- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2022-10-19 10:24:37+13:00
- Desc:
- Add readme to link the documentation on overleaf.
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/701/rawfile/6741283829975cd4f084159e7734dcbece29f7b1/Components/default_values_0.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="default_values" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../cellLib/Components/units.cellml">
<units name="ms" units_ref="ms"/>
<units name="mV" units_ref="mV"/>
<units name="mM" units_ref="mM"/>
<units name="pA" units_ref="pA"/>
<units name="pF" units_ref="pF"/>
<units name="cmsq" units_ref="cmsq"/>
<units name="per_ms" units_ref="per_ms"/>
<units name="nS_per_pF" units_ref="nS_per_pF"/>
<units name="uJ_per_K_mmol" units_ref="uJ_per_K_mmol"/>
<units name="C_per_mol" units_ref="C_per_mol"/>
<units name="cm3" units_ref="cm3"/>
<units name="per_cmsq" units_ref="per_cmsq"/>
<units name="cm3_per_s" units_ref="cm3_per_s"/>
<units name="mM_per_ms" units_ref="mM_per_ms"/>
<units name="per_mMsq_ms" units_ref="per_mMsq_ms"/>
<units name="per_mM_ms" units_ref="per_mM_ms"/>
<units name="uN_per_um" units_ref="uN_per_um"/>
<units name="uN_ms_per_um" units_ref="uN_ms_per_um"/>
<units name="uN" units_ref="uN"/>
<units name="um" units_ref="um"/>
<units name="pA_per_pF" units_ref="pA_per_pF"/>
<units name="um_per_ms" units_ref="um_per_ms"/>
<units name="mF_per_cmsq" units_ref="mF_per_cmsq"/>
</import>
<units name="mol2_per_J_s_cmsq">
<unit exponent="2" units="mole"/>
<unit exponent="-1" units="joule"/>
<unit exponent="-1" units="second"/>
<unit exponent="-1" units="cmsq"/>
</units>
<units name="nmol2_per_J_s_cmsq">
<unit prefix="nano" units="mol2_per_J_s_cmsq"/>
</units>
<component name="constants">
<!--var R: J_per_K_mol {init: 8.314, pub: out};-->
<variable initial_value="8314" name="R" public_interface="out" units="uJ_per_K_mmol"/>
<!-- var F: C_per_mmol {init: 96.48534, pub: out};-->
<variable initial_value="96485" name="F" public_interface="out" units="C_per_mol"/>
<!--var F: mC_per_mmol {init: 96485, pub: out};-->
<variable initial_value="1" name="z_Na" public_interface="out" units="dimensionless"/>
<variable initial_value="2" name="z_Ca" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="z_K" public_interface="out" units="dimensionless"/>
<variable initial_value="-1" name="z_Cl" public_interface="out" units="dimensionless"/>
</component>
<component name="model_parameters">
<variable initial_value="308" name="T" public_interface="out" units="kelvin"/>
<!--var Cm: pF_per_cmsq {init: 1.4e6, pub: out};-->
<!-- var Cm: uF_per_cmsq {init: 1.4, pub: out};-->
<variable initial_value="1.4e-3" name="Cm" public_interface="out" units="mF_per_cmsq"/>
<variable initial_value="7.422e-5" name="Ac" public_interface="out" units="cmsq"/>
<variable initial_value="2.65e-8" name="Vc" public_interface="out" units="cm3"/>
<variable initial_value="2.5" name="Cao" public_interface="out" units="mM"/>
<variable initial_value="5.4" name="Ko" public_interface="out" units="mM"/>
<variable initial_value="140" name="Nao" public_interface="out" units="mM"/>
<variable initial_value="0.5" name="Mgo" public_interface="out" units="mM"/>
<variable initial_value="146.4" name="Clo" public_interface="out" units="mM"/>
<variable initial_value="2.1" name="Q10Ca" public_interface="out" units="dimensionless"/>
<variable initial_value="3.1" name="Q10K" public_interface="out" units="dimensionless"/>
<variable initial_value="2.45" name="Q10Na" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="Q10h" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="Q10Cl" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="Q10KCa" public_interface="out" units="dimensionless"/>
<variable initial_value="308" name="T0CaL" public_interface="out" units="kelvin"/>
<variable initial_value="308" name="T0CaT" public_interface="out" units="kelvin"/>
<variable initial_value="308" name="T0K" public_interface="out" units="kelvin"/>
