- Author:
- Shelley Fong <s.fong@auckland.ac.nz>
- Date:
- 2021-08-30 16:26:13+12:00
- Desc:
- Tidying up files
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/6d7/rawfile/7a36015b3f70ec9820982a063bb41e8bf3b87260/BG_LCC_flat.cellml
<?xml version="1.0" encoding="utf-8"?>
<!--
This CellML file was generated on 25/08/2021 at 1:58:37 at PM using:
COR (0.9.31.1409)
Copyright 2002-2021 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.cellml.org/
-->
<model name="LCC" cmeta:id="LCC" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<units xmlns="http://www.cellml.org/cellml/1.0#" name="per_second">
<unit units="second" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="J_per_K_per_mol">
<unit units="joule"/>
<unit units="kelvin" exponent="-1"/>
<unit units="mole" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="J_per_C">
<unit units="joule"/>
<unit units="coulomb" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="C_per_mol">
<unit units="coulomb"/>
<unit units="mole" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="fmol">
<unit units="mole" prefix="femto"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="fmol_per_L">
<unit units="mole" prefix="femto"/>
<unit units="litre" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="fmol_per_L_per_sec">
<unit units="fmol_per_L"/>
<unit units="second" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="per_sec_per_fmol_per_L">
<unit units="second" exponent="-1"/>
<unit units="fmol_per_L" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="per_fmol">
<unit units="fmol" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="fmol_per_sec">
<unit units="fmol"/>
<unit units="second" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="J_per_mol">
<unit units="joule"/>
<unit units="mole" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="mM">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="uM">
<unit units="mole" prefix="micro"/>
<unit units="litre" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="mM_per_sec">
<unit units="mM"/>
<unit units="second" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="uM_per_sec">
<unit units="uM"/>
<unit units="second" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="pL">
<unit units="litre" prefix="pico"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="fA">
<unit units="ampere" prefix="femto"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="fC">
<unit units="coulomb" prefix="femto"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="fF">
<unit units="farad" prefix="femto"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="millivolt">
<unit units="volt" prefix="milli"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="microm3">
<unit units="metre" prefix="micro" exponent="3"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="m_to_u">
<unit units="second" prefix="micro"/>
<unit units="second" prefix="milli"/>
</units>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="membrane">
<variable name="t" units="second" public_interface="out"/>
<variable name="Vmem" units="volt"/>
<variable name="q_membrane" units="fC" initial_value="-13039" public_interface="out"/>
<variable name="C_m" units="fF" initial_value="153400" public_interface="out"/>
<variable name="RT" units="J_per_mol" initial_value="2494.34" public_interface="out"/>
<variable name="F" units="C_per_mol" initial_value="96485" public_interface="out"/>
<variable name="vol_o" units="microm3" initial_value="1e4" public_interface="out"/>
<variable name="q_Cao" units="fmol" initial_value="9.3276" public_interface="out"/>
<variable name="q_Cai" units="fmol" initial_value="0.00456" public_interface="out"/>
<variable name="q_Ko" units="fmol" initial_value="27.9828" public_interface="out"/>
<variable name="q_Ki" units="fmol" initial_value="5510" public_interface="out"/>
<variable name="v_CaGHK_i" units="fmol_per_sec" public_interface="in"/>
<variable name="v_CaGHK_o" units="fmol_per_sec" public_interface="in"/>
<variable name="v_KGHK_i" units="fmol_per_sec" public_interface="in"/>
<variable name="v_KGHK_o" units="fmol_per_sec" public_interface="in"/>
<variable name="v_E" units="fA"/>
<variable name="zCa" units="dimensionless" initial_value="2" public_interface="out"/>
<variable name="zK" units="dimensionless" initial_value="1" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>v_E</ci>
<apply>
<times/>
<ci>zCa</ci>
<ci>F</ci>
<apply>
<plus/>
<ci>v_CaGHK_o</ci>
<ci>v_KGHK_o</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_Cai</ci>
