Location: Model of excitation-contraction in uterine myocytes from a pregnant rat @ 674128382997 / Components / cppEqs.cellml
- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2022-10-19 10:24:37+13:00
- Desc:
- Add readme to link the documentation on overleaf.
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/701/rawfile/6741283829975cd4f084159e7734dcbece29f7b1/Components/cppEqs.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="cpp" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#">
<!-- Your code goes here-->
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
<ci>ICaL_d_steady_state</ci>
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<divide/>
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<plus/>
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<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
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<ci>ICaL_d_Tau</ci>
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<plus/>
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<apply>
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<divide/>
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<plus/>
<ci>V</ci>
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<ci>ICaL_f_steady_state</ci>
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<exp/>
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<divide/>
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<plus/>
<ci>V</ci>
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<minus/>
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<ci>IC50_nif</ci>
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<ci>Cai</ci>
<ci>KmCaL</ci>
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<divide/>
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<minus/>
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<ci>V</ci>
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</apply>
<!--best fit to data 14xxxx. This provides closest IV curve, despite being odd fit to activation-->
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<eq/>
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<plus/>
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<plus/>
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<divide/>
<cn cellml:units="dimensionless">0.98</cn>
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<plus/>
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<exp/>
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<divide/>
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<plus/>
<ci>V</ci>
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<ci>V</ci>
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<power/>
<ci>ICaT_b</ci>
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<ci>ICaT_g</ci>
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<ci>V</ci>
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<ci>I_Na</ci>
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<divide/>
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<plus/>
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<eq/>
<ci>I_KA</ci>
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<times/>
<ci>gKA</ci>
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<power/>
<ci>IKA_s</ci>
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<exp/>
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<power/>
<ci>IKA_x</ci>
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<minus/>
<ci>V</ci>
<ci>EK</ci>
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<ci>iKCa</ci>
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<times/>
<cn cellml:units="dimensionless" type="e-notation">1<sep/>4</cn>
<ci>PBKCa</ci>
<ci>V</ci>
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<divide/>
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<times/>
<ci>Faraday</ci>
<ci>Faraday</ci>
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<times/>
<ci>R</ci>
<ci>Temperature</ci>
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<divide/>
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<minus/>
<ci>Ko</ci>
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<times/>
<ci>Ki</ci>
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<plus/>
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<divide/>
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<times/>
<ci>V</ci>
<ci>Faraday</ci>
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<times/>
<ci>R</ci>
<ci>Temperature</ci>
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<divide/>
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<power/>
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<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>Faraday</ci>
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<times/>
<ci>R</ci>
<ci>Temperature</ci>
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<cn cellml:units="dimensionless">2</cn>
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<divide/>
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<power/>
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<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>Faraday</ci>
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<times/>
<ci>R</ci>
<ci>Temperature</ci>
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<cn cellml:units="dimensionless">6</cn>
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<minus/>
<cn cellml:units="dimensionless">1</cn>
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<cn cellml:units="dimensionless">1</cn>
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<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>Faraday</ci>
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<times/>
<ci>R</ci>
<ci>Temperature</ci>