<variable initial_value="308" name="T0Na" public_interface="out" units="kelvin"/>
<variable initial_value="308" name="T0h" public_interface="out" units="kelvin"/>
<variable initial_value="308" name="T0Cl" public_interface="out" units="kelvin"/>
<variable initial_value="308" name="T0KCa" public_interface="out" units="kelvin"/>
<variable initial_value="0.318" name="g_CaL" public_interface="out" units="nS_per_pF"/>
<variable initial_value="1e-12" name="nif" public_interface="out" units="mM"/>
<!-- var nif: mM {init: 0, pub: out};-->
<variable initial_value="1e-6" name="IC50_nif" public_interface="out" units="mM"/>
<variable initial_value="45" name="E_CaL" public_interface="out" units="mV"/>
<variable initial_value="0.6e-3" name="K_mCaL" public_interface="out" units="mM"/>
<variable initial_value="12" name="tau_f1" public_interface="out" units="ms"/>
<variable initial_value="0.02319" name="g_CaT" public_interface="out" units="nS_per_pF"/>
<variable initial_value="42" name="E_CaT" public_interface="out" units="mV"/>
<variable initial_value="0.1152" name="g_Na" public_interface="out" units="nS_per_pF"/>
<variable initial_value="0.2048" name="g_K1" public_interface="out" units="nS_per_pF"/>
<variable initial_value="0.0315" name="g_K2" public_interface="out" units="nS_per_pF"/>
<variable initial_value="0.001418" name="g_KA" public_interface="out" units="nS_per_pF"/>
<variable initial_value="5.94e6" name="N_BKCa" public_interface="out" units="per_cmsq"/>
<variable initial_value="100" name="C_est" public_interface="out" units="pF"/>
<variable initial_value="0.84" name="tau_pf" public_interface="out" units="ms"/>
<variable initial_value="35.9" name="tau_ps" public_interface="out" units="ms"/>
<variable initial_value="3.9e-12" name="P_BKCa" public_interface="out" units="cm3_per_s"/>
<variable initial_value="0.0004" name="g_Kleak" public_interface="out" units="nS_per_pF"/>
<variable initial_value="0.04065" name="g_h" public_interface="out" units="nS_per_pF"/>
<variable initial_value="0.35" name="P_NaK" public_interface="out" units="dimensionless"/>
<variable initial_value="0.1875" name="g_Cl" public_interface="out" units="nS_per_pF"/>
<variable initial_value="0.25698" name="K_dCl" public_interface="out" units="mM"/>
<variable initial_value="0.69" name="tau_n" public_interface="out" units="ms"/>
<variable initial_value="3.5e-6" name="J_pCa" public_interface="out" units="mM_per_ms"/>
<variable initial_value="0.5e-3" name="K_mpCa" public_interface="out" units="mM"/>
<variable initial_value="2" name="hpCa" public_interface="out" units="dimensionless"/>
<variable initial_value="1.7" name="g_NaK" public_interface="out" units="nS_per_pF"/>
<variable initial_value="2" name="K_dK" public_interface="out" units="mM"/>
<variable initial_value="1.5" name="n_K" public_interface="out" units="dimensionless"/>
<variable initial_value="22" name="K_dNa" public_interface="out" units="mM"/>
<variable initial_value="2" name="n_Na" public_interface="out" units="dimensionless"/>
<variable initial_value="1.75e-5" name="J_NaCamax" public_interface="out" units="mM_per_ms"/>
<variable initial_value="0.3e-3" name="K_mAllo" public_interface="out" units="mM"/>
<variable initial_value="4" name="n_Allo" public_interface="out" units="dimensionless"/>
<variable initial_value="0.27" name="k_sat" public_interface="out" units="dimensionless"/>
<variable initial_value="0.35" name="gamma" public_interface="out" units="dimensionless"/>
<variable initial_value="30" name="K_mNai" public_interface="out" units="mM"/>
<variable initial_value="7e-3" name="K_mCai" public_interface="out" units="mM"/>
<variable initial_value="87.5" name="K_mNao" public_interface="out" units="mM"/>
<variable initial_value="1.3" name="K_mCao" public_interface="out" units="mM"/>
<variable initial_value="3.58e-10" name="L_NaKCl" public_interface="out" units="nmol2_per_J_s_cmsq"/>
<variable initial_value="1" name="R_NaKCl" public_interface="out" units="dimensionless"/>
