- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-09-29 14:19:13+13:00
- Desc:
- correct the interface def and add individual currents for clamp experiment
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/701/rawfile/f5b5a6cc798b55f4a6f6a30cc839d5698a5a598c/Components/ICaT.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="ICaT" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../cellLib/Components/units.cellml">
<units name="ms" units_ref="ms"/>
<units name="pA_per_pF" units_ref="pA_per_pF"/>
<units name="pA" units_ref="pA"/>
<units name="mV" units_ref="mV"/>
<units name="nS_per_pF" units_ref="nS_per_pF"/>
<units name="nS" units_ref="nS"/>
<units name="pF_per_cmsq" units_ref="pF_per_cmsq"/>
<units name="cmsq" units_ref="cmsq"/>
</import>
<import xlink:href="../cellLib/Components/Ionic_currents.cellml">
<component component_ref="Ionic_currents" name="I_pA"/>
</import>
<import xlink:href="../cellLib/Components/gating_kinetics.cellml">
<component component_ref="gating_kinetics" name="b_gate"/>
</import>
<import xlink:href="../cellLib/Components/gating_kinetics.cellml">
<component component_ref="gating_kinetics" name="g_gate"/>
</import>
<import xlink:href="ICaT_gating.cellml">
<component component_ref="b_inf" name="b_inf"/>
<component component_ref="g_inf" name="g_inf"/>
<component component_ref="tau_b" name="tau_b"/>
<component component_ref="tau_g" name="tau_g"/>
</import>
<component name="ICaT">
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="I_CaT" private_interface="in" public_interface="out" units="pA_per_pF"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="E_CaT" private_interface="out" public_interface="in" units="mV"/>
<variable name="g_CaT" private_interface="out" public_interface="in" units="nS_per_pF"/>
<variable name="Cm" private_interface="out" public_interface="in" units="pF_per_cmsq"/>
<variable name="Ac" private_interface="out" public_interface="in" units="cmsq"/>
<variable name="T" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="T0CaT" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="Q10Ca" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="b_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="b" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="g_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="g" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="P_CaT" private_interface="out" public_interface="out" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_CaT</ci>
<apply>
<times/>
<apply>
<power/>
<ci>b</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>g</ci>
</apply>
</apply>
</math>
</component>
<component name="convert_I_pA">
<variable name="I_CaT" public_interface="out" units="pA_per_pF"/>
<variable name="g_CaT_ns" public_interface="out" units="nS"/>
<variable name="I_pA" public_interface="in" units="pA"/>
<variable name="g_CaT" public_interface="in" units="nS_per_pF"/>
<variable name="Cm" public_interface="in" units="pF_per_cmsq"/>
<variable name="Ac" public_interface="in" units="cmsq"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_CaT_ns</ci>
<apply>
<times/>
<ci>g_CaT</ci>
<ci>Cm</ci>
<ci>Ac</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_CaT</ci>
<apply>
<divide/>
<ci>I_pA</ci>
<apply>
<times/>
<ci>Cm</ci>
<ci>Ac</ci>
</apply>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="ICaT">
<component_ref component="I_pA"/>
<component_ref component="convert_I_pA"/>
<component_ref component="b_gate"/>
<component_ref component="g_gate"/>
<component_ref component="b_inf"/>
<component_ref component="g_inf"/>
<component_ref component="tau_b"/>
<component_ref component="tau_g"/>
</component_ref>
</group>
<connection>
<map_components component_1="ICaT" component_2="b_inf"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ICaT" component_2="g_inf"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ICaT" component_2="tau_b"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ICaT" component_2="tau_g"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ICaT" component_2="b_gate"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Q10Ca" variable_2="Q_10"/>
<map_variables variable_1="T0CaT" variable_2="T_0"/>
<map_variables variable_1="b_init" variable_2="X_init"/>
<map_variables variable_1="b" variable_2="X"/>
</connection>
<connection>
<map_components component_1="ICaT" component_2="g_gate"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Q10Ca" variable_2="Q_10"/>
<map_variables variable_1="T0CaT" variable_2="T_0"/>
<map_variables variable_1="g_init" variable_2="X_init"/>
<map_variables variable_1="g" variable_2="X"/>
</connection>
<connection>
<map_components component_1="b_inf" component_2="b_gate"/>
<map_variables variable_1="X_inf" variable_2="X_inf"/>
</connection>
<connection>
<map_components component_1="g_inf" component_2="g_gate"/>
<map_variables variable_1="X_inf" variable_2="X_inf"/>
</connection>
<connection>
<map_components component_1="tau_b" component_2="b_gate"/>
<map_variables variable_1="tau" variable_2="tau_X"/>
</connection>
<connection>
<map_components component_1="tau_g" component_2="g_gate"/>
<map_variables variable_1="tau" variable_2="tau_X"/>
</connection>
<connection>
<map_components component_1="ICaT" component_2="I_pA"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="E_CaT" variable_2="E"/>
<map_variables variable_1="P_CaT" variable_2="PO"/>
</connection>
<connection>
<map_components component_1="convert_I_pA" component_2="I_pA"/>
<map_variables variable_1="I_pA" variable_2="I"/>
<map_variables variable_1="g_CaT_ns" variable_2="g_max"/>
</connection>
<connection>
<map_components component_1="ICaT" component_2="convert_I_pA"/>
<map_variables variable_1="I_CaT" variable_2="I_CaT"/>
<map_variables variable_1="g_CaT" variable_2="g_CaT"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="Ac" variable_2="Ac"/>
</connection>
</model>