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<divide/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>Faraday</ci>
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<times/>
<ci>R</ci>
<ci>Temperature</ci>
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<cn cellml:units="dimensionless">2</cn>
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<divide/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>Faraday</ci>
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<times/>
<ci>R</ci>
<ci>Temperature</ci>
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<cn cellml:units="dimensionless">6</cn>
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<eq/>
<ci>iKCa</ci>
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<divide/>
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<times/>
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<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless" type="e-notation">1<sep/>4</cn>
<ci>PBKCa</ci>
<ci>V</ci>
<ci>Faraday</ci>
<ci>Faraday</ci>
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<times/>
<ci>R</ci>
<ci>Temperature</ci>
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<minus/>
<ci>Ko</ci>
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<times/>
<ci>Ki</ci>
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<exp/>
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<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>Faraday</ci>
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<times/>
<ci>R</ci>
<ci>Temperature</ci>
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<minus/>
<cn cellml:units="dimensionless">1</cn>
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<exp/>
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<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>Faraday</ci>
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<times/>
<ci>R</ci>
<ci>Temperature</ci>
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<eq/>
<ci>PKCa</ci>
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<plus/>
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<times/>
<cn cellml:units="dimensionless">0.17</cn>
<ci>IKCa_pf</ci>
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<times/>
<cn cellml:units="dimensionless">0.83</cn>
<ci>IKCa_ps</ci>
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<eq/>
<ci>V_KCa_half</ci>
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<minus/>
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<times/>
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<minus/>
<cn cellml:units="dimensionless">41.7</cn>
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<log/>
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<cn cellml:units="dimensionless">10</cn>
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<ci>Cai</ci>
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<cn cellml:units="dimensionless">128.2</cn>
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<eq/>
<ci>IKCa_p_steady_state</ci>
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<divide/>
<cn cellml:units="dimensionless">1</cn>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<exp/>
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<divide/>
<apply>
<minus/>
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<minus/>
<ci>V</ci>
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<cn cellml:units="dimensionless">18.25</cn>
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<eq/>
<ci>IKCa_pf_Tau</ci>
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<eq/>
<ci>IKCa_ps_Tau</ci>
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<eq/>
<ci>I_KCa</ci>
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<divide/>
<apply>
<times/>
<ci>Cell_Area</ci>
<ci>NBKCa</ci>
<ci>PKCa</ci>
<ci>iKCa</ci>
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<cn cellml:units="dimensionless">100</cn>
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<eq/>
<ci>Eh</ci>
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<times/>
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<divide/>
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<times/>
<ci>R</ci>
<ci>Temperature</ci>
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<log/>
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<divide/>
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<plus/>
<ci>Ko</ci>
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<times/>
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<divide/>
<ci>PNa</ci>
<ci>PK</ci>
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<plus/>
<ci>Ki</ci>
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<times/>
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<divide/>
<ci>PNa</ci>
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<ci>Nai</ci>
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<eq/>
<ci>Ih_y_steady_state</ci>
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<divide/>
<cn cellml:units="dimensionless">1</cn>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<divide/>
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<plus/>
<ci>V</ci>
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<ci>Ih_y_Tau</ci>
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<divide/>
<cn cellml:units="dimensionless">1</cn>
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<plus/>
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<times/>
<cn cellml:units="dimensionless" type="e-notation">3.5<sep/>-6</cn>
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<exp/>
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<times/>
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<minus/>
<cn cellml:units="dimensionless">0.0497</cn>
