- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-09-14 17:32:05+12:00
- Desc:
- Add NS currents
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/701/rawfile/1e8a68c9f92122aab2a28b05b34afe5aac611fdf/Components/INaK.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="INaK" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../cellLib/Components/units.cellml">
<units name="nS_per_pF" units_ref="nS_per_pF"/>
<units name="pA_per_pF" units_ref="pA_per_pF"/>
<units name="mV" units_ref="mV"/>
<units name="mM" units_ref="mM"/>
<units name="C_per_mmol" units_ref="C_per_mmol"/>
<units name="J_per_K_mol" units_ref="J_per_K_mol"/>
</import>
<import xlink:href="../cellLib/Components/Hillfcn.cellml">
<component component_ref="Hillfcn" name="k_NaK"/>
</import>
<import xlink:href="../cellLib/Components/Hillfcn.cellml">
<component component_ref="Hillfcn" name="n_NaK"/>
</import>
<component name="INaK">
<variable name="I_NaK" public_interface="out" units="pA_per_pF"/>
<variable name="g_NaK" public_interface="in" units="nS_per_pF"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="R" public_interface="in" units="J_per_K_mol"/>
<variable name="F" public_interface="in" units="C_per_mmol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="K_dNa" public_interface="in" units="mM"/>
<variable name="Nai" private_interface="out" public_interface="in" units="mM"/>
<variable name="n_Na" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="Nao" private_interface="out" public_interface="in" units="mM"/>
<variable name="K_dK" private_interface="out" public_interface="in" units="mM"/>
<variable name="Ko" private_interface="out" public_interface="in" units="mM"/>
<variable name="n_K" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="x_K" private_interface="out" units="dimensionless"/>
<variable name="x_Na" private_interface="out" units="dimensionless"/>
<variable name="k_NaK" private_interface="in" units="dimensionless"/>
<variable name="n_NaK" private_interface="in" units="dimensionless"/>
<variable name="f_NaK" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>x_K</ci>
<apply>
<divide/>
<ci>K_dK</ci>
<ci>Ko</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>x_Na</ci>
<apply>
<divide/>
<ci>K_dNa</ci>
<ci>Nai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>f_NaK</ci>
<apply>
<divide/>
<cn cellml:units="mV">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.125</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.00219</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Nao</ci>
<cn cellml:units="mM">49.71</cn>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.9</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NaK</ci>
<apply>
<times/>
<ci>g_NaK</ci>
<ci>f_NaK</ci>
<ci>k_NaK</ci>
<ci>n_NaK</ci>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="INaK">
<component_ref component="k_NaK"/>
<component_ref component="n_NaK"/>
</component_ref>
</group>
<connection>
<map_components component_1="INaK" component_2="k_NaK"/>
<map_variables variable_1="x_K" variable_2="x"/>
<map_variables variable_1="n_K" variable_2="n"/>
<map_variables variable_1="k_NaK" variable_2="H"/>
</connection>
<connection>
<map_components component_1="INaK" component_2="n_NaK"/>
<map_variables variable_1="x_Na" variable_2="x"/>
<map_variables variable_1="n_Na" variable_2="n"/>
<map_variables variable_1="n_NaK" variable_2="H"/>
</connection>
</model>
