- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-09-29 14:19:13+13:00
- Desc:
- correct the interface def and add individual currents for clamp experiment
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/701/rawfile/f5b5a6cc798b55f4a6f6a30cc839d5698a5a598c/Components/INSCa.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="INSCa" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../cellLib/Components/units.cellml">
<units name="pA_per_pF" units_ref="pA_per_pF"/>
<units name="pA" units_ref="pA"/>
<units name="nS" units_ref="nS"/>
<units name="mV" units_ref="mV"/>
<units name="mM" units_ref="mM"/>
<units name="nS_per_pF" units_ref="nS_per_pF"/>
<units name="J_per_K_mol" units_ref="J_per_K_mol"/>
<units name="C_per_mmol" units_ref="C_per_mmol"/>
<units name="pF_per_cmsq" units_ref="pF_per_cmsq"/>
<units name="cmsq" units_ref="cmsq"/>
</import>
<import xlink:href="../cellLib/Components/Ionic_currents.cellml">
<component component_ref="Ionic_currents" name="I_NSCa_pA"/>
</import>
<import xlink:href="../cellLib/Components/Nernst_potential.cellml">
<component component_ref="Nernst_potential" name="E_NS"/>
</import>
<import xlink:href="../cellLib/Components/Hillfcn.cellml">
<component component_ref="Hillfcn" name="H_Mg"/>
</import>
<import xlink:href="g_Xo.cellml">
<component component_ref="g_Xo" name="g_Cao"/>
</import>
<component name="INSCa">
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="g_NS" private_interface="out" public_interface="in" units="nS_per_pF"/>
<variable name="Cm" private_interface="out" public_interface="in" units="pF_per_cmsq"/>
<variable name="Ac" private_interface="out" public_interface="in" units="cmsq"/>
<variable name="R" private_interface="out" public_interface="in" units="J_per_K_mol"/>
<variable name="F" private_interface="out" public_interface="in" units="C_per_mmol"/>
<variable name="T" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="P_Ca" public_interface="in" units="dimensionless"/>
<variable name="P_Cap" units="dimensionless"/>
<variable name="PCa_PCs" public_interface="in" units="dimensionless"/>
<variable name="PNa_PCs" public_interface="in" units="dimensionless"/>
<variable name="PK_PCs" public_interface="in" units="dimensionless"/>
<variable name="Nao" private_interface="out" public_interface="in" units="mM"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Cao" private_interface="out" public_interface="in" units="mM"/>
<variable name="Cai" public_interface="in" units="mM"/>
<variable name="Ko" private_interface="out" public_interface="in" units="mM"/>
<variable name="Ki" public_interface="in" units="mM"/>
<variable name="X_o" private_interface="out" units="mM"/>
<variable name="X_i" private_interface="out" units="mM"/>
<variable name="Mgo" private_interface="out" public_interface="in" units="mM"/>
<variable name="K_dMg" public_interface="in" units="mM"/>
<variable name="f_Mg" units="dimensionless"/>
<variable name="H_Mg" private_interface="in" units="dimensionless"/>
<variable name="x_h" private_interface="out" units="dimensionless"/>
<variable initial_value="1.3" name="n_h" private_interface="out" units="dimensionless"/>
<variable name="g_Cao" private_interface="in" units="dimensionless"/>
<variable initial_value="0.000525" name="g_s" private_interface="out" units="dimensionless"/>
<variable initial_value="1" name="z_NS" private_interface="out" units="dimensionless"/>
<variable name="P_NSCa" private_interface="out" public_interface="out" units="dimensionless"/>
<variable name="I_NSCa" private_interface="in" public_interface="out" units="pA_per_pF"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_NSCa</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.15</cn>
<ci>f_Mg</ci>
<ci>g_Cao</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>x_h</ci>
<apply>
<divide/>
<ci>Mgo</ci>
<ci>K_dMg</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>f_Mg</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.9</cn>
<ci>H_Mg</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_Cap</ci>
<apply>
<divide/>
<ci>P_Ca</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>X_o</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>PNa_PCs</ci>
<ci>Nao</ci>
</apply>
<apply>
<times/>
<ci>PK_PCs</ci>
<ci>Ko</ci>
</apply>
<apply>
<times/>
<ci>P_Cap</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>PCa_PCs</ci>
<ci>Cao</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>X_i</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>PNa_PCs</ci>
<ci>Nai</ci>
</apply>
<apply>
<times/>
<ci>PK_PCs</ci>
<ci>Ki</ci>
</apply>
<apply>
<times/>
<ci>P_Cap</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>PCa_PCs</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="INSCa" component_2="H_Mg"/>
<map_variables variable_1="x_h" variable_2="x"/>
<map_variables variable_1="n_h" variable_2="n"/>
<map_variables variable_1="H_Mg" variable_2="H"/>
</connection>
<component name="convert_I_NSCa_pA">
<variable name="I_NSCa" public_interface="out" units="pA_per_pF"/>
<variable name="g_NS_ns" public_interface="out" units="nS"/>
<variable name="I_NSCa_pA" public_interface="in" units="pA"/>
<variable name="g_NS" public_interface="in" units="nS_per_pF"/>
<variable name="Cm" public_interface="in" units="pF_per_cmsq"/>
<variable name="Ac" public_interface="in" units="cmsq"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_NS_ns</ci>
<apply>
<times/>
<ci>g_NS</ci>
<ci>Cm</ci>
<ci>Ac</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NSCa</ci>
<apply>
<divide/>
<ci>I_NSCa_pA</ci>
<apply>
<times/>
<ci>Cm</ci>
<ci>Ac</ci>
</apply>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="INSCa">
<component_ref component="I_NSCa_pA"/>
<component_ref component="convert_I_NSCa_pA"/>
<component_ref component="E_NS"/>
<component_ref component="H_Mg"/>
<component_ref component="g_Cao"/>
</component_ref>
</group>
<connection>
<map_components component_1="INSCa" component_2="I_NSCa_pA"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="P_NSCa" variable_2="PO"/>
</connection>
<connection>
<map_components component_1="INSCa" component_2="g_Cao"/>
<map_variables variable_1="g_s" variable_2="g_s"/>
<map_variables variable_1="Cao" variable_2="X_o"/>
<map_variables variable_1="g_Cao" variable_2="g_Xo"/>
</connection>
<connection>
<map_components component_1="INSCa" component_2="E_NS"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="z_NS" variable_2="z"/>
<map_variables variable_1="X_i" variable_2="X_i"/>
<map_variables variable_1="X_o" variable_2="X_o"/>
</connection>
<connection>
<map_components component_1="E_NS" component_2="I_NSCa_pA"/>
<map_variables variable_1="E" variable_2="E"/>
</connection>
<connection>
<map_components component_1="convert_I_NSCa_pA" component_2="I_NSCa_pA"/>
<map_variables variable_1="I_NSCa_pA" variable_2="I"/>
<map_variables variable_1="g_NS_ns" variable_2="g_max"/>
</connection>
<connection>
<map_components component_1="INSCa" component_2="convert_I_NSCa_pA"/>
<map_variables variable_1="I_NSCa" variable_2="I_NSCa"/>
<map_variables variable_1="g_NS" variable_2="g_NS"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="Ac" variable_2="Ac"/>
</connection>
</model>