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<ci>V</ci>
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<times/>
<cn cellml:units="dimensionless">0.04</cn>
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<exp/>
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<times/>
<cn cellml:units="dimensionless">0.0521</cn>
<ci>V</ci>
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<ci>Ih_y_Tau</ci>
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<divide/>
<cn cellml:units="dimensionless">1</cn>
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<plus/>
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<times/>
<cn cellml:units="dimensionless" type="e-notation">3.5<sep/>-6</cn>
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<plus/>
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<minus/>
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<times/>
<cn cellml:units="dimensionless">0.0487</cn>
<ci>V</ci>
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<divide/>
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<power/>
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<times/>
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<minus/>
<cn cellml:units="dimensionless">0.0487</cn>
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<ci>V</ci>
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<divide/>
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<power/>
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<times/>
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<minus/>
<cn cellml:units="dimensionless">0.0487</cn>
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<ci>V</ci>
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<times/>
<cn cellml:units="dimensionless">0.04</cn>
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<cn cellml:units="dimensionless">0.0521</cn>
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<power/>
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<times/>
<cn cellml:units="dimensionless">0.0521</cn>
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<ci>I_h</ci>
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<times/>
<ci>gh</ci>
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<power/>
<ci>Ih_y</ci>
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<minus/>
<ci>V</ci>
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<ci>ICl_c_steady_state</ci>
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<divide/>
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<divide/>
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<minus/>
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<minus/>
<ci>V</ci>
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<ci>ICl_c1_Tau</ci>
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<minus/>
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<divide/>
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<divide/>
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<minus/>
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<minus/>
<ci>V</ci>
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<ci>ICl_c2_Tau</ci>
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<minus/>
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<ci>V</ci>
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<divide/>
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<plus/>
<ci>V</ci>
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<ci>gCl_value</ci>
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<times/>
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<plus/>
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<times/>
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<times/>
<cn cellml:units="dimensionless">0.0564</cn>
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<ci>gCl_value</ci>
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<exp/>
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<times/>
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<minus/>
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<times/>
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<divide/>
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<times/>
<ci>gCl_value</ci>
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<plus/>
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<ci>V</ci>
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<ci>I_Cl</ci>
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<divide/>
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<times/>
<ci>gCl_value</ci>
<ci>Cai</ci>
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<plus/>
<ci>Cai</ci>
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<minus/>
<ci>V</ci>
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<eq/>
<ci>I_Capump</ci>
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<divide/>
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<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>zCa</ci>
<ci>Faraday</ci>
<ci>Cell_Volume</ci>
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<times/>
<ci>Membrane_Capacitance</ci>
<ci>Cell_Area</ci>
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<ci>JpCa</ci>
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<divide/>
<ci>KpCa</ci>
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<power/>
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<divide/>
<ci>KdK</ci>
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<ci>nNaK</ci>
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<divide/>
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<plus/>
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<divide/>
<ci>KdNa</ci>
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<divide/>