</apply>
<ci>v_CaGHK_i</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_Cao</ci>
</apply>
<ci>v_CaGHK_o</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_Ki</ci>
</apply>
<ci>v_KGHK_i</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_Ko</ci>
</apply>
<ci>v_KGHK_o</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_membrane</ci>
</apply>
<apply>
<minus/>
<ci>v_E</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Vmem</ci>
<apply>
<divide/>
<ci>q_membrane</ci>
<ci>C_m</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="BG_LCC">
<variable name="t" units="second" public_interface="in" private_interface="out"/>
<variable name="RT" units="J_per_mol" public_interface="in" private_interface="out"/>
<variable name="F" units="C_per_mol" public_interface="in" private_interface="out"/>
<variable name="C_m" units="fF" public_interface="in"/>
<variable name="K_Cai" units="per_fmol" initial_value="0.0102432"/>
<variable name="K_Cao" units="per_fmol" initial_value="0.0751143"/>
<variable name="K_Ki" units="per_fmol" initial_value="0.00578984"/>
<variable name="K_Ko" units="per_fmol" initial_value="0.0424574"/>
<variable name="kappa_LCC_Ca1" units="fmol_per_sec" initial_value="115.689"/>
<variable name="kappa_LCC_Ca2" units="fmol_per_sec" initial_value="216.336"/>
<variable name="kappa_LCC_K1" units="fmol_per_sec" initial_value="0.160891"/>
<variable name="kappa_LCC_K2" units="fmol_per_sec" initial_value="0.300862"/>
<variable name="Cao" units="mM"/>
<variable name="vol_o" units="microm3" public_interface="in"/>
<variable name="zCa" units="dimensionless" public_interface="in"/>
<variable name="zK" units="dimensionless" public_interface="in"/>
<variable name="q_Cai" units="fmol" public_interface="in"/>
<variable name="q_Cao" units="fmol" public_interface="in"/>
<variable name="q_Ki" units="fmol" public_interface="in"/>
<variable name="q_Ko" units="fmol" public_interface="in"/>
<variable name="q_E" units="fC" public_interface="in"/>
<variable name="mu_E" units="J_per_C" private_interface="out"/>
<variable name="mu_mem_Ca" units="J_per_mol"/>
<variable name="mu_mem_K" units="J_per_mol"/>
<variable name="v_CaGHK_i" units="fmol_per_sec" public_interface="out"/>
<variable name="v_CaGHK_o" units="fmol_per_sec" public_interface="out"/>
<variable name="v_KGHK_i" units="fmol_per_sec" public_interface="out"/>
<variable name="v_KGHK_o" units="fmol_per_sec" public_interface="out"/>
<variable name="mu_Cai" units="J_per_mol" private_interface="out"/>
<variable name="mu_Cao" units="J_per_mol"/>
<variable name="mu_Ki" units="J_per_mol"/>
<variable name="mu_Ko" units="J_per_mol"/>
<variable name="mu_S111" units="J_per_mol" private_interface="in"/>
<variable name="mu_S121" units="J_per_mol" private_interface="in"/>
<variable name="Af_LCC_Ca1" units="J_per_mol"/>
<variable name="Ar_LCC_Ca1" units="J_per_mol"/>
<variable name="Am_LCC_Ca1" units="J_per_mol"/>
<variable name="v_LCC_Ca1" units="fmol_per_sec" public_interface="out"/>
<variable name="Af_LCC_Ca2" units="J_per_mol"/>
<variable name="Ar_LCC_Ca2" units="J_per_mol"/>
<variable name="Am_LCC_Ca2" units="J_per_mol"/>
<variable name="v_LCC_Ca2" units="fmol_per_sec" public_interface="out"/>
<variable name="Af_LCC_K1" units="J_per_mol"/>
<variable name="Ar_LCC_K1" units="J_per_mol"/>
<variable name="Am_LCC_K1" units="J_per_mol"/>
<variable name="v_LCC_K1" units="fmol_per_sec" public_interface="out"/>
<variable name="Af_LCC_K2" units="J_per_mol"/>
<variable name="Ar_LCC_K2" units="J_per_mol"/>
<variable name="Am_LCC_K2" units="J_per_mol"/>
<variable name="v_LCC_K2" units="fmol_per_sec" public_interface="out"/>
<variable name="v_fCa00" units="fmol_per_sec" private_interface="in"/>
<variable name="v_fCa01" units="fmol_per_sec" private_interface="in"/>
<variable name="v_fCa02" units="fmol_per_sec" private_interface="in"/>
<variable name="v_fCa10" units="fmol_per_sec" private_interface="in"/>
<variable name="v_fCa11" units="fmol_per_sec" private_interface="in"/>
<variable name="v_fCa12" units="fmol_per_sec" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>mu_Cai</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Cai</ci>
<ci>q_Cai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Cao</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Cao</ci>
<ci>q_Cao</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Ki</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Ki</ci>
