Location: BG_PLB @ bdc41c1cc38a / BG_PLB.cellml

Author:
Shelley Fong <s.fong@auckland.ac.nz>
Date:
2022-02-18 13:32:23+13:00
Desc:
Updating way cellml is written
Permanent Source URI:
https://models.physiomeproject.org/workspace/6d1/rawfile/bdc41c1cc38a5bf33b62e6b5432fc23e17a15dfa/BG_PLB.cellml

<?xml version='1.0' encoding='UTF-8'?>
<!-- PLB module, 
 5 Aug 21 - not containing Inhib1 reactions (this is a separate module)
            Use [Ip] where [Ip] = [Ip] + [Ip_S2]
            Use [PKACI] where [PKACI] = [PKACI] + [PKACI_S2]-->
<model name="BG_PLB" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
    <import xlink:href="units_and_constants/units_BG.cellml">
        <units name="per_sec" units_ref="per_sec"/>
        <units name="J_per_K_per_mol" units_ref="J_per_K_per_mol"/>
        <units name="C_per_mol" units_ref="C_per_mol"/>
        <units name="fmol" units_ref="fmol"/>
        <units name="fmol_per_L" units_ref="fmol_per_L"/>
        <units name="fmol_per_L_per_sec" units_ref="fmol_per_L_per_sec"/>
        <units name="per_sec_per_fmol_per_L" units_ref="per_sec_per_fmol_per_L"/>
        <units name="per_fmol" units_ref="per_fmol"/>
        <units name="fmol_per_sec" units_ref="fmol_per_sec"/>
        <units name="J_per_mol" units_ref="J_per_mol"/>
        <units name="mM" units_ref="mM"/>
        <units name="uM" units_ref="uM"/>
        <units name="mM_per_sec" units_ref="mM_per_sec"/>
        <units name="uM_per_sec" units_ref="uM_per_sec"/>
        <units name="pL" units_ref="pL"/>
        <units name="m_to_u" units_ref="m_to_u"/>
    </import>
    <import xlink:href="units_and_constants/constants_BG.cellml">
        <component component_ref="constants" name="constants"/>
    </import>
    <component name="environment">
        <variable name="time" public_interface="out" units="second"/>
        <variable initial_value="4.028E+00" name="q_PLB" public_interface="out" units="fmol"/>
        <variable initial_value="1.117E-03" name="q_PKACI" public_interface="out" units="fmol"/>
        <variable initial_value="1e-13" name="q_PLB_PKACI" public_interface="out" units="fmol"/>
        <variable initial_value="3.382E-02" name="q_PP1" public_interface="out" units="fmol"/>
        <variable initial_value="1e-13" name="q_PLBp_PP1" public_interface="out" units="fmol"/>
        <variable initial_value="1.560E-01" name="q_PLBp" public_interface="out" units="fmol"/>
        <variable initial_value="9.994E-04" name="q_Ip" public_interface="out" units="fmol"/>
        <variable initial_value="1e-13" name="q_Ip_PP1" public_interface="out" units="fmol"/>
        <!-- From submodule-->
        <variable name="v_PLBph1" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_PLBph2" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_PLBd1" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_PLBd2" public_interface="in" units="fmol_per_sec"/>
        <variable name="v_Inh" public_interface="in" units="fmol_per_sec"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_PLB</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_PLBd2</ci>
                    <ci>v_PLBph1</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_PKACI</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_PLBph2</ci>
                    <ci>v_PLBph1</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_PLB_PKACI</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_PLBph1</ci>
                    <ci>v_PLBph2</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_PP1</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <ci>v_PLBd2</ci>
                        <ci>v_PLBd1</ci>
                    </apply>
                    <ci>v_Inh</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_PLBp_PP1</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_PLBd1</ci>
                    <ci>v_PLBd2</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_PLBp</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_PLBph2</ci>
                    <ci>v_PLBd1</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_Ip</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>v_Inh</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>q_Ip_PP1</ci>
                </apply>
                <ci>v_Inh</ci>
            </apply>
        </math>
    </component>
    <component name="PLB_parameters">