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<minus/>
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<times/>
<ci>R</ci>
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<minus/>
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<ci>gNaK</ci>
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<exp/>
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<times/>
<ci>NaCa_energy_barrier</ci>
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<minus/>
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<divide/>
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<plus/>
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<divide/>
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<ci>nallo</ci>
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<eq/>
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<plus/>
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<times/>
<ci>ksat</ci>
<ci>barrier_1</ci>
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<eq/>
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<apply>
<plus/>
<apply>
<times/>
<ci>KmCao</ci>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>KmNao</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cai</ci>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>KmNai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cao</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Cai</ci>
<ci>KmCai</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E4</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>Cao</ci>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cai</ci>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>KmCai</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>KmNai</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_E</ci>
<apply>
<divide/>
<ci>E1</ci>
<apply>
<times/>
<ci>E2</ci>
<apply>
<plus/>
<ci>E3</ci>
<ci>E4</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>INaCa_JNaCa</ci>
<apply>
<times/>
<ci>Allo</ci>
<ci>delta_E</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NaCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>INaCa_JNaCa</ci>
<ci>zCa</ci>
<ci>Cell_Volume</ci>
<ci>Faraday</ci>
</apply>
<apply>
<times/>
<ci>Cell_Area</ci>
<ci>Membrane_Capacitance</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="I_NaKCl">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>I_NaKCl</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>RNaKCl</ci>
</apply>
<ci>zCl</ci>
<ci>Cell_Area</ci>
<ci>LNaKCl</ci>
<ci>R</ci>
<ci>Faraday</ci>
<ci>Temperature</ci>
<apply>
<log/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Nao</ci>
<ci>Ko</ci>
</apply>
<apply>
<times/>
<ci>Nai</ci>
<ci>Ki</ci>
</apply>
</apply>
<apply>
<power/>
<apply>
<divide/>
<ci>Clo</ci>
<ci>Cli</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="I_SOC">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Psoc</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Cai</ci>
<ci>Kmsoc</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>IsocNa</ci>
<apply>
<times/>
<ci>gsocNa</ci>
<ci>Psoc</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>ENa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>IsocCa</ci>
<apply>
<times/>
<ci>gsocCa</ci>
<ci>Psoc</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>ECa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_SOC</ci>
<apply>
<plus/>
<ci>IsocCa</ci>
<ci>IsocNa</ci>
</apply>
</apply>
</math>
</component>
<component name="I_NSCC">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Ens</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>Temperature</ci>
</apply>
<ci>Faraday</ci>
</apply>
<apply>
<log/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci>PNa_PCs</ci>
<ci>Nao</ci>
</apply>
<apply>
<times/>
<ci>PK_PCs</ci>
<ci>Ko</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>PCa_PCs</ci>
<ci>Cao</ci>
<ci>Cao</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>Faraday</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>Temperature</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>PNa_PCs</ci>
<ci>Nai</ci>
</apply>
<apply>
<times/>
<ci>PK_PCs</ci>
<ci>Ki</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>PCa_PCs</ci>
<ci>Cai</ci>
<ci>Cai</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>Faraday</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>Temperature</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<!--should there be a permeability of calcium-->
<!--factor in here near PCa_PCs? if so, what is it?-->
<apply>
<eq/>
<ci>Inscc_fMg_steady_state</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.1</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.9</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Mgo</ci>
<ci>KdMg</ci>
</apply>
<cn cellml:units="dimensionless">1.3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>gnscc_Ca</ci>
<apply>
<divide/>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.03</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<cn cellml:units="dimensionless">150</cn>
<apply>
<plus/>
<ci>Cao</ci>
<cn cellml:units="dimensionless" type="e-notation">1<sep/>-8</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">0.000525</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>gnscc_Na</ci>
<apply>
<divide/>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.03</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<cn cellml:units="dimensionless">150</cn>
<apply>
<plus/>
<ci>Nao</ci>
<cn cellml:units="dimensionless" type="e-notation">1<sep/>-8</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">0.0123</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>gnscc_K</ci>
<apply>
<divide/>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.03</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<cn cellml:units="dimensionless">150</cn>