<ci>q_Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Ko</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Ko</ci>
<ci>q_Ko</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Cao</ci>
<apply>
<divide/>
<apply>
<times/>
<cn type="e-notation" cellml:units="dimensionless">1 <sep/>
-3</cn>
<ci>q_Cao</ci>
</apply>
<ci>vol_o</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_mem_Ca</ci>
<apply>
<times/>
<ci>zCa</ci>
<ci>F</ci>
<ci>mu_E</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_mem_K</ci>
<apply>
<times/>
<ci>zK</ci>
<ci>F</ci>
<ci>mu_E</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_LCC_Ca1</ci>
<apply>
<plus/>
<ci>mu_Cai</ci>
<ci>mu_mem_Ca</ci>
<ci>mu_S111</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_LCC_Ca1</ci>
<apply>
<plus/>
<ci>mu_Cao</ci>
<ci>mu_S111</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Am_LCC_Ca1</ci>
<ci>mu_mem_Ca</ci>
</apply>
<apply>
<eq/>
<ci>v_LCC_Ca1</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>kappa_LCC_Ca1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_LCC_Ca1</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_LCC_Ca1</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Am_LCC_Ca1</ci>
<cn cellml:units="J_per_mol">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>kappa_LCC_Ca1</ci>
<ci>Am_LCC_Ca1</ci>
</apply>
<ci>RT</ci>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Am_LCC_Ca1</ci>
<ci>RT</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_LCC_Ca1</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_LCC_Ca1</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>Af_LCC_Ca2</ci>
<apply>
<plus/>
<ci>mu_Cai</ci>
<ci>mu_mem_Ca</ci>
<ci>mu_S121</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_LCC_Ca2</ci>
<apply>
<plus/>
<ci>mu_Cao</ci>
<ci>mu_S121</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Am_LCC_Ca2</ci>
<ci>mu_mem_Ca</ci>
</apply>
<apply>
<eq/>
<ci>v_LCC_Ca2</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>kappa_LCC_Ca2</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_LCC_Ca2</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_LCC_Ca2</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Am_LCC_Ca2</ci>
<cn cellml:units="J_per_mol">0</cn>
</apply>
</piece>
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<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>kappa_LCC_Ca2</ci>
<ci>Am_LCC_Ca2</ci>
</apply>
<ci>RT</ci>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Am_LCC_Ca2</ci>
<ci>RT</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_LCC_Ca2</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_LCC_Ca2</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
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<apply>
<eq/>
<ci>Af_LCC_K1</ci>
<apply>
<plus/>
<ci>mu_Ki</ci>
<ci>mu_mem_K</ci>
<ci>mu_S111</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_LCC_K1</ci>
<apply>
<plus/>
<ci>mu_Ko</ci>
<ci>mu_S111</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Am_LCC_K1</ci>
<ci>mu_mem_K</ci>
</apply>
<apply>
<eq/>
<ci>v_LCC_K1</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>kappa_LCC_K1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_LCC_K1</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_LCC_K1</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Am_LCC_K1</ci>
<cn cellml:units="J_per_mol">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>kappa_LCC_K1</ci>
<ci>Am_LCC_K1</ci>
</apply>
<ci>RT</ci>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Am_LCC_K1</ci>
<ci>RT</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_LCC_K1</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_LCC_K1</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>Af_LCC_K2</ci>
<apply>
<plus/>
<ci>mu_Ki</ci>
<ci>mu_mem_K</ci>
<ci>mu_S121</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_LCC_K2</ci>
<apply>
<plus/>
<ci>mu_Ko</ci>
<ci>mu_S121</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Am_LCC_K2</ci>
<ci>mu_mem_K</ci>
</apply>
<apply>
<eq/>
<ci>v_LCC_K2</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>kappa_LCC_K2</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_LCC_K2</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_LCC_K2</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Am_LCC_K2</ci>
<cn cellml:units="J_per_mol">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>kappa_LCC_K2</ci>
<ci>Am_LCC_K2</ci>
</apply>
<ci>RT</ci>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Am_LCC_K2</ci>