        <variable initial_value="45.5263" name="kappa_PLBph1" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="6.55904" name="kappa_PLBph2" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.386674" name="kappa_PLBd1" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="1.21269" name="kappa_PLBd2" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="431.435" name="kappa_Inh" public_interface="out" units="fmol_per_sec"/>
        <variable initial_value="0.00235741" name="K_PLB" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.395191" name="K_PKACI" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.638527" name="K_PLB_PKACI" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.361989" name="K_PP1" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.203757" name="K_PLBp_PP1" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.326014" name="K_PLBp" public_interface="out" units="per_fmol"/>
        <variable initial_value="5.41093" name="K_Ip" public_interface="out" units="per_fmol"/>
        <variable initial_value="0.0673793" name="K_Ip_PP1" public_interface="out" units="per_fmol"/>
    </component>
    <component name="PLB">
        <variable name="time" public_interface="in" units="second"/>
        <variable name="R" public_interface="in" units="J_per_K_per_mol"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <!-- PLB parameters-->
        <variable name="kappa_PLBph1" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_PLBph2" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_PLBd1" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_PLBd2" public_interface="in" units="fmol_per_sec"/>
        <variable name="kappa_Inh" public_interface="in" units="fmol_per_sec"/>
        <variable name="K_PLB" public_interface="in" units="per_fmol"/>
        <variable name="K_PKACI" public_interface="in" units="per_fmol"/>
        <variable name="K_PLB_PKACI" public_interface="in" units="per_fmol"/>
        <variable name="K_PP1" public_interface="in" units="per_fmol"/>
        <variable name="K_PLBp_PP1" public_interface="in" units="per_fmol"/>
        <variable name="K_PLBp" public_interface="in" units="per_fmol"/>
        <variable name="K_Ip" public_interface="in" units="per_fmol"/>
        <variable name="K_Ip_PP1" public_interface="in" units="per_fmol"/>
        <variable name="v_PLBph1" public_interface="out" units="fmol_per_sec"/>
        <variable name="v_PLBph2" public_interface="out" units="fmol_per_sec"/>
        <variable name="v_PLBd1" public_interface="out" units="fmol_per_sec"/>
        <variable name="v_PLBd2" public_interface="out" units="fmol_per_sec"/>
        <variable name="v_Inh" public_interface="out" units="fmol_per_sec"/>
        <variable name="mu_PLB" units="J_per_mol"/>
        <variable name="mu_PKACI" units="J_per_mol"/>
        <variable name="mu_PLB_PKACI" units="J_per_mol"/>
        <variable name="mu_PP1" units="J_per_mol"/>
        <variable name="mu_PLBp_PP1" units="J_per_mol"/>
        <variable name="mu_PLBp" units="J_per_mol"/>
        <variable name="mu_Ip" units="J_per_mol"/>
        <variable name="mu_Ip_PP1" units="J_per_mol"/>
        <!-- Input from global environment-->
        <variable name="q_PLB" public_interface="in" units="fmol"/>
        <variable name="q_PKACI" public_interface="in" units="fmol"/>
        <variable name="q_PLB_PKACI" public_interface="in" units="fmol"/>
        <variable name="q_PP1" public_interface="in" units="fmol"/>
        <variable name="q_PLBp_PP1" public_interface="in" units="fmol"/>
        <variable name="q_PLBp" public_interface="in" units="fmol"/>
        <variable name="q_Ip" public_interface="in" units="fmol"/>
        <variable name="q_Ip_PP1" public_interface="in" units="fmol"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>mu_PLB</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_PLB</ci>
                            <ci>q_PLB</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_PKACI</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_PKACI</ci>
                            <ci>q_PKACI</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_PLB_PKACI</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_PLB_PKACI</ci>
                            <ci>q_PLB_PKACI</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_PP1</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_PP1</ci>
                            <ci>q_PP1</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_PLBp_PP1</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_PLBp_PP1</ci>
