- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2022-10-19 10:24:37+13:00
- Desc:
- Add readme to link the documentation on overleaf.
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/701/rawfile/6741283829975cd4f084159e7734dcbece29f7b1/Components/IKA.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="IKA" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../cellLib/Components/units.cellml">
<units name="ms" units_ref="ms"/>
<units name="pA_per_pF" units_ref="pA_per_pF"/>
<units name="pA" units_ref="pA"/>
<units name="nS" units_ref="nS"/>
<units name="mV" units_ref="mV"/>
<units name="mM" units_ref="mM"/>
<units name="nS_per_pF" units_ref="nS_per_pF"/>
<units name="uJ_per_K_mmol" units_ref="uJ_per_K_mmol"/>
<units name="C_per_mol" units_ref="C_per_mol"/>
<units name="pF" units_ref="pF"/>
</import>
<import xlink:href="../cellLib/Components/Ionic_currents.cellml">
<component component_ref="Ionic_currents" name="I_pA"/>
</import>
<import xlink:href="../cellLib/Components/E_Nernst.cellml">
<component component_ref="E_K" name="E_K"/>
</import>
<import xlink:href="../cellLib/Components/gating_kinetics.cellml">
<component component_ref="gating_kinetics" name="s_gate"/>
</import>
<import xlink:href="../cellLib/Components/gating_kinetics.cellml">
<component component_ref="gating_kinetics" name="x_gate"/>
</import>
<import xlink:href="IKA_gating.cellml">
<component component_ref="s_inf" name="s_inf"/>
<component component_ref="x_inf" name="x_inf"/>
<component component_ref="tau_s" name="tau_s"/>
<component component_ref="tau_x" name="tau_x"/>
</import>
<component name="IKA">
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="I_KA" private_interface="in" public_interface="out" units="pA_per_pF"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="g_KA" private_interface="out" public_interface="in" units="nS_per_pF"/>
<variable name="C_est" private_interface="out" public_interface="in" units="pF"/>
<variable name="R" private_interface="out" public_interface="in" units="uJ_per_K_mmol"/>
<variable name="F" private_interface="out" public_interface="in" units="C_per_mol"/>
<variable name="T" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="T0K" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="Q10K" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="Ko" private_interface="out" public_interface="in" units="mM"/>
<variable name="Ki" private_interface="out" public_interface="in" units="mM"/>
<variable name="s_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="s" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="x_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="x" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="P_KA" private_interface="out" public_interface="out" units="dimensionless"/>
<variable name="s_inf" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="x_inf" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="tau_s" private_interface="in" public_interface="out" units="ms"/>
<variable name="tau_x" private_interface="in" public_interface="out" units="ms"/>
<!--P_KA = s*x;-->
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_KA</ci>
<apply>
<times/>
<ci>s</ci>
<apply>
<exp/>
<ci>x</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="convert_I_pA">
<variable name="I_KA" public_interface="out" units="pA_per_pF"/>
<variable name="g_KA_ns" public_interface="out" units="nS"/>
<variable name="I_pA" public_interface="in" units="pA"/>
<variable name="g_KA" public_interface="in" units="nS_per_pF"/>
<variable name="C_est" public_interface="in" units="pF"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_KA_ns</ci>
<apply>
<times/>
<ci>g_KA</ci>
<ci>C_est</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_KA</ci>
<apply>
<divide/>
<ci>I_pA</ci>
<ci>C_est</ci>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="IKA">
<component_ref component="I_pA"/>
<component_ref component="convert_I_pA"/>
<component_ref component="E_K"/>
<component_ref component="s_gate"/>
<component_ref component="x_gate"/>
<component_ref component="s_inf"/>
<component_ref component="x_inf"/>
<component_ref component="tau_s"/>
<component_ref component="tau_x"/>
</component_ref>
</group>
<connection>
<map_components component_1="IKA" component_2="s_inf"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="s_inf" variable_2="X_inf"/>
</connection>
<connection>
<map_components component_1="IKA" component_2="x_inf"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="x_inf" variable_2="X_inf"/>
</connection>
<connection>
<map_components component_1="IKA" component_2="tau_s"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="tau_s" variable_2="tau"/>
</connection>
<connection>
<map_components component_1="IKA" component_2="tau_x"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="tau_x" variable_2="tau"/>
</connection>
<connection>
<map_components component_1="IKA" component_2="s_gate"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Q10K" variable_2="Q_10"/>
<map_variables variable_1="T0K" variable_2="T_0"/>
<map_variables variable_1="s_init" variable_2="X_init"/>
<map_variables variable_1="s" variable_2="X"/>
</connection>
<connection>
<map_components component_1="IKA" component_2="x_gate"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Q10K" variable_2="Q_10"/>
<map_variables variable_1="T0K" variable_2="T_0"/>
<map_variables variable_1="x_init" variable_2="X_init"/>
<map_variables variable_1="x" variable_2="X"/>
</connection>
<connection>
<map_components component_1="s_inf" component_2="s_gate"/>
<map_variables variable_1="X_inf" variable_2="X_inf"/>
</connection>
<connection>
<map_components component_1="x_inf" component_2="x_gate"/>
<map_variables variable_1="X_inf" variable_2="X_inf"/>
</connection>
<connection>
<map_components component_1="tau_s" component_2="s_gate"/>
<map_variables variable_1="tau" variable_2="tau_X"/>
</connection>
<connection>
<map_components component_1="tau_x" component_2="x_gate"/>
<map_variables variable_1="tau" variable_2="tau_X"/>
</connection>
<connection>
<map_components component_1="IKA" component_2="I_pA"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="P_KA" variable_2="PO"/>
</connection>
<connection>
<map_components component_1="IKA" component_2="E_K"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="E_K" component_2="I_pA"/>
<map_variables variable_1="E_K" variable_2="E"/>
</connection>
<connection>
<map_components component_1="convert_I_pA" component_2="I_pA"/>
<map_variables variable_1="I_pA" variable_2="I"/>
<map_variables variable_1="g_KA_ns" variable_2="g_max"/>
</connection>
<connection>
<map_components component_1="IKA" component_2="convert_I_pA"/>
<map_variables variable_1="I_KA" variable_2="I_KA"/>
<map_variables variable_1="g_KA" variable_2="g_KA"/>
<map_variables variable_1="C_est" variable_2="C_est"/>
</connection>
</model>
