and q_AC_ATP;
vars q_AC_ATP and q_AC_ATP_global;
vars q_Gsa_GTP_AC_mcAMP and q_Gsa_GTP_AC;
vars q_Gsa_GTP_AC and q_Gsa_GTP_AC_global;
vars q_Gsa_GTP_AC_ATP_mcAMP and q_Gsa_GTP_AC_ATP;
vars q_Gsa_GTP_AC_ATP and q_Gsa_GTP_AC_ATP_global;
vars q_FSK_AC_mcAMP and q_FSK_AC;
vars q_FSK_AC and q_FSK_AC_global;
vars q_FSK_AC_ATP_mcAMP and q_FSK_AC_ATP;
vars q_FSK_AC_ATP and q_FSK_AC_ATP_global;
vars q_PDE_mcAMP and q_PDE;
vars q_PDE and q_PDE_global;
vars q_PDE_cAMP_mcAMP and q_PDE_cAMP;
vars q_PDE_cAMP and q_PDE_cAMP_global;
vars q_five_AMP_mcAMP and q_five_AMP;
vars q_five_AMP and q_five_AMP_global;
vars q_IBMX_mcAMP and q_IBMX;
vars q_IBMX and q_IBMX_global;
vars q_PDEinh_mcAMP and q_PDEinh;
vars q_PDEinh and q_PDEinh_global;
vars q_Gsa_GTP_mcAMP and q_Gsa_GTP;
vars q_Gsa_GTP and q_Gsa_GTP_global;
vars q_FSK_mcAMP and q_FSK;
vars q_FSK and q_FSK_global;
vars q_Gia_GTP_mcAMP and q_Gia_GTP;
vars q_Gia_GTP and q_Gia_GTP_global;
vars q_ACinh_mcAMP and q_ACinh;
vars q_ACinh and q_ACinh_global;
vars q_PPi_mcAMP and q_PPi;
vars q_PPi and q_PPi_global;
enddef;
def map between environment and GPCR_B1AR_reduced for
vars time and time;
vars q_RB1_inactive_mGPCR_B1AR_reduced and q_RB1_inactive;
vars q_RB1_inactive and q_RB1_inactive_global;
vars q_L_RB1_inactive_mGPCR_B1AR_reduced and q_L_RB1_inactive;
vars q_L_RB1_inactive and q_L_RB1_inactive_global;
vars q_LB1_mGPCR_B1AR_reduced and q_LB1;
vars q_LB1 and q_LB1_global;
vars q_RB1_mGPCR_B1AR_reduced and q_RB1;
vars q_RB1 and q_RB1_global;
vars q_Gs_mGPCR_B1AR_reduced and q_Gs;
vars q_Gs and q_Gs_global;
vars q_RB1_Gs_mGPCR_B1AR_reduced and q_RB1_Gs;
vars q_RB1_Gs and q_RB1_Gs_global;
vars q_L_RB1_mGPCR_B1AR_reduced and q_L_RB1;
vars q_L_RB1 and q_L_RB1_global;
vars q_L_RB1_Gs_mGPCR_B1AR_reduced and q_L_RB1_Gs;
vars q_L_RB1_Gs and q_L_RB1_Gs_global;
vars q_Gsa_GTP_mGPCR_B1AR_reduced and q_Gsa_GTP;
vars q_Gsa_GTP and q_Gsa_GTP_global;
vars q_Gsbetagamma_mGPCR_B1AR_reduced and q_Gsbetagamma;
vars q_Gsbetagamma and q_Gsbetagamma_global;
vars q_Gsa_GDP_mGPCR_B1AR_reduced and q_Gsa_GDP;
vars q_Gsa_GDP and q_Gsa_GDP_global;
vars q_GTP_mGPCR_B1AR_reduced and q_GTP;
vars q_GTP and q_GTP_global;
vars q_GDP_mGPCR_B1AR_reduced and q_GDP;
vars q_GDP and q_GDP_global;
vars q_Pi_mGPCR_B1AR_reduced and q_Pi;
vars q_Pi and q_Pi_global;
vars q_RB1_tag_mGPCR_B1AR_reduced and q_RB1_tag;
vars q_RB1_tag and q_RB1_tag_global;
vars q_L_RB1_tag_mGPCR_B1AR_reduced and q_L_RB1_tag;
vars q_L_RB1_tag and q_L_RB1_tag_global;
vars q_RB1_GRKArr_mGPCR_B1AR_reduced and q_RB1_GRKArr;
vars q_RB1_GRKArr and q_RB1_GRKArr_global;