<apply>
<plus/>
<ci>Ko</ci>
<cn cellml:units="dimensionless" type="e-notation">1<sep/>-8</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">0.0123</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>InsCa</ci>
<apply>
<times/>
<ci>InsCa_mag</ci>
<cn cellml:units="dimensionless">0.15</cn>
<ci>Inscc_fMg_steady_state</ci>
<ci>gnscc_Ca</ci>
<ci>gns</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>Ens</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>InsNa</ci>
<apply>
<times/>
<ci>InsNa_mag</ci>
<ci>Inscc_fMg_steady_state</ci>
<ci>gnscc_Na</ci>
<ci>gns</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>Ens</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>InsK</ci>
<apply>
<times/>
<ci>InsK_mag</ci>
<cn cellml:units="dimensionless">1.19</cn>
<ci>Inscc_fMg_steady_state</ci>
<ci>gnscc_K</ci>
<ci>gns</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>Ens</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Insleak</ci>
<apply>
<times/>
<ci>Insleak_mag</ci>
<ci>g_leak</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>Ens</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NSCC</ci>
<apply>
<plus/>
<ci>InsCa</ci>
<ci>InsNa</ci>
<ci>InsK</ci>
<ci>Insleak</ci>
</apply>
</apply>
</math>
</component>
<component name="ISR">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Iup</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Iup_max</ci>
<ci>Cai</ci>
</apply>
<apply>
<plus/>
<ci>Cai</ci>
<ci>Kmup</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Itr</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Ca_u</ci>
<ci>Ca_r</ci>
</apply>
<ci>zCa</ci>
<ci>Faraday</ci>
<ci>vol_u</ci>
<ci>conc_red</ci>
</apply>
<ci>tau_tr</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Irel</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Frel</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>R10</ci>
<ci>R10</ci>
</apply>
<ci>Rleak</ci>
</apply>
<apply>
<minus/>
<ci>Ca_r</ci>
<ci>Cai</ci>
</apply>
<ci>zCa</ci>
<ci>Faraday</ci>
<ci>vol_r</ci>
<ci>conc_red</ci>
</apply>
<ci>tau_rel</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>Ca_u</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Iup</ci>
<ci>Itr</ci>
</apply>
<apply>
<times/>
<ci>zCa</ci>
<ci>Faraday</ci>
<ci>vol_u</ci>
<ci>conc_red</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>Ca_r</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Itr</ci>
<ci>Irel</ci>
</apply>
<apply>
<times/>
<ci>zCa</ci>
<ci>Faraday</ci>
<ci>vol_r</ci>
<ci>conc_red</ci>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CSQN</ci>
<ci>K_CSQN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>K_CSQN</ci>
<ci>Ca_r</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Itotal">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Itotal</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>Ih_mag</ci>
<ci>Ih</ci>
</apply>
<apply>
<times/>
<ci>ICaL_mag</ci>
<ci>ICaL_nif</ci>
</apply>
<apply>
<times/>
<ci>ICaT_mag</ci>
<ci>ICaT</ci>
</apply>
<apply>
<times/>
<ci>INa_mag</ci>
<ci>INa</ci>
</apply>
<apply>
<times/>
<ci>IK1_mag</ci>
<ci>IK1</ci>
</apply>
<apply>
<times/>
<ci>IK2_mag</ci>
<ci>IK2</ci>
</apply>
<apply>
<times/>
<ci>IKA_mag</ci>
<ci>IKA</ci>
</apply>
<apply>
<times/>
<ci>IKCa_mag</ci>
<ci>IKCa</ci>
</apply>
<apply>
<times/>
<ci>Inscc_mag</ci>
<ci>Inscc</ci>
</apply>
<apply>
<times/>
<ci>ICl_mag</ci>
<ci>ICl</ci>
</apply>
<apply>
<times/>
<ci>ICapump_mag</ci>
<ci>ICapump</ci>
</apply>
<apply>
<times/>
<ci>INaK_mag</ci>
<ci>INaK</ci>
</apply>
<apply>
<times/>
<ci>INaCa_mag</ci>
<ci>INaCa</ci>
</apply>
<ci>Isus</ci>
<apply>
<times/>
<ci>Isoc_mag</ci>
<ci>Isoc</ci>
</apply>
<apply>
<times/>
<ci>IKleak_mag</ci>
<ci>IKleak</ci>
</apply>
<apply>
<times/>
<ci>INaKCl_mag</ci>
<ci>INaKCl</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ICa_tot</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>ICaL_mag</ci>
<ci>ICaL_nif</ci>
</apply>
<apply>
<times/>
<ci>ICaT_mag</ci>
<ci>ICaT</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>INaCa_mag</ci>
<ci>INaCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>InsCa_mag</ci>
<ci>InsCa</ci>
</apply>
<apply>
<times/>
<ci>IsocCa_mag</ci>
<ci>IsocCa</ci>
</apply>
<apply>
<times/>
<ci>ICapump_mag</ci>
<ci>ICapump</ci>
</apply>
<apply>
<times/>
<ci>Iup_mag</ci>
<ci>Iup</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Irel_mag</ci>
<ci>Irel</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>Cai</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Cell_Area</ci>
</apply>
<ci>Membrane_Capacitance</ci>
</apply>
<apply>
<times/>
<ci>zCa</ci>
<ci>Cell_Volume</ci>
<ci>Faraday</ci>
</apply>
</apply>
<ci>ICa_tot</ci>
<ci>CaBuffer</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>frac1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Scm</ci>
<ci>Kd</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Kd</ci>
<ci>Cai</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>frac2</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Bf</ci>
<ci>Kdb</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Kdb</ci>
<ci>Cai</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>CaBuffer</ci>
<apply>
<times/>
<ci>FBCa</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>frac1</ci>
<ci>frac2</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>IK_tot</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>IK1_mag</ci>
<ci>IK1</ci>
</apply>
<apply>
<times/>
<ci>IK2_mag</ci>
<ci>IK2</ci>
</apply>
<apply>
<times/>
<ci>IKA_mag</ci>
<ci>IKA</ci>
</apply>
<apply>
<times/>
<ci>IKCa_mag</ci>
<ci>IKCa</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>InsK_mag</ci>
<ci>InsK</ci>
</apply>
</apply>
<apply>
<times/>
<ci>IKleak_mag</ci>
<ci>IKleak</ci>
</apply>
<apply>
<times/>
<ci>INaKCl_mag</ci>