                            <ci>q_PLBp_PP1</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_PLBp</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_PLBp</ci>
                            <ci>q_PLBp</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_Ip</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_Ip</ci>
                            <ci>q_Ip</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu_Ip_PP1</ci>
                <apply>
                    <times/>
                    <ci>R</ci>
                    <ci>T</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <ci>K_Ip_PP1</ci>
                            <ci>q_Ip_PP1</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_PLBph1</ci>
                <apply>
                    <times/>
                    <ci>kappa_PLBph1</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_PLB</ci>
                                    <ci>mu_PKACI</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_PLB_PKACI</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_PLBph2</ci>
                <apply>
                    <times/>
                    <ci>kappa_PLBph2</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_PLB_PKACI</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_PLBp</ci>
                                    <ci>mu_PKACI</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_PLBd1</ci>
                <apply>
                    <times/>
                    <ci>kappa_PLBd1</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_PLBp</ci>
                                    <ci>mu_PP1</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_PLBp_PP1</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_PLBd2</ci>
                <apply>
                    <times/>
                    <ci>kappa_PLBd2</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_PLBp_PP1</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_PLB</ci>
                                    <ci>mu_PP1</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_Inh</ci>
                <apply>
                    <times/>
                    <ci>kappa_Inh</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>mu_PP1</ci>
                                    <ci>mu_Ip</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>mu_Ip_PP1</ci>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <connection>
        <map_components component_1="environment" component_2="PLB"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="q_PLB" variable_2="q_PLB"/>
        <map_variables variable_1="q_PKACI" variable_2="q_PKACI"/>
        <map_variables variable_1="q_PLB_PKACI" variable_2="q_PLB_PKACI"/>
        <map_variables variable_1="q_PP1" variable_2="q_PP1"/>
        <map_variables variable_1="q_PLBp_PP1" variable_2="q_PLBp_PP1"/>
        <map_variables variable_1="q_PLBp" variable_2="q_PLBp"/>
        <map_variables variable_1="q_Ip" variable_2="q_Ip"/>
        <map_variables variable_1="q_Ip_PP1" variable_2="q_Ip_PP1"/>
        <map_variables variable_1="v_PLBph1" variable_2="v_PLBph1"/>
        <map_variables variable_1="v_PLBph2" variable_2="v_PLBph2"/>
        <map_variables variable_1="v_PLBd1" variable_2="v_PLBd1"/>
        <map_variables variable_1="v_PLBd2" variable_2="v_PLBd2"/>
        <map_variables variable_1="v_Inh" variable_2="v_Inh"/>
    </connection>
    <connection>
        <map_components component_1="PLB_parameters" component_2="PLB"/>
        <map_variables variable_1="kappa_PLBph1" variable_2="kappa_PLBph1"/>
        <map_variables variable_1="kappa_PLBph2" variable_2="kappa_PLBph2"/>
        <map_variables variable_1="kappa_PLBd1" variable_2="kappa_PLBd1"/>
        <map_variables variable_1="kappa_PLBd2" variable_2="kappa_PLBd2"/>
        <map_variables variable_1="kappa_Inh" variable_2="kappa_Inh"/>
        <map_variables variable_1="K_PLB" variable_2="K_PLB"/>
        <map_variables variable_1="K_PKACI" variable_2="K_PKACI"/>
        <map_variables variable_1="K_PLB_PKACI" variable_2="K_PLB_PKACI"/>
        <map_variables variable_1="K_PP1" variable_2="K_PP1"/>
        <map_variables variable_1="K_PLBp_PP1" variable_2="K_PLBp_PP1"/>
        <map_variables variable_1="K_PLBp" variable_2="K_PLBp"/>
        <map_variables variable_1="K_Ip" variable_2="K_Ip"/>
        <map_variables variable_1="K_Ip_PP1" variable_2="K_Ip_PP1"/>
    </connection>
    <connection>
        <map_components component_1="constants" component_2="PLB"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
    </connection>
</model>