- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-09-15 10:52:00+12:00
- Desc:
- Add intracellular concentrations
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/701/rawfile/5eb92ff17b0b2907de48a0950e613845781bf4e9/Components/INa.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="INa" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../cellLib/Components/units.cellml">
<units name="ms" units_ref="ms"/>
<units name="pA_per_pF" units_ref="pA_per_pF"/>
<units name="pA" units_ref="pA"/>
<units name="nS" units_ref="nS"/>
<units name="mV" units_ref="mV"/>
<units name="mM" units_ref="mM"/>
<units name="nS_per_pF" units_ref="nS_per_pF"/>
<units name="J_per_K_mol" units_ref="J_per_K_mol"/>
<units name="C_per_mmol" units_ref="C_per_mmol"/>
<units name="pF_per_cmsq" units_ref="pF_per_cmsq"/>
<units name="cmsq" units_ref="cmsq"/>
</import>
<import xlink:href="../cellLib/Components/Ionic_currents.cellml">
<component component_ref="Ionic_currents" name="I_pA"/>
</import>
<import xlink:href="../cellLib/Components/E_Nernst.cellml">
<component component_ref="E_Na" name="E_Na"/>
</import>
<import xlink:href="../cellLib/Components/gating_kinetics.cellml">
<component component_ref="gating_kinetics" name="m_gate"/>
</import>
<import xlink:href="../cellLib/Components/gating_kinetics.cellml">
<component component_ref="gating_kinetics" name="h_gate"/>
</import>
<import xlink:href="INa_gating.cellml">
<component component_ref="m_inf" name="m_inf"/>
<component component_ref="h_inf" name="h_inf"/>
<component component_ref="tau_m" name="tau_m"/>
<component component_ref="tau_h" name="tau_h"/>
</import>
<component name="INa">
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="I_Na" private_interface="in" public_interface="out" units="pA_per_pF"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="g_Na" private_interface="out" public_interface="in" units="nS_per_pF"/>
<variable name="Cm" private_interface="out" public_interface="in" units="pF_per_cmsq"/>
<variable name="Ac" private_interface="out" public_interface="in" units="cmsq"/>
<variable name="R" private_interface="out" public_interface="in" units="J_per_K_mol"/>
<variable name="F" private_interface="out" public_interface="in" units="C_per_mmol"/>
<variable name="T" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="T0Na" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="Q10Na" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="Nao" private_interface="out" public_interface="in" units="mM"/>
<variable name="Nai" private_interface="out" public_interface="in" units="mM"/>
<variable name="m_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="m" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="h_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="h" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="P_Na" private_interface="out" public_interface="out" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_Na</ci>
<apply>
<times/>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>h</ci>
</apply>
</apply>
</math>
</component>
<component name="convert_I_pA">
<variable name="I_Na" public_interface="out" units="pA_per_pF"/>
<variable name="g_Na_ns" public_interface="out" units="nS"/>
<variable name="I_pA" public_interface="in" units="pA"/>
<variable name="g_Na" public_interface="in" units="nS_per_pF"/>
<variable name="Cm" public_interface="in" units="pF_per_cmsq"/>
<variable name="Ac" public_interface="in" units="cmsq"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_Na_ns</ci>
<apply>
<times/>
<ci>g_Na</ci>
<ci>Cm</ci>
<ci>Ac</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_Na</ci>
<apply>
<divide/>
<ci>I_pA</ci>
<apply>
<times/>
<ci>Cm</ci>
<ci>Ac</ci>
</apply>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="INa">
<component_ref component="I_pA"/>
<component_ref component="convert_I_pA"/>
<component_ref component="E_Na"/>
<component_ref component="m_gate"/>
<component_ref component="h_gate"/>
<component_ref component="m_inf"/>
<component_ref component="h_inf"/>
<component_ref component="tau_m"/>
<component_ref component="tau_h"/>
</component_ref>
</group>
<connection>
<map_components component_1="INa" component_2="m_inf"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="INa" component_2="h_inf"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="INa" component_2="tau_m"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="INa" component_2="tau_h"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="INa" component_2="m_gate"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Q10Na" variable_2="Q_10"/>
<map_variables variable_1="T0Na" variable_2="T_0"/>
<map_variables variable_1="m_init" variable_2="X_init"/>
<map_variables variable_1="m" variable_2="X"/>
</connection>
<connection>
<map_components component_1="INa" component_2="h_gate"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Q10Na" variable_2="Q_10"/>
<map_variables variable_1="T0Na" variable_2="T_0"/>
<map_variables variable_1="h_init" variable_2="X_init"/>
<map_variables variable_1="h" variable_2="X"/>
</connection>
<connection>
<map_components component_1="m_inf" component_2="m_gate"/>
<map_variables variable_1="X_inf" variable_2="X_inf"/>
</connection>
<connection>
<map_components component_1="h_inf" component_2="h_gate"/>
<map_variables variable_1="X_inf" variable_2="X_inf"/>
</connection>
<connection>
<map_components component_1="tau_m" component_2="m_gate"/>
<map_variables variable_1="tau" variable_2="tau_X"/>
</connection>
<connection>
<map_components component_1="tau_h" component_2="h_gate"/>
<map_variables variable_1="tau" variable_2="tau_X"/>
</connection>
<connection>
<map_components component_1="INa" component_2="I_pA"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="P_Na" variable_2="PO"/>
</connection>
<connection>
<map_components component_1="INa" component_2="E_Na"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
</connection>
<connection>
<map_components component_1="E_Na" component_2="I_pA"/>
<map_variables variable_1="E_Na" variable_2="E"/>
</connection>
<connection>
<map_components component_1="convert_I_pA" component_2="I_pA"/>
<map_variables variable_1="I_pA" variable_2="I"/>
<map_variables variable_1="g_Na_ns" variable_2="g_max"/>
</connection>
<connection>
<map_components component_1="INa" component_2="convert_I_pA"/>
<map_variables variable_1="I_Na" variable_2="I_Na"/>
<map_variables variable_1="g_Na" variable_2="g_Na"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="Ac" variable_2="Ac"/>
</connection>
</model>