<ci>RT</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_LCC_K2</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_LCC_K2</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>mu_E</ci>
<apply>
<divide/>
<ci>q_E</ci>
<ci>C_m</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_CaGHK_i</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>zCa</ci>
<apply>
<plus/>
<ci>v_fCa10</ci>
<ci>v_fCa11</ci>
<ci>v_fCa02</ci>
<ci>v_fCa01</ci>
<ci>v_fCa00</ci>
<ci>v_fCa12</ci>
</apply>
</apply>
<ci>v_LCC_Ca1</ci>
</apply>
<ci>v_LCC_Ca2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_CaGHK_o</ci>
<apply>
<plus/>
<ci>v_LCC_Ca2</ci>
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<apply>
<divide/>
<ci>Af_f3_010</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_f3_010</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_f1_100</ci>
<apply>
<plus/>
<ci>mu_S100_LCC</ci>
<apply>
<times/>
<ci>z_ff1</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_f1_100</ci>
<apply>
<plus/>
<ci>mu_S110_LCC</ci>
<apply>
<times/>
<ci>z_rf1</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f1_100</ci>
<apply>
<times/>
<ci>kappa_f1_100</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_f1_100</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_f1_100</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_f2_100</ci>
<apply>
<plus/>
<ci>mu_S100_LCC</ci>
<apply>
<times/>
<ci>z_ff2</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_f2_100</ci>
<apply>
<plus/>
<ci>mu_S120_LCC</ci>
<apply>
<times/>
<ci>z_rf2</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f2_100</ci>
<apply>
<times/>
<ci>kappa_f2_100</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_f2_100</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_f2_100</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_f3_110</ci>
<apply>
<plus/>
<ci>mu_S110_LCC</ci>
<apply>
<times/>
<ci>z_ff3</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_f3_110</ci>
<apply>
<plus/>
<ci>mu_S120_LCC</ci>
<apply>
<times/>
<ci>z_rf3</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f3_110</ci>
<apply>
<times/>
<ci>kappa_f3_110</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_f3_110</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_f3_110</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_d001</ci>
<apply>
<plus/>
<ci>mu_S001_LCC</ci>
<apply>
<times/>
<ci>z_fd</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_d001</ci>
<apply>
<plus/>
<ci>mu_S101_LCC</ci>
<apply>
<times/>
<ci>z_rd</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_d001</ci>
<apply>
<times/>
<ci>kappa_d001</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_d001</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_d001</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_d011</ci>
<apply>
<plus/>
<ci>mu_S011_LCC</ci>
<apply>
<times/>
<ci>z_fd</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_d011</ci>
<apply>
<plus/>
<ci>mu_S111_LCC</ci>
<apply>
<times/>
<ci>z_rd</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_d011</ci>
<apply>
<times/>
<ci>kappa_d011</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_d011</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_d011</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_d021</ci>
<apply>
<plus/>
<ci>mu_S021_LCC</ci>
<apply>
<times/>
<ci>z_fd</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_d021</ci>
<apply>
<plus/>
<ci>mu_S121_LCC</ci>
<apply>
<times/>
<ci>z_rd</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_d021</ci>
<apply>
<times/>
<ci>kappa_d021</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_d021</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_d021</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_f1_001</ci>
<apply>
<plus/>
<ci>mu_S001_LCC</ci>
<apply>
<times/>
<ci>z_ff1</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_f1_001</ci>
<apply>
<plus/>
<ci>mu_S011_LCC</ci>
<apply>
<times/>
<ci>z_rf1</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f1_001</ci>
<apply>
<times/>
<ci>kappa_f1_001</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_f1_001</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_f1_001</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_f2_001</ci>
<apply>
<plus/>
<ci>mu_S001_LCC</ci>
<apply>
<times/>
<ci>z_ff2</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_f2_001</ci>
<apply>
<plus/>
<ci>mu_S021_LCC</ci>
<apply>
<times/>
<ci>z_rf2</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f2_001</ci>
<apply>
<times/>
