- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2022-10-19 10:24:37+13:00
- Desc:
- Add readme to link the documentation on overleaf.
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/701/rawfile/6741283829975cd4f084159e7734dcbece29f7b1/Components/ICaL.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="ICaL" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../cellLib/Components/units.cellml">
<units name="ms" units_ref="ms"/>
<units name="mM" units_ref="mM"/>
<units name="pA_per_pF" units_ref="pA_per_pF"/>
<units name="pA" units_ref="pA"/>
<units name="mV" units_ref="mV"/>
<units name="nS_per_pF" units_ref="nS_per_pF"/>
<units name="nS" units_ref="nS"/>
<units name="pF" units_ref="pF"/>
</import>
<import xlink:href="../cellLib/Components/Ionic_currents.cellml">
<component component_ref="Ionic_currents" name="I_pA"/>
</import>
<import xlink:href="../cellLib/Components/gating_kinetics.cellml">
<component component_ref="gating_kinetics" name="d_gate"/>
</import>
<import xlink:href="../cellLib/Components/gating_kinetics.cellml">
<component component_ref="gating_kinetics" name="f1_gate"/>
</import>
<import xlink:href="../cellLib/Components/gating_kinetics.cellml">
<component component_ref="gating_kinetics" name="f2_gate"/>
</import>
<import xlink:href="../cellLib/Components/Hillfcn.cellml">
<component component_ref="Hillfcn" name="Hillfcn"/>
</import>
<import xlink:href="../cellLib/Components/Hillfcn.cellml">
<component component_ref="Hillfcn" name="Hill_nif"/>
</import>
<import xlink:href="ICaL_gating.cellml">
<component component_ref="d_inf" name="d_inf"/>
<component component_ref="f_inf" name="f_inf"/>
<component component_ref="tau_d" name="tau_d"/>
<component component_ref="tau_f2" name="tau_f2"/>
</import>
<component name="ICaL">
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="I_CaL" private_interface="in" public_interface="out" units="pA_per_pF"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="E_CaL" private_interface="out" public_interface="in" units="mV"/>
<variable name="g_CaL" public_interface="in" units="nS_per_pF"/>
<variable name="C_est" private_interface="out" public_interface="in" units="pF"/>
<variable name="T" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="T0CaL" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="Q10Ca" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="nif" public_interface="in" units="mM"/>
<variable name="IC50_nif" public_interface="in" units="mM"/>
<variable initial_value="1" name="n_nif" private_interface="out" units="dimensionless"/>
<variable name="x_nif" private_interface="out" units="dimensionless"/>
<variable name="Hill_nif" private_interface="in" units="dimensionless"/>
<variable name="g_CaL_nif" private_interface="out" units="nS_per_pF"/>
<variable name="Cai" private_interface="out" public_interface="in" units="mM"/>
<variable name="K_mCaL" public_interface="in" units="mM"/>
<variable name="tau_f1" private_interface="out" public_interface="in" units="ms"/>
<variable name="x_h" private_interface="out" units="dimensionless"/>
<variable initial_value="1" name="n_h" private_interface="out" units="dimensionless"/>
<variable name="f_Ca" private_interface="in" units="dimensionless"/>
<variable name="d_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="d" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="f1_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="f_1" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="f2_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="f_2" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="P_CaL" private_interface="out" public_interface="out" units="dimensionless"/>
<variable name="d_inf" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="f_inf" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="tau_d" private_interface="in" public_interface="out" units="ms"/>
<variable name="tau_f2" private_interface="in" public_interface="out" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_CaL</ci>
<apply>
<times/>
<apply>
<power/>
<ci>d</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>f_Ca</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.8</cn>
<ci>f_1</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.2</cn>
<ci>f_2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>x_h</ci>
<apply>
<divide/>
<ci>Cai</ci>
<ci>K_mCaL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>x_nif</ci>
<apply>
<divide/>
<ci>nif</ci>
<ci>IC50_nif</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>g_CaL_nif</ci>
<apply>
<times/>
<ci>g_CaL</ci>
<ci>Hill_nif</ci>
</apply>
</apply>
</math>