<ci>INaKCl</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>INaK_mag</ci>
<ci>INaK</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="RR">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>R00</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>Kr1</ci>
<ci>Cai</ci>
</apply>
<ci>Kr2</ci>
</apply>
</apply>
<ci>Cai</ci>
<ci>R00</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>R10</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>Kr1</ci>
<ci>Cai</ci>
<ci>Cai</ci>
<ci>R00</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>K_r1</ci>
<apply>
<times/>
<ci>Kr2</ci>
<ci>Cai</ci>
</apply>
</apply>
<ci>R10</ci>
</apply>
</apply>
<apply>
<times/>
<ci>K_r2</ci>
<ci>R11</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>R01</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>Kr2</ci>
<ci>Cai</ci>
<ci>R00</ci>
</apply>
<apply>
<times/>
<ci>K_r1</ci>
<ci>R11</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>K_r2</ci>
<apply>
<times/>
<ci>Kr1</ci>
<ci>Cai</ci>
<ci>Cai</ci>
</apply>
</apply>
<ci>R01</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>R11</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>Kr2</ci>
<ci>Cai</ci>
<ci>R10</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>K_r1</ci>
<ci>K_r2</ci>
</apply>
<ci>R11</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Kr1</ci>
<ci>Cai</ci>
<ci>Cai</ci>
<ci>R01</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="force">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Fp</ci>
<apply>
<times/>
<ci>kp</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_p</ci>
<apply>
<minus/>
<ci>lc</ci>
<ci>lc0</ci>
</apply>
</apply>
<ci>lc0</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Fx</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>kx1</ci>
<ci>AMp</ci>
</apply>
<apply>
<times/>
<ci>kx2</ci>
<ci>AM</ci>
</apply>
</apply>
<ci>lx</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>beta</ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<minus/>
<ci>la</ci>
<ci>lopt</ci>
</apply>
<ci>lopt</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Fa</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>fAMp</ci>
<ci>AMp</ci>
<apply>
<plus/>
<ci>vx</ci>
<ci>la</ci>
</apply>
</apply>
<apply>
<times/>
<ci>fAM</ci>
<ci>AM</ci>
<ci>la</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>beta</ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>la</ci>
</apply>
<ci>lopt</ci>
</apply>
<ci>lopt</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Fs</ci>
<ci>Fa</ci>
</apply>
<apply>
<eq/>
<ci>Ft</ci>
<apply>
<plus/>
<ci>Fa</ci>
<ci>Fp</ci>
</apply>
</apply>
<!-- Following lengths are initialised in main program-->
<apply>
<eq/>
<ci>ls</ci>
<apply>
<plus/>
<ci>ls</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>dt</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>mu_s</ci>
</apply>
<apply>
<minus/>
<ci>Fs</ci>
<apply>
<times/>
<ci>ks</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_s</ci>
<apply>
<minus/>
<ci>ls</ci>
<ci>ls0</ci>
</apply>
</apply>
<ci>ls0</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>la</ci>
<apply>
<plus/>
<ci>la</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>dt</ci>
<apply>
<minus/>
<apply>
<divide/>
<ci>Fa</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>beta</ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<minus/>
<ci>la</ci>
<ci>lopt</ci>
</apply>
<ci>lopt</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>fAMp</ci>
<ci>AMp</ci>
<ci>vx</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>fAM</ci>
<ci>AM</ci>
</apply>
<apply>
<times/>
<ci>fAMp</ci>
<ci>AMp</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>lx</ci>
<apply>
<minus/>
<apply>
<minus/>
<ci>lc</ci>
<ci>la</ci>
</apply>
<ci>ls</ci>
</apply>
</apply>
</math>
</component>
<component name="KCBC">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>MLCK</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Wortmannin</ci>
<ci>MLCK_max</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Cai</ci>
<ci>K_MLCK</ci>
</apply>
<ci>pM</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K1</ci>
<apply>
<divide/>
<ci>MLCK</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>KCa_MLCK</ci>
<ci>Cai</ci>
</apply>
<ci>nM</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K6</ci>
<ci>K1</ci>
</apply>
<apply>
<eq/>
<ci>M</ci>
<apply>
<plus/>
<ci>M</ci>
<apply>
<times/>
<ci>dt</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<ci>K1</ci>
</apply>
<ci>M</ci>
</apply>
<apply>
<times/>
<ci>K2</ci>
<ci>Mp</ci>
</apply>
<apply>
<times/>
<ci>K7</ci>
<ci>AM</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Mp</ci>
<apply>
<plus/>
<ci>Mp</ci>
<apply>
<times/>
<ci>dt</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>K4</ci>
<ci>AMp</ci>
</apply>
<apply>
<times/>
<ci>K1</ci>
<ci>M</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>K2</ci>
<ci>K3</ci>
</apply>
<ci>Mp</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>AMp</ci>
<apply>
<plus/>
<ci>AMp</ci>
<apply>
<times/>
<ci>dt</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>K3</ci>
<ci>Mp</ci>
</apply>
<apply>
<times/>
<ci>K6</ci>
<ci>AM</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>K4</ci>
<ci>K5</ci>
</apply>
<ci>AMp</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>AM</ci>
<apply>
<plus/>
<ci>AM</ci>
<apply>
<times/>
<ci>dt</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>K5</ci>
<ci>AMp</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>K7</ci>
<ci>K6</ci>
</apply>
<ci>AM</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Frac_phos</ci>
<apply>
<plus/>
<ci>AMp</ci>
<ci>Mp</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Frac_stress</ci>
<apply>
<plus/>
<ci>AMp</ci>
<ci>AM</ci>
</apply>
</apply>
</math>
</component>
</model>