<variable initial_value="87" name="E_Ca" public_interface="out" units="mV"/>
<variable initial_value="5.75e-4" name="g_SOCNa" public_interface="out" units="nS_per_pF"/>
<variable initial_value="8.3e-5" name="g_SOCCa" public_interface="out" units="nS_per_pF"/>
<variable initial_value="0.1e-3" name="K_mSOC" public_interface="out" units="mM"/>
<variable initial_value="0.0123" name="g_NS" public_interface="out" units="nS_per_pF"/>
<variable initial_value="0.007748" name="g_leak" public_interface="out" units="nS_per_pF"/>
<variable initial_value="0.28" name="K_dMg" public_interface="out" units="mM"/>
<variable initial_value="0.9" name="PNa_PCs" public_interface="out" units="dimensionless"/>
<variable initial_value="1.3" name="PK_PCs" public_interface="out" units="dimensionless"/>
<variable initial_value="0.89" name="PCa_PCs" public_interface="out" units="dimensionless"/>
<variable initial_value="0.346" name="P_Ca" public_interface="out" units="dimensionless"/>
<variable initial_value="0.35" name="P_Na" public_interface="out" units="dimensionless"/>
<variable initial_value="0.6" name="I_sus" public_interface="out" units="pA"/>
<variable initial_value="20" name="F_BCa" public_interface="out" units="dimensionless"/>
<variable initial_value="0.3" name="S_CM" public_interface="out" units="mM"/>
<variable initial_value="0.2" name="B_F" public_interface="out" units="mM"/>
<variable initial_value="2.6e-4" name="K_d" public_interface="out" units="mM"/>
<variable initial_value="5.3981e-4" name="K_dB" public_interface="out" units="mM"/>
<variable initial_value="0.668" name="I_up0" public_interface="out" units="pA"/>
<variable initial_value="0.01" name="K_mup" public_interface="out" units="mM"/>
<variable initial_value="1.33e-9" name="Vol_u" public_interface="out" units="cm3"/>
<variable initial_value="1.33e-11" name="Vol_r" public_interface="out" units="cm3"/>
<variable initial_value="180" name="tau_tr" public_interface="out" units="ms"/>
<variable initial_value="0.015" name="tau_rel" public_interface="out" units="ms"/>
<variable initial_value="0.2" name="F_rel" public_interface="out" units="dimensionless"/>
<variable initial_value="15" name="CSQN" public_interface="out" units="mM"/>
<variable initial_value="0.8" name="K_CSQN" public_interface="out" units="mM"/>
<variable initial_value="75.07e-4" name="R_leak" public_interface="out" units="dimensionless"/>
<variable initial_value="2500" name="K_r1" public_interface="out" units="per_mMsq_ms"/>
<variable initial_value="0.0076" name="K_r1minus" public_interface="out" units="per_ms"/>
<variable initial_value="1.05" name="K_r2" public_interface="out" units="per_mM_ms"/>
<variable initial_value="0.084" name="K_r2minus" public_interface="out" units="per_ms"/>
<variable initial_value="0.84" name="MLCK_max" public_interface="out" units="dimensionless"/>
<variable initial_value="721.746e-6" name="K_MLCK" public_interface="out" units="mM"/>
<variable initial_value="1.08e-3" name="K_CaMLCK" public_interface="out" units="mM"/>
<variable initial_value="1" name="C_ms" public_interface="out" units="per_ms"/>
<variable initial_value="1" name="p_M" public_interface="out" units="dimensionless"/>
<variable initial_value="8.7613" name="n_M" public_interface="out" units="dimensionless"/>
<variable initial_value="0.4" name="K_2" public_interface="out" units="per_ms"/>
<variable initial_value="1.8" name="K_3" public_interface="out" units="per_ms"/>
<variable initial_value="0.1" name="K_4" public_interface="out" units="per_ms"/>
<variable initial_value="0.4" name="K_5" public_interface="out" units="per_ms"/>
<variable initial_value="0.045" name="K_7" public_interface="out" units="per_ms"/>
<variable initial_value="120" name="l_c" public_interface="out" units="um"/>
<variable initial_value="40" name="l_c0" public_interface="out" units="um"/>
<variable initial_value="30" name="l_s0" public_interface="out" units="um"/>
<variable initial_value="100" name="l_opt" public_interface="out" units="um"/>