vars q_L_RB1_GRKArr_mGPCR_B1AR_reduced and q_L_RB1_GRKArr;
vars q_L_RB1_GRKArr and q_L_RB1_GRKArr_global;
vars q_GRKArr_mGPCR_B1AR_reduced and q_GRKArr;
vars q_GRKArr and q_GRKArr_global;
enddef;
def map between environment and GPCR_M2_reduced for
vars time and time;
vars q_RM2_inactive_mGPCR_M2_reduced and q_RM2_inactive;
vars q_RM2_inactive and q_RM2_inactive_global;
vars q_L_RM2_inactive_mGPCR_M2_reduced and q_L_RM2_inactive;
vars q_L_RM2_inactive and q_L_RM2_inactive_global;
vars q_LM2_mGPCR_M2_reduced and q_LM2;
vars q_LM2 and q_LM2_global;
vars q_RM2_mGPCR_M2_reduced and q_RM2;
vars q_RM2 and q_RM2_global;
vars q_Gi_mGPCR_M2_reduced and q_Gi;
vars q_Gi and q_Gi_global;
vars q_RM2_Gi_mGPCR_M2_reduced and q_RM2_Gi;
vars q_RM2_Gi and q_RM2_Gi_global;
vars q_L_RM2_mGPCR_M2_reduced and q_L_RM2;
vars q_L_RM2 and q_L_RM2_global;
vars q_L_RM2_Gi_mGPCR_M2_reduced and q_L_RM2_Gi;
vars q_L_RM2_Gi and q_L_RM2_Gi_global;
vars q_Gia_GTP_mGPCR_M2_reduced and q_Gia_GTP;
vars q_Gia_GTP and q_Gia_GTP_global;
vars q_Gibetagamma_mGPCR_M2_reduced and q_Gibetagamma;
vars q_Gibetagamma and q_Gibetagamma_global;
vars q_Gia_GDP_mGPCR_M2_reduced and q_Gia_GDP;
vars q_Gia_GDP and q_Gia_GDP_global;
vars q_GTP_mGPCR_M2_reduced and q_GTP;
vars q_GTP and q_GTP_global;
vars q_GDP_mGPCR_M2_reduced and q_GDP;
vars q_GDP and q_GDP_global;
vars q_Pi_mGPCR_M2_reduced and q_Pi;
vars q_Pi and q_Pi_global;
vars q_RM2_tag_mGPCR_M2_reduced and q_RM2_tag;
vars q_RM2_tag and q_RM2_tag_global;
vars q_L_RM2_tag_mGPCR_M2_reduced and q_L_RM2_tag;
vars q_L_RM2_tag and q_L_RM2_tag_global;
vars q_RM2_GRKArr_mGPCR_M2_reduced and q_RM2_GRKArr;
vars q_RM2_GRKArr and q_RM2_GRKArr_global;
vars q_L_RM2_GRKArr_mGPCR_M2_reduced and q_L_RM2_GRKArr;
vars q_L_RM2_GRKArr and q_L_RM2_GRKArr_global;
vars q_GRKArr_mGPCR_M2_reduced and q_GRKArr;
vars q_GRKArr and q_GRKArr_global;
enddef;
def map between BG_parameters and cAMP for
vars kappa_1a and kappa_1a;
vars kappa_1b and kappa_1b;
vars kappa_2a and kappa_2a;
vars kappa_2b and kappa_2b;
vars kappa_3a and kappa_3a;
vars kappa_3b and kappa_3b;
vars kappa_4a and kappa_4a;
vars kappa_4b and kappa_4b;
vars kappa_5 and kappa_5;
vars kappa_6 and kappa_6;
vars kappa_7 and kappa_7;
vars kappa_GiAC and kappa_GiAC;
vars K_ATP and K_ATP;
vars K_cAMP and K_cAMP;
vars K_AC and K_AC;
vars K_AC_ATP and K_AC_ATP;
vars K_Gsa_GTP_AC and K_Gsa_GTP_AC;
vars K_Gsa_GTP_AC_ATP and K_Gsa_GTP_AC_ATP;
vars K_FSK_AC and K_FSK_AC;
vars K_FSK_AC_ATP and K_FSK_AC_ATP;
vars K_PDE and K_PDE;
vars K_PDE_cAMP and K_PDE_cAMP;
vars K_five_AMP and K_five_AMP;
