- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-09-15 10:52:00+12:00
- Desc:
- Add intracellular concentrations
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/701/rawfile/5eb92ff17b0b2907de48a0950e613845781bf4e9/Components/IK2.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="IK2" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../cellLib/Components/units.cellml">
<units name="ms" units_ref="ms"/>
<units name="pA_per_pF" units_ref="pA_per_pF"/>
<units name="pA" units_ref="pA"/>
<units name="nS" units_ref="nS"/>
<units name="mV" units_ref="mV"/>
<units name="mM" units_ref="mM"/>
<units name="nS_per_pF" units_ref="nS_per_pF"/>
<units name="J_per_K_mol" units_ref="J_per_K_mol"/>
<units name="C_per_mmol" units_ref="C_per_mmol"/>
<units name="pF_per_cmsq" units_ref="pF_per_cmsq"/>
<units name="cmsq" units_ref="cmsq"/>
</import>
<import xlink:href="../cellLib/Components/Ionic_currents.cellml">
<component component_ref="Ionic_currents" name="I_pA"/>
</import>
<import xlink:href="../cellLib/Components/E_Nernst.cellml">
<component component_ref="E_K" name="E_K"/>
</import>
<import xlink:href="../cellLib/Components/gating_kinetics.cellml">
<component component_ref="gating_kinetics" name="p_gate"/>
</import>
<import xlink:href="../cellLib/Components/gating_kinetics.cellml">
<component component_ref="gating_kinetics" name="k1_gate"/>
</import>
<import xlink:href="../cellLib/Components/gating_kinetics.cellml">
<component component_ref="gating_kinetics" name="k2_gate"/>
</import>
<import xlink:href="IK2_gating.cellml">
<component component_ref="p_inf" name="p_inf"/>
<component component_ref="k_inf" name="k_inf"/>
<component component_ref="tau_p" name="tau_p"/>
<component component_ref="tau_k1" name="tau_k1"/>
<component component_ref="tau_k2" name="tau_k2"/>
</import>
<component name="IK2">
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="I_K2" private_interface="in" public_interface="out" units="pA_per_pF"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="g_K2" private_interface="out" public_interface="in" units="nS_per_pF"/>
<variable name="Cm" private_interface="out" public_interface="in" units="pF_per_cmsq"/>
<variable name="Ac" private_interface="out" public_interface="in" units="cmsq"/>
<variable name="R" private_interface="out" public_interface="in" units="J_per_K_mol"/>
<variable name="F" private_interface="out" public_interface="in" units="C_per_mmol"/>
<variable name="T" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="T0K" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="Q10K" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="Ko" private_interface="out" public_interface="in" units="mM"/>
<variable name="Ki" private_interface="out" public_interface="in" units="mM"/>
<variable name="p_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="p" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="k1_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="k_1" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="k2_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="k_2" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="P_K2" private_interface="out" public_interface="out" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_K2</ci>
<apply>
<times/>
<ci>p</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.75</cn>
<ci>k_1</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.25</cn>
<ci>k_2</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="convert_I_pA">
<variable name="I_K2" public_interface="out" units="pA_per_pF"/>
<variable name="g_K2_ns" public_interface="out" units="nS"/>
<variable name="I_pA" public_interface="in" units="pA"/>
<variable name="g_K2" public_interface="in" units="nS_per_pF"/>
<variable name="Cm" public_interface="in" units="pF_per_cmsq"/>
<variable name="Ac" public_interface="in" units="cmsq"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_K2_ns</ci>
<apply>
<times/>
<ci>g_K2</ci>
<ci>Cm</ci>
<ci>Ac</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_K2</ci>
<apply>
<divide/>
<ci>I_pA</ci>
<apply>
<times/>
<ci>Cm</ci>
<ci>Ac</ci>
</apply>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="IK2">
<component_ref component="I_pA"/>
<component_ref component="convert_I_pA"/>
<component_ref component="E_K"/>
<component_ref component="p_gate"/>
<component_ref component="k1_gate"/>
<component_ref component="k2_gate"/>
<component_ref component="p_inf"/>
<component_ref component="k_inf"/>
<component_ref component="tau_p"/>
<component_ref component="tau_k1"/>
<component_ref component="tau_k2"/>
</component_ref>
</group>
<connection>
<map_components component_1="IK2" component_2="p_inf"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="IK2" component_2="k_inf"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="IK2" component_2="tau_p"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="IK2" component_2="tau_k1"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="IK2" component_2="tau_k2"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="IK2" component_2="p_gate"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Q10K" variable_2="Q_10"/>
<map_variables variable_1="T0K" variable_2="T_0"/>
<map_variables variable_1="p_init" variable_2="X_init"/>
<map_variables variable_1="p" variable_2="X"/>
</connection>
<connection>
<map_components component_1="IK2" component_2="k1_gate"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Q10K" variable_2="Q_10"/>
<map_variables variable_1="T0K" variable_2="T_0"/>
<map_variables variable_1="k1_init" variable_2="X_init"/>
<map_variables variable_1="k_1" variable_2="X"/>
</connection>
<connection>
<map_components component_1="IK2" component_2="k2_gate"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Q10K" variable_2="Q_10"/>
<map_variables variable_1="T0K" variable_2="T_0"/>
<map_variables variable_1="k2_init" variable_2="X_init"/>
<map_variables variable_1="k_2" variable_2="X"/>
</connection>
<connection>
<map_components component_1="p_inf" component_2="p_gate"/>
<map_variables variable_1="X_inf" variable_2="X_inf"/>
</connection>
<connection>
<map_components component_1="k_inf" component_2="k1_gate"/>
<map_variables variable_1="X_inf" variable_2="X_inf"/>
</connection>
<connection>
<map_components component_1="k_inf" component_2="k2_gate"/>
<map_variables variable_1="X_inf" variable_2="X_inf"/>
</connection>
<connection>
<map_components component_1="tau_p" component_2="p_gate"/>
<map_variables variable_1="tau" variable_2="tau_X"/>
</connection>
<connection>
<map_components component_1="tau_k1" component_2="k1_gate"/>
<map_variables variable_1="tau" variable_2="tau_X"/>
</connection>
<connection>
<map_components component_1="tau_k2" component_2="k2_gate"/>
<map_variables variable_1="tau" variable_2="tau_X"/>
</connection>
<connection>
<map_components component_1="IK2" component_2="I_pA"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="P_K2" variable_2="PO"/>
</connection>
<connection>
<map_components component_1="IK2" component_2="E_K"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="E_K" component_2="I_pA"/>
<map_variables variable_1="E_K" variable_2="E"/>
</connection>
<connection>
<map_components component_1="convert_I_pA" component_2="I_pA"/>
<map_variables variable_1="I_pA" variable_2="I"/>
<map_variables variable_1="g_K2_ns" variable_2="g_max"/>
</connection>
<connection>
<map_components component_1="IK2" component_2="convert_I_pA"/>
<map_variables variable_1="I_K2" variable_2="I_K2"/>
<map_variables variable_1="g_K2" variable_2="g_K2"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="Ac" variable_2="Ac"/>
</connection>
</model>