<variable initial_value="12.5" name="k_x1" public_interface="out" units="uN_per_um"/>
<variable initial_value="8.8" name="k_x2" public_interface="out" units="uN_per_um"/>
<variable initial_value="0.2" name="k_s" public_interface="out" units="uN"/>
<variable initial_value="0.1" name="k_p" public_interface="out" units="uN"/>
<variable initial_value="5" name="v_x" public_interface="out" units="um_per_ms"/>
<variable initial_value="1.3" name="f_AMp" public_interface="out" units="uN_ms_per_um"/>
<variable initial_value="85.5" name="f_AM" public_interface="out" units="uN_ms_per_um"/>
<variable initial_value="0.01" name="mu_s" public_interface="out" units="uN_ms_per_um"/>
<variable initial_value="4.5" name="alpha_s" public_interface="out" units="dimensionless"/>
<variable initial_value="0.1" name="alpha_p" public_interface="out" units="dimensionless"/>
<variable initial_value="7.5" name="beta" public_interface="out" units="dimensionless"/>
</component>
<component name="initial_conditions">
<variable initial_value="8.97e-5" name="Cai_init" public_interface="out" units="mM"/>
<variable initial_value="4" name="Nai_init" public_interface="out" units="mM"/>
<variable initial_value="140" name="Ki_init" public_interface="out" units="mM"/>
<variable initial_value="130" name="Cli_init" public_interface="out" units="mM"/>
<variable initial_value="0.0273854" name="Cau_init" public_interface="out" units="mM"/>
<variable initial_value="0.0232185" name="Car_init" public_interface="out" units="mM"/>
<variable initial_value="0.0133195" name="d_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.938986" name="f1_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.938986" name="f2_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.179073" name="b_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.0308496" name="g_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.129659" name="m_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.360711" name="h_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.0741461" name="q_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.151067" name="r1_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.108987" name="r2_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.0794842" name="p_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.0060484" name="ps_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.0060484" name="pf_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.995353" name="k1_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.954862" name="k2_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.0385646" name="s_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.644685" name="x_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.00212991" name="y_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.00089031" name="c1_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.00089031" name="c2_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.440717" name="n_init" public_interface="out" units="dimensionless"/>
<variable initial_value="30.08" name="ls_init" public_interface="out" units="um"/>
<variable initial_value="25.3" name="la_init" public_interface="out" units="um"/>
<variable initial_value="64.62" name="lx_init" public_interface="out" units="um"/>
<variable initial_value="0.97" name="M_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.01" name="Mp_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.01" name="AM_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.01" name="AMp_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.001196" name="R00_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.0033" name="R10_init" public_interface="out" units="dimensionless"/>
<variable initial_value="0.9955" name="R01_init" public_interface="out" units="dimensionless"/>
<variable initial_value="4e-6" name="R11_init" public_interface="out" units="dimensionless"/>
</component>
</model>