vars K_IBMX and K_IBMX;
vars K_PDEinh and K_PDEinh;
vars K_Gsa_GTP and K_Gsa_GTP;
vars K_FSK and K_FSK;
vars K_Gia_GTP and K_Gia_GTP;
vars K_ACinh and K_ACinh;
vars K_PPi and K_PPi;
enddef;
def map between BG_parameters and GPCR_B1AR_reduced for
vars kappa_Rswitch_B1 and kappa_Rswitch_B1;
vars kappa_LRswitch_B1 and kappa_LRswitch_B1;
vars kappa_C_B1 and kappa_C_B1;
vars kappa_R_B1 and kappa_R_B1;
vars kappa_L_B1 and kappa_L_B1;
vars kappa_Act1_Gs and kappa_Act1_Gs;
vars kappa_Act2_Gs and kappa_Act2_Gs;
vars kappa_Hyd_Gs and kappa_Hyd_Gs;
vars kappa_Reassoc_Gs and kappa_Reassoc_Gs;
vars kappa_InternR_B1 and kappa_InternR_B1;
vars kappa_InternLR_B1 and kappa_InternLR_B1;
vars K_RB1_inactive and K_RB1_inactive;
vars K_L_RB1_inactive and K_L_RB1_inactive;
vars K_LB1 and K_LB1;
vars K_RB1 and K_RB1;
vars K_Gs and K_Gs;
vars K_RB1_Gs and K_RB1_Gs;
vars K_L_RB1 and K_L_RB1;
vars K_L_RB1_Gs and K_L_RB1_Gs;
vars K_Gsa_GTP and K_Gsa_GTP;
vars K_Gsbetagamma and K_Gsbetagamma;
vars K_Gsa_GDP and K_Gsa_GDP;
vars K_GTP and K_GTP;
vars K_GDP and K_GDP;
vars K_Pi and K_Pi;
vars K_RB1_tag and K_RB1_tag;
vars K_L_RB1_tag and K_L_RB1_tag;
vars K_RB1_GRKArr and K_RB1_GRKArr;
vars K_L_RB1_GRKArr and K_L_RB1_GRKArr;
vars K_GRKArr and K_GRKArr;
enddef;
def map between BG_parameters and GPCR_M2_reduced for
vars kappa_Rswitch_M2 and kappa_Rswitch_M2;
vars kappa_LRswitch_M2 and kappa_LRswitch_M2;
vars kappa_C_M2 and kappa_C_M2;
vars kappa_R_M2 and kappa_R_M2;
vars kappa_L_M2 and kappa_L_M2;
vars kappa_Act1_Gi and kappa_Act1_Gi;
vars kappa_Act2_Gi and kappa_Act2_Gi;
vars kappa_Hyd_Gi and kappa_Hyd_Gi;
vars kappa_Reassoc_Gi and kappa_Reassoc_Gi;
vars kappa_InternR_M2 and kappa_InternR_M2;
vars kappa_InternLR_M2 and kappa_InternLR_M2;
vars K_RM2_inactive and K_RM2_inactive;
vars K_L_RM2_inactive and K_L_RM2_inactive;
vars K_LM2 and K_LM2;
vars K_RM2 and K_RM2;
vars K_Gi and K_Gi;
vars K_RM2_Gi and K_RM2_Gi;
vars K_L_RM2 and K_L_RM2;
vars K_L_RM2_Gi and K_L_RM2_Gi;
vars K_Gia_GTP and K_Gia_GTP;
vars K_Gibetagamma and K_Gibetagamma;
vars K_Gia_GDP and K_Gia_GDP;
vars K_GTP and K_GTP;
vars K_GDP and K_GDP;
vars K_Pi and K_Pi;
vars K_RM2_tag and K_RM2_tag;
vars K_L_RM2_tag and K_L_RM2_tag;
vars K_RM2_GRKArr and K_RM2_GRKArr;
vars K_L_RM2_GRKArr and K_L_RM2_GRKArr;
vars K_GRKArr and K_GRKArr;
enddef;
def map between constants and cAMP for
vars R and R;
vars T and T;
enddef;
def map between constants and GPCR_B1AR_reduced for
vars R and R;
vars T and T;
enddef;
def map between constants and GPCR_M2_reduced for
vars R and R;
vars T and T;
enddef;
enddef;