</component>
<component name="convert_I_pA">
<variable name="I_CaL" public_interface="out" units="pA_per_pF"/>
<variable name="g_CaL_ns" public_interface="out" units="nS"/>
<variable name="I_pA" public_interface="in" units="pA"/>
<variable name="g_CaL" public_interface="in" units="nS_per_pF"/>
<variable name="C_est" public_interface="in" units="pF"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_CaL_ns</ci>
<apply>
<times/>
<ci>g_CaL</ci>
<ci>C_est</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_CaL</ci>
<apply>
<divide/>
<ci>I_pA</ci>
<ci>C_est</ci>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="ICaL">
<component_ref component="I_pA"/>
<component_ref component="convert_I_pA"/>
<component_ref component="d_gate"/>
<component_ref component="f1_gate"/>
<component_ref component="f2_gate"/>
<component_ref component="d_inf"/>
<component_ref component="f_inf"/>
<component_ref component="tau_d"/>
<component_ref component="tau_f2"/>
<component_ref component="Hillfcn"/>
<component_ref component="Hill_nif"/>
</component_ref>
</group>
<connection>
<map_components component_1="ICaL" component_2="Hillfcn"/>
<map_variables variable_1="x_h" variable_2="x"/>
<map_variables variable_1="n_h" variable_2="n"/>
<map_variables variable_1="f_Ca" variable_2="H"/>
</connection>
<connection>
<map_components component_1="ICaL" component_2="Hill_nif"/>
<map_variables variable_1="x_nif" variable_2="x"/>
<map_variables variable_1="n_nif" variable_2="n"/>
<map_variables variable_1="Hill_nif" variable_2="H"/>
</connection>
<connection>
<map_components component_1="ICaL" component_2="d_inf"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="d_inf" variable_2="X_inf"/>
</connection>
<connection>
<map_components component_1="ICaL" component_2="f_inf"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="f_inf" variable_2="X_inf"/>
</connection>
<connection>
<map_components component_1="ICaL" component_2="tau_d"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="tau_d" variable_2="tau"/>
</connection>
<connection>
<map_components component_1="ICaL" component_2="tau_f2"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="tau_f2" variable_2="tau"/>
</connection>
<connection>
<map_components component_1="ICaL" component_2="d_gate"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Q10Ca" variable_2="Q_10"/>
<map_variables variable_1="T0CaL" variable_2="T_0"/>
<map_variables variable_1="d_init" variable_2="X_init"/>
<map_variables variable_1="d" variable_2="X"/>
</connection>
<connection>
<map_components component_1="ICaL" component_2="f1_gate"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Q10Ca" variable_2="Q_10"/>
<map_variables variable_1="T0CaL" variable_2="T_0"/>
<map_variables variable_1="f1_init" variable_2="X_init"/>
<map_variables variable_1="f_1" variable_2="X"/>
<map_variables variable_1="tau_f1" variable_2="tau_X"/>
</connection>
<connection>
<map_components component_1="ICaL" component_2="f2_gate"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Q10Ca" variable_2="Q_10"/>
<map_variables variable_1="T0CaL" variable_2="T_0"/>
<map_variables variable_1="f2_init" variable_2="X_init"/>
<map_variables variable_1="f_2" variable_2="X"/>
</connection>
<connection>
<map_components component_1="d_inf" component_2="d_gate"/>
<map_variables variable_1="X_inf" variable_2="X_inf"/>
</connection>
<connection>
<map_components component_1="f_inf" component_2="f1_gate"/>
<map_variables variable_1="X_inf" variable_2="X_inf"/>
</connection>
<connection>
<map_components component_1="f_inf" component_2="f2_gate"/>
<map_variables variable_1="X_inf" variable_2="X_inf"/>
</connection>
<connection>
<map_components component_1="tau_d" component_2="d_gate"/>
<map_variables variable_1="tau" variable_2="tau_X"/>
</connection>
<connection>
<map_components component_1="tau_f2" component_2="f2_gate"/>
<map_variables variable_1="tau" variable_2="tau_X"/>
</connection>
<connection>
<map_components component_1="ICaL" component_2="I_pA"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="E_CaL" variable_2="E"/>
<map_variables variable_1="P_CaL" variable_2="PO"/>
</connection>
<connection>
<map_components component_1="convert_I_pA" component_2="I_pA"/>
<map_variables variable_1="I_pA" variable_2="I"/>
<map_variables variable_1="g_CaL_ns" variable_2="g_max"/>
</connection>
<connection>
<map_components component_1="ICaL" component_2="convert_I_pA"/>
<map_variables variable_1="I_CaL" variable_2="I_CaL"/>
<map_variables variable_1="g_CaL_nif" variable_2="g_CaL"/>
<map_variables variable_1="C_est" variable_2="C_est"/>
</connection>
</model>