<ci>kappa_f2_001</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_f2_001</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_f2_001</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_f3_011</ci>
<apply>
<plus/>
<ci>mu_S011_LCC</ci>
<apply>
<times/>
<ci>z_ff3</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_f3_011</ci>
<apply>
<plus/>
<ci>mu_S021_LCC</ci>
<apply>
<times/>
<ci>z_rf3</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f3_011</ci>
<apply>
<times/>
<ci>kappa_f3_011</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_f3_011</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_f3_011</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_f1_101</ci>
<apply>
<plus/>
<ci>mu_S101_LCC</ci>
<apply>
<times/>
<ci>z_ff1</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_f1_101</ci>
<apply>
<plus/>
<ci>mu_S111_LCC</ci>
<apply>
<times/>
<ci>z_rf1</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f1_101</ci>
<apply>
<times/>
<ci>kappa_f1_101</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_f1_101</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_f1_101</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_f2_101</ci>
<apply>
<plus/>
<ci>mu_S101_LCC</ci>
<apply>
<times/>
<ci>z_ff2</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_f2_101</ci>
<apply>
<plus/>
<ci>mu_S121_LCC</ci>
<apply>
<times/>
<ci>z_rf2</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f2_101</ci>
<apply>
<times/>
<ci>kappa_f2_101</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_f2_101</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_f2_101</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_f3_111</ci>
<apply>
<plus/>
<ci>mu_S111_LCC</ci>
<apply>
<times/>
<ci>z_ff3</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_f3_111</ci>
<apply>
<plus/>
<ci>mu_S121_LCC</ci>
<apply>
<times/>
<ci>z_rf3</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f3_111</ci>
<apply>
<times/>
<ci>kappa_f3_111</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_f3_111</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_f3_111</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S000_LCC</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_d000</ci>
</apply>
<ci>v_f1_000</ci>
</apply>
<ci>v_f2_000</ci>
</apply>
<ci>v_fCa00</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_S000_LCC</ci>
</apply>
<ci>v_S000_LCC</ci>
</apply>
<apply>
<eq/>
<ci>mu_S000_LCC</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_000_LCC</ci>
<ci>q_S000_LCC</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S010_LCC</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_d010</ci>
</apply>
<ci>v_f3_010</ci>
</apply>
<ci>v_f1_100</ci>
</apply>
<ci>v_fCa01</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_S010_LCC</ci>
</apply>
<ci>v_S010_LCC</ci>
</apply>
<apply>
<eq/>
<ci>mu_S010_LCC</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_010_LCC</ci>
<ci>q_S010_LCC</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S020_LCC</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_d020</ci>
</apply>
<ci>v_f3_010</ci>
<ci>v_f2_000</ci>
</apply>
<ci>v_fCa02</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_S020_LCC</ci>
</apply>
<ci>v_S020_LCC</ci>
</apply>
<apply>
<eq/>
<ci>mu_S020_LCC</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_020_LCC</ci>
<ci>q_S020_LCC</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S100_LCC</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_f2_100</ci>
</apply>
<ci>v_d000</ci>
</apply>
<ci>v_f1_100</ci>
</apply>
<ci>v_fCa10</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_S100_LCC</ci>
</apply>
<ci>v_S100_LCC</ci>
</apply>
<apply>
<eq/>
<ci>mu_S100_LCC</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_100_LCC</ci>
<ci>q_S100_LCC</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S110_LCC</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>v_f1_100</ci>
<ci>v_d010</ci>
</apply>
<ci>v_fCa11</ci>
</apply>
<ci>v_f3_110</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_S110_LCC</ci>
</apply>
<ci>v_S110_LCC</ci>
</apply>
<apply>
<eq/>
<ci>mu_S110_LCC</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_110_LCC</ci>
<ci>q_S110_LCC</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S120_LCC</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>v_f2_100</ci>
<ci>v_d020</ci>
</apply>
<ci>v_fCa12</ci>
</apply>
<ci>v_f3_110</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_S120_LCC</ci>
</apply>
<ci>v_S120_LCC</ci>
</apply>
<apply>
<eq/>
<ci>mu_S120_LCC</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_120_LCC</ci>
<ci>q_S120_LCC</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S001_LCC</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_d001</ci>
</apply>
<ci>v_f1_001</ci>
</apply>
<ci>v_f2_001</ci>
</apply>
<ci>v_fCa00</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_S001_LCC</ci>
</apply>
<ci>v_S001_LCC</ci>
</apply>
<apply>
<eq/>
<ci>mu_S001_LCC</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_001_LCC</ci>
<ci>q_S001_LCC</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S011_LCC</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_d011</ci>
</apply>
<ci>v_f3_011</ci>
</apply>
<ci>v_f1_101</ci>
<ci>v_fCa01</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_S011_LCC</ci>
</apply>
<ci>v_S011_LCC</ci>
</apply>
<apply>
<eq/>
<ci>mu_S011_LCC</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_011_LCC</ci>
<ci>q_S011_LCC</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S021_LCC</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_d021</ci>
</apply>
<ci>v_f3_011</ci>
<ci>v_f2_001</ci>
<ci>v_fCa02</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_S021_LCC</ci>
</apply>
<ci>v_S021_LCC</ci>
</apply>
<apply>
<eq/>
<ci>mu_S021_LCC</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_021_LCC</ci>
<ci>q_S021_LCC</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S101_LCC</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_f2_101</ci>
</apply>
<ci>v_d001</ci>
</apply>
<ci>v_f1_101</ci>
</apply>
<ci>v_fCa10</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_S101_LCC</ci>
</apply>
<ci>v_S101_LCC</ci>
</apply>
<apply>
<eq/>
<ci>mu_S101_LCC</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_101_LCC</ci>
<ci>q_S101_LCC</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S111_LCC</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>v_f1_101</ci>
<ci>v_d011</ci>
<ci>v_fCa11</ci>
</apply>
<ci>v_f3_111</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_S111_LCC</ci>
</apply>
<ci>v_S111_LCC</ci>
</apply>
<apply>
<eq/>
<ci>mu_S111_LCC</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_111_LCC</ci>
<ci>q_S111_LCC</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S121_LCC</ci>
<apply>
<plus/>
<ci>v_f2_101</ci>
<ci>v_d021</ci>
<ci>v_fCa12</ci>
<ci>v_f3_111</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_S121_LCC</ci>
</apply>
<ci>v_S121_LCC</ci>
</apply>
<apply>
<eq/>
<ci>mu_S121_LCC</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_121_LCC</ci>
<ci>q_S121_LCC</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<group xmlns="http://www.cellml.org/cellml/1.0#">
<relationship_ref relationship="encapsulation"/>
<component_ref component="BG_LCC">
<component_ref component="LCC_states_BG"/>
</component_ref>
</group>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="membrane" component_2="BG_LCC"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="RT" variable_2="RT"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="q_Cai" variable_2="q_Cai"/>
<map_variables variable_1="q_Cao" variable_2="q_Cao"/>
<map_variables variable_1="q_Ki" variable_2="q_Ki"/>
<map_variables variable_1="q_Ko" variable_2="q_Ko"/>
<map_variables variable_1="q_membrane" variable_2="q_E"/>
<map_variables variable_1="C_m" variable_2="C_m"/>
<map_variables variable_1="vol_o" variable_2="vol_o"/>
<map_variables variable_1="v_CaGHK_i" variable_2="v_CaGHK_i"/>
<map_variables variable_1="v_CaGHK_o" variable_2="v_CaGHK_o"/>
<map_variables variable_1="v_KGHK_i" variable_2="v_KGHK_i"/>
<map_variables variable_1="v_KGHK_o" variable_2="v_KGHK_o"/>
<map_variables variable_1="zCa" variable_2="zCa"/>
<map_variables variable_1="zK" variable_2="zK"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="BG_LCC" component_2="LCC_states_BG"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="RT" variable_2="RT"/>
<map_variables variable_1="mu_E" variable_2="Vmem"/>
<map_variables variable_1="mu_Cai" variable_2="mu_Cai"/>
<map_variables variable_1="mu_S111" variable_2="mu_S111_LCC"/>
<map_variables variable_1="mu_S121" variable_2="mu_S121_LCC"/>
<map_variables variable_1="v_fCa00" variable_2="v_fCa00"/>
<map_variables variable_1="v_fCa01" variable_2="v_fCa01"/>
<map_variables variable_1="v_fCa02" variable_2="v_fCa02"/>
<map_variables variable_1="v_fCa10" variable_2="v_fCa10"/>
<map_variables variable_1="v_fCa11" variable_2="v_fCa11"/>
<map_variables variable_1="v_fCa12" variable_2="v_fCa12"/>
</connection>
</model>